Timing of vasopressor initiation and mortality in septic shock: A cohort study

Critical Care

Volumn 18, Issue 3, 2014, Pages

  Beck, Vance ^a   Chateau, Dan ^b   Bryson, Gregory L ^a   Pisipati, Amarnath ^b   Zanotti, Sergio ^c   Parrillo, Joseph E ^d   Kumar, Anand ^b  

^a UNIVERSITY OF OTTAWA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c Department of Medical Microbiology University of Manitoba ^*  (United States)

^d RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOBUTAMINE; DOPAMINE; HYPERTENSIVE AGENT; NORADRENALIN; STEROID; VASOCONSTRICTOR AGENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AGE DISTRIBUTION; ANTIMICROBIAL THERAPY; APACHE; ARTICLE; ASSISTED VENTILATION; CANADA; COHORT ANALYSIS; CORRELATION ANALYSIS; FEMALE; FLUID THERAPY; HEMATOLOGIC MALIGNANCY; HOSPITAL DISCHARGE; HUMAN; HYPERTENSION; HYPOTENSION; INTENSIVE CARE UNIT; LENGTH OF STAY; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; MEDICAL DOCUMENTATION; MEDICAL RECORD REVIEW; METASTASIS; MORTALITY; MULTICENTER STUDY; NEUTROPENIA; PRIORITY JOURNAL; SAUDI ARABIA; SEPTIC SHOCK; TREATMENT DURATION; UNITED STATES; AGED; CLINICAL TRIAL; MIDDLE AGED; RETROSPECTIVE STUDY; SHOCK, SEPTIC; TIME; TRENDS;

AGED; COHORT STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; MORTALITY; RETROSPECTIVE STUDIES; SHOCK, SEPTIC; TIME FACTORS; VASOCONSTRICTOR AGENTS;

EID: 84902546297     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc13868     Document Type: Article

References (42)

1. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348:1546-1554. 10.1056/NEJMoa022139, 12700374.
2. Kumar A, Ellis P, Arabi Y, Roberts D, Light B, Parrillo JE, Dodek P, Wood G, Kumar A, Simon D, Peters C, Ahsan M, Chateau D, . Cooperative Antimicrobial Therapy of Septic Shock Datbase Research Group Initiation of inappropriate antimicrobial therapy results in a five-fold reduction of survival in human septic shock. Chest 2009, 136:1237-1248. Cooperative Antimicrobial Therapy of Septic Shock Datbase Research Group.
3. Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, Gårdlund B, Marshall JC, Rhodes A, Artigas A, Payen D, Tenhunen J, Al-Khalidi HR, Thompson V, Janes J, Macias WL, Vangerow B, Williams MD. Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med 2012, 366:2055-2064. 10.1056/NEJMoa1202290, 22616830.
4. Hotchkiss RS, Karl IE. Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. JAMA 1992, 267:1503-1510. 10.1001/jama.1992.03480110079038, 1538541.
5. De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 2002, 166:98-104. 10.1164/rccm.200109-016OC, 12091178.
6. Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL. Persistent-microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 2004, 32:1825-1831. 10.1097/01.CCM.0000138558.16257.3F, 15343008.
7. Ledoux D, Astiz ME, Carpati CM, Rackow EC. Effects of perfusion pressure on tissue perfusion in septic shock. Crit Care Med 2000, 28:2729-2732. 10.1097/00003246-200008000-00007, 10966242.
8. Parker MM, Shelhamer JH, Bacharach SL, Green MV, Natanson C, Frederick TM, Damske BA, Parrillo JE. Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 1984, 100:483-490. 10.7326/0003-4819-100-4-483, 6703540.
9. Kumar A, Haery C, Parrillo JE. Myocardial dysfunction in septic shock: Part I, clinical manifestation of cardiovascular dysfunction. J Cardiothorac Vasc Anesth 2001, 15:364-376. 10.1053/jcan.2001.22317, 11426372.
10. Annane D, Bellissant E, Cavaillon JM, Annane D, Bellissant E, Cavaillon JM. Septic shock. Lancet 2005, 365:63-78. 10.1016/S0140-6736(04)17667-8, 15639681.
11. Trzeciak S, Dellinger RP, Parrillo JE, Guglielmi M, Bajaj J, Abate NL, Arnold RC, Colilla S, Zanotti S, Hollenberg SM. Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med 1998, 49:88-98.
12. Gutteriez G, Brown SD. Response of the macrocirculation. Pathophysiology of Shock, Sepsis and Organ Failure 1993, 215-229. Berlin: Springer, Schlag R, Redl H.
13. Terborg C, Schummer W, Albrecht M, Reinhart K, Weiller C, Rother J. Dysfunction of vasomotor reactivity in severe sepsis and septic shock. Intensive Care Med 2001, 27:1231-1234. 10.1007/s001340101005, 11534574.
14. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M, . Early Goal-Directed Therapy Collaborative Group Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345:1368-1377. 10.1056/NEJMoa010307, 11794169, Early Goal-Directed Therapy Collaborative Group.
15. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent J-L, Moreno R, . Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013, 41:580-637. 10.1097/CCM.0b013e31827e83af, 23353941, Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup.
16. Subramanian S, Yilmaz M, Rehman A, Hubmayr RD, Afessa B, Gajic O. Liberal vs. conservative vasopressor use to maintain mean arterial blood pressure during resuscitation of septic shock: an observational study. Intensive Care Med 2008, 34:157-162. 10.1007/s00134-007-0862-1, 17924093.
17. Morimatsu H, Singh K, Uchino S, Bellomo R, Hart G. Early and exclusive use of norepinephrine in septic shock. Resuscitation 2004, 62:249-254. 10.1016/j.resuscitation.2004.03.016, 15294412.
18. Bone R. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992, 20:864-874. 10.1097/00003246-199206000-00025, 1597042.
19. Sollet JP, Garber GE. Selecting patients with severe sepsis for drotrecogin alfa (activated) therapy. Am J Surg 2002, 184:S11-S18. 10.1016/S0002-9610(02)01132-7, 12521613.
20. Knaus WA, Draper EA. APACHE II: a severity of disease classification system. Crit Care Med 1985, 13:818-829. 10.1097/00003246-198510000-00009, 3928249.
21. Baez AA, Lane PL, Sorondo B, Giraldez EM. Predictive effect of out-of-hospital time in outcomes of severely injured young adult and elderly patients. Prehosp Disaster Med 2006, 21:427-430.
22. Wood KE. Major pulmonary embolism: review of a pathophysiologic approach to the golden hour of hemodynamically significant pulmonary embolism. Chest 2002, 121:877-905. 10.1378/chest.121.3.877, 11888976.
23. Blow O, Magliore L, Claridge JA, Butler K, Young JS. The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma. J Trauma 1999, 47:964-969. 10.1097/00005373-199911000-00028, 10568731.
