Improving the Recognition of, and Response to In-Hospital Sepsis

Current Infectious Disease Reports

Volumn 18, Issue 7, 2016, Pages

  Chan, Peter ^a   Peake, Sandra ^b   Bellomo, Rinaldo ^c   Jones, Daryl ^d,e  

^a WESTERN HOSPITAL   (Australia)

^b QUEEN ELIZABETH HOSPITAL   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d AUSTIN HOSPITAL   (Australia)

^e MONASH UNIVERSITY   (Australia)

Author keywords

Deteriorating patient; Early intervention; Rapid response team; Sepsis; Severe sepsis

Indexed keywords

ANTIBIOTIC AGENT; BIOLOGICAL MARKER; C REACTIVE PROTEIN; PROCALCITONIN;

ABNORMAL LABORATORY RESULT; CLINICAL FEATURE; EARLY GOAL DIRECTED THERAPY; EARLY INTERVENTION; EMERGENCY WARD; HEALTH CARE DISPARITY; HEALTH CARE MANAGEMENT; HEALTH CARE POLICY; HEALTH CARE PRACTICE; HUMAN; INTEGRATED HEALTH CARE SYSTEM; INTENSIVE CARE UNIT; MEDICAL DOCUMENTATION; META ANALYSIS (TOPIC); MORTALITY; MULTICENTER STUDY (TOPIC); PRACTICE GUIDELINE; PREVALENCE; RANDOMIZED CONTROLLED TRIAL (TOPIC); RAPID RESPONSE TEAM; REVIEW; SENSITIVITY AND SPECIFICITY; SEPSIS; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; STAFF TRAINING; SYSTEMATIC REVIEW (TOPIC); SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; THERAPY DELAY; VITAL SIGN;

EID: 84971221986     PISSN: 15233847     EISSN: 15343146     Source Type: Journal    
DOI: 10.1007/s11908-016-0528-7     Document Type: Review

References (82)

