메뉴 건너뛰기




Volumn 22, Issue 18, 2016, Pages 4427-4437

Thrombin activation and liver inflammation in advanced hepatitis C virus infection

Author keywords

Coagulation; Fibrogenesis; Hepatitis C virus; Liver cirrhosis; Parenchymal extinction; Portal thrombosis; Protein C

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING INHIBITOR; PROCOAGULANT; PROTEIN C; PROTEIN S; THROMBIN; THROMBOPLASTIN;

EID: 84970950194     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v22.i18.4427     Document Type: Article
Times cited : (42)

References (94)
  • 1
    • 84883303489 scopus 로고    scopus 로고
    • Decreased tissue factor pathway inhibitor (TFPI)-dependent anticoagulant capacity in patients with cirrhosis who have decreased protein S but normal TFPI plasma levels
    • [PMID: 23841464]
    • Potze W, Arshad F, Adelmeijer J, Blokzijl H, van den Berg AP, Meijers JC, Porte RJ, Lisman T. Decreased tissue factor pathway inhibitor (TFPI)-dependent anticoagulant capacity in patients with cirrhosis who have decreased protein S but normal TFPI plasma levels. Br J Haematol 2013; 162: 819-826 [PMID: 23841464 DOI: 10.1111/bjh.12462]
    • (2013) Br J Haematol , vol.162 , pp. 819-826
    • Potze, W.1    Arshad, F.2    Adelmeijer, J.3    Blokzijl, H.4    van den Berg, A.P.5    Meijers, J.C.6    Porte, R.J.7    Lisman, T.8
  • 2
    • 84877112046 scopus 로고    scopus 로고
    • Antithrombin
    • [PMID: 23546728]
    • Hepner M, Karlaftis V. Antithrombin. Methods Mol Biol 2013; 992: 355-364 [PMID: 23546728 DOI: 10.1007/978-1-62703-339-8 _28]
    • (2013) Methods Mol Biol , vol.992 , pp. 355-364
    • Hepner, M.1    Karlaftis, V.2
  • 3
    • 84962374819 scopus 로고    scopus 로고
    • Antithrombin: anti-inflammatory properties and clinical applications
    • [PMID: 26676884]
    • Levy JH, Sniecinski RM, Welsby IJ, Levi M. Antithrombin: anti-inflammatory properties and clinical applications. Thromb Haemost 2016; 115: 712-728 [PMID: 26676884 DOI: 10.1160/ TH15-08-0687]
    • (2016) Thromb Haemost , vol.115 , pp. 712-728
    • Levy, J.H.1    Sniecinski, R.M.2    Welsby, I.J.3    Levi, M.4
  • 4
    • 84957547722 scopus 로고    scopus 로고
    • The M358R variant of a1-proteinase inhibitor inhibits coagulation factor VIIa
    • [PMID: 26797521]
    • Sheffield WP, Bhakta V. The M358R variant of a1-proteinase inhibitor inhibits coagulation factor VIIa. Biochem Biophys Res Commun 2016; 470: 710-713 [PMID: 26797521 DOI: 10.1016/ j.bbrc.2016.01.069]
    • (2016) Biochem Biophys Res Commun , vol.470 , pp. 710-713
    • Sheffield, W.P.1    Bhakta, V.2
  • 5
    • 84952636616 scopus 로고    scopus 로고
    • Tissue Factor Pathway Inhibitor: Multiple Anticoagulant Activities for a Single Protein
    • [PMID: 26603155]
    • Mast AE. Tissue Factor Pathway Inhibitor: Multiple Anticoagulant Activities for a Single Protein. Arterioscler Thromb Vasc Biol 2016; 36: 9-14 [PMID: 26603155 DOI: 10.1161/ATVBAHA.115.305996]
    • (2016) Arterioscler Thromb Vasc Biol , vol.36 , pp. 9-14
    • Mast, A.E.1
  • 6
    • 84880608510 scopus 로고    scopus 로고
    • Structure-function and regulation of ADAMTS-13 protease
    • [PMID: 23809107]
    • Zheng XL. Structure-function and regulation of ADAMTS-13 protease. J Thromb Haemost 2013; 11 Suppl 1: 11-23 [PMID: 23809107 DOI: 10.1111/jth.12221]
    • (2013) J Thromb Haemost , vol.11 , pp. 11-23
    • Zheng, X.L.1
  • 7
    • 14044259258 scopus 로고    scopus 로고
    • Thrombin activatable fibrinolysis inhibitor (TAFI) at the interface between coagulation and fibrinolysis
    • [PMID: 15692247]
    • Bouma BN, Mosnier LO. Thrombin activatable fibrinolysis inhibitor (TAFI) at the interface between coagulation and fibrinolysis. Pathophysiol Haemost Thromb 2003; 33: 375-381 [PMID: 15692247]
    • (2003) Pathophysiol Haemost Thromb , vol.33 , pp. 375-381
    • Bouma, B.N.1    Mosnier, L.O.2
  • 8
    • 0030059648 scopus 로고    scopus 로고
    • Anticardiolipin antibodies in chronic hepatitis C: implication of hepatitis C virus as the cause of the antiphospholipid syndrome
    • [PMID: 8591841]
    • Prieto J, Yuste JR, Beloqui O, Civeira MP, Riezu JI, Aguirre B, Sangro B. Anticardiolipin antibodies in chronic hepatitis C: implication of hepatitis C virus as the cause of the antiphospholipid syndrome. Hepatology 1996; 23: 199-204 [PMID: 8591841 DOI: 10.1002/hep.510230201]
    • (1996) Hepatology , vol.23 , pp. 199-204
    • Prieto, J.1    Yuste, J.R.2    Beloqui, O.3    Civeira, M.P.4    Riezu, J.I.5    Aguirre, B.6    Sangro, B.7
