Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: Selective inhibitors of dopamine D 1 receptor

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 15, 2012, Pages 4862-4871

  Qian, Wangke ^a,b   Lu, Weijian ^b   Sun, Haifeng ^b   Li, Zeng ^b   Zhu, Liyuan ^b   Zhao, Rui ^c   Zhang, Lei ^b   Zhou, Shengbin ^b   Zhou, Yu ^b   Jiang, Hualiang ^b   Zhen, Xuechu ^b,c   Liu, Hong ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c SOOCHOW UNIVERSITY   (China)

Author keywords

Antagonist; Anti substance abuse; Dopamine receptor; Tetrahydroprotoberberine

Indexed keywords

1,2,3 TRIMETHOXY 10,11 METHYLENEDIOXYTETRAHYDROPROTOBERBERINE; 1,2,3,9,11 PENTAMETHOXY 12 HYDROMETHYLTETRAHYDROPROTOBERBERINE; 1,2,3,9,11 PENTAMETHOXYTETRAHYDROPROTOBERBERINE; 1,3 DIMETHOXY 4 HYDROMETHYL 10,11 METHYLENEDIOXYTETRAHYDROPROTOBERBERINE; 1,3,11 TRIMETHOXY 4 HYDROMETHYLTETRAHYDROPROTOBERBERINE; 1,3,9,11 TETRAMETHOXY 2 HYDROXYTETRAHYDROPROTOBERBERINE; 1,3,9,11 TETRAMETHOXYTETRAHYDROPROTOBERBERINE; 1,3,9,12 TETRAMETHOXY 4 HYDROMETHYLTETRAHYDROPROTOBERBERINE; 2 (BENZYLOXY) 1,3,9,11 TETRAMETHOXYTETRAHYDROPROTOBERBERINE; 2 (BENZYLOXY) 3,11 DIMETHOXYTETRAHYDROPROTOBERBERINE; 2 HYDROXY 3 METHOXY 9,11 DIMETHYLTETRAHYDROPROTOBERBERINE; 2 HYDROXY 3,11 DIMETHOXYTETRAHYDROPROTOBERBERINE; 2 HYDROXY 3,9,11 TRIMETHOXY 12 HYDROXYMETHYLTETRAHYDROPROTOBERBERINE; 2 HYDROXY 3,9,11 TRIMETHOXYTETRAHYDROPROTOBERBERINE; 2,3 DIMETHYLOXY 9,11 DIMETHYLTETRAHYDROPROTOBERBERINE; 2,3 METHYLENEDIOXY 11 METHOXYTETRAHYDROPROTOBERBERINE; 2,3 METHYLENEDIOXY 9,11 DIMETHOXY 12 HYDROMETHYLTETRAHYDROPROTOBERBERINE; 2,3 METHYLENEDIOXY 9,11 DIMETHOXYLTETRAHYDROPROTOBERBERINE; 2,3,11 TRIMETHOXYTETRAHYDROPROTOBERBERINE; 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 2,3,9,11 TETRAMETHOXY 12 HYDROXYMETHYLTETRAHYDROPROTOBERBERINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; BERBINE DERIVATIVE; DOPAMINE 1 RECEPTOR; DOPAMINE 1 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; STEPHOLIDINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; IC 50; MOLECULAR MODEL; PHARMACOPHORE; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION;

BERBERINE ALKALOIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTORS, DOPAMINE D1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863983458     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.05.057     Document Type: Article

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