Development and statistical optimization of chitosan and eudragit based gastroretentive controlled release multiparticulate system for bioavailability enhancement of metformin HCl

Journal of Pharmaceutical Investigation

Volumn 46, Issue 3, 2016, Pages 239-252

  Sahu, Atul Kumar ^a   Verma, Amita ^b  

^a Shambhunath Institute of Pharmacy   (India)

^b SAM HIGGINBOTTOM UNIVERSITY OF AGRICULTURE   (India)

Author keywords

Full factorial design; Kinetic modeling; Metformin hydrochloride; NIDDM; Pharmacokinetics

Indexed keywords

CHITOSAN; EUDRAGIT; EUDRAGIT RS; METFORMIN;

ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG RELEASE; DRUG SOLUBILITY; ENCAPSULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SYNTHESIS; TEMPERATURE; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 84971510684     PISSN: 20935552     EISSN: 20936214     Source Type: Journal    
DOI: 10.1007/s40005-016-0229-0     Document Type: Article

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