  • 9
    • 0032033411 scopus 로고    scopus 로고
    • Prevalence of antiphospholipid antibodies in patients with chronic liver disease related to alcohol or hepatitis C virus: correlation with liver injury
    • [PMID: 9523848]
    • Biron C, Andréani H, Blanc P, Ramos J, Ducos J, Guigue N, Michel H, Larrey D, Schved JF. Prevalence of antiphospholipid antibodies in patients with chronic liver disease related to alcohol or hepatitis C virus: correlation with liver injury. J Lab Clin Med 1998; 131: 243-250 [PMID: 9523848 DOI: 10.1016/S0022-2143(98)90096-8]
    • (1998) J Lab Clin Med , vol.131 , pp. 243-250
    • Biron, C.1    Andréani, H.2    Blanc, P.3    Ramos, J.4    Ducos, J.5    Guigue, N.6    Michel, H.7    Larrey, D.8    Schved, J.F.9
  • 10
    • 84939888295 scopus 로고    scopus 로고
    • Thromboembolic events among patients with hepatitis C virus infection and cirrhosis: a matched-cohort study
    • [PMID: 25047758]
    • Enger C, Forssen UM, Bennett D, Theodore D, Shantakumar S, McAfee A. Thromboembolic events among patients with hepatitis C virus infection and cirrhosis: a matched-cohort study. Adv Ther 2014; 31: 891-903 [PMID: 25047758 DOI: 10.1007/ s12325-014-0138-4]
    • (2014) Adv Ther , vol.31 , pp. 891-903
    • Enger, C.1    Forssen, U.M.2    Bennett, D.3    Theodore, D.4    Shantakumar, S.5    McAfee, A.6
  • 11
    • 84942523039 scopus 로고    scopus 로고
    • Hepatitis C Virus Infection Associated With an Increased Risk of Deep Vein Thrombosis: A Population-Based Cohort Study
    • [PMID: 26402820]
    • Wang CC, Chang CT, Lin CL, Lin IC, Kao CH. Hepatitis C Virus Infection Associated With an Increased Risk of Deep Vein Thrombosis: A Population-Based Cohort Study. Medicine (Baltimore) 2015; 94: e1585 [PMID: 26402820 DOI: 10.1097/ MD.0000000000001585]
    • (2015) Medicine (Baltimore) , vol.94
    • Wang, C.C.1    Chang, C.T.2    Lin, C.L.3    Lin, I.C.4    Kao, C.H.5
  • 12
    • 84873186066 scopus 로고    scopus 로고
    • Portopulmonary hypertension in cirrhotic patients: Prevalence, clinical features and risk factors
    • [PMID: 23403613]
    • Chen HS, Xing SR, Xu WG, Yang F, Qi XL, Wang LM, Yang CQ. Portopulmonary hypertension in cirrhotic patients: Prevalence, clinical features and risk factors. Exp Ther Med 2013; 5: 819-824 [PMID: 23403613 DOI: 10.3892/etm.2013.918]
    • (2013) Exp Ther Med , vol.5 , pp. 819-824
    • Chen, H.S.1    Xing, S.R.2    Xu, W.G.3    Yang, F.4    Qi, X.L.5    Wang, L.M.6    Yang, C.Q.7
  • 14
    • 0034009949 scopus 로고    scopus 로고
    • Anticardiolipin antibodies in patients with chronic hepatitis C virus infection: characterization in relation to antiphospholipid syndrome
    • [PMID: 10702499]
    • Ordi-Ros J, Villarreal J, Monegal F, Sauleda S, Esteban I, Vilardell M. Anticardiolipin antibodies in patients with chronic hepatitis C virus infection: characterization in relation to antiphospholipid syndrome. Clin Diagn Lab Immunol 2000; 7: 241-244 [PMID: 10702499]
    • (2000) Clin Diagn Lab Immunol , vol.7 , pp. 241-244
    • Ordi-Ros, J.1    Villarreal, J.2    Monegal, F.3    Sauleda, S.4    Esteban, I.5    Vilardell, M.6
  • 15
    • 0029438528 scopus 로고
    • Increased rate of thrombin generation in hepatitis C virus cirrhotic patients. Relationship to venous thrombosis
    • [PMID: 8605614]
    • Violi F, Ferro D, Basili S, Artini M, Valesini G, Levrero M, Cordova C. Increased rate of thrombin generation in hepatitis C virus cirrhotic patients. Relationship to venous thrombosis. J Investig Med 1995; 43: 550-554 [PMID: 8605614]
    • (1995) J Investig Med , vol.43 , pp. 550-554
    • Violi, F.1    Ferro, D.2    Basili, S.3    Artini, M.4    Valesini, G.5    Levrero, M.6    Cordova, C.7
  • 16
    • 84970976869 scopus 로고    scopus 로고
    • Thrombosis Associated with Viral Hepatitis
    • [PMID: 26357629]
    • Galli L, Gerdes VE, Guasti L, Squizzato A. Thrombosis Associated with Viral Hepatitis. J Clin Transl Hepatol 2014; 2: 234-239 [PMID: 26357629 DOI: 10.14218/JCTH.2014.00031]
    • (2014) J Clin Transl Hepatol , vol.2 , pp. 234-239
    • Galli, L.1    Gerdes, V.E.2    Guasti, L.3    Squizzato, A.4
  • 17
    • 0025951404 scopus 로고
    • Clinical significance of endothelial damage markers in essential mixed cryoglobulinemia
    • [PMID: 1950376]
    • Toschi V, Fiorini GF, Motta A, Renoldi P, Paracchini ML, Gibelli A. Clinical significance of endothelial damage markers in essential mixed cryoglobulinemia. Acta Haematol 1991; 86: 90-94 [PMID: 1950376]
