-
1
-
-
84857623883
-
Epidemiology of brain metastases
-
PID: 22012633
-
Nayak L, Lee EQ, Wen PY. Epidemiology of brain metastases. Curr Oncol Rep. 2012;14:48–54.
-
(2012)
Curr Oncol Rep
, vol.14
, pp. 48-54
-
-
Nayak, L.1
Lee, E.Q.2
Wen, P.Y.3
-
2
-
-
32844461627
-
Brain metastasis—evidence based management
-
COI: 1:CAS:528:DC%2BD28XjsVyitbw%3D, PID: 17998665
-
Biswas G, Bhagwat R, Khurana R, Menon H, Prasad N, Parikh PM. Brain metastasis—evidence based management. J Cancer Res Ther. 2006;2:5–13.
-
(2006)
J Cancer Res Ther
, vol.2
, pp. 5-13
-
-
Biswas, G.1
Bhagwat, R.2
Khurana, R.3
Menon, H.4
Prasad, N.5
Parikh, P.M.6
-
3
-
-
33644835157
-
Changing patterns of bone and brain metastases in patients with colorectal cancer
-
PID: 16098251
-
Sundermeyer ML, Meropol NJ, Rogatko A, Wang H, Cohen SJ. Changing patterns of bone and brain metastases in patients with colorectal cancer. Clin Colorectal Cancer. 2005;5:108–13.
-
(2005)
Clin Colorectal Cancer
, vol.5
, pp. 108-113
-
-
Sundermeyer, M.L.1
Meropol, N.J.2
Rogatko, A.3
Wang, H.4
Cohen, S.J.5
-
4
-
-
84898043674
-
Emerging opportunities for the combination of molecularly targeted drugs with radiotherapy
-
COI: 1:STN:280:DC%2BC2crhtlCqsg%3D%3D, This paper provides a broad summary of clinical trials over the preceding 5 years that combine targeted drugs and radiotherapy across many areas of oncology
-
Searle EJ, Illidge TM, Stratford IJ. Emerging opportunities for the combination of molecularly targeted drugs with radiotherapy. Clin Oncol (R Coll Radiol). 2014;26:266–76. This paper provides a broad summary of clinical trials over the preceding 5 years that combine targeted drugs and radiotherapy across many areas of oncology.
-
(2014)
Clin Oncol (R Coll Radiol)
, vol.26
, pp. 266-276
-
-
Searle, E.J.1
Illidge, T.M.2
Stratford, I.J.3
-
5
-
-
0026561856
-
Development of immunotherapeutic strategies for the treatment of malignant neoplasms
-
COI: 1:STN:280:DyaK383oslOgug%3D%3D, PID: 1599805
-
Talmadge JE. Development of immunotherapeutic strategies for the treatment of malignant neoplasms. Biotherapy. 1992;4:215–36.
-
(1992)
Biotherapy
, vol.4
, pp. 215-236
-
-
Talmadge, J.E.1
-
6
-
-
79551468957
-
Strategizing the clone wars: pharmacological control of cellular sensitivity to radiation
-
PID: 21263160
-
Kimple RJ. Strategizing the clone wars: pharmacological control of cellular sensitivity to radiation. Mol Interv. 2010;10:341–53.
-
(2010)
Mol Interv
, vol.10
, pp. 341-353
-
-
Kimple, R.J.1
-
7
-
-
84912138328
-
Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial
-
Gondi V, Pugh SL, Tome WA, et al. Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial. J Clin Oncol Off J Am Soc Clin Oncol. 2014;32:3810–6.
-
(2014)
J Clin Oncol Off J Am Soc Clin Oncol
, vol.32
, pp. 3810-3816
-
-
Gondi, V.1
Pugh, S.L.2
Tome, W.A.3
-
8
-
-
84903433004
-
Why and how to spare the hippocampus during brain radiotherapy: the developing role of hippocampal avoidance in cranial radiotherapy
-
Kazda T, Jancalek R, Pospisil P, et al. Why and how to spare the hippocampus during brain radiotherapy: the developing role of hippocampal avoidance in cranial radiotherapy. Radiat Oncol (Lond Engl). 2014;9:139.
-
(2014)
Radiat Oncol (Lond Engl)
, vol.9
, pp. 139
-
-
Kazda, T.1
Jancalek, R.2
Pospisil, P.3
-
9
-
-
84957583663
-
The rationale for targeted therapies and stereotactic radiosurgery in the treatment of brain metastases
-
PID: 26764249, This review provides an overview of strategies that combine targeted therapies and stereotactic radiosurgery
-
Moraes FY, Taunk NK, Marta GN, Suh JH, Yamada Y. The rationale for targeted therapies and stereotactic radiosurgery in the treatment of brain metastases. Oncologist. 2016;21:244–51. This review provides an overview of strategies that combine targeted therapies and stereotactic radiosurgery.