1. Stearns-Kurosawa D, Osuchowski MF, Valentine C, et al. The pathogensis of sepsis. Annu Rev Pathol. 2011;6:19–48.
2. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/ Society of Critical Care Medicine. Chest. 1992;101(6):1644–55.
3. Dellinger RP, Levy MM, Carlet JM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med. 2008;34(1):17–60.
4. Bochicchio GV, Napolitano LM, Joshi M, et al. Systemic inflammatory response syndrome score at admission independently predicts infection in blunt trauma patients. J Trauma. 2001;50:817–20.
5. Malone DL, Kuhls D, Napolitano LM, et al. Back to basics: validation of the admission systemic inflammatory response syndrome score in predicting outcome in trauma. J Trauma. 2001;51:458–63.
6. Napolitano LM, Ferrer T, McCarter R, et al. Systemic inflammatory response syndrome score at admission independently predicts mortality and length of stay in trauma patients. J Trauma. 2000;49:647–52.
7. Yoshimoto Y, Tanaka T, Hoya K. Acute systemic inflammatory response syndrome in subarachnoid hemorrhage. Stroke. 2001;32:1989–93.
8. Afessa B. Systemic inflammatory response syndrome in patients hospitalized for gastrointestinal bleeding. Crit Care Med. 1999;27:554–7.
9. Sun D, Aikawa N. The natural history of the systemic inflammatory response syndrome and the evaluation of SIRS criteria as a predictor of severity in patients hospitalized through emergency services. Keio J Med. 1999;48:28–37.
10. Asayama K, Aikawa N. Evaluation of systemic inflammatory response syndrome criteria as a predictor of mortality in emergency patients transported by ambulance. Keio J Med. 1998;47:19–27.
11. Sprung CL, Sakr Y, Vincent JL, et al. An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence in Acutely Ill Patients (SOAP) study. Intensive Care Med. 2006;32(3):421–7.
12. Pittet D, Rangel-Frausto S, Li N, et al. Systemic inflammatory response syndrome, sepsis, severe sepsis and septic shock: incidence, morbidities and outcomes in surgical ICU patients. Intensive Care Med. 1995;21(4):302–9.
13. Vincent JL. Dear SIRS, I’m sorry to say that I don’t like you.. Crit Care Med. 1997;25(2):372–4.
14. Kaukonen KM, Bailey M, Pilcher D, et al. Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med. 2015;372(17):1629–38.
15. Vincent JL, Opal SM, Marshall JC, Tracey KJ. Sepsis definitions: time for change. Lancet. 2013;381(9868):774–5.
16. Churpek MM, Zadravecz FJ, Winslow C, et al. Incidence and prognostic value of the systemic inflammatory response syndrome and organ dysfunctions in ward patients. Am J Respir Crit Care Med. 2015;192(8):958–64.
17. Klein Klouwenberg PM, Ong DS, Bonten MJ, Cremer OL. Classification of sepsis, severe sepsis and septic shock: the impact of minor variations in data capture and definition of SIRS criteria. Intensive Care Med. 2012;38(5):811–9.
18. Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ ATS/SIS international sepsis definitions conference. Crit Care Med. 2003;31(4):1250–6.
19. Dugas AF, Mackenhauer J, Salciccioli JD, et al. Prevalence and characteristics of nonlactate and lactate expressors in septic shock. J Crit Care. 2012;27(4):344–50.
20. Pedro Póvoa C-reactive protein: a valuable marker of sepsis. Intensive Care Med. 2002; 28: 235–243.
21. Uzzan B, Cohen R, Nicolas P, et al. Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med. 2006;34:1996–2003.
22. Lee SH, Chan RC, Wu JY, et al. Diagnostic value of procalcitonin for bacterial infection in elderly patients—a systemic review and meta-analysis. Int J Clin Pract. 2013;67(12):1350–7.
23. Tang BM, Eslick GD, Craig JC, et al. Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis. Lancet Infect Dis. 2007;7(3):210–7.
24. Albrich WC, Harbarth S. Pros and cons of using biomarkers versus clinical decisions in start and stop decisions for antibiotics in the critical care setting. Intensive Care Med. 2015;41(10):1739–51.
25. Marshall JC, Reinhart K. International Sepsis Forum. Biomarkers of sepsis. Crit Care Med. 2009;37(7):2290–8.
26. Skibsted S, Bhasin MK, Aird WC, Shapiro NI. Bench-to-bedside review: future novel diagnostics for sepsis—a systems biology approach. Crit Care. 2013;17(5):231.
27. Finfer S, Bellomo R, Lipman J, et al. Adult population incidence of severe sepsis in Australian and New Zealand intensive care units. Intensive Care Med. 2004;30(4):589–96.
28. Martin CM, Priestap F, Fisher H, et al. STAR Registry Investigators. A prospective, observational registry of patients with severe sepsis: the Canadian Sepsis Treatment and Response Registry. Crit Care Med. 2009;37(1):81–8.