    • (1991) Acta Haematol , vol.86 , pp. 90-94
    • Toschi, V.1    Fiorini, G.F.2    Motta, A.3    Renoldi, P.4    Paracchini, M.L.5    Gibelli, A.6
  • 21
    • 0033790858 scopus 로고    scopus 로고
    • Cytokines and hemostasis
    • [PMID: 10980636]
    • Grignani G, Maiolo A. Cytokines and hemostasis. Haematologica 2000; 85: 967-972 [PMID: 10980636]
    • (2000) Haematologica , vol.85 , pp. 967-972
    • Grignani, G.1    Maiolo, A.2
  • 22
    • 0026495339 scopus 로고
    • Retinoic acid counteracts both the downregulation of thrombomodulin and the induction of tissue factor in cultured human endothelial cells exposed to tumor necrosis factor
    • [PMID: 1330076]
    • Ishii H, Horie S, Kizaki K, Kazama M. Retinoic acid counteracts both the downregulation of thrombomodulin and the induction of tissue factor in cultured human endothelial cells exposed to tumor necrosis factor. Blood 1992; 80: 2556-2562 [PMID: 1330076]
    • (1992) Blood , vol.80 , pp. 2556-2562
    • Ishii, H.1    Horie, S.2    Kizaki, K.3    Kazama, M.4
  • 23
    • 0023875704 scopus 로고
    • Cytokine activation of vascular endothelium. Effects on tissuetype plasminogen activator and type 1 plasminogen activator inhibitor
    • [PMID: 3128548]
    • Schleef RR, Bevilacqua MP, Sawdey M, Gimbrone MA, Loskutoff DJ. Cytokine activation of vascular endothelium. Effects on tissuetype plasminogen activator and type 1 plasminogen activator inhibitor. J Biol Chem 1988; 263: 5797-5803 [PMID: 3128548]
    • (1988) J Biol Chem , vol.263 , pp. 5797-5803
    • Schleef, R.R.1    Bevilacqua, M.P.2    Sawdey, M.3    Gimbrone, M.A.4    Loskutoff, D.J.5
  • 24
    • 84928556929 scopus 로고    scopus 로고
    • A matched crosssectional study of the association between circulating tissue factor activity, immune activation and advanced liver fibrosis in hepatitis C infection
    • [PMID: 25884329]
    • Hodowanec AC, Lee RD, Brady KE, Gao W, Kincaid S, Plants J, Bahk M, Mackman N, Landay AL, Huhn GD. A matched crosssectional study of the association between circulating tissue factor activity, immune activation and advanced liver fibrosis in hepatitis C infection. BMC Infect Dis 2015; 15: 190 [PMID: 25884329 DOI: 10.1186/s12879-015-0920-1]
    • (2015) BMC Infect Dis , vol.15 , pp. 190
    • Hodowanec, A.C.1    Lee, R.D.2    Brady, K.E.3    Gao, W.4    Kincaid, S.5    Plants, J.6    Bahk, M.7    Mackman, N.8    Landay, A.L.9    Huhn, G.D.10
  • 25
    • 0141996919 scopus 로고    scopus 로고
    • Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense
    • [PMID: 12851650]
    • Gear AR, Camerini D. Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense. Microcirculation 2003; 10: 335-350 [PMID: 12851650 DOI: 10.1038/sj.mn.7800198]
    • (2003) Microcirculation , vol.10 , pp. 335-350
    • Gear, A.R.1    Camerini, D.2
  • 27
    • 0034930778 scopus 로고    scopus 로고
    • Activation of blood platelets in chronic hepatitis and liver cirrhosis P-selectin expression on blood platelets and secretory activity of beta-thromboglobulin and platelet factor-4
    • [PMID: 11462931]
    • Panasiuk A, Prokopowicz D, Zak J, Matowicka-Karna J, Osada J, Wysocka J. Activation of blood platelets in chronic hepatitis and liver cirrhosis P-selectin expression on blood platelets and secretory activity of beta-thromboglobulin and platelet factor-4. Hepatogastroenterology 2001; 48: 818-822 [PMID: 11462931]
    • (2001) Hepatogastroenterology , vol.48 , pp. 818-822
    • Panasiuk, A.1    Prokopowicz, D.2    Zak, J.3    Matowicka-Karna, J.4    Osada, J.5    Wysocka, J.6
  • 28
    • 0042442463 scopus 로고    scopus 로고
    • Hematologic disorders associated with hepatitis C virus infection and their management
    • [PMID: 12905138]
    • Dieterich DT, Spivak JL. Hematologic disorders associated with hepatitis C virus infection and their management. Clin Infect Dis 2003; 37: 533-541 [PMID: 12905138 DOI: 10.1086/376971]
    • (2003) Clin Infect Dis , vol.37 , pp. 533-541
    • Dieterich, D.T.1    Spivak, J.L.2
  • 29
  • 30
    • 35448975065 scopus 로고    scopus 로고
    • Review article: the pathophysiology of thrombocytopenia in hepatitis C virus infection and chronic liver disease
    • [PMID: 17958515]
    • Weksler BB. Review article: the pathophysiology of thrombocytopenia in hepatitis C virus infection and chronic liver disease. Aliment Pharmacol Ther 2007; 26 Suppl 1: 13-19 [PMID: 17958515 DOI: 10.1111/j.1365-2036.2007.03512.x]
    • (2007) Aliment Pharmacol Ther , vol.26 , pp. 13-19