-
(2016)
Oncologist
, vol.21
, pp. 244-251
-
-
Moraes, F.Y.1
Taunk, N.K.2
Marta, G.N.3
Suh, J.H.4
Yamada, Y.5
-
10
-
-
17144371349
-
Mechanisms of enhanced radiation response following epidermal growth factor receptor signaling inhibition by erlotinib (Tarceva)
-
COI: 1:CAS:528:DC%2BD2MXjt1yrsrc%3D, PID: 15833866
-
Chinnaiyan P, Huang S, Vallabhaneni G, et al. Mechanisms of enhanced radiation response following epidermal growth factor receptor signaling inhibition by erlotinib (Tarceva). Cancer Res. 2005;65:3328–35.
-
(2005)
Cancer Res
, vol.65
, pp. 3328-3335
-
-
Chinnaiyan, P.1
Huang, S.2
Vallabhaneni, G.3
-
11
-
-
84857815877
-
Immunologic correlates of the abscopal effect in a patient with melanoma
-
COI: 1:CAS:528:DC%2BC38XktFOgurw%3D, PID: 22397654
-
Postow MA, Callahan MK, Barker CA, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med. 2012;366:925–31.
-
(2012)
N Engl J Med
, vol.366
, pp. 925-931
-
-
Postow, M.A.1
Callahan, M.K.2
Barker, C.A.3
-
12
-
-
84934317841
-
Trial watch: radioimmunotherapy for oncological indications
-
PID: 25941606, This manuscript is a comprehensive and extensively referenced overview of immunotherapy combined with radiation therapy which is updated every few years
-
Bloy N, Pol J, Manic G, et al. Trial watch: radioimmunotherapy for oncological indications. Oncoimmunology. 2014;3:954929. This manuscript is a comprehensive and extensively referenced overview of immunotherapy combined with radiation therapy which is updated every few years.
-
(2014)
Oncoimmunology
, vol.3
, pp. 954929
-
-
Bloy, N.1
Pol, J.2
Manic, G.3
-
14
-
-
84866162680
-
A placebo-controlled, randomized phase II study of maintenance enzastaurin following whole brain radiation therapy in the treatment of brain metastases from lung cancer
-
Gronberg BH, Ciuleanu T, Flotten O, et al. A placebo-controlled, randomized phase II study of maintenance enzastaurin following whole brain radiation therapy in the treatment of brain metastases from lung cancer. Lung Cancer. 2012;78:63–69.
-
(2012)
Lung Cancer
, vol.78
, pp. 63-69
-
-
Gronberg, B.H.1
Ciuleanu, T.2
Flotten, O.3
-
15
-
-
84921318186
-
A phase II trial of capecitabine concomitantly with whole-brain radiotherapy followed by capecitabine and sunitinib for brain metastases from breast cancer
-
Niravath P, Tham YL, Wang T, et al. A phase II trial of capecitabine concomitantly with whole-brain radiotherapy followed by capecitabine and sunitinib for brain metastases from breast cancer. Oncologist. 2015;20:13.
-
(2015)
Oncologist
, vol.20
, pp. 13
-
-
Niravath, P.1
Tham, Y.L.2
Wang, T.3
-
16
-
-
4344694453
-
Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System
-
Barnholtz-Sloan JS, Sloan AE, Davis FG, Vigneau FD, Lai P, Sawaya RE. Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J Clin Oncol Off J Am Soc Clin Oncol. 2004;22:2865–72.
-
(2004)
J Clin Oncol Off J Am Soc Clin Oncol
, vol.22
, pp. 2865-2872
-
-
Barnholtz-Sloan, J.S.1
Sloan, A.E.2
Davis, F.G.3
Vigneau, F.D.4
Lai, P.5
Sawaya, R.E.6
-
17
-
-
78650462766
-
The SATURN trial: the value of maintenance erlotinib in patients with non-small-cell lung cancer
-
COI: 1:CAS:528:DC%2BC3cXhsFGltbbO
-
Neal JW. The SATURN trial: the value of maintenance erlotinib in patients with non-small-cell lung cancer. Future Oncol (Lond Engl). 2010;6:1827–32.
-
(2010)
Future Oncol (Lond Engl)
, vol.6
, pp. 1827-1832
-
-
Neal, J.W.1
-
18
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
-
COI: 1:CAS:528:DC%2BC38XjsVCgsbk%3D, PID: 22285168
-
Rosell R, Carcereny E, Gervais R, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet. 2012;13:239–46.
