메뉴 건너뛰기




Volumn 173, Issue 12, 2016, Pages 2001-2015

The role of metformin and resveratrol in the prevention of hypoxia-inducible factor 1α accumulation and fibrosis in hypoxic adipose tissue

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; COLLAGEN TYPE 3; COLLAGEN TYPE 3ALPHA; COLLAGEN TYPE 6; COLLAGEN TYPE 6ALPHA; ELASTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INITIATION FACTOR 2ALPHA; INOSITOL REQUIRING ENZYME 1ALPHA; INTERLEUKIN 6; METFORMIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN IRE1; PROTEIN LYSINE 6 OXIDASE; RESVERATROL; SIRTUIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; STILBENE DERIVATIVE;

EID: 84971216547     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.13493     Document Type: Article
Times cited : (63)

References (35)
  • 3
    • 84897353217 scopus 로고    scopus 로고
    • Metformin inhibits angiotensin II-induced differentiation of cardiac fibroblasts into myofibroblasts
    • Bai J, Zhang N, Hua Y, Wang B, Ling L, Ferro A, et al., (2013). Metformin inhibits angiotensin II-induced differentiation of cardiac fibroblasts into myofibroblasts. PLoS One 8: e72120.
    • (2013) PLoS One , vol.8 , pp. e72120
    • Bai, J.1    Zhang, N.2    Hua, Y.3    Wang, B.4    Ling, L.5    Ferro, A.6
  • 4
    • 84910634437 scopus 로고    scopus 로고
    • Resveratrol inhibits epithelial-mesenchymal transition and renal fibrosis by antagonizing the hedgehog signaling pathway
    • Bai Y, Lu H, Wu C, Liang Y, Wang S, Lin C, et al., (2014). Resveratrol inhibits epithelial-mesenchymal transition and renal fibrosis by antagonizing the hedgehog signaling pathway. Biochem Pharmacol 92: 484-493.
    • (2014) Biochem Pharmacol , vol.92 , pp. 484-493
    • Bai, Y.1    Lu, H.2    Wu, C.3    Liang, Y.4    Wang, S.5    Lin, C.6
  • 5
    • 80052910300 scopus 로고    scopus 로고
    • Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients
    • Brasnyó P, Molnár GA, Mohás M, Markóal L, Laczyal B, Cseh J, et al., (2011). Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Brit J Nutr 106: 383-389.
    • (2011) Brit J Nutr , vol.106 , pp. 383-389
    • Brasnyó, P.1    Molnár, G.A.2    Mohás, M.3    Markóal, L.4    Laczyal, B.5    Cseh, J.6
  • 6
    • 84928635872 scopus 로고    scopus 로고
    • Activation of SIRT3 by resveratrol ameliorates cardiac fibrosis and improves cardiac function via TGF-β/Smad3 pathway
    • Chen T, Li J, Liu J, Li N, Wang S, Liu H, et al., (2015). Activation of SIRT3 by resveratrol ameliorates cardiac fibrosis and improves cardiac function via TGF-β/Smad3 pathway. Am J Physiol-Heart C 308: H424-H434.
    • (2015) Am J Physiol-Heart C , vol.308 , pp. H424-H434
    • Chen, T.1    Li, J.2    Liu, J.3    Li, N.4    Wang, S.5    Liu, H.6
  • 8
    • 84876286546 scopus 로고    scopus 로고
    • Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats
    • Di Pascoli M, Diví M, Rodríguez-Vilarrupla A, Rosado E, Gracia-Sancho J, Vilaseca M, et al., (2013). Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats. J Hepatol 58: 904-910.
    • (2013) J Hepatol , vol.58 , pp. 904-910
    • Di Pascoli, M.1    Diví, M.2    Rodríguez-Vilarrupla, A.3    Rosado, E.4    Gracia-Sancho, J.5    Vilaseca, M.6
  • 9
    • 36549014136 scopus 로고    scopus 로고
    • Compound C inhibits hypoxic activation of HIF-1 independent of AMPK
    • Emerling BM, Viollet B, Tormos KV, Chandel NS, (2007). Compound C inhibits hypoxic activation of HIF-1 independent of AMPK. FEBS Lett 581: 5727-5731.
    • (2007) FEBS Lett , vol.581 , pp. 5727-5731
    • Emerling, B.M.1    Viollet, B.2    Tormos, K.V.3    Chandel, N.S.4
  • 12
    • 33744976813 scopus 로고    scopus 로고
    • Metformin inhibits cytokine-induced nuclear factor κb activation via AMP-activated protein kinase activation in vascular endothelial cells
    • Hattori Y, Suzuki K, Hattori S, Kasai K, (2006). Metformin inhibits cytokine-induced nuclear factor κB activation via AMP-activated protein kinase activation in vascular endothelial cells. Hypertension 47: 1183-1188.
    • (2006) Hypertension , vol.47 , pp. 1183-1188
