Prenatal organophosphorus pesticide exposure and child neurodevelopment at 24 months: An analysis of four birth cohorts

Environmental Health Perspectives

Volumn 124, Issue 6, 2016, Pages 822-830

  Engel, Stephanie M ^a   Bradman, Asa ^b   Wolff, Mary S ^c   Rauh, Virginia A ^d   Harley, Kim G ^b   Yang, Jenny H ^a   Hoepner, Lori A ^d   Barr, Dana Boyd ^e   Yolton, Kimberly ^f   Vedar, Michelle G ^b   Xu, Yingying ^f   Hornung, Richard W ^f   Wetmur, James G ^c   Chen, Jia ^c   Holland, Nina T ^b   Perera, Frederica P ^d   Whyatt, Robin M ^d   Lanphear, Bruce P ^g   Eskenazi, Brenda ^b  

^a IL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d Columbia University ^*  (United States)

^e EMORY UNIVERSITY   (United States)

^f CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^g SIMON FRASER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL ETHER; DICHLORVOS; DIETHYLAMINE; ORGANOPHOSPHATE PESTICIDE; PESTICIDE; POLLUTANT;

ADULT; ARTICLE; CHILD; COHORT ANALYSIS; ENVIRONMENTAL HEALTH; FEMALE; GENE FREQUENCY; GENETIC HETEROGENEITY; GENETIC POLYMORPHISM; GOVERNMENT; HEALTH CARE QUALITY; HUMAN; LIMIT OF DETECTION; MAJOR CLINICAL STUDY; MALE; NERVE CELL DIFFERENTIATION; PREGNANT WOMAN; PRENATAL CARE; PRENATAL DRUG EXPOSURE; PRESCHOOL CHILD; PRIORITY JOURNAL; PSYCHOMOTOR DEVELOPMENT; YOUNG ADULT; CHILD DEVELOPMENT; DRUG EFFECTS; EPIDEMIOLOGY; GROWTH, DEVELOPMENT AND AGING; INFANT; MATERNAL EXPOSURE; METABOLISM; NERVOUS SYSTEM; NETHERLANDS; POLLUTANT; PREGNANCY; PRENATAL EXPOSURE; STATISTICS AND NUMERICAL DATA; TOXICITY;

CHILD DEVELOPMENT; CHILD, PRESCHOOL; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; INFANT; MATERNAL EXPOSURE; NERVOUS SYSTEM; NETHERLANDS; PESTICIDES; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS;

EID: 84971500838     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1409474     Document Type: Article

References (43)