-
(2012)
Lancet
, vol.13
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
-
19
-
-
4143110253
-
Gefitinib in patients with brain metastases from non-small-cell lung cancer: a prospective trial
-
COI: 1:STN:280:DC%2BD2czgt1Squg%3D%3D, PID: 15205197
-
Ceresoli GL, Cappuzzo F, Gregorc V, Bartolini S, Crino L, Villa E. Gefitinib in patients with brain metastases from non-small-cell lung cancer: a prospective trial. Ann Oncol. 2004;15:1042–7.
-
(2004)
Ann Oncol
, vol.15
, pp. 1042-1047
-
-
Ceresoli, G.L.1
Cappuzzo, F.2
Gregorc, V.3
Bartolini, S.4
Crino, L.5
Villa, E.6
-
20
-
-
67651102970
-
Phase I study of concurrent whole brain radiotherapy and erlotinib for multiple brain metastases from non-small-cell lung cancer
-
COI: 1:CAS:528:DC%2BD1MXoslGhtr4%3D, PID: 19289264
-
Lind JS, Lagerwaard FJ, Smit EF, Senan S. Phase I study of concurrent whole brain radiotherapy and erlotinib for multiple brain metastases from non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2009;74:1391–6.
-
(2009)
Int J Radiat Oncol Biol Phys
, vol.74
, pp. 1391-1396
-
-
Lind, J.S.1
Lagerwaard, F.J.2
Smit, E.F.3
Senan, S.4
-
21
-
-
84856235127
-
Outcome, quality of life and cognitive function of patients with brain metastases from non-small cell lung cancer treated with whole brain radiotherapy combined with gefitinib or temozolomide. A randomised phase II trial of the Swiss Group for Clinical Cancer Research (SAKK 70/03)
-
PID: 22093943
-
Pesce GA, Klingbiel D, Ribi K, et al. Outcome, quality of life and cognitive function of patients with brain metastases from non-small cell lung cancer treated with whole brain radiotherapy combined with gefitinib or temozolomide. A randomised phase II trial of the Swiss Group for Clinical Cancer Research (SAKK 70/03). Eur J Cancer. 2012;48:377–84.
-
(2012)
Eur J Cancer
, vol.48
, pp. 377-384
-
-
Pesce, G.A.1
Klingbiel, D.2
Ribi, K.3
-
22
-
-
84875720245
-
Phase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer
-
COI: 1:CAS:528:DC%2BC3sXltVagtbw%3D, This is a well-executed, moderately sized (40 patients) trial that suggested a survival advantage for patients with EGFR-mutated NSCLC compared to wild-type NSCLC
-
Welsh JW, Komaki R, Amini A, et al. Phase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer. J Clin Oncol Off J Am Soc Clin Oncol. 2013;31:895–902. This is a well-executed, moderately sized (40 patients) trial that suggested a survival advantage for patients with EGFR-mutated NSCLC compared to wild-type NSCLC.
-
(2013)
J Clin Oncol Off J Am Soc Clin Oncol
, vol.31
, pp. 895-902
-
-
Welsh, J.W.1
Komaki, R.2
Amini, A.3
-
23
-
-
84925539431
-
Comparison of gefitinib versus VMP in the combination with radiotherapy for multiple brain metastases from non-small cell lung cancer
-
COI: 1:CAS:528:DC%2BC2cXhvVSqs7vE, PID: 25319074
-
Wang F, Ning F, Liu C, et al. Comparison of gefitinib versus VMP in the combination with radiotherapy for multiple brain metastases from non-small cell lung cancer. Cell Biochem Biophys. 2015;71:1261–5.
-
(2015)
Cell Biochem Biophys
, vol.71
, pp. 1261-1265
-
-
Wang, F.1
Ning, F.2
Liu, C.3
-
24
-
-
84885224003
-
Phase II study of whole brain radiotherapy with or without erlotinib in patients with multiple brain metastases from lung adenocarcinoma
-
Zhuang H, Yuan Z, Wang J, Zhao L, Pang Q, Wang P. Phase II study of whole brain radiotherapy with or without erlotinib in patients with multiple brain metastases from lung adenocarcinoma. Drug Des Dev Ther. 2013;7:1179–86.
-
(2013)
Drug Des Dev Ther
, vol.7
, pp. 1179-1186
-
-
Zhuang, H.1
Yuan, Z.2
Wang, J.3
Zhao, L.4
Pang, Q.5
Wang, P.6
-
25
-
-
84875239644
-
A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: Radiation Therapy Oncology Group 0320
-
COI: 1:CAS:528:DC%2BC3sXitFCgs7c%3D, PID: 23391814
-
Sperduto PW, Wang M, Robins HI, et al. A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: Radiation Therapy Oncology Group 0320. Int J Radiat Oncol Biol Phys. 2013;85:1312–8.