    • Hattori, Y.1    Suzuki, K.2    Hattori, S.3    Kasai, K.4
  • 13
    • 34047119110 scopus 로고    scopus 로고
    • Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation
    • Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka S, Segawa K, et al., (2007). Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 56: 901-911.
    • (2007) Diabetes , vol.56 , pp. 901-911
    • Hosogai, N.1    Fukuhara, A.2    Oshima, K.3    Miyata, Y.4    Tanaka, S.5    Segawa, K.6
  • 14
    • 80053408653 scopus 로고    scopus 로고
    • Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice
    • Jiang C, Qu A, Matsubara T, Chanturyia T, Jou W, Gavrilova O, et al., (2011). Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice. Diabetes 60: 2484-2495.
    • (2011) Diabetes , vol.60 , pp. 2484-2495
    • Jiang, C.1    Qu, A.2    Matsubara, T.3    Chanturyia, T.4    Jou, W.5    Gavrilova, O.6
  • 15
    • 0037371153 scopus 로고    scopus 로고
    • Lysyl oxidase: Properties, specificity, and biological roles inside and outside of the cell
    • Kagan HM, Li W, (2003). Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem 88: 660-672.
    • (2003) J Cell Biochem , vol.88 , pp. 660-672
    • Kagan, H.M.1    Li, W.2
  • 16
    • 62849107819 scopus 로고    scopus 로고
    • Metabolic dysregulation and adipose tissue fibrosis: Role of collagen VI
    • Khan T, Muise ES, Iyengar P, Wang ZV, Chandalia M, Abate N, et al., (2009). Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol 29: 1575-1591.
    • (2009) Mol Cell Biol , vol.29 , pp. 1575-1591
    • Khan, T.1    Muise, E.S.2    Iyengar, P.3    Wang, Z.V.4    Chandalia, M.5    Abate, N.6
  • 18
    • 84922255495 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase inhibits ER stress and renal fibrosis
    • Kim H, Moon SY, Kim JS, Baek CH, Kim M, Min JY, et al., (2015). Activation of AMP-activated protein kinase inhibits ER stress and renal fibrosis. Am J Physiol-Renal 308: F226-F236.
    • (2015) Am J Physiol-Renal , vol.308 , pp. F226-F236
    • Kim, H.1    Moon, S.Y.2    Kim, J.S.3    Baek, C.H.4    Kim, M.5    Min, J.Y.6
  • 20
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
    • Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, et al., (2006). Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell 127: 1109-1122.
    • (2006) Cell , vol.127 , pp. 1109-1122
    • Lagouge, M.1    Argmann, C.2    Gerhart-Hines, Z.3    Meziane, H.4    Lerin, C.5    Daussin, F.6
  • 21
    • 65249119817 scopus 로고    scopus 로고
    • Adipokines, inflammation, and visceral adiposity across the menopausal transition: A prospective study
    • Lee CG, Carr MC, Murdoch SJ, Mitchell E, Woods NF, Wener MH, et al., (2009). Adipokines, inflammation, and visceral adiposity across the menopausal transition: a prospective study. J Clin Endocrinol Metab 94: 1104-1110.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 1104-1110
    • Lee, C.G.1    Carr, M.C.2    Murdoch, S.J.3    Mitchell, E.4    Woods, N.F.5    Wener, M.H.6
  • 22
    • 84902075318 scopus 로고    scopus 로고
    • 2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity
    • 2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity. Cell 157: 1339-1352.
    • (2014) Cell , vol.157 , pp. 1339-1352
    • Lee, Y.S.1    Kim, J.W.2    Osborne, O.3    Ohda, Y.4    Sasik, R.5    Schenk, S.6
  • 23
    • 84928346634 scopus 로고    scopus 로고
    • Implementing guidelines on reporting research using animals (ARRIVE etc.): New requirements for publication in BJP
    • McGrath JC, Lilley E, (2015). Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP. Br J Pharmacol 172: 3189-3193.
    • (2015) Br J Pharmacol , vol.172 , pp. 3189-3193
    • McGrath, J.C.1    Lilley, E.2
  • 24
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex i of the mitochondrial respiratory chain
    • Owen MR, Doran E, Halestrap AP, (2000). Evidence that metformin exerts its anti-diabetic effects through inhibition of complex I of the mitochondrial respiratory chain. Biochem J 348: 607-614.
    • (2000) Biochem J , vol.348 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 25