    • Weksler, B.B.1
  • 31
    • 0034780858 scopus 로고    scopus 로고
    • Treatment of hepatitis C related thrombocytopenia with interferon alpha
    • [PMID: 11754404]
    • Rajan S, Liebman HA. Treatment of hepatitis C related thrombocytopenia with interferon alpha. Am J Hematol 2001; 68: 202-209 [PMID: 11754404 DOI: 10.1002/ajh.1180]
    • (2001) Am J Hematol , vol.68 , pp. 202-209
    • Rajan, S.1    Liebman, H.A.2
  • 32
  • 35
    • 0033042073 scopus 로고    scopus 로고
    • Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation
    • [PMID: 10205219]
    • Goulis J, Chau TN, Jordan S, Mehta AB, Watkinson A, Rolles K, Burroughs AK. Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation. Gut 1999; 44: 754-758 [PMID: 10205219]
    • (1999) Gut , vol.44 , pp. 754-758
    • Goulis, J.1    Chau, T.N.2    Jordan, S.3    Mehta, A.B.4    Watkinson, A.5    Rolles, K.6    Burroughs, A.K.7
  • 36
    • 21344460746 scopus 로고    scopus 로고
    • The role of thrombopoietin in the thrombocytopenia of patients with liver cirrhosis
    • [PMID: 15929762]
    • Rios R, Sangro B, Herrero I, Quiroga J, Prieto J. The role of thrombopoietin in the thrombocytopenia of patients with liver cirrhosis. Am J Gastroenterol 2005; 100: 1311-1316 [PMID: 15929762]
    • (2005) Am J Gastroenterol , vol.100 , pp. 1311-1316
    • Rios, R.1    Sangro, B.2    Herrero, I.3    Quiroga, J.4    Prieto, J.5
  • 37
    • 0030063669 scopus 로고    scopus 로고
    • Thrombocytopenia associated with hepatitis C viral infection
    • [PMID: 8907565]
    • Nagamine T, Ohtuka T, Takehara K, Arai T, Takagi H, Mori M. Thrombocytopenia associated with hepatitis C viral infection. J Hepatol 1996; 24: 135-140 [PMID: 8907565]
    • (1996) J Hepatol , vol.24 , pp. 135-140
    • Nagamine, T.1    Ohtuka, T.2    Takehara, K.3    Arai, T.4    Takagi, H.5    Mori, M.6
  • 38
    • 33750607556 scopus 로고    scopus 로고
    • Platelet autoantibodies are common in hepatitis C infection, irrespective of the presence of thrombocytopenia
    • [PMID: 17042765]
    • Panzer S, Seel E, Brunner M, Körmöczi GF, Schmid M, Ferenci P, Peck-Radosavljevic M. Platelet autoantibodies are common in hepatitis C infection, irrespective of the presence of thrombocytopenia. Eur J Haematol 2006; 77: 513-517 [PMID: 17042765]
    • (2006) Eur J Haematol , vol.77 , pp. 513-517
    • Panzer, S.1    Seel, E.2    Brunner, M.3    Körmöczi, G.F.4    Schmid, M.5    Ferenci, P.6    Peck-Radosavljevic, M.7
  • 39
    • 79955657337 scopus 로고    scopus 로고
    • Thrombocytopenia in chronic hepatitis C
    • [PMID: 21188328]
    • Olariu M, Olariu C, Olteanu D. Thrombocytopenia in chronic hepatitis C. J Gastrointestin Liver Dis 2010; 19: 381-385 [PMID: 21188328]
    • (2010) J Gastrointestin Liver Dis , vol.19 , pp. 381-385
    • Olariu, M.1    Olariu, C.2    Olteanu, D.3
  • 40
    • 84902668983 scopus 로고    scopus 로고
    • Pathogenesis of liver cirrhosis
    • [PMID: 24966602]
    • Zhou WC, Zhang QB, Qiao L. Pathogenesis of liver cirrhosis. World J Gastroenterol 2014; 20: 7312-7324 [PMID: 24966602 DOI: 10.3748/wjg.v20.i23.7312]
    • (2014) World J Gastroenterol , vol.20 , pp. 7312-7324
    • Zhou, W.C.1    Zhang, Q.B.2    Qiao, L.3
  • 41
    • 79960241376 scopus 로고    scopus 로고
    • The coagulopathy of chronic liver disease
    • [PMID: 21751907]
    • Tripodi A, Mannucci PM. The coagulopathy of chronic liver disease. N Engl J Med 2011; 365: 147-156 [PMID: 21751907 DOI: 10.1056/NEJMra1011170]
    • (2011) N Engl J Med , vol.365 , pp. 147-156
    • Tripodi, A.1    Mannucci, P.M.2
  • 42
    • 53849098372 scopus 로고    scopus 로고
    • Deep vein thrombosis and pulmonary embolism in cirrhosis patients
    • [PMID: 18443906]
    • Gulley D, Teal E, Suvannasankha A, Chalasani N, Liangpunsakul S. Deep vein thrombosis and pulmonary embolism in cirrhosis patients. Dig Dis Sci 2008; 53: 3012-3017 [PMID: 18443906 DOI: 10.1007/s10620-008-0265-3]
    • (2008) Dig Dis Sci , vol.53 , pp. 3012-3017
    • Gulley, D.1    Teal, E.2    Suvannasankha, A.3    Chalasani, N.4    Liangpunsakul, S.5
  • 45
    • 84901236365 scopus 로고    scopus 로고
    • Deep vein thrombosis and pulmonary embolism in cirrhotic patients: systematic review
    • [PMID: 24914335]
    • Aggarwal A, Puri K, Liangpunsakul S. Deep vein thrombosis and pulmonary embolism in cirrhotic patients: systematic review. World J Gastroenterol 2014; 20: 5737-5745 [PMID: 24914335 DOI: 10.3748/wjg.v20.i19.5737]