-
(2013)
Int J Radiat Oncol Biol Phys
, vol.85
, pp. 1312-1318
-
-
Sperduto, P.W.1
Wang, M.2
Robins, H.I.3
-
26
-
-
84905218794
-
-
Lee SM, Lewanski CR, Counsell N, et al. Randomized trial of erlotinib plus whole-brain radiotherapy for NSCLC patients with multiple brain metastases. 106. Despite most patients having EGFR wild-type tumors, this is one of the few randomized trials that tests the paradigm of targeted therapy with radiotherapy for brain metastases
-
Lee SM, Lewanski CR, Counsell N, et al. Randomized trial of erlotinib plus whole-brain radiotherapy for NSCLC patients with multiple brain metastases. J Nat Cancer Inst 2014;106. Despite most patients having EGFR wild-type tumors, this is one of the few randomized trials that tests the paradigm of targeted therapy with radiotherapy for brain metastases.
-
(2014)
J Nat Cancer Inst
-
-
-
27
-
-
84939562715
-
A phase II study of icotinib and whole-brain radiotherapy in Chinese patients with brain metastases from non-small cell lung cancer
-
COI: 1:CAS:528:DC%2BC2MXhtFGlu7jM, PID: 26148750, This small randomized trial suggested a survival benefit for patients with EGFR mutated vs wild-type tumors and also documented CSF levels of icotinib
-
Fan Y, Huang Z, Fang L, et al. A phase II study of icotinib and whole-brain radiotherapy in Chinese patients with brain metastases from non-small cell lung cancer. Cancer Chemother Pharmacol. 2015;76:517–23. This small randomized trial suggested a survival benefit for patients with EGFR mutated vs wild-type tumors and also documented CSF levels of icotinib.
-
(2015)
Cancer Chemother Pharmacol
, vol.76
, pp. 517-523
-
-
Fan, Y.1
Huang, Z.2
Fang, L.3
-
28
-
-
84959338411
-
Next-generation epidermal growth factor receptor tyrosine kinase inhibitors in epidermal growth factor receptor -mutant non-small cell lung cancer
-
Tan CS, Cho BC, Soo RA. Next-generation epidermal growth factor receptor tyrosine kinase inhibitors in epidermal growth factor receptor -mutant non-small cell lung cancer. Lung Cancer (Amst Neth). 2016;93:59–68.
-
(2016)
Lung Cancer (Amst Neth)
, vol.93
, pp. 59-68
-
-
Tan, C.S.1
Cho, B.C.2
Soo, R.A.3
-
29
-
-
70349336416
-
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
-
COI: 1:CAS:528:DC%2BD1MXht1WisbvF
-
Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol Off J Am Soc Clin Oncol. 2009;27:4247–53.
-
(2009)
J Clin Oncol Off J Am Soc Clin Oncol
, vol.27
, pp. 4247-4253
-
-
Shaw, A.T.1
Yeap, B.Y.2
Mino-Kenudson, M.3
-
30
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
COI: 1:CAS:528:DC%2BD2sXosVSrtrs%3D, PID: 17625570
-
Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448:561–6.
-
(2007)
Nature
, vol.448
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
-
31
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
COI: 1:CAS:528:DC%2BC3sXhtVSnu7%2FM, PID: 23724913
-
Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013;368:2385–94.
-
(2013)
N Engl J Med
, vol.368
, pp. 2385-2394
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
-
32
-
-
84929508050
-
Clinical experience with crizotinib in patients with advanced ALK-rearranged non-small-cell lung cancer and brain metastases
-
COI: 1:CAS:528:DC%2BC2MXhsFKmt7%2FM
-
Costa DB, Shaw AT, Ou SH, et al. Clinical experience with crizotinib in patients with advanced ALK-rearranged non-small-cell lung cancer and brain metastases. J Clin Oncol Off J Am Soc Clin Oncol. 2015;33:1881–8.
-
(2015)
J Clin Oncol Off J Am Soc Clin Oncol
, vol.33
, pp. 1881-1888
-
-
Costa, D.B.1
Shaw, A.T.2
Ou, S.H.3
-
34
-
-
33845599378
-
Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier
-
COI: 1:CAS:528:DC%2BD28Xht1yrt7bO, PID: 17159499
-
Stemmler HJ, Schmitt M, Willems A, Bernhard H, Harbeck N, Heinemann V. Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier. Anti-Cancer Drugs. 2007;18:23–8.
-
(2007)
Anti-Cancer Drugs
, vol.18
, pp. 23-28
-
-
Stemmler, H.J.1
Schmitt, M.2
Willems, A.3
Bernhard, H.4
Harbeck, N.5
Heinemann, V.6
-
35
-
-
62549135630
-
Trastuzumab treatment improves brain metastasis outcomes through control and durable prolongation of systemic extracranial disease in HER2-overexpressing breast cancer patients
-
COI: 1:CAS:528:DC%2BD1MXjt1Gjsb8%3D, PID: 19240719
-
Park YH, Park MJ, Ji SH, et al. Trastuzumab treatment improves brain metastasis outcomes through control and durable prolongation of systemic extracranial disease in HER2-overexpressing breast cancer patients. Br J Cancer. 2009;100:894–900.
