Decreased serum Vitamin D levels in early spontaneous pregnancy loss

European Journal of Clinical Nutrition

Volumn 70, Issue 9, 2016, Pages 1004-1008

  Hou, W ^a,b   Yan, X T ^a   Bai, C M ^b   Zhang, X W ^a,c   Hui, L Y ^a   Yu, X W ^a  

^a THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

^b Reproductive Center Maternal and Child Health Hospital of Shaanxi Province   (China)

^c Fourth Hospital of Xi'an City   (China)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; 25 HYDROXYVITAMIN D 1 ALPHA HYDROXYLASE; CALCIUM; OXIDOREDUCTASE; PARATHYROID HORMONE; PHOSPHORUS; UNCLASSIFIED DRUG; 25-HYDROXYVITAMIN D; CALCIDIOL 1 MONOOXYGENASE; VITAMIN D;

ADULT; ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; FIRST TRIMESTER PREGNANCY; GESTATION PERIOD; HUMAN; MAJOR CLINICAL STUDY; NULLIPARA; SPONTANEOUS ABORTION; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; ANALOGS AND DERIVATIVES; BLOOD; CASE CONTROL STUDY; COMPLICATION; GESTATIONAL AGE; ODDS RATIO; PARITY; PREGNANCY; PREGNANCY COMPLICATION; PREGNANCY OUTCOME;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ABORTION, SPONTANEOUS; ADULT; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; GESTATIONAL AGE; GRAVIDITY; HUMANS; ODDS RATIO; PARITY; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84969988032     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2016.83     Document Type: Article

References (43)

1. Yinping H Spontaneous abortion In: Yue J Obesterics and Gynecology. 7th edn, People's Health Publishing House: Beijing, 2008, pp 83-86
2. The Practice Committee of the American Society for Reproductive Medicine. Evaluation and treatment of recurrent pregnancy loss: a committee opinion. Fertil Steril 2012; 98: 1103-1111
3. Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357: 266-281
4. Bikle DD. Vitamin D regulation of immune function. Vitam Horm 2011; 86: 1-21
5. Lagishetty V, Liu NQ, Hewison M. Vitamin D metabolism and innate immunity. Mol Cell Endocrinol 2011; 347: 97-105
6. Lerchbaum E, Rabe T. Vitamin D and female fertility. Curr Opin Obstet Gynecol 2014; 26: 145-150
7. Woo J, Lam CWK, Leung J, Lau WY, Lau E, Xu L et al. Very high rates of Vitamin D insufficiency in women of child-bearing age living in Beijing and Hong Kong. Br J Nutr 2008; 99: 1330-1334
8. Song SJ, Zhou L, Si SY, Jl Liu, Jl Zhou, Feng K et al. The high prevalence of Vitamin D deficiency and its related maternal factors in pregnant women in Beijing. PLoS One 2013; 8: e85081
9. Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM. Maternal Vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab 2007; 92: 3517-3522
10. Cho GJ, Hong SC, Oh MJ, Kim HJ. Vitamin D deficiency in gestational diabetes mellitus and the role of the placenta. Am J Obstet Gynecol 2013; 209: e1-e8
11. Bodnar LM, Krohn MA, Simhan HN. Maternal Vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J Nutr 2009; 139: 1157-1161
12. Leffelaar ER, Vrijkotte TG, van Eijsden M. Maternal early pregnancy Vitamin Dstatus in relation to fetal and neonatal growth: results of the multiethnic Amsterdam Born Children and their Development cohort. Br J Nutr 2010; 104: 108-117
13. Christakos S, Dhawan P, Benn B, Porta A, Hediger M, Oh GT et al. Vitamin D: Molecular mechanism of action. Ann N Y Acad Sci 2007; 1116: 340-348
14. Diaz L, Sanchez I, Avila E, Halhali A, Vilchis F, Larrea F. Identification of a 25-hydroxyVitamin D3 1alpha-hydroxylase gene transcription product in cultures of human syncytiotrophoblast cells. J Clin Endocrinol Metab 2000; 85: 2543-2549
15. Whitsett JA, Ho M, Tsang RC, Norman EJ, Adams KG. Synthesis of 1,25-dihydroxyVitamin D3 by human placenta in vitro. J Clin Endocrinol Metab 1981; 53: 484-488
16. Vitamin D Working Group of Osteoporosis Committee of China Gerontological Society. Application guideline for Vitamin D and bone health in adult Chinese (2014 Standard Edition). Chin J Osteoporos 2014; 20: 1011-1030
17. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP et al. Evaluation, treatment, and prevention of Vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96: 1911-1930
18. Hossein-nezhad A, Holick MF. Vitamin D for health: a global perspective. Mayo Clin Proc 2013; 88: 720-755
19. Bodnar LM, Simhan HN. Vitamin D may be a link to black-white disparities in adverse birth outcomes. Obstet Gynecol Surv 2010; 65: 273-284
20. Rosen CJ. Clinical practice. Vitamin D insufficiency. N Engl J Med 2011; 364: 248-254
21. Wagner CL, Taylor SN, Johnson DD, Hollis BW. The role of Vitamin D in pregnancy and lactation: emerging concepts. Women Health 2012; 8: 323-340
22. Shin JS, Choi MY, Longtine MS, Nelson DM. Vitamin D effects on pregnancy and the placenta. Placenta 2010; 31: 1027-1034
23. Adams JS, Hewison M. Extrarenal expression of the 25-hydroxyVitamin D-1-hydroxylase. Arch Biochem Biophys 2012; 523: 95-102
24. Hewison M, Burke F, Evans KN, Lammas D, Sansom DM, Liu P et al. Extra-renal 25-hydroxyVitamin D3-1alpha-hydroxylase in human health and disease. J Steroid Biochem Mol Biol 2007; 103: 316-321
25. Weisman Y, Harell A, Edelstein S, David M, Spirer Z, Golander A. alpha, 25-DihydroxyVitamin D3 and 24,25-dihydroxyVitamin D3 in vitro synthesis by human decidua and placenta. Nature 1979; 281: 317-319
26. Ota K, Dambaeva S, Han AR, Beaman K, Gilman-Sachs A, Kwak-Kim J. Vitamin D deficiency may be a risk factor for recurrent pregnancy losses by increasing cellular immunity and autoimmunity. Hum Reprod 2014; 29: 208-219
27. Twig G, Shina A, Amital H, Shoenfeld Y. Pