Transduced Tat-DJ-1 protein inhibits cytokines-induced pancreatic RINm5F cell death

BMB Reports

Volumn 49, Issue 5, 2016, Pages 297-302

  Jo, Hyo Sang ^a   Yeo, Hyeon Ji ^a   Cha, Hyun Ju ^a   Kim, Sang Jin ^a   Cho, Su Bin ^a   Park, Jung Hwan ^a   Lee, Chi Hern ^a   Yeo, Eun Ji ^a   Choi, Yeon Joo ^a   Eum, Won Sik ^a   Choi, Soo Young ^a  

^a Hallym University   (South Korea)

Author keywords

Cytokines; Protein therapy; Tat DJ 1; Toxicity; Wild type and mutants

Indexed keywords

CYTOKINE; HYBRID PROTEIN; PROTEIN DEGLYCASE DJ-1; TRANSACTIVATOR PROTEIN;

ANIMAL; CELL DEATH; CELL LINE; DRUG EFFECTS; GENETIC TRANSDUCTION; HUMAN; METABOLISM; PANCREAS; PATHOLOGY; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CELL DEATH; CELL LINE; CYTOKINES; HUMANS; PANCREAS; PROTEIN DEGLYCASE DJ-1; RATS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; TRANSDUCTION, GENETIC;

EID: 84970021665     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2016.49.5.058     Document Type: Article

References (35)

1. Eizirik DL, Colli ML and Ortis F (2009) The role of inflammation in insulitis and beta-cell loss in type 1 diabetes Nat Rev Endocrinol 5, 219-226
2. Cnop M, Vidal J, Hull RL et al (2007) Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes. Diabetes Care 30, 677-682
3. Shaw JE, Sicree RA and Zimmet PZ (2010) Global estimates of the prevalence of diabetes for 2010 and 2030 Diabetes Res Clin Pr 87, 4-14
4. Agrawal NK, Maiti R, Dash D and Pandey BL (2007) Cilostazol reduces inflammatory burden and oxidative stress in hypertensive type 2 diabetes mellitus patients. Pharmacol Res 56, 118-123
5. Lundh M, Scully SS, Mandrup-Poulsen T and Wagner BK (2013) Small-molecule inhibition of inflammatory beta cell death. Diabetes Obes Metab 15, Suppl 3, 176-184
6. Tang FM, Liu ZZ, Zhao LX, Yang XH, Zhao JJ and Shi J (2013) Effect of glycose control in type 2-diabetes patients on inflammatory factors. Biomed Eng Clin Med 17, 474-476
7. Donath MY and Shoelson SE (2011) Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 11, 98-107
8. Nagakubo D, Taira T, Kitaura H et al (1997) DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun 231, 509-513
9. Inden M, Taira T, Kitamura Y et al (2006) PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model. Neurobiol Dis 24, 144-158
10. Kim RH, Smith PD, Aleyashin H et al (2005) Hypersensitive of DJ-1-deficient mice to 1-methtyl-4-phenyl-1, 2, 3, 6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci U S A 102, 5215-5220
11. Yu HH, Xu Q, Chen HP et al (2013) Stable overexpression of DJ-1 protects H9c2 cells against oxidative stress under a hypoxia condition. Cell Biochem Funct 31, 643-651
12. Kim W, Kim DW, Jeong HJ et al (2014) Tat-DJ-1 protects neurons from ischemic damage in the ventral horn of rabbit spinal cord via increasing antioxidant levels. Neurochem Res 39, 187-193
13. Bonifati V, Oostra BA and Heutink P (2004) Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease. J Mol Med 82, 163-174
14. van den Berg A and Dowdy SF (2011) Protein transduction domain delivery of therapeutic macromolecules. Curr Opin Biotechnol 22, 888-893
15. Kubo E, Fatma N, Akagi Y, Beier DR, Singh SP and Singh DP (2008) TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacity. Am J Physiol Cell Physiol 294, C842-C855
16. Kim MJ, Jeong HJ, Kim DW et al (2014) PEP-1-PON1 protect regulates inflammatory response in Raw 264.7 macrophages and ameliorates inflammation in a TPAinduced animal model. PLoS One 9, e86034
17. Zho Z, Li Y, Yuan C, Zhang Y and Qu L (2015) Oral administration of TAT-PTD-Diapause hormone fusion protein interferes with Helicoverpa armigera (Lepidoptera: noctuidae) development. J Insect Sci 15, 123
18. Ramsey JD and Flynn NH (2015) Cell-penetrating peptides transport therapeutics into cells. Pharmcol Therapeut 154, 78-86
19. Hou CL, Huang Q, Wei Y et al (2012) Protein transduction domain-Ha20 fusion protein protects endothelial cells against high glucose-induced injury. Genet Mol Res 11, 1899-1908
20. Kim MJ, Park MY, Kim DW et al (2015) Transduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson's disease model. Biomaterials 64, 45-56
21. Kim YN, Kim DW, Jo HS et al (2015) Tat-CBR1 inhibits inflammatory response through the suppression of NK-kB and MAPKs activation in macrophages and TPA-induced ear edema in mice. Toxicol Applied Pharmacol 286, 124-134
22. Eom SA, Kim DW, Shin MJ et al (2015) Protective effects of PEP-1-Catalase on stress-induced cellular toxicity and MPTP-induced Parkinson's disease. BMB Rep 48, 395-400
23. Yokota T, Sugawara K, Ito K, Takahashi R, Ariga H and Mizusawa H (2003) Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. Biochem Biophys Res Commun 312, 1342-1348
24. Lakshminarasimhan M, Maldonado MT, Zhou W, Fink AL and Wilson MA (2008) Structural impact of three Parkinsonism-associated missense mutations on human DJ-1. Biochem 47, 1381-1392
25. Macedo MG, Anar B, Bronner IF et al (2003) The DJ-1L166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes. Hum Mol Genet 12, 2807-2816
26. Rabinovitch A and Suarez-Pinzon WL (1998) Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus. Biochem Pharmacol 55, 1139-1149
27. Papaccio G, Nicoletti F, Pisanti FA, Galdieri M and Bendtzen K (2002) An imidazoline compound completely counteracts interleukin-1[beta] toxic effects to rat pancreatic islet [beta] cells. Mol Med 8, 536-545
28. Burkart V and Kolb H (1993) Protection of islet cells from inflammatory cell death in vitro. Clin Exp Immunol 93, 273-278
29. Riedl SJ and Shi Y (2004) Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol 5, 897-907
30. Ghavami S, Hashemi M, Ande SR et al (2009) Apoptosis and cancer: mutations within caspase genes. J Med Genet 46, 497-510
31. Fulda S and Debatin KM (2006) Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 25, 4798-4811
32. Reed JC (2006) Proapoptotic multidomain Bcl-2/Bax-family protein: Mechanisms, physiological roles, and therapeutic opportunities. Cell Death Differ 13, 1378-1386
33. Kwon HY, Eum WS, Jang HW et al (2000) Transduction of Cu, Zn-superoxide dismutase mediated by an HIV-1 Tat protein basic domain into mammalian cells. FEBS Lett 485, 163-167
34. Bradford MA (1976) Rapid and sensitive method for the quantitation of microgram quantities utilizing the principle of protein-dye binding. Anal Biochem 72, 248-254
35. Seo WY, Youn GS, Choi SY and Park J (2015) Butein, a tetrahydroxychalcone, suppresses pro-inflammatory responses in HaCaT keratinocytes. BMB Rep 48, 495-500