-
(2009)
Br J Cancer
, vol.100
, pp. 894-900
-
-
Park, Y.H.1
Park, M.J.2
Ji, S.H.3
-
36
-
-
84890439476
-
A phase I study of lapatinib with whole brain radiotherapy in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer brain metastases
-
COI: 1:CAS:528:DC%2BC3sXhslGlsbjN, PID: 24197661, Despite being a phase I trial, prolonged responses were observed with this combination
-
Lin NU, Freedman RA, Ramakrishna N, et al. A phase I study of lapatinib with whole brain radiotherapy in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer brain metastases. Breast Cancer Res Treat. 2013;142:405–14. Despite being a phase I trial, prolonged responses were observed with this combination.
-
(2013)
Breast Cancer Res Treat
, vol.142
, pp. 405-414
-
-
Lin, N.U.1
Freedman, R.A.2
Ramakrishna, N.3
-
37
-
-
77149126422
-
Safety and efficacy results of the advanced renal cell carcinoma sorafenib expanded access program in North America
-
COI: 1:CAS:528:DC%2BC3cXjs1GrtLg%3D, PID: 20082451
-
Stadler WM, Figlin RA, McDermott DF, et al. Safety and efficacy results of the advanced renal cell carcinoma sorafenib expanded access program in North America. Cancer. 2010;116:1272–80.
-
(2010)
Cancer
, vol.116
, pp. 1272-1280
-
-
Stadler, W.M.1
Figlin, R.A.2
McDermott, D.F.3
-
38
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
COI: 1:CAS:528:DC%2BD2sXksVKitg%3D%3D, PID: 17215530
-
Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 2007;356:125–34.
-
(2007)
N Engl J Med
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
39
-
-
33744984843
-
Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
-
COI: 1:CAS:528:DC%2BD28XmtVOmtrk%3D
-
Ratain MJ, Eisen T, Stadler WM, et al. Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol Off J Am Soc Clin Oncol. 2006;24:2505–12.
-
(2006)
J Clin Oncol Off J Am Soc Clin Oncol
, vol.24
, pp. 2505-2512
-
-
Ratain, M.J.1
Eisen, T.2
Stadler, W.M.3
-
40
-
-
84967245484
-
Radiotherapy for brain metastases from renal cell carcinoma in the targeted therapy era: the University of Rochester experience
-
Bates JE, Youn P, Peterson CR, et al. Radiotherapy for brain metastases from renal cell carcinoma in the targeted therapy era: the University of Rochester experience. Am J Clin Oncol 2015.
-
(2015)
Am J Clin Oncol
-
-
Bates, J.E.1
Youn, P.2
Peterson, C.R.3
-
41
-
-
4344609724
-
The treatment of brain metastases in melanoma patients
-
COI: 1:CAS:528:DC%2BD2cXmvFCltr0%3D, PID: 15325032
-
Bafaloukos D, Gogas H. The treatment of brain metastases in melanoma patients. Cancer Treat Rev. 2004;30:515–20.
-
(2004)
Cancer Treat Rev
, vol.30
, pp. 515-520
-
-
Bafaloukos, D.1
Gogas, H.2
-
42
-
-
84864722943
-
NRAS mutation status is an independent prognostic factor in metastatic melanoma
-
COI: 1:CAS:528:DC%2BC38XhtFaksr7O, PID: 22180178
-
Jakob JA, Bassett Jr RL, Ng CS, et al. NRAS mutation status is an independent prognostic factor in metastatic melanoma. Cancer. 2012;118:4014–23.
-
(2012)
Cancer
, vol.118
, pp. 4014-4023
-
-
Jakob, J.A.1
Bassett, R.L.2
Ng, C.S.3
-
43
-
-
84868205659
-
Targeted therapy in brain metastasis
-
COI: 1:CAS:528:DC%2BC38XhsFCltrzO, PID: 22820413
-
Soffietti R, Trevisan E, Ruda R. Targeted therapy in brain metastasis. Curr Opin Oncol. 2012;24:679–86.
-
(2012)
Curr Opin Oncol
, vol.24
, pp. 679-686
-
-
Soffietti, R.1
Trevisan, E.2
Ruda, R.3
-
44
-
-
84891648456
-
Phase II trial (BREAK-2) of the BRAF inhibitor dabrafenib (GSK2118436) in patients with metastatic melanoma
-
COI: 1:CAS:528:DC%2BC3sXhs1ahur7M
-
Ascierto PA, Minor D, Ribas A, et al. Phase II trial (BREAK-2) of the BRAF inhibitor dabrafenib (GSK2118436) in patients with metastatic melanoma. J Clin Oncol Off J Am Soc Clin Oncol. 2013;31:3205–11.