    • (2014) World J Gastroenterol , vol.20 , pp. 5737-5745
    • Aggarwal, A.1    Puri, K.2    Liangpunsakul, S.3
  • 46
  • 48
    • 84879175412 scopus 로고    scopus 로고
    • Thrombomodulin and the vascular endothelium: insights into functional, regulatory, and therapeutic aspects
    • [PMID: 23604713]
    • Martin FA, Murphy RP, Cummins PM. Thrombomodulin and the vascular endothelium: insights into functional, regulatory, and therapeutic aspects. Am J Physiol Heart Circ Physiol 2013; 304: H1585-H1597 [PMID: 23604713 DOI: 10.1152/ ajpheart.00096.2013]
    • (2013) Am J Physiol Heart Circ Physiol , vol.304 , pp. H1585-H1597
    • Martin, F.A.1    Murphy, R.P.2    Cummins, P.M.3
  • 49
    • 47249084343 scopus 로고    scopus 로고
    • Advances in understanding pathogenic mechanisms of thrombophilic disorders
    • [PMID: 18574041]
    • Dahlbäck B. Advances in understanding pathogenic mechanisms of thrombophilic disorders. Blood 2008; 112: 19-27 [PMID: 18574041 DOI: 10.1182/blood-2008-01-077909]
    • (2008) Blood , vol.112 , pp. 19-27
    • Dahlbäck, B.1
  • 50
    • 84908248996 scopus 로고    scopus 로고
    • Associations of coagulation factor V Leiden and prothrombin G20210A mutations with Budd-Chiari syndrome and portal vein thrombosis: a systematic review and meta-analysis
    • [PMID: 24793031]
    • Qi X, Ren W, De Stefano V, Fan D. Associations of coagulation factor V Leiden and prothrombin G20210A mutations with Budd-Chiari syndrome and portal vein thrombosis: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2014; 12: 1801-12. e7 [PMID: 24793031 DOI: 10.1016/j.cgh.2014.04.026]
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 1801-1812
    • Qi, X.1    Ren, W.2    De Stefano, V.3    Fan, D.4
  • 51
    • 84933187666 scopus 로고    scopus 로고
    • Thrombophilic factor analysis in cirrhotic patients with portal vein thrombosis
    • [PMID: 25115839]
    • Saugel B, Lee M, Feichtinger S, Hapfelmeier A, Schmid RM, Siveke JT. Thrombophilic factor analysis in cirrhotic patients with portal vein thrombosis. J Thromb Thrombolysis 2015; 40: 54-60 [PMID: 25115839 DOI: 10.1007/s11239-014-1124-z]
    • (2015) J Thromb Thrombolysis , vol.40 , pp. 54-60
    • Saugel, B.1    Lee, M.2    Feichtinger, S.3    Hapfelmeier, A.4    Schmid, R.M.5    Siveke, J.T.6
  • 52
    • 0038637369 scopus 로고    scopus 로고
    • Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infection
    • [PMID: 12865283]
    • Wright M, Goldin R, Hellier S, Knapp S, Frodsham A, Hennig B, Hill A, Apple R, Cheng S, Thomas H, Thursz M. Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infection. Gut 2003; 52: 1206-1210 [PMID: 12865283 DOI: 10.1136/gut.52.8.1206]
    • (2003) Gut , vol.52 , pp. 1206-1210
    • Wright, M.1    Goldin, R.2    Hellier, S.3    Knapp, S.4    Frodsham, A.5    Hennig, B.6    Hill, A.7    Apple, R.8    Cheng, S.9    Thomas, H.10    Thursz, M.11
  • 53
    • 1842531895 scopus 로고    scopus 로고
    • Factor V Leiden as a risk factor for cirrhosis in chronic hepatitis C
    • [PMID: 15057924]
    • Poujol-Robert A, Boëlle PY, Poupon R, Robert A. Factor V Leiden as a risk factor for cirrhosis in chronic hepatitis C. Hepatology 2004; 39: 1174-1175 [PMID: 15057924 DOI: 10.1002/hep.20166]
    • (2004) Hepatology , vol.39 , pp. 1174-1175
    • Poujol-Robert, A.1    Boëlle, P.Y.2    Poupon, R.3    Robert, A.4
  • 55
    • 0035081179 scopus 로고    scopus 로고
    • Pulmonary fibrosis is increased in mice carrying the factor V Leiden mutation following bleomycin injury
    • [PMID: 11307811]
    • Xu Z, Westrick RJ, Shen YC, Eitzman DT. Pulmonary fibrosis is increased in mice carrying the factor V Leiden mutation following bleomycin injury. Thromb Haemost 2001; 85: 441-444 [PMID: 11307811]
    • (2001) Thromb Haemost , vol.85 , pp. 441-444
    • Xu, Z.1    Westrick, R.J.2    Shen, Y.C.3    Eitzman, D.T.4
  • 57
    • 84942789718 scopus 로고    scopus 로고
    • Hemostasis abnormalities in cirrhosis
    • [PMID: 26203733]
    • Tripodi A. Hemostasis abnormalities in cirrhosis. Curr Opin Hematol 2015; 22: 406-412 [PMID: 26203733 DOI: 10.1097/ MOH.0000000000000164]
    • (2015) Curr Opin Hematol , vol.22 , pp. 406-412
    • Tripodi, A.1
  • 59
    • 34447309717 scopus 로고    scopus 로고
    • ADAMTS13 activity to antigen ratio in physiological and pathological conditions associated with an increased risk of thrombosis
    • [PMID: 17608762]
