SEPSIS KILLS: Early intervention saves lives

Medical Journal of Australia

Volumn 204, Issue 2, 2016, Pages 1.e1-1.e7

  Burrell, Anthony R ^a   McLaws, Mary Louise ^b   Fullick, Mary ^a   Sullivan, Rosemary B ^a   Sindhusake, Doungkamol ^a  

^a Clinical Excellence Commission   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BIOLOGICAL MARKER; LACTIC ACID;

ANXIETY; ARTICLE; BLOOD CULTURE; DISEASE SEVERITY; EARLY INTERVENTION; EMERGENCY HEALTH SERVICE; FLUID RESUSCITATION; HEALTH PROGRAM; HUMAN; INFLAMMATION; INTENSIVE CARE; LACTATE BLOOD LEVEL; LINKAGE ANALYSIS; MORTALITY RATE; OUTCOME ASSESSMENT; RISK FACTOR; SEPSIS; SEPTIC SHOCK; AGED; BACTEREMIA; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; EARLY DIAGNOSIS; EPIDEMIOLOGY; FLUID THERAPY; INCIDENCE; LENGTH OF STAY; MICROBIOLOGY; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; NEW SOUTH WALES; PRACTICE GUIDELINE; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; STATISTICS AND NUMERICAL DATA; SURVIVAL RATE; TIME FACTOR;

AGED; ANTI-BACTERIAL AGENTS; BACTEREMIA; BIOMARKERS; BLOOD; EARLY DIAGNOSIS; EMERGENCY SERVICE, HOSPITAL; FLUID THERAPY; GUIDELINES AS TOPIC; HUMANS; INCIDENCE; LACTIC ACID; LENGTH OF STAY; MIDDLE AGED; NEW SOUTH WALES; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE; TIME FACTORS;

EID: 84956601877     PISSN: 0025729X     EISSN: 13265377     Source Type: Journal    
DOI: 10.5694/mja15.00657     Document Type: Article

References (25)

1. Mayr FB, Yende S, Angus DC. Epidemiology of severe sepsis. Virulence 2014; 5: 4-11.
2. Wang HE, Shapiro NI, Griffin R, et al. Chronic medical conditions and risk of sepsis. PLoS One 2012; 7: e48307.
3. Dellinger RP, Levy MM, Rhodes A, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013; 41: 580-637.
4. Kaukonen K-M, Bailey M, Pilcher D, et al. Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med 2015; 372: 1629-1638.
5. Gray A, Ward K, Lees F, et al. The epidemiology of adults with severe sepsis and septic shock in Scottish emergency departments. Emerg Med J 2013; 30: 397-401.
6. Clinical Excellence Commission. Recognition and management of sepsis (clinical focus report). Sydney: CEC, 2012. http://www.cec.health.nsw.gov.au/__data/assets/pdf_file/0004/259375/patient-safety-reportsepsis-2012.pdf (accessed Nov 2015).
7. Clinical Excellence Commission. 2011 Quality Systems Assessment self assessment. Supplementary report e sepsis. Sydney: CEC, 2012. http://www.cec.health.nsw.gov.au/__data/assets/pdf_file/0009/259308/2011-qsathematic- report-sepsis_qsa_final.pdf (accessed Nov 2015).
8. Hughes C, Pain C, Braithwaite J, Hillman K. “Between the flags”: implementing a rapid response system at scale. BMJ Qual Saf 2014; 23: 714-717.
9. Australasian College for Emergency Medicine. Policy on the Australasian Triage Scale. (Policy P06.). July 2013. https://www.acem.org.au/getattachment/693998d7-94be-4ca7-a0e7-3d74cc9b733f/Policy-on-the-Australasian-Triage-Scale.aspx (accessed Nov 2015)
10. Sundararajan V, Macisaac CM, Presneill JJ, et al. Epidemiology of sepsis in Victoria, Australia. Crit Care Med 2005; 33: 71-80.
11. Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34: 1589-1596.
12. Puskarich MA, Trzeciak S, Shapiro NI, et al. Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med 2011; 39: 2066-2071.
13. Ferrer R, Martin-Loeches I, Phillips G, et al. Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med 2014; 42: 1749-1755.
14. Kaukonen KM, Bailey M, Suzuki S, et al. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000e2012. JAMA 2014; 311: 1308-1316.
15. Peake SL, Delaney A, Bailey M, et al. Goal-directed resuscitation for patients with early septic shock. N Engl J Med 2014; 371: 1496-1506.
16. Mikkelsen ME, Miltiades AN, Gaieski DF, et al. Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med 2009; 37: 1670-1677.
17. Whittaker SA, Fuchs BD, Gaieski DF, et al. Epidemiology and outcomes in patients with severe sepsis admitted to the hospital wards. J Crit Care 2015; 30: 78-84.
18. Esteban A, Frutos-Vivar F, Ferguson ND, et al. Sepsis incidence and outcome: contrasting the intensive care unit with the hospital ward. Crit Care Med 2007; 35: 1284-1289.
19. Gao F, Melody T, Daniels DF, et al. The impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis: a prospective observational study. Crit Care 2005; 9: R764-R770.
20. Marwick CA, Guthrie B, Pringle JE, et al. A multifaceted intervention to improve sepsis management in general hospital wards with evaluation using segmented regression of interrupted time series. BMJ Qual Saf 2014; 23: e2.
21. Jaderling G, Bell M, Martling CR, et al. ICU admittance by a rapid response team versus conventional admittance, characteristics, and outcome. Crit Care Med 2013; 41: 725-731.
22. Liu V, Escobar GJ, Greene JD, et al. Hospital deaths in patients with sepsis from 2 independent cohorts. JAMA 2014; 312: 90-92.
23. Runciman WB, Hunt TD, Hannaford NA, et al. CareTrack: assessing the appropriateness of health care delivery in Australia. Med J Aust 2012; 197: 100-105. https://www.mja.com.au/journal/2012/197/2/caretrackassessing-appropriateness-healthcare-delivery-australia
24. Kumar A, Ellis P, Arabi Y, et al. Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest 2009; 136: 1237-1248.
25. Cross G, Bilgrami I, Eastwood G, et al. The epidemiology of sepsis during rapid response team reviews in a teaching hospital. Anaesth Intensive Care 2015; 43: 193-198.