Formulation and evaluation of novel solid lipid microparticles as a sustained release system for the delivery of metformin hydrochloride

Drug Delivery

Volumn 20, Issue 3-4, 2013, Pages 102-111

  Momoh, M A ^a   Kenechukwu, F C ^a   Attama, A A ^a  

^a UNIVERSITY OF NIGERIA   (Nigeria)

Author keywords

Anti diabetic; Encapsulation efficiency; Metformin hydrochloride; Release; Solid lipid microparticles

Indexed keywords

BUFFER; GLUCOSE; MACROGOL 4000; METFORMIN; PHOSPHATIDYLCHOLINE; SOLID LIPID NANOPARTICLE;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SCREENING; DRUG STABILITY; EMULSION; FEMALE; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; MALE; MICELLE; MORPHOLOGY; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PRODUCTIVITY; RAT; SURFACE CHARGE; SUSTAINED DRUG RELEASE; ZETA POTENTIAL;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DIABETES MELLITUS, EXPERIMENTAL; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; FEMALE; GOATS; HYPOGLYCEMIC AGENTS; LIPID METABOLISM; MALE; METFORMIN; MICROSPHERES; NANOPARTICLES; PARTICLE SIZE; RANDOM ALLOCATION; RATS;

EID: 84879018579     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2013.779329     Document Type: Article

References (24)

1. Attama AA, Muller-Goymann CC. (2007). Investigation of surfacemodified solid lipid nanocontainers formulated with a heterolipidtemplated homolipid. Int J Pharm 334:179-89 (Pubitemid 46400318)
2. Attama AA, Muller-Goymann CC. (2006). A critical study of novel physically structured lipid matrices composed of a homolipid from Capra hircus and theobroma oil. Int J Pharm 322:67-78 (Pubitemid 44331526)
3. Attama AA, Nzekwe IT, Nnamani PO, et al. (2003). The use of solid self-emulsifying systems in the delivery of diclofenac. Int J Pharm 262:23-8 (Pubitemid 36966690)
4. Attama AA, Okafor CE, Builders PF, Okorie, O. (2009). Formulation and in vitro evaluation of a PEGylated microscopic lipospheres delivery system for ceftriaxone sodium. Drug Deliv 16: 448-57
5. Azeem A, Anwer MK, Talegaonkar S. (2009). Niosomes in sustained and targeted drug delivery: Some recent advances. J Drug Target 17: 671-89
6. Banerjee A, Roychoudhury J, Ali N. (2008). Stearylamine-bearing cationic liposomes kill leishmania parasites through surface exposed negatively charged phosphatidylserine. J Antimicrob Chemother 61: 103-10
7. Berchane NS, Carson KH, Rice-Ficht AC, Andrews MJ. (2007). Effect of mean diameter and polydispersity of PLG microspheres on drug release: Experiment and theory. Int J Pharm 337:118-26 (Pubitemid 46756043)
8. Chung YI, Kim YC, Kim YH, et al. (2010). The effect of surface functionalization of PLGA nanoparticles by heparin-or chitosanconjugated pluronic on tumor targeting. J Control Rel 143: 374-82
9. Friedrich I, Muller-Goymann CC. (2003). Characterization of solidified reverse micellar solutions (SRMS) and production development of SRMS-based nanosuspensions. Eur J Pharm Biopharm 56: 111-19 (Pubitemid 36802054)
10. Friedrich I, Papantoniou I, Muller-Goymann CC. (2000). Physicochemical characterization of a reverse micellar solution after loading with different drugs. Pharmazie 55:755-8
11. Friedrich I, Reichi S, Muller-Goymann CC. (2005). Drug release and permeation studies of nanosuspensions based on solidified reverse micellar solutions (SRMS). Int J Pharm 305:167-75 (Pubitemid 41562227)
12. Gursoy RN, Benita S. (2004). Self emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother 58:173-82 (Pubitemid 38479922)
13. Guruswami S, Kumar V, Mishra DN. (2006). Characterization and in vitro dissolution studies of solid systems of valdecoxib with chitosan. Chem Pharm Bull 54:1102-6 (Pubitemid 44166399)
14. Hauss DS. (2009). Oral lipid based formulations. Adv Drug Del Rev 57: 667-76
15. Hu FQ, Yuan H, Zhang HH, Fang M. (2002). Preparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization. Int J Pharm 239:121-8 (Pubitemid 34615801)
16. Jaspart S, Bertholet P, Piel G, et al. (2007). Solid lipid microparticles as sustained release system for pulmonary drug delivery. Eur J Pharm Biopharm 65:47-56 (Pubitemid 44827691)
17. Mao S, Germershaus O, Fischer D, et al. (2005). Uptake and transport of peg-graft-Trimethyl-chitosan copolymer-insulin nanocomplexes by epithelial cells. Pharmacol Res 22:2058-68 (Pubitemid 41821585)
18. Momoh MA, Adikwu MU, Ibezim CE, Attama AA. (2011). Effect of metformin and Vernonia amygdalina leaf extract loaded PEGylated-mucin formulation on haematological, kidney and liver indices of healthy and diabetes rats. J Pharm Res 4:3455-9
19. Muller RH, Mader K, Gohla S. (2000). Solid lipid nanoparticles (SLN) for controlled drug delivery: A review of the state of the art. Eur J Pharm Biopharm 50:161-77 (Pubitemid 30326695)
20. Nnamani PO, Attama AA, Ibezim CE, Adikwu MU. (2010). SRMS 142-based solid lipid microparticles: Application in oral delivery of glibenclamide to diabetic rats. Eur J Pharm Biopharm 76:68-74
21. Porter NL, Trevaskis WN. (2007). Charman, lipids and lipid-based formulations: Optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Disc 6:231-48
22. Reithermeier H, Hermann J, Gopferich A. (2001). Development and characterization of lipid microparticles as a drug carrier for somatostatin. Int J Pharm 218:133-43 (Pubitemid 32406164)
23. Schwarz C, Mehnert W, Lucks JS, Muller RH. (1994). Solid lipid nanoparticles (SLN) for controlled drug delivery. I Production, characterization and sterilization. J Control Rel 30:83-96 (Pubitemid 24173181)
24. Wong L, Galligan C, Li A, Wan PO. (1992). Preparation and characterization of sustained-release ibuprofen-cetostearyl alcohol microspheres. Int J Pharm 83:95-114