Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation

Oncotarget

Volumn 7, Issue 21, 2016, Pages 30307-30322

  Szaflarski, Witold ^a,b,c   Fay, Marta M ^a,b   Kedersha, Nancy ^a,b   Zabel, Maciej ^c   Anderson, Paul ^a,b   Ivanov, Pavel ^a,b,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

Cancer; Chemotherapy; Stress granules; Stress response; Translation initiation

Indexed keywords

INITIATION FACTOR 2ALPHA; INITIATION FACTOR 4E; NAVELBINE; PACLITAXEL; RIBONUCLEOPROTEIN; RNA; TAXANE DERIVATIVE; VINBLASTINE; VINCA ALKALOID; VINCRISTINE; ANTINEOPLASTIC AGENT; INITIATION FACTOR 2;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL METABOLISM; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DEFENSE MECHANISM; GENE EXPRESSION; HUMAN; HUMAN CELL; LUNG CANCER; MOLECULAR MECHANICS; OPEN READING FRAME; OSTEOSARCOMA; POLYSOME; PROTEIN PHOSPHORYLATION; RNA METABOLISM; STRESS; STRESS INDUCED TRANSLATIONAL REPRESSION; TRANSLATION INITIATION; UTERINE CERVIX CANCER; A-549 CELL LINE; ANIMAL; CELL CULTURE; CELL GRANULE; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; MCF-7 CELL LINE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGICAL STRESS; PROTEIN SYNTHESIS; RNA INTERFERENCE; TUMOR CELL LINE;

A549 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; CYTOPLASMIC GRANULES; EUKARYOTIC INITIATION FACTOR-2; HUMANS; MCF-7 CELLS; MICE, KNOCKOUT; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; RNA INTERFERENCE; STRESS, PHYSIOLOGICAL; VINCA ALKALOIDS; VINCRISTINE;

EID: 84971509036     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.8728     Document Type: Article

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