Loss of nicastrin from oligodendrocytes results in hypomyelination and schizophrenia with compulsive behavior

Journal of Biological Chemistry

Volumn 291, Issue 22, 2016, Pages 11647-11656

  Dries, Daniel R ^a,c   Zhu, Yi ^a   Brooks, Mieu M ^a   Forero, Diego A ^d   Adachi, Megumi ^b   Cenik, Basar ^a   West, James M ^a   Han, Yu Hong ^a   Yu, Cong ^a   Arbella, Jennifer ^c   Nordin, Annelie ^e   Adolfsson, Rolf ^e   Del Favero, Jurgen ^f   Lu, Q Richard ^b,g   Callaerts, Patrick ^h   Birnbaum, Shari G ^b   Yu, Gang ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c JUNIATA COLLEGE   (United States)

^d CENTRO DE INVESTIGACIONES   (Colombia)

^e UMEÅ UNIVERSITY   (Sweden)

^f UNIVERSITY OF ANTWERP   (Belgium)

^g CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^h UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALS; NEUROPHYSIOLOGY;

BIOLOGICAL UNDERPINNINGS; CENTRAL NERVOUS SYSTEMS; DOPAMINE SIGNALING; GENETIC ALTERATIONS; NEURODEVELOPMENT; OBSESSIVE-COMPULSIVE DISORDERS; PATHOLOGICAL LESIONS; PSYCHIATRIC DISORDERS;

DISEASES;

DOPAMINE; GAMMA SECRETASE; NICASTRIN; MEMBRANE PROTEIN; NICASTRIN PROTEIN; SECRETASE;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MODEL; DOPAMINE SIGNALING; ENZYME ACTIVITY; FEMALE; GENE DELETION; GENE LOCUS; HEREDITY; HUMAN; HYPOMYELINATION; HYPOTHESIS; IN VIVO STUDY; KNOCKOUT MOUSE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MOLECULAR DYNAMICS; MOUSE; MYELIN DEFICIENCY; MYELINATION HYPOTHESIS; NICASTRIN GENE; NONHUMAN; OBSESSIVE COMPULSIVE DISORDER; OLIGODENDROGLIA; PHENOTYPE; PRIORITY JOURNAL; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; COMPULSION; GENETICS; METABOLISM; MYELIN SHEATH;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; COMPULSIVE BEHAVIOR; FEMALE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MIDDLE AGED; MYELIN SHEATH; OLIGODENDROGLIA; SCHIZOPHRENIA;

EID: 84971324160     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.715078     Document Type: Article

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