1. Barr DB, Allen R, Olsson AO, Bravo R, Caltabiano LM, Montesano A, et al. 2005. Concentrations of selective metabolites of organophosphorus pesticides in the United States population. Environ Res 99(3): 314-326.
2. Barr DB, Wong LY, Bravo R, Weerasekera G, Odetokun M, Restrepo P, et al. 2011. Urinary concentrations of dialkylphosphate metabolites of organophosphorus pesticides: National Health and Nutrition Examination Survey 1999-2004. Int J Environ Res Public Health 8(8): 3063-3098.
3. Bayley N. 1993. Bayley Scales of Infant Development. 2nd ed. San Antonio, TX: Harcourt Brace & Company.
4. Berkowitz GS, Obel J, Deych E, Lapinski R, Godbold J, Liu Z, et al. 2003. Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohort. Environ Health Perspect 111: 79-84, doi: 10. 1289/ ehp. 5619.
5. Berkowitz GS, Wetmur JG, Birman-Deych E, Obel J, Lapinski RH, Godbold JH, et al. 2004. In uteropesticide exposure, maternal paraoxonase activity, and head circumference. Environ Health Perspect 112: 388-391, doi: 10. 1289/ehp. 6414.
6. Bravo R, Caltabiano LM, Weerasekera G, Whitehead RD, Fernandez C, Needham LL, et al. 2004. Measurement of dialkyl phosphate metabolites of organophosphorus pesticides in human urine using lyophilization with gas chromatography-tandem mass spectrometry and isotope dilution quantification. J Expo Anal Environ Epidemiol 14(3): 249-259.
7. Caldwell BM, Bradley RH. 1984. Administration Manual: Home Observation For Measurement of the Environment. Revised ed. Little Rock, AR: University of Arkansas at Little Rock.
8. Chen A, Yolton K, Rauch SA, Webster GM, Hornung R, Sjödin A, et al. 2014. Prenatal polybrominated diphenyl ether exposures and neurodevelopment in U. S. children through 5 years of age: the HOME Study. Environ Health Perspect 122: 856-862, doi: 10. 1289/ehp. 1307562.
9. Chen J, Chan W, Wallenstein S, Berkowitz G, Wetmur JG. 2005. Haplotype-phenotype relationships of paraoxonase-1. Cancer Epidemiol Biomarkers Prev 14(3): 731-734.
10. Chen J, Kumar M, Chan W, Berkowitz G, WetmurJG. 2003. Increased influence of genetic variation on PON1 activity in neonates. Environ Health Perspect 111: 1403-1409, doi: 10. 1289/ehp. 6105.
11. Chen L, Zhao T, Pan C, Ross JH, Krieger RI. 2012. Preformed biomarkers including dialkylphosphates (DAPs) in produce may confound biomonitoring in pesticide exposure and risk assessment. J Agric Food Chem 60(36): 9342-9351.
12. Cole SR, Hernán MA. 2008. Constructing inverse probability weights for marginal structural models. Am J Epidemiol 168(6): 656-664.
13. Costa LG, Richter RJ, Li WF, Cole T, Guizzetti M, Furlong CE. 2003. Paraoxonase (PON 1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers 8(1): 1-12.
14. Curl CL, Fenske RA, Kissel JC, Shirai JH, Moate TF, Griffith W, et al. 2002. Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children. Environ Health Perspect 110: A787-A792.
15. Desquilbet L, Mariotti F. 2010. Dose-response analyses using restricted cubic spline functions in public health research. Stat Med 29(9): 1037-1057.
16. Deziel NC, Friesen MC, Hoppin JA, Hines CJ, Thomas K, Freeman LE. 2015. A review of nonoccupational pathways for pesticide exposure in women living in agricultural areas. Environ Health Perspect 123: 515-524, doi: 10. 1289/ehp. 1408273.
17. Engel SM, Berkowitz GS, Barr DB, Teitelbaum SL, Siskind J, Meisel SJ, et al. 2007. Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort. Am J Epidemiol 165(12): 1397-1404.
18. Engel SM, Wetmur J, Chen J, Zhu C, Barr DB, Canfield RL, et al. 2011. Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood. Environ Health Perspect 119: 1182-1188, doi: 10. 1289/ehp. 1003183.
19. Eskenazi B, Harley K, Bradman A, Weltzien E, Jewell NP, Barr DB, et al. 2004. Association of in uteroorganophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population. Environ Health Perspect 112: 1116-1124, doi: 10. 1289/ehp. 6789.
20. Eskenazi B, Marks AR, Bradman A, Harley K, Barr DB, Johnson C, et al. 2007. Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Environ Health Perspect 115: 792-798, doi: 10. 1289/ehp. 9828.
21. Fukuto TR. 1990. Mechanism of action of organophosphorus and carbamate insecticides. Environ Health Perspect 87: 245-254.