    • Feys HB, Canciani MT, Peyvandi F, Deckmyn H, Vanhoorelbeke K, Mannucci PM. ADAMTS13 activity to antigen ratio in physiological and pathological conditions associated with an increased risk of thrombosis. Br J Haematol 2007; 138: 534-540 [PMID: 17608762 DOI: 10.1111/j.1365-2141.2007.06688.x]
    • (2007) Br J Haematol , vol.138 , pp. 534-540
    • Feys, H.B.1    Canciani, M.T.2    Peyvandi, F.3    Deckmyn, H.4    Vanhoorelbeke, K.5    Mannucci, P.M.6
  • 60
    • 39849108394 scopus 로고    scopus 로고
    • Hyperfibrinolysis in alcoholic cirrhosis: relative plasminogen activator inhibitor type 1 deficiency
    • [PMID: 17870147]
    • Ferguson JW, Helmy A, Ludlam C, Webb DJ, Hayes PC, Newby DC. Hyperfibrinolysis in alcoholic cirrhosis: relative plasminogen activator inhibitor type 1 deficiency. Thromb Res 2008; 121: 675-680 [PMID: 17870147 DOI: 10.1016/j.thromres.2007.07.008]
    • (2008) Thromb Res , vol.121 , pp. 675-680
    • Ferguson, J.W.1    Helmy, A.2    Ludlam, C.3    Webb, D.J.4    Hayes, P.C.5    Newby, D.C.6
  • 61
    • 0038798847 scopus 로고    scopus 로고
    • Deficiency of thrombin activatable fibrinolysis inhibitor in cirrhosis is associated with increased plasma fibrinolysis
    • [PMID: 12830006]
    • Colucci M, Binetti BM, Branca MG, Clerici C, Morelli A, Semeraro N, Gresele P. Deficiency of thrombin activatable fibrinolysis inhibitor in cirrhosis is associated with increased plasma fibrinolysis. Hepatology 2003; 38: 230-237 [PMID: 12830006 DOI: 10.1053/jhep.2003.50277]
    • (2003) Hepatology , vol.38 , pp. 230-237
    • Colucci, M.1    Binetti, B.M.2    Branca, M.G.3    Clerici, C.4    Morelli, A.5    Semeraro, N.6    Gresele, P.7
  • 62
    • 84937812371 scopus 로고    scopus 로고
    • The Fibrinolytic Status in Liver Diseases
    • [PMID: 26049070]
    • Leebeek FW, Rijken DC. The Fibrinolytic Status in Liver Diseases. Semin Thromb Hemost 2015; 41: 474-480 [PMID: 26049070 DOI: 10.1055/s-0035-1550437]
    • (2015) Semin Thromb Hemost , vol.41 , pp. 474-480
    • Leebeek, F.W.1    Rijken, D.C.2
  • 63
    • 0027957942 scopus 로고
    • Endothelial activation and circulating vascular adhesion molecules in alcoholic liver disease
    • [PMID: 7509770]
    • Adams DH, Burra P, Hubscher SG, Elias E, Newman W. Endothelial activation and circulating vascular adhesion molecules in alcoholic liver disease. Hepatology 1994; 19: 588-594 [PMID: 7509770 DOI: 10.1002/hep.1840190308]
    • (1994) Hepatology , vol.19 , pp. 588-594
    • Adams, D.H.1    Burra, P.2    Hubscher, S.G.3    Elias, E.4    Newman, W.5
  • 64
    • 84906070153 scopus 로고    scopus 로고
    • Endotoxin-induced endothelial fibrosis is dependent on expression of transforming growth factors β1 and β2
    • [PMID: 24935972]
    • Echeverría C, Montorfano I, Tapia P, Riedel C, Cabello-Verrugio C, Simon F. Endotoxin-induced endothelial fibrosis is dependent on expression of transforming growth factors β1 and β2. Infect Immun 2014; 82: 3678-3686 [PMID: 24935972 DOI: 10.1128/ IAI.02158-14]
    • (2014) Infect Immun , vol.82 , pp. 3678-3686
    • Echeverría, C.1    Montorfano, I.2    Tapia, P.3    Riedel, C.4    Cabello-Verrugio, C.5    Simon, F.6
  • 65
    • 0036255482 scopus 로고    scopus 로고
    • Markers of endothelial damage in organ dysfunction and sepsis
    • [PMID: 12004252]
    • Reinhart K, Bayer O, Brunkhorst F, Meisner M. Markers of endothelial damage in organ dysfunction and sepsis. Crit Care Med 2002; 30: S302-S312 [PMID: 12004252 DOI: 10.1097/00003246-200210000-00049]
    • (2002) Crit Care Med , vol.30 , pp. S302-S312
    • Reinhart, K.1    Bayer, O.2    Brunkhorst, F.3    Meisner, M.4
  • 66
    • 34948902899 scopus 로고    scopus 로고
    • Beta2-integrins and acquired glycoprotein IIb/IIIa (GPIIb/IIIa) receptors cooperate in NF-kappaB activation of human neutrophils
    • [PMID: 17644514]
    • Salanova B, Choi M, Rolle S, Wellner M, Luft FC, Kettritz R. Beta2-integrins and acquired glycoprotein IIb/IIIa (GPIIb/IIIa) receptors cooperate in NF-kappaB activation of human neutrophils. J Biol Chem 2007; 282: 27960-27969 [PMID: 17644514 DOI: 10.1074/jbc.M704039200]
    • (2007) J Biol Chem , vol.282 , pp. 27960-27969
    • Salanova, B.1    Choi, M.2    Rolle, S.3    Wellner, M.4    Luft, F.C.5    Kettritz, R.6
  • 67
    • 0034161567 scopus 로고    scopus 로고
    • Surface expression and functional characterization of alpha-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin
    • [PMID: 10688826]
    • Alberio L, Safa O, Clemetson KJ, Esmon CT, Dale GL. Surface expression and functional characterization of alpha-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin. Blood 2000; 95: 1694-1702 [PMID: 10688826]
