Haplotype-phenotype relationships of paraoxonase-1

Cancer Epidemiology Biomarkers and Prevention

Volumn 14, Issue 3, 2005, Pages 731-734

  Chen, Jia ^a   Chan, Wendy ^a   Wallenstein, Sylvan ^a   Berkowitz, Gertrud ^a   Wetmur, James G ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARYLDIALKYLPHOSPHATASE; ARYLDIALKYLPHOSPHATASE 1; ORGANOPHOSPHATE PESTICIDE; PHENYLACETIC ACID; UNCLASSIFIED DRUG;

ADULT; AFRICAN AMERICAN; ARTICLE; CAUCASIAN; CONTROLLED STUDY; DNA POLYMORPHISM; ENZYME ACTIVITY; ETHNIC GROUP; FEMALE; GENE; GENE LINKAGE DISEQUILIBRIUM; HAPLOTYPE; HISPANIC; HUMAN; HYDROLYSIS; MATERNAL BLOOD; NEWBORN; NORMAL HUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PON1 GENE; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL ANALYSIS; UMBILICAL CORD BLOOD;

ADULT; ALGORITHMS; ARTERIOSCLEROSIS; ARYLDIALKYLPHOSPHATASE; ETHNIC GROUPS; FEMALE; HAPLOTYPES; HUMANS; INFANT, NEWBORN; MALE; NERVOUS SYSTEM; PHENOTYPE; POLYMORPHISM, GENETIC; PREGNANCY; RISK FACTORS; XENOBIOTICS;

EID: 16844374769     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-04-0538     Document Type: Article

References (14)

1. Jakubowski H, Ambrosius WT, Pratt JH. Genetic determinants of homocysteine thiolactonase activity in humans: implications for atherosclerosis. FEBS Lett 2001;491:35-9.
2. Gan KN, Smolen A, Eckerson HW, Ladu BN. Purification of human serum paraoxonase arylesterase-evidence for one esterase catalyzing both activities. Drug Metabolism and Disposition 1991;19:100-6.
3. Shih DM, Gu LJ, Xia YR, Navab M, Li WF, Hama S, et al. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature 1998;394:284-7.
4. Kerridge I, Lincz L, Scorgie F, Hickey D, Granter N, Spencer A. Association between xenobiotic gene polymorphisms and non-Hodgkin's lymphoma risk. Br J Haematol 2002;118:477-81.
5. Chen J, Kumar M, Chan W, Berkowitz G, Wetmur JG. Increased influence of genetic variation on PON1 activity in neonates. Environ Health Perspect 2003;111:1403-9.
6. Brophy VH, Jampsa RL, Clendenning JB, McKinstry LA, Jarvik GP, Furlong CE. Effects of 5′ regulatory-region polymorphisms on paraoxonase-gene (PON1) expression. Am J Hum Genet 2001;68:1428-36.
7. Davies HG, Richter RJ, Keifer M, Broomfield CA, Sowalla J, Furlong CE. The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin. Nat Genet 1996;14:334-6.
8. Leviev I, Deakin S, James RW. Decreased stability of the M54 isoform of paraoxonase as a contributory factor to variations in human serum paraoxonase concentrations. J Lipid Res 2001;42:528-35.
9. Germer S, Holland MJ, Higuchi R. High-throughput SNP allele-frequency determination in pooled DNA samples by kinetic PCR. Genome Res 2000;10:258-66.
10. Stram DO, Haiman CA, Hirschhorn JN, Altshuler D, Kolonel LN, Henderson BE, et al. Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the multiethnic cohort study. Hum Hered 2003;55:27-36.
11. Excoffier L, Slatkin M. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol Biol Evol 1995;12:921-7.
12. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001;68:978-89.
13. Stephens M, Donnelly P. A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 2003;73:1162-9.
14. Jarvik GP, Hatsukami TS, Carlson C, et al. Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease. Arterioscler Thromb Vase Biol 2003;23:1465-71.