-
(2013)
J Clin Oncol Off J Am Soc Clin Oncol
, vol.31
, pp. 3205-3211
-
-
Ascierto, P.A.1
Minor, D.2
Ribas, A.3
-
45
-
-
84861083983
-
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial
-
COI: 1:CAS:528:DC%2BC38Xnt1Kmtbo%3D
-
Falchook GS, Long GV, Kurzrock R, et al. Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. Lancet (Lond Engl). 2012;379:1893–901.
-
(2012)
Lancet (Lond Engl)
, vol.379
, pp. 1893-1901
-
-
Falchook, G.S.1
Long, G.V.2
Kurzrock, R.3
-
46
-
-
84893661769
-
Vemurafenib in patients with BRAF(V600) mutation-positive melanoma with symptomatic brain metastases: final results of an open-label pilot study
-
COI: 1:CAS:528:DC%2BC3sXhvV2gtbbP, PID: 24295639
-
Dummer R, Goldinger SM, Turtschi CP, et al. Vemurafenib in patients with BRAF(V600) mutation-positive melanoma with symptomatic brain metastases: final results of an open-label pilot study. Eur J Cancer. 2014;50:611–21.
-
(2014)
Eur J Cancer
, vol.50
, pp. 611-621
-
-
Dummer, R.1
Goldinger, S.M.2
Turtschi, C.P.3
-
47
-
-
84868120907
-
Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial
-
COI: 1:CAS:528:DC%2BC38Xhs1WqurzP, PID: 23051966
-
Long GV, Trefzer U, Davies MA, et al. Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial. Lancet. 2012;13:1087–95.
-
(2012)
Lancet
, vol.13
, pp. 1087-1095
-
-
Long, G.V.1
Trefzer, U.2
Davies, M.A.3
-
48
-
-
84957575093
-
-
J Neuro-Oncol: This single institution experience that combined stereotactic radiosurgery and BRAF inhibitors suggested a survival benefit for patients with BRAF-mutated tumors who received BRAF inhibitors compared to BRAF wild-type tumors treated with radiation alone
-
Wolf A, Zia S, Verma R, et al. Impact on overall survival of the combination of BRAF inhibitors and stereotactic radiosurgery in patients with melanoma brain metastases. J Neuro-Oncol. 2016. This single institution experience that combined stereotactic radiosurgery and BRAF inhibitors suggested a survival benefit for patients with BRAF-mutated tumors who received BRAF inhibitors compared to BRAF wild-type tumors treated with radiation alone.
-
(2016)
Impact on overall survival of the combination of BRAF inhibitors and stereotactic radiosurgery in patients with melanoma brain metastases
-
-
Wolf, A.1
Zia, S.2
Verma, R.3
-
49
-
-
84971283058
-
-
Society for Melanoma Research Congress, Philadelphia
-
Kefford R, Maio M, Arance A, et al. Vemurafenib in metastatic melanoma patients with brain metastases: an open-label, single-arm, phase 2, multi-center study. Philadelphia: Society for Melanoma Research Congress; 2013.
-
(2013)
Vemurafenib in metastatic melanoma patients with brain metastases: an open-label, single-arm, phase 2, multi-center study
-
-
Kefford, R.1
Maio, M.2
Arance, A.3
-
50
-
-
84883065232
-
Serious skin toxicity with the combination of BRAF inhibitors and radiotherapy
-
This report highlights the potential for increased toxicity when radiation and targeted therapies are combined
-
Satzger I, Degen A, Asper H, Kapp A, Hauschild A, Gutzmer R. Serious skin toxicity with the combination of BRAF inhibitors and radiotherapy. J Clin Oncol Off J Am Soc Clin Oncol. 2013;31:e220–2. This report highlights the potential for increased toxicity when radiation and targeted therapies are combined.
-
(2013)
J Clin Oncol Off J Am Soc Clin Oncol
, vol.31
, pp. e220-e222
-
-
Satzger, I.1
Degen, A.2
Asper, H.3
Kapp, A.4
Hauschild, A.5
Gutzmer, R.6
-
51
-
-
84880645432
-
Vemurafenib and radiosensitization
-
PID: 23699661
-
Boussemart L, Boivin C, Claveau J, et al. Vemurafenib and radiosensitization. JAMA Dermatol. 2013;149:855–7.