    • 84901193933 scopus 로고    scopus 로고
    • Insulin sensitizers for the treatment of non-alcoholic fatty liver disease
    • Ozturk ZA, Kadayifci A, (2014). Insulin sensitizers for the treatment of non-alcoholic fatty liver disease. World J Hepatol 6: 199-206.
    • (2014) World J Hepatol , vol.6 , pp. 199-206
    • Ozturk, Z.A.1    Kadayifci, A.2
  • 26
    • 84891791940 scopus 로고    scopus 로고
    • The IUPHAR/BPS guide to PHARMACOLOGY: An expert-driven knowledge base of drug targets and their ligands
    • Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SP, Buneman OP, et al., (2014). The IUPHAR/BPS guide to PHARMACOLOGY: an expert-driven knowledge base of drug targets and their ligands. Nucleic Acids Res 42: D1098-D1106.
    • (2014) Nucleic Acids Res , vol.42 , pp. D1098-D1106
    • Pawson, A.J.1    Sharman, J.L.2    Benson, H.E.3    Faccenda, E.4    Alexander, S.P.5    Buneman, O.P.6
  • 27
    • 44849100198 scopus 로고    scopus 로고
    • NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha
    • Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, et al., (2008). NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature 453: 807-811.
    • (2008) Nature , vol.453 , pp. 807-811
    • Rius, J.1    Guma, M.2    Schachtrup, C.3    Akassoglou, K.4    Zinkernagel, A.S.5    Nizet, V.6
  • 29
    • 84856739946 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in physiology and medicine
    • Semenza GL, (2012). Hypoxia-inducible factors in physiology and medicine. Cell 148: 399-408.
    • (2012) Cell , vol.148 , pp. 399-408
    • Semenza, G.L.1
  • 30
    • 84874752310 scopus 로고    scopus 로고
    • Selective inhibition of hypoxia-inducible factor 1α ameliorates adipose tissue dysfunction
    • Sun K, Halberg N, Khan M, Magalang UJ, Scherer PE, et al., (2013a). Selective inhibition of hypoxia-inducible factor 1α ameliorates adipose tissue dysfunction. Mol Cell Biol 33: 904-917.
    • (2013) Mol Cell Biol , vol.33 , pp. 904-917
    • Sun, K.1    Halberg, N.2    Khan, M.3    Magalang, U.J.4    Scherer, P.E.5
  • 31
    • 84885180828 scopus 로고    scopus 로고
    • Fibrosis and adipose tissue dysfunction
    • Sun K, Tordjman J, Clément K, (2013b). Fibrosis and adipose tissue dysfunction. Cell Metab 18: 470-477.
    • (2013) Cell Metab , vol.18 , pp. 470-477
    • Sun, K.1    Tordjman, J.2    Clément, K.3
  • 32
    • 84906482561 scopus 로고    scopus 로고
    • Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1
    • Sun Y, Li J, Xiao N, Wang M, Kou J, Qi L, et al., (2014). Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1. Pharmacol Res 89: 19-28.
    • (2014) Pharmacol Res , vol.89 , pp. 19-28
    • Sun, Y.1    Li, J.2    Xiao, N.3    Wang, M.4    Kou, J.5    Qi, L.6
  • 33
    • 79952391694 scopus 로고    scopus 로고
    • Tubular injury in a rat model of type 2 diabetes is prevented by metformin: A possible role of HIF-1α expression and oxygen metabolism
    • Takiyama Y, Harumi T, Watanabe J, Fujita Y, Honjo J, Shimizu N, et al., (2011). Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism. Diabetes 60: 981-992.
    • (2011) Diabetes , vol.60 , pp. 981-992
    • Takiyama, Y.1    Harumi, T.2    Watanabe, J.3    Fujita, Y.4    Honjo, J.5    Shimizu, N.6
  • 34
    • 84872290190 scopus 로고    scopus 로고
    • Hypoxia and adipose tissue function and dysfunction in obesity
    • Trayhurn P, (2013). Hypoxia and adipose tissue function and dysfunction in obesity. Physiol Rev 93: 1-21.
    • (2013) Physiol Rev , vol.93 , pp. 1-21
    • Trayhurn, P.1
  • 35
    • 77954777802 scopus 로고    scopus 로고
    • Metformin attenuates cardiac fibrosis by inhibiting the TGF β1-Smad3 signalling pathway
    • Xiao H, Ma X, Feng W, Fu Y, Lu Z, Xu M, et al., (2010). Metformin attenuates cardiac fibrosis by inhibiting the TGF β1-Smad3 signalling pathway. Cardiovasc Res 87: 504-513.
    • (2010) Cardiovasc Res , vol.87 , pp. 504-513
    • Xiao, H.1    Ma, X.2    Feng, W.3    Fu, Y.4    Lu, Z.5    Xu, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.