    • (2000) Blood , vol.95 , pp. 1694-1702
    • Alberio, L.1    Safa, O.2    Clemetson, K.J.3    Esmon, C.T.4    Dale, G.L.5
  • 69
    • 84884416415 scopus 로고    scopus 로고
    • Coagulopathy in cirrhosis-the role of the platelet in hemostasis
    • [PMID: 23669288]
    • Tapper EB, Robson SC, Malik R. Coagulopathy in cirrhosis-the role of the platelet in hemostasis. J Hepatol 2013; 59: 889-890 [PMID: 23669288 DOI: 10.1016/j.jhep.2013.03.040]
    • (2013) J Hepatol , vol.59 , pp. 889-890
    • Tapper, E.B.1    Robson, S.C.2    Malik, R.3
  • 70
    • 84884417589 scopus 로고    scopus 로고
    • Circulating platelet derived microparticles are not increased in patients with cirrhosis
    • [PMID: 23816702]
    • Rautou PE, Vion AC, Valla D, Boulanger CM. Circulating platelet derived microparticles are not increased in patients with cirrhosis. J Hepatol 2013; 59: 912 [PMID: 23816702 DOI: 10.1016/ j.jhep.2013.05.048]
    • (2013) J Hepatol , vol.59 , pp. 912
    • Rautou, P.E.1    Vion, A.C.2    Valla, D.3    Boulanger, C.M.4
  • 72
    • 0029907283 scopus 로고    scopus 로고
    • Existence of a platelet-adhesion defect in patients with cirrhosis independent of hematocrit: studies under flow conditions
    • [PMID: 8903388]
    • Ordinas A, Escolar G, Cirera I, Viñas M, Cobo F, Bosch J, Terés J, Rodés J. Existence of a platelet-adhesion defect in patients with cirrhosis independent of hematocrit: studies under flow conditions. Hepatology 1996; 24: 1137-1142 [PMID: 8903388 DOI: 10.1002/ hep.510240526]
    • (1996) Hepatology , vol.24 , pp. 1137-1142
    • Ordinas, A.1    Escolar, G.2    Cirera, I.3    Viñas, M.4    Cobo, F.5    Bosch, J.6    Terés, J.7    Rodés, J.8
  • 73
    • 0014205147 scopus 로고
    • Platelet aggregation in patients with Laennec's cirrhosis of the liver
    • [PMID: 6024565]
    • Thomas DP, Ream VJ, Stuart RK. Platelet aggregation in patients with Laennec's cirrhosis of the liver. N Engl J Med 1967; 276: 1344-1348 [PMID: 6024565 DOI: 10.1056/NEJM196706152762403]
    • (1967) N Engl J Med , vol.276 , pp. 1344-1348
    • Thomas, D.P.1    Ream, V.J.2    Stuart, R.K.3
  • 76
    • 0031891508 scopus 로고    scopus 로고
    • Expression of the thrombin receptor in human liver: up-regulation during acute and chronic injury
    • [PMID: 9462645]
    • Marra F, DeFranco R, Grappone C, Milani S, Pinzani M, Pellegrini G, Laffi G, Gentilini P. Expression of the thrombin receptor in human liver: up-regulation during acute and chronic injury. Hepatology 1998; 27: 462-471 [PMID: 9462645 DOI: 10.1002/hep.510270221]
    • (1998) Hepatology , vol.27 , pp. 462-471
    • Marra, F.1    DeFranco, R.2    Grappone, C.3    Milani, S.4    Pinzani, M.5    Pellegrini, G.6    Laffi, G.7    Gentilini, P.8
  • 77
    • 0036189530 scopus 로고    scopus 로고
    • Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors
    • [PMID: 11867180]
    • Gaça MD, Zhou X, Benyon RC. Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors. J Hepatol 2002; 36: 362-369 [PMID: 11867180 DOI: 10.1016/S0168-8278(01)00285-9]
    • (2002) J Hepatol , vol.36 , pp. 362-369
    • Gaça, M.D.1    Zhou, X.2    Benyon, R.C.3
  • 78
    • 0029098308 scopus 로고
    • Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: potential role in liver injury
    • [PMID: 7657283]
    • Marra F, Grandaliano G, Valente AJ, Abboud HE. Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: potential role in liver injury. Hepatology 1995; 22: 780-787 [PMID: 7657283 DOI: 10.1002/ hep.1840220314]
    • (1995) Hepatology , vol.22 , pp. 780-787
    • Marra, F.1    Grandaliano, G.2    Valente, A.J.3    Abboud, H.E.4
  • 79
    • 0023074815 scopus 로고
    • Activation of blood coagulation in Crohn's disease. Increased plasma fibrinopeptide A levels and enhanced generation of monocyte tissue factor activity
    • [PMID: 3792769]
    • Edwards RL, Levine JB, Green R, Duffy M, Mathews E, Brande W, Rickles FR. Activation of blood coagulation in Crohn's disease. Increased plasma fibrinopeptide A levels and enhanced generation of monocyte tissue factor activity. Gastroenterology 1987; 92: 329-337 [PMID: 3792769]
    • (1987) Gastroenterology , vol.92 , pp. 329-337
    • Edwards, R.L.1    Levine, J.B.2    Green, R.3    Duffy, M.4    Mathews, E.5    Brande, W.6    Rickles, F.R.7
  • 80
    • 0024840085 scopus 로고
    • Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells
    • [PMID: 2592560]