29. Salvo I, de Cian W, Musicco M, et al. The Italian SEPSIS study: preliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis and septic shock. Intensive Care Med. 1995;21 Suppl 2:S244–9.
30. Quenot JP, Binquet C, Kara F, et al. The epidemiology of septic shock in French intensive care units: the prospective multicenter cohort EPISS study. Crit Care. 2013;17(2):R65.
31. Annane D, Aegerter P, Jars-Guincestre MC, Guidet B. CUB-Réa Network. Current epidemiology of septic shock: the CUB-Réa Network. Am J Respir Crit Care Med. 2003;168(2):165–72.
32. Whittaker SA, Fuchs BD, Gaieski DF, et al. Epidemiology and outcomes in patients with severe sepsis admitted to the hospital wards. J Crit Care. 2015;30(1):78–84.
33. Peake SL, Bailey M, Bellomo R, ARISE Investigators, for the Australian and New Zealand Intensive Care Society Clinical Trials Group, et al. Australasian resuscitation of sepsis evaluation (ARISE): a multi-centre, prospective, inception cohort study. Resuscitation. 2009;80(7):811–8.
34. ARISE; ANZICS APD Management Committee. The outcome of patients with sepsis and septic shock presenting to emergency departments in Australia and New Zealand. Crit Care Resusc. 2007;9(1):8–18.
35. Filbin MR, Arias SA, Camargo Jr CA, et al. Sepsis visits and antibiotic utilization in U.S. emergency departments. Crit Care Med. 2014;42(3):528–35.
36. Powell ES, Khare RK, Courtney DM, et al. Volume of emergency department admissions for sepsis is related to inpatient mortality: results of a nationwide cross-sectional analysis. N Engl J Med. 2003;348(16):1546–54.
37. Martin GS, Mannino DM, Eaton S, et al. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348(16):1546–54.
38. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med. 2007;35(5):1244–50.
39. Brun-Buisson C, Meshaka P, Pinton P, et al. EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. Intensive Care Med. 2004;30:580–8.
40. Rangel-Frausto S, Pittet D, Costigan M, et al. The natural history of the systemic inflammatory response syndrome (SIRS). JAMA. 1995;273(2):117–23.
41. Douglas L, Casamento A, Robbins R, et al. Point prevalence of patients fulfilling SIRS criteria in a teaching hospital. Intern Med J. 2016;46:223–5.
42. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345(19):1368–77.
43. Peake SL, Delaney A, Bailey M, ARISE Investigators; ANZICS Clinical Trials Group, et al. Goal-directed resuscitation for patients with early septic shock. N Engl J Med. 2014;371(16):1496–506.
44. Mouncey PR, Osborn TM, Power GS, et al. ProMISe Trial Investigators. Trial of early, goal-directed resuscitation for septic shock. N Engl J Med. 2015;372(14):1301–11.
45. Yealy DM, Kellum JA, Huang DT, ProCESS Investigators, et al. A randomized trial of protocol-based care for early septic shock. N Engl J Med. 2014;370(18):1683–93.
46. Kaukonen KM, Bailey M, Suzuki S, et al. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000–2012. JAMA. 2014;311(13):1308–16.
47. Kaukonen KM, Bailey M, Bellomo R. Systemic inflammatory response syndrome criteria for severe sepsis. N Engl J Med. 2015;373(9):881.
48. Singer M, Deutschman, CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016
49. Gloria Vazquez-Grande MD, Anand Kumar MD. Optimizing antimicrobial therapy of sepsis and septic shock: focus on antibiotic combination therapy. Semin Respir Crit Care Med. 2015;36:154–66.
50. Johnson MT, Reichley R, Hoppe-Bauer J, et al. Impact of previous antibiotic therapy on outcome of Gram-negative severe sepsis. Crit Care Med. 2011;39(8):1859–65.
51. de Groot B, Ansems A, Gerling DH, et al. The association between time to antibiotics and relevant clinical outcomes in emergency department patients with various stages of sepsis: a prospective multi-center study. Crit Care. 2015;19:194.
52. Lodise Jr TP, Lomaestro B, Drusano GL. Piperacillin-tazobactam for Pseudomonas aeruginosa infection: clinical implications of an extended- infusion dosing strategy. Clin Infect Dis. 2007;44(3):357–63.
53. Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34(6):1589–96.
54. Kaasch AJ, Rieg S, Kuetscher J, Brodt HR, preSABATO study group, et al. Delay in the administration of appropriate antimicrobial therapy in Staphylococcus aureus bloodstream infection: a prospective multicenter hospital-based cohort study. Infection. 2013;41(5):979–85.
55. Garnacho-Montero J, Gutiérrez-Pizarraya A, Escoresca-Ortega A, et al. De-escalation of empirical therapy is associated with lower mortality in patients with severe sepsis and septic shock. Intensive Care Med. 2014;40(1):32–40.
56. Varpula M, Tallgren M, Saukkonen K, et al. Hemodynamic variables related to outcome in septic shock. Intensive Care Med. 2005;31:1066–71.