24. Boersma E, Maas AC, Deckers JW, Simoons ML. Early thrombolytic treatment in acute myocardial infarction: reappraisal of the golden hour. Lancet 1996, 348:771-775. 10.1016/S0140-6736(96)02514-7, 8813982.
25. Sebesta P, Klika T, Zdrahal P, Kramar J. Ruptured abdominal aortic aneurysm: role of initial delay on survival. J Mal Vasc 1998, 23:361-367.
26. Sebat F, Musthafa AA, Johnson D, Kramer AA, Shoffner D, Eliason M, Henry K, Spurlock B. Effect of a rapid response system for patients in shock on time to treatment and mortality during 5 years. Crit Care Med 2007, 35:2568-2575. 10.1097/01.CCM.0000287593.54658.89, 17901831.
27. Gaieski DF, Pines JM, Band RA, Mikkelson ME, Massone R, Furia FF, Shofer FS, Goyal M. Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Crit Care Med 2010, 38:1045-1053. 10.1097/CCM.0b013e3181cc4824, 20048677.
28. Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, Suppes R, Feinstein D, Zanotti S, Taiberg L, Gurka D, Kumar A, Cheang C. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006, 34:1589-1596. 10.1097/01.CCM.0000217961.75225.E9, 16625125.
29. Valles J, Rello J, Ochagavia A, Garnacho J, Alcala MA. Community-acquired bloodstream infection in critically ill adult patients: impact of shock and inappropriate antibiotic therapy on survival. Chest 2003, 123:1615-1624. 10.1378/chest.123.5.1615, 12740282.
30. Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP. The natural history of the systemic inflammatory response syndrome (SIRS), a prospective study. JAMA 1995, 273:117-123. 10.1001/jama.1995.03520260039030, 7799491.
31. Varpula M, Tallgren M, Saukkonen K, Voipio-Pulkki LM, PettilΣ V. Hemodynamic variables related to outcome in septic shock. Intensive Care Med 2005, 31:1066-1071. 10.1007/s00134-005-2688-z, 15973520.
32. Dünser MW, Takala J, Ulmer H, Mayr VD, Luckner G, Jochberger S, Daudel F, Lepper P, Hasibeder WR, Jakob SM. Arterial blood pressure during early sepsis and outcome. Intensive Care Med 2009, 35:1225-1233. 10.1007/s00134-009-1427-2, 19189077.
33. Annane D, Vignon P, Renault A, Bollaert PE, Charpentier C, Martin C, Troché G, Ricard JD, Nitenberg G, Papazian L, Azoulay E, Bellissant E. Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial. Lancet 2007, 370:676-684. 10.1016/S0140-6736(07)61344-0, 17720019.
34. Russell JA, Walley KR, Singer J, Gordon AC, Hebert PC, Cooper J, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ, Ayers D. Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 2008, 58:877-887.
35. De Backer D, Biston P, Devriendt J, Madl C, Chochrad D, Aldecoa C, Brasseur A, Defrance P, Gottignies P, Vincent JL. Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med 2010, 362:779-789. 10.1056/NEJMoa0907118, 20200382.
36. Sennoun N, Montemont C, Gibot S, Lacolley P, Levy B. Comparative effects of early versus delayed use of norepinephrine in resuscitated endotoxic shock. Crit Care Med 2007, 35:1736-1740. 10.1097/01.CCM.0000269028.28521.08, 17522580.
37. Correa TD, Vuda M, Blaser AR, Takala J, Djafarzadeh S, Dunser MW, Silva E, Lensch M, Wilkens L, Jakob SM. Effect of treatment delay on disease severity and need for resuscitation in porcine fecal peritonitis. Crit Care Med 2012, 40:2841-2849. 10.1097/CCM.0b013e31825b916b, 22890256.
38. Kumar A, Haery C, Paladugu B, Kumar A, Symeoneides S, Taiberg L, Osman J, Trenholme G, Opal SM, Goldfarb R, Parillo JE. The duration of hypotension before the initiation of antibiotic treatment is a critical determinant of survival in a murine model of Escherichia coli septic shock: association with serum lactate and inflammatory cytokine levels. J Infect Dis 2006, 193:251-258. 10.1086/498909, 16362889.
39. Frimodt-Moller N, Thomsen VF. The pneumococcus and the mouse protection test: inoculum, dosage and timing. Acta Pathol Microbiol Immunol Scand B 1986, 94:33-37.
40. Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, Nyeko R, Mtove G, Reyburn H, Lang T, Brent B, Evans JA, Tibenderana JK, Crawley J, Russell EC, Levin M, Babiker AG, Gibb DM. Mortality after fluid bolus in African children with severe infection. N Engl J Med 2011, 364:2483-2495. 10.1056/NEJMoa1101549, 21615299.
41. Boyd JH, Forbes J, Nakada T, Walley KR, Russell JA. Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med 2011, 39:259-265. 10.1097/CCM.0b013e3181feeb15, 20975548.
42. Waechter J, Kumar A, Lapinsky S, Marshall J, Dodek P, Arabi Y, Parrillo J, Dellinger R, Garland A, . the Cooperative Antimicrobial Therapy of Septic Shock Database Research Group Interplay between fluids and vasoactive agents on mortality in septic shock: a multicenter, observational study. Crit Care Med 2014, in press, the Cooperative Antimicrobial Therapy of Septic Shock Database Research Group.