    • Pinzani M, Gesualdo L, Sabbah GM, Abboud HE. Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. J Clin Invest 1989; 84: 1786-1793 [PMID: 2592560 DOI: 10.1172/ JCI114363]
    • (1989) J Clin Invest , vol.84 , pp. 1786-1793
    • Pinzani, M.1    Gesualdo, L.2    Sabbah, G.M.3    Abboud, H.E.4
  • 83
    • 0029048868 scopus 로고
    • Hepatic and portal vein thrombosis in cirrhosis: possible role in development of parenchymal extinction and portal hypertension
    • [PMID: 7737629]
    • Wanless IR, Wong F, Blendis LM, Greig P, Heathcote EJ, Levy G. Hepatic and portal vein thrombosis in cirrhosis: possible role in development of parenchymal extinction and portal hypertension. Hepatology 1995; 21: 1238-1247 [PMID: 7737629 DOI: 10.1002/ hep.1840210505]
    • (1995) Hepatology , vol.21 , pp. 1238-1247
    • Wanless, I.R.1    Wong, F.2    Blendis, L.M.3    Greig, P.4    Heathcote, E.J.5    Levy, G.6
  • 84
    • 0029075551 scopus 로고
    • Role of thrombosis in the pathogenesis of congestive hepatic fibrosis (cardiac cirrhosis)
    • [PMID: 7737628]
    • Wanless IR, Liu JJ, Butany J. Role of thrombosis in the pathogenesis of congestive hepatic fibrosis (cardiac cirrhosis). Hepatology 1995; 21: 1232-1237 [PMID: 7737628 DOI: 10.1002/ hep.1840210504]
    • (1995) Hepatology , vol.21 , pp. 1232-1237
    • Wanless, I.R.1    Liu, J.J.2    Butany, J.3
  • 85
    • 1942423097 scopus 로고    scopus 로고
    • The pathogenesis of nonalcoholic steatohepatitis and other fatty liver diseases: a four-step model including the role of lipid release and hepatic venular obstruction in the progression to cirrhosis
    • [PMID: 15085490]
    • Wanless IR, Shiota K. The pathogenesis of nonalcoholic steatohepatitis and other fatty liver diseases: a four-step model including the role of lipid release and hepatic venular obstruction in the progression to cirrhosis. Semin Liver Dis 2004; 24: 99-106 [PMID: 15085490 DOI: 10.1055/s-2004-823104]
    • (2004) Semin Liver Dis , vol.24 , pp. 99-106
    • Wanless, I.R.1    Shiota, K.2
  • 86
    • 0036234428 scopus 로고    scopus 로고
    • Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis
    • [PMID: 11981751]
    • Corpechot C, Barbu V, Wendum D, Kinnman N, Rey C, Poupon R, Housset C, Rosmorduc O. Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. Hepatology 2002; 35: 1010-1021 [PMID: 11981751 DOI: 10.1053/jhep.2002.32524]
    • (2002) Hepatology , vol.35 , pp. 1010-1021
    • Corpechot, C.1    Barbu, V.2    Wendum, D.3    Kinnman, N.4    Rey, C.5    Poupon, R.6    Housset, C.7    Rosmorduc, O.8
  • 87
    • 84925879130 scopus 로고    scopus 로고
    • Hepatic arterial vasodilation is independent of portal hypertension in early stages of cirrhosis
    • [PMID: 25793622]
    • Moeller M, Thonig A, Pohl S, Ripoll C, Zipprich A. Hepatic arterial vasodilation is independent of portal hypertension in early stages of cirrhosis. PLoS One 2015; 10: e0121229 [PMID: 25793622 DOI: 10.1371/journal.pone.0121229]
    • (2015) PLoS One , vol.10
    • Moeller, M.1    Thonig, A.2    Pohl, S.3    Ripoll, C.4    Zipprich, A.5
  • 89
    • 17844385292 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients
    • [PMID: 15834927]
    • Adinolfi LE, Ingrosso D, Cesaro G, Cimmino A, D'Antò M, Capasso R, Zappia V, Ruggiero G. Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients. Hepatology 2005; 41: 995-1003 [PMID: 15834927 DOI: 10.1002/hep.20664]
    • (2005) Hepatology , vol.41 , pp. 995-1003
    • Adinolfi, L.E.1    Ingrosso, D.2    Cesaro, G.3    Cimmino, A.4    D'Antò, M.5    Capasso, R.6    Zappia, V.7    Ruggiero, G.8
  • 93
    • 84907849358 scopus 로고    scopus 로고
    • Antifibrotic effect of heparin on liver fibrosis model in rats
    • [PMID: 23494756]
    • Shah B, Shah G. Antifibrotic effect of heparin on liver fibrosis model in rats. World J Gastrointest Pharmacol Ther 2012; 3: 86-92 [PMID: 23494756 DOI: 10.4292/wjgpt.v3.i6.86]
    • (2012) World J Gastrointest Pharmacol Ther , vol.3 , pp. 86-92
    • Shah, B.1    Shah, G.2
  • 94
    • 84874667028 scopus 로고    scopus 로고
    • Anticoagulation in patients with liver cirrhosis: complication or therapeutic opportunity?
    • [PMID: 23300140]
    • Jairath V, Burroughs AK. Anticoagulation in patients with liver cirrhosis: complication or therapeutic opportunity? Gut 2013; 62: 479-482 [PMID: 23300140 DOI: 10.1136/gutjnl-2012-303088]
    • (2013) Gut , vol.62 , pp. 479-482
    • Jairath, V.1    Burroughs, A.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.