The association of mitochondrial content with prevalent and incident type 2 diabetes

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 4, 2010, Pages 1909-1915

  Reiling, Erwin ^a   Ling, Charlotte ^b   Uitterlinden, André G ^c   Van't Riet, Esther ^d   Welschen, Laura M C ^d   Ladenvall, Claes ^b   Almgren, Peter ^b   Lyssenko, Valeriya ^b   Nijpels, Giel ^d   Van Hove, Els C ^a   Maassen, Johannes A ^a,d   De Geus, Eco J C ^e   Boomsma, Dorret I ^e   Dekker, Jacqueline M ^d   Groop, Leif ^b,f   Willemsen, Gonneke ^d   'T Hart, Leen M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^e VU UNIVERSITY AMSTERDAM   (Netherlands)

^f HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ADULT; ARTICLE; BLOOD SAMPLING; CASE CONTROL STUDY; CHEEK; CLINICAL ASSESSMENT; CONTROLLED STUDY; DNA CONTENT; FEMALE; GENETIC ASSOCIATION; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MITOCHONDRION; NETHERLANDS; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROSPECTIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; TWINS; CYTOLOGY; EPITHELIUM CELL; FINLAND; GENETICS; METABOLISM; MOUTH MUCOSA; REGISTER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; DNA, MITOCHONDRIAL; EPITHELIAL CELLS; FEMALE; FINLAND; HUMANS; MALE; MITOCHONDRIA; MOUTH MUCOSA; NETHERLANDS; PROSPECTIVE STUDIES; REGISTRIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77951635228     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-1775     Document Type: Article

References (39)

1. Calvo S, Jain M, Xie X, Sheth SA, Chang B, Goldberger OA, Spinazzola A, Zeviani M, Carr SA, Mootha VK 2006 Systematic identification of human mitochondrial disease genes through integrative genomics. Nat Genet 38:576-582
2. Falkenberg M, Larsson NG, Gustafsson CM 2007 DNA replication and transcription in mammalian mitochondria. Annu Rev Biochem 76:679-699
3. Naviaux RK, Nyhan WL, Barshop BA, Poulton J, Markusic D, Karpinski NC, Haas RH 1999 Mitochondrial DNA polymerase γ deficiency and mtDNA depletion in a child with Alpers' syndrome. Ann Neurol 45:54-58
4. Silva JP, Köhler M, Graff C, Oldfors A, Magnuson MA, Berggren PO, Larsson NG 2000 Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes. Nat Genet 26:336-340
5. Curran JE, Johnson MP, Dyer TD, Göring HH, Kent JW, Charlesworth JC, Borg AJ, Jowett JB, Cole SA, MacCluer JW, Kissebah AH, Moses EK, Blangero J 2007 Genetic determinants of mitochondrial content. Hum Mol Genet 16:1504-1514
6. Xing J, Chen M, Wood CG, Lin J, Spitz MR, Ma J, Amos CI, Shields PG, Benowitz NL, Gu J, de Andrade M, Swan GE, Wu X 2008 Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma. J Natl Cancer Inst 100:1104-1112
7. Brinkman K, Smeitink JA, Romijn JA, Reiss P 1999 Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy. Lancet 354:1112-1115
8. Maassen JA, 't Hart LM, Ouwens DM 2007 Lessons that can be learned from patients with diabetogenic mutations in mitochondrial DNA: implications for common type 2 diabetes. Curr Opin Clin Nutr Metab Care 10:693-697
9. Blümer RM, van Vonderen MG, Sutinen J, Hassink E, Ackermans M, van Agtmael MA, Yki-Jarvinen H, Danner SA, Reiss P, Sauerwein HP 2008 Zidovudine/lamivudine contributes to insulin resistance within 3 months of starting combination antiretroviral therapy. AIDS 22:227-236
10. Lee HK, Song JH, Shin CS, Park DJ, Park KS, Lee KU, Koh CS 1998 Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 42:161-167
11. Singh R, Hattersley AT,Harries LW 2007 Reduced peripheral blood mitochondrial DNA content is not a risk factor for type 2 diabetes. Diabet Med 24:784-787 (Pubitemid 47012132)
12. Park KS, Song JH, Lee KU, Choi CS, Koh JJ, Shin CS, Lee HK 1999 Peripheral blood mitochondrial DNA content correlates with lipid oxidation rate during euglycemic clamps in healthy young men. Diabetes Res Clin Pract 46:149-154
13. Park KS, Lee KU, Song JH, Choi CS, Shin CS, Park DJ, Kim SK, Koh JJ, Lee HK 2001 Peripheral blood mitochondrial DNA content is inversely correlated with insulin secretion during hyperglycemic clamp studies in healthy young men. Diabetes Res Clin Pract 52: 97-102
14. Song J, Oh JY, Sung YA, Pak YK, Park KS, Lee HK 2001 Peripheral blood mitochondrial DNA content is related to insulin sensitivity in offspring of type 2 diabetic patients. Diabetes Care 24:865-869
15. Weng SW, Lin TK, Liou CW, Chen SD, Wei YH, Lee HC, Chen IY, Hsieh CJ, Wang PW 2009 Peripheral blood mitochondrial DNA content and dysregulation of glucose metabolism. Diabetes Res Clin Pract 83:94-99
16. Serradas P, Giroix MH, Saulnier C, Gangnerau MN, Borg LA, Welsh M, Portha B, Welsh N 1995 Mitochondrial deoxyribonucleic acid content is specifically decreased in adult, but not fetal, pancreatic islets of the Goto-Kakizaki rat, a genetic model of noninsulin-dependent diabetes. Endocrinology 136:5623-5631
17. Boomsma DI, Vink JM, van Beijsterveldt TC, de Geus EJ, Beem AL, Mulder EJ, Derks EM, Riese H, Willemsen GA, Bartels M, van den Berg M, Kupper NH, Polderman TJ, Posthuma D, Rietveld MJ, Stubbe JH, Knol LI, Stroet T, van Baal GC 2002 Netherlands Twin Register: a focus on longitudinal research. Twin Res 5:401-406
18. Boomsma DI, de Geus EJ, Vink JM, Stubbe JH, Distel MA,Hottenga JJ, Posthuma D, van Beijsterveldt TC, Hudziak JJ, Bartels M, Willemsen G 2006 Netherlands Twin Register: from twins to twin families. Twin Res Hum Genet 9:849-857
19. Boomsma DI, Beem AL, van den Berg M, Dolan CV, Koopmans JR, Vink JM, de Geus EJ, Slagboom PE 2000 Netherlands twin family study of anxious depression (NETSAD). Twin Res 3:323-334