-
(2013)
JAMA Dermatol
, vol.149
, pp. 855-857
-
-
Boussemart, L.1
Boivin, C.2
Claveau, J.3
-
52
-
-
82955237229
-
A phase 1b trial of the combination of the antiangiogenic agent sunitinib and radiation therapy for patients with primary and metastatic central nervous system malignancies
-
COI: 1:CAS:528:DC%2BC3MXhsFGktrrO, PID: 21647871
-
Wuthrick EJ, Kamrava M, Curran Jr WJ, et al. A phase 1b trial of the combination of the antiangiogenic agent sunitinib and radiation therapy for patients with primary and metastatic central nervous system malignancies. Cancer. 2011;117:5548–59.
-
(2011)
Cancer
, vol.117
, pp. 5548-5559
-
-
Wuthrick, E.J.1
Kamrava, M.2
Curran, W.J.3
-
53
-
-
84942500983
-
Phase II trial of sunitinib as adjuvant therapy after stereotactic radiosurgery in patients with 1-3 newly diagnosed brain metastases
-
COI: 1:CAS:528:DC%2BC2MXhtlSjur3N
-
Ahluwalia MS, Chao ST, Parsons MW, et al. Phase II trial of sunitinib as adjuvant therapy after stereotactic radiosurgery in patients with 1-3 newly diagnosed brain metastases. J Neuro-Oncol. 2015;124:485–91.
-
(2015)
J Neuro-Oncol
, vol.124
, pp. 485-491
-
-
Ahluwalia, M.S.1
Chao, S.T.2
Parsons, M.W.3
-
54
-
-
84882369765
-
Concurrent whole brain radiotherapy and bortezomib for brain metastasis
-
Lao CD, Friedman J, Tsien CI, et al. Concurrent whole brain radiotherapy and bortezomib for brain metastasis. Radiat Oncol (Lond Engl). 2013;8:204.
-
(2013)
Radiat Oncol (Lond Engl)
, vol.8
, pp. 204
-
-
Lao, C.D.1
Friedman, J.2
Tsien, C.I.3
-
55
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
COI: 1:CAS:528:DC%2BC3MXjsFeqtrk%3D, PID: 21376230
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–74.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
56
-
-
23844440660
-
T cell-mediated immunotherapy of metastases: state of the art in 2005
-
COI: 1:CAS:528:DC%2BD2MXmvFemu7w%3D, PID: 16050783
-
Schirrmacher V. T cell-mediated immunotherapy of metastases: state of the art in 2005. Expert Opin Biol Ther. 2005;5:1051–68.
-
(2005)
Expert Opin Biol Ther
, vol.5
, pp. 1051-1068
-
-
Schirrmacher, V.1
-
57
-
-
84926525215
-
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
-
COI: 1:CAS:528:DC%2BC2MXktVCnsbw%3D, PID: 25754329, This report elucidates the mechanism of interaction between combination of radiation, anti-CTLA4 and anti-PD-L1 to suggest a combination that should be explored in patients
-
Twyman-Saint Victor C, Rech AJ, Maity A, et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature. 2015;520:373–7. This report elucidates the mechanism of interaction between combination of radiation, anti-CTLA4 and anti-PD-L1 to suggest a combination that should be explored in patients.
-
(2015)
Nature
, vol.520
, pp. 373-377
-
-
Twyman-Saint Victor, C.1
Rech, A.J.2
Maity, A.3
-
58
-
-
84891849910
-
Antitumor immune responses induced by ionizing irradiation and further immune stimulation
-
COI: 1:CAS:528:DC%2BC3sXhsVOktLbI, PID: 24052136
-
Frey B, Rubner Y, Kulzer L, et al. Antitumor immune responses induced by ionizing irradiation and further immune stimulation. Cancer Immunol Immunother. 2014;63:29–36.
-
(2014)
Cancer Immunol Immunother
, vol.63
, pp. 29-36
-
-
Frey, B.1
Rubner, Y.2
Kulzer, L.3
-
59
-
-
84864559660
-
Radiosurgery for melanoma brain metastases in the ipilimumab era and the possibility of longer survival
-
PID: 22702482
-
Knisely JP, Yu JB, Flanigan J, Sznol M, Kluger HM, Chiang VL. Radiosurgery for melanoma brain metastases in the ipilimumab era and the possibility of longer survival. J Neurosurg. 2012;117:227–33.
-
(2012)
J Neurosurg
, vol.117
, pp. 227-233
-
-
Knisely, J.P.1
Yu, J.B.2
Flanigan, J.3
Sznol, M.4
Kluger, H.M.5
Chiang, V.L.6
-
60
-
-
84930760492
-
Extended trastuzumab therapy improves the survival of HER2-positive breast cancer patients following surgery and radiotherapy for brain metastases
-
COI: 1:CAS:528:DC%2BC3sXhvVGht77F, PID: 24649283
-
Okita Y, Narita Y, Suzuki T, et al. Extended trastuzumab therapy improves the survival of HER2-positive breast cancer patients following surgery and radiotherapy for brain metastases. Mol Clin Oncol. 2013;1:995–1001.