22. Grube A, Donaldson D, Kiely T, Wu L. 2011. Pesticides Industry Sales and Usage: 2006 and 2007 Market Estimates. EPA 733-R-11-001. Washington, DC: U. S. Environmental Protection Agency.
23. Holland N, Furlong C, Bastaki M, Richter R, Bradman A, Huen K, et al. 2006. Paraoxonase polymorphisms, haplotypes, and enzyme activity in Latino mothers and newborns. Environ Health Perspect 114: 985-991, doi: 10. 1289/ehp. 8540.
24. Icenogle LM, Christopher NC, Blackwelder WP, Caldwell DP, Qiao D, Seidler FJ, et al. 2004. Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation. Neurotoxicol Teratol 26(1): 95-101.
25. Levin ED, Addy N, Baruah A, Elias A, Christopher NC, Seidler FJ, et al. 2002. Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations. Neurotoxicol Teratol 24(6): 733-741.
26. Lu C, Bravo R, Caltabiano LM, Irish RM, Weerasekera G, Barr DB. 2005. The presence of dialkylphosphates in fresh fruit juices: implication for organophosphorus pesticide exposure and risk assessments. J Toxicol Environ Health A 68(3): 209-227.
27. Martin JA, Hamilton BE, Osterman MJK, Curtin SC, Mathews TJ. 2015. Births: Final Data for 2013. Natl Vital Stat Rep 64(1): 1-65.
28. Quirós-Alcalá L, Bradman A, Smith K, Weerasekera G, Odetokun M, Barr DB, et al. 2012. Organophosphorous pesticide breakdown products in house dust and children's urine. J Expo Sci Environ Epidemiol 22(6): 559-568.
29. Rauch SA, Braun JM, Barr DB, Calafat AM, Khoury J, Montesano AM, et al. 2012. Associations of prenatal exposure to organophosphate pesticide metabolites with gestational age and birth weight. Environ Health Perspect 120: 1055-1060, doi: 10. 1289/ehp. 1104615.
30. Rauh VA, Garfinkel R, Perera FP, Andrews HF, Hoepner L, Barr DB, et al. 2006. Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children. Pediatrics 118(6): e1845-e1859.
31. Ray DE, Richards PG. 2001. The potential for toxic effects of chronic, low-dose exposure to organophosphates. Toxicol Lett 120(1-3): 343-351.
32. Ricceri L, Markina N, Valanzano A, Fortuna S, Cometa MF, Meneguz A, et al. 2003. Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice. Toxicol Appl Pharmacol 191(3): 189-201.
33. Spaan S, Pronk A, Koch HM, Jusko TA, Jaddoe VW, Shaw PA, et al. 2015. Reliability of concentrations of organophosphate pesticide metabolites in serial urine specimens from pregnancy in the Generation R Study. J Expo Sci Environ Epidemiol 25(3): 286-294.
34. Timofeeva OA, Roegge CS, Seidler FJ, Slotkin TA, Levin ED. 2008. Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon. Neurotoxicol Teratol 30(1): 38-45.
35. U. S. EPA (U. S. Environmental Protection Agency). 2000. Chlorpyrifos. Revised Risk Assessment and Agreement with Registrants. Washington, DC: U. S. EPA, Office of Pesticide Programs.
36. U. S. EPA. 2001. Diazinon Revised Risk Assessment and Agreement with Registrants. Washington DC: U. S. EPA, Office of Pesticide Programs.
37. Vatanparast J, Naseh M, Baniasadi M, HaghdoostYazdi H. 2013. Developmental exposure to chlorpyrifos and diazinon differentially affect passive avoidance performance and nitric oxide synthasecontaining neurons in the basolateral complex of the amygdala. Brain Res 1494: 17-27.
38. Westreich D, Cole SR. 2010. Invited commentary: positivity in practice. Am J Epidemiol 171(6): 674-677.
39. Wetmur JG, Kumar M, Zhang L, Palomeque C, Wallenstein S, Chen J. 2005. Molecular haplotyping by linking emulsion PCR: analysis of paraoxonase 1 haplotypes and phenotypes. Nucleic Acids Res 33(8): 2615-2619.
40. Whyatt RM, Camann D, Perera FP, Rauh VA, Tang D, Kinney PL, et al. 2005. Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth. Toxicol Appl Pharmacol 206(2): 246-254.
41. Whyatt RM, Rauh V, Barr DB, Camann DE, Andrews HF, Garfinkel R, et al. 2004. Prenatal insecticide exposures and birth weight and length among an urban minority cohort. Environ Health Perspect 112: 1125-1132, doi: 10. 1289/ehp. 6641.
42. Yolton K, Xu Y, Sucharew H, Succop P, Altaye M, Popelar A, et al. 2013. Impact of low-level gestational exposure to organophosphate pesticides on neurobehavior in early infancy: a prospective study. Environ Health 12(1): 79, doi: 10. 1186/1476-069X-12-79.
43. Zhang X, Driver JH, Li Y, Ross JH, Krieger RI. 2008. Dialkylphosphates (DAPs) in fruits and vegetables may confound biomonitoring in organophosphorus insecticide exposure and risk assessment. J Agric Food Chem 56(22): 10638-10645