20. Vink JM, Beem AL, Posthuma D, Neale MC, Willemsen G, Kendler KS, Slagboom PE, Boomsma DI 2004 Linkage analysis of smoking initiation and quantity in Dutch sibling pairs. Pharmacogenomics J 4:274-282
21. Reiling E, van Vliet-Ostaptchouk JV, van 't Riet E, van Haeften TW, Arp PA, Hansen T, Kremer D, Groenewoud MJ, van Hove EC, Romijn JA, Smit JW, Nijpels G, Heine RJ, Uitterlinden AG, Pedersen O, Slagboom PE, Maassen JA, Hofker MH, 't Hart LM, Dekker JM 2009 Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. Eur J Hum Genet 17:1056-1062
22. World Health Organization 1999 Definition, diagnosis and classification of diabetes mellitus, report of a WHO consultation. Part 1: Diagnosis and classification of diabetes mellitus. Geneva: WHO/NCD/NCS/99.2
23. Groop L, Forsblom C, Lehtovirta M, Tuomi T, Karanko S, Nissén M, Ehrnström BO, Forsén B, Isomaa B, Snickars B, Taskinen MR 1996 Metabolic consequences of a family history of NIDDM (the Botnia study): evidence for sex-specific parental effects. Diabetes 45:1585-1593
24. Hofman A, Breteler MM, van Duijn CM, Krestin GP, Pols HA, Stricker BH, Tiemeier H, Uitterlinden AG, Vingerling JR, Witteman JC 2007 The Rotterdam Study: objectives and design update. Eur J Epidemiol 22:819-829
25. Stolk RP, Pols HA, Lamberts SW, de Jong PT, Hofman A, Grobbee DE 1997 Diabetes mellitus, impaired glucose tolerance, and hyperinsulinemia in an elderly population. The Rotterdam Study. Am J Epidemiol 145:24-32 (Pubitemid 27009054)
26. Szuhai K, Ouweland J, Dirks R, Lemaître M, Truffert J, Janssen G, Tanke H, Holme E, Maassen J, Raap A 2001 Simultaneous A8344G heteroplasmy and mitochondrial DNA copy number quantification in myoclonus epilepsy and ragged-red fibers (MERRF) syndrome by a multiplex molecular beacon based real-time fluorescence PCR. Nucleic Acids Res 29:E13
27. Andreu AL, Martinez R, Marti R, García-Arumí E 2009 Quantification of mitochondrial DNA copy number: pre-analytical factors. Mitochondrion 9:242-246
28. Guo W, Jiang L, Bhasin S, Khan SM, Swerdlow RH 2009 DNA extraction procedures meaningfully influence qPCR-based mtDNA copy number determination. Mitochondrion 9:261-265
29. Boomsma D, Busjahn A, Peltonen L 2002 Classical twin studies and beyond. Nat Rev Genet 3:872-882
30. Neale MC,Cardon L 1992 Methodology for genetic studies of twins and families. Dordrecht, The Netherlands: Kluwer Academic Publishers
31. Neale MC, Boker SM, Xie G, Maes HH 2003 MX: Statistical modelling. 6th ed. Virginia Commonwealth University, Department of Psychiatry
32. Tan D, Goerlitz DS, Dumitrescu RG, Han D, Seillier-Moiseiwitsch F, Spernak SM, Orden RA, Chen J, Goldman R, Shields PG 2008 Associations between cigarette smoking and mitochondrial DNA abnormalities in buccal cells. Carcinogenesis 29:1170-1177
33. Nair KS, Bigelow ML, Asmann YW, Chow LS, Coenen-Schimke JM, Klaus KA, Guo ZK, Sreekumar R, Irving BA 2008 Asian Indians have enhanced skeletal muscle mitochondrial capacity to produce ATP in association with severe insulin resistance. Diabetes 57:1166-1175
34. Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI 2004 Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 350:664-671
35. Barazzoni R, Short KR, Nair KS 2000 Effects of aging on mitochondrial DNA copy number and cytochrome c oxidase gene expression in rat skeletal muscle, liver, and heart. J Biol Chem 275: 3343-3347
36. Short KR, Bigelow ML, Kahl J, Singh R, Coenen-Schimke J, Raghavakaimal S, Nair KS 2005 Decline in skeletal muscle mitochondrial function with aging in humans. Proc Natl Acad Sci USA 102:5618-5623
37. Cree LM, Patel SK, Pyle A, Lynn S, Turnbull DM, Chinnery PF, Walker M 2008 Age-related decline in mitochondrial DNA copy number in isolated human pancreatic islets. Diabetologia 51:1440-1443
38. 't Hart LM, Jansen JJ, Lemkes HH, de Knijff P, Maassen JA 1996 Heteroplasmy levels of a mitochondrial gene mutation associated with diabetes mellitus decrease in leucocyte DNA upon aging. Hum Mutat 7:193-197
39. Rajasimha HK, Chinnery PF, Samuels DC 2008 Selection against pathogenic mtDNA mutations in a stem cell population leads to the loss of the 3243A3G mutation in blood. Am J Hum Genet 82: 333-343