57. Dünser MW, Takala J, Ulmer H, et al. Arterial blood pressure during early sepsis and outcome. Intensive Care Med. 2009;35:1225–33.
58. Permpikul C, Sringam P, Tongyoo S. Therapeutic goal achievements during severe sepsis and septic shock resuscitation and their association with patients’ outcomes. J Med Assoc Thai. 2014;97 Suppl 3:S176–83.
59. Beck V, Chateau D, Bryson GL, Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group, et al. Timing of vasopressor initiation and mortality in septic shock: a cohort study. Crit Care. 2014;18(3):R97.
60. Waechter J, Kumar A, Lapinsky SE, Marshall J, Dodek P, Arabi Y, et al. Interaction between fluids and vasoactive agents on mortality in septic shock: a multicentre, observational study. Crit Care Med. 2014;42:2158–68.
61. Marik P, Bellomo R. A rational approach to fluid therapy in sepsis. Br J Anaesth. 2016;116(3):339–49.
62. Belletti A, Castro ML, Silvetti S, et al. The effect of inotropes and vasopressors on mortality: a meta-analysis of randomized clinical trials. Br J Anaesth. 2015;115(5):656–75.
63. Kato R, Pinsky MR. Personalizing blood pressure management in septic shock. Ann Intensive Care. 2015;5(1):41.
64. Marik PE, Varon J. Goal-directed therapy for severe sepsis. N Engl J Med. 2002;346(13):1025–6.
65. Angus DC, Barnato AE, Bell D, et al. A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators. Intensive Care Med. 2015;41(9):1549–60.
66. Peake SL, Bailey M, Bellomo R, ARISE Investigators, for the Australian and New Zealand Intensive Care Society Clinical Trials Group, et al. Australasian resuscitation of sepsis evaluation (ARISE): a multi-centre, prospective, inception cohort study. Resuscitation. 2009;80:811–8.
67. Jones DA, DeVita M, Bellomo R. Rapid-response teams. NEJM. 2011;365(2):139–46.
68. Cross G, Bilgrami I, Eastwood G, et al. The epidemiology of sepsis during rapid response team reviews in a teaching hospital. Anaesth Intensive Care. 2015;43(2):193–8.
69. Jones D, Duke G, Green J, et al. Medical emergency team syndromes and an approach to their management. Crit Care. 2006;10(1):R30.
70. Schneider A, Calzavacca P, Mercer I, et al. The epidemiology and outcome of medical emergency team call patient treated with non-invasive ventilation. Resuscitation. 2011;82(9):1218–23.
71. Jaderling G, Bell M, Martling C, et al. ICU admittance by a rapid response team versus conventional admittance, characteristics, and outcome. Crit Care Med. 2013;41(3):725–31.
72. Miano TA, Powell E, Schweickert WD, et al. Effect of an antibiotic algorithm on the adequacy of empiric antibiotic therapy given by a medical emergency team. J Crit Care. 2012;27(1):45–50.
73. Sarani B, Brenner SR, Gabel B, et al. Improving sepsis care through systems change: the impact of a medical emergency team. Jt Comm J Qual Patient Saf. 2008;34:179–82.
74. Medical Emergency Team End-of-Life Care investigators. The timing of rapid response team activations: a multicentre international study. Crit Care Resusc. 2013;15:15–20.
75. Considine J, Charlesworth D, Currey J. Characteristics and outcomes of patients requiring rapid response system activation within hours of emergency admission. Crit Care Resusc. 2014;16(3):184–9.
76. McGain F, Cretikos MA, Jones D, et al. Documentation of clinical review and vital signs after major surgery. Med J Aust. 2008;189(7):380–3.
77. Preece MH, Hill A, Horswill MS, et al. Supporting the detection of patient deterioration: observation chart design affects the recognition of abnormal vital signs. Resuscitation. 2012;83(9):1111–8.
78. Currey JP, Jungquist CR. A critical assessment of monitoring practices, patient deterioration, and alarm fatigue on inpatient wards: a review. Patient Saf Surg. 2014;27(8):29.
79. Burrell AR, McLaws ML, Fullick M, et al. SEPSIS KILLS: early intervention saves lives. Med J Aust. 2016;204(2):73.
80. Nguyen SQ, Mwakalindile E, Booth JS, et al. Automated electronic medical record sepsis detection in the emergency department. Peer J. 2014;2:e343.
81. Alsolamy S, Al Salamah M, Al Thagafi M, et al. Diagnostic accuracy of a screening electronic alert tool for severe sepsis and septic shock in the emergency department. BMC Med Inform Decis Mak. 2014;14:105.
82. Australian Commission on Safety and Quality in Health Care. National consensus statement: essential elements for recognising and responding to clinical deterioration. Sydney: ACSQHC, 2010. http://www.safetyandquality.gov.au/internet/safety/publishing.nsf/Content/F329E60CC4149933CA25777 40009229C/$File/national_consensus_statement.pdf (accessed Feb 2016)