-
(2013)
Mol Clin Oncol
, vol.1
, pp. 995-1001
-
-
Okita, Y.1
Narita, Y.2
Suzuki, T.3
-
61
-
-
84959919017
-
Clinical outcomes of melanoma brain metastases treated with stereotactic radiation and anti-PD-1 therapy
-
COI: 1:STN:280:DC%2BC28rlsVWjsw%3D%3D, PID: 26712903
-
Ahmed KA, Stallworth DG, Kim Y, et al. Clinical outcomes of melanoma brain metastases treated with stereotactic radiation and anti-PD-1 therapy. Ann Oncol. 2016;27:434–41.
-
(2016)
Ann Oncol
, vol.27
, pp. 434-441
-
-
Ahmed, K.A.1
Stallworth, D.G.2
Kim, Y.3
-
62
-
-
85005893688
-
Survival of melanoma patients with brain metastases treated with ipilimumab and stereotactic radiosurgery
-
COI: 1:CAS:528:DC%2BC2MXhsV2gu7s%3D, PID: 25164960
-
Tazi K, Hathaway A, Chiuzan C, Shirai K. Survival of melanoma patients with brain metastases treated with ipilimumab and stereotactic radiosurgery. Cancer Med. 2015;4:1–6.
-
(2015)
Cancer Med
, vol.4
, pp. 1-6
-
-
Tazi, K.1
Hathaway, A.2
Chiuzan, C.3
Shirai, K.4
-
63
-
-
84928938600
-
Stereotactic radiosurgery for melanoma brain metastases in patients receiving ipilimumab: safety profile and efficacy of combined treatment
-
PID: 25754629, This single institution review suggests favorable local control and indicates the possibility of pseudoprogression with combined therapy
-
Kiess AP, Wolchok JD, Barker CA, et al. Stereotactic radiosurgery for melanoma brain metastases in patients receiving ipilimumab: safety profile and efficacy of combined treatment. Int J Radiat Oncol Biol Phys. 2015;92:368–75. This single institution review suggests favorable local control and indicates the possibility of pseudoprogression with combined therapy.
-
(2015)
Int J Radiat Oncol Biol Phys
, vol.92
, pp. 368-375
-
-
Kiess, A.P.1
Wolchok, J.D.2
Barker, C.A.3
-
64
-
-
84860446616
-
Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial
-
COI: 1:CAS:528:DC%2BC38Xmslyhsb4%3D, PID: 22456429
-
Margolin K, Ernstoff MS, Hamid O, et al. Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial. Lancet. 2012;13:459–65.
-
(2012)
Lancet
, vol.13
, pp. 459-465
-
-
Margolin, K.1
Ernstoff, M.S.2
Hamid, O.3
-
65
-
-
84860495477
-
Treatment of brain metastases in patients with melanoma
-
PID: 22456430
-
Fisher R, Larkin J. Treatment of brain metastases in patients with melanoma. Lancet. 2012;13:434–5.
-
(2012)
Lancet
, vol.13
, pp. 434-435
-
-
Fisher, R.1
Larkin, J.2
-
66
-
-
80051984486
-
It is time to include patients with brain tumors in phase I trials in oncology
-
Wen PY, Schiff D, Cloughesy TF, et al. It is time to include patients with brain tumors in phase I trials in oncology. J Clin Oncol Off J Am Soc Clin Oncol. 2011;29:3211–3.
-
(2011)
J Clin Oncol Off J Am Soc Clin Oncol
, vol.29
, pp. 3211-3213
-
-
Wen, P.Y.1
Schiff, D.2
Cloughesy, T.F.3
-
67
-
-
84959900334
-
Stereotactic radiation and checkpoint inhibitors in melanoma patients with BM: a question of drug, timing or both?
-
COI: 1:STN:280:DC%2BC28nhs1KitQ%3D%3D, PID: 26782954
-
Dhermain F, Deutsch E. Stereotactic radiation and checkpoint inhibitors in melanoma patients with BM: a question of drug, timing or both? Ann Oncol. 2016;27:371–2.
-
(2016)
Ann Oncol
, vol.27
, pp. 371-372
-
-
Dhermain, F.1
Deutsch, E.2
-
68
-
-
84872028852
-
The biology of brain metastasis
-
COI: 1:CAS:528:DC%2BC3sXpsVygug%3D%3D, PID: 23115057
-
Langley RR, Fidler IJ. The biology of brain metastasis. Clin Chem. 2013;59:180–9.
-
(2013)
Clin Chem
, vol.59
, pp. 180-189
-
-
Langley, R.R.1
Fidler, I.J.2
|