Directly activating the integrin αIIbβ3 initiates outside-in signaling by causing αIIbβ3 clustering

Journal of Biological Chemistry

Volumn 291, Issue 22, 2016, Pages 11706-11716

  Fong, Karen P ^a   Zhu, Hua ^a   Span, Lisa M ^a   Moore, David T ^b   Yoon, Kyungchul ^a   Tamura, Ryo ^c   Yin, Hang ^c   Degrado, William F ^d   Bennett, Joel S ^a  

^a Hematology/Oncology Division   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINS; CHEMICAL ACTIVATION; ENZYME ACTIVITY; ENZYMES; INDIUM PLATING; LIGANDS; MOLECULES; PEPTIDES; PLATELETS;

AUTOPHOSPHORYLATION; CARBOXYL TERMINUS; CONFORMATIONAL CHANGE; EXOGENOUS PEPTIDES; EXTRACELLULAR LIGANDS; INTRACELLULAR SIGNALS; LIGAND-BINDING SITES; TRANSMEMBRANE DOMAIN;

BIOACTIVITY;

ALPHA2BBETA3 INTEGRIN; FOCAL ADHESION KINASE; GLYCOPROTEIN; KINDLIN 3; MONOCLONAL ANTIBODY; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE; TALIN 1; UNCLASSIFIED DRUG; CSK TYROSINE-PROTEIN KINASE; FIBRINOGEN RECEPTOR; PEPTIDE FRAGMENT;

ARTICLE; AUTOPHOSPHORYLATION; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; THROMBOCYTE; CHEMISTRY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; METABOLISM; PHOSPHORYLATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

BLOOD PLATELETS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; SRC-FAMILY KINASES; SYK KINASE;

EID: 84971238785     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.716613     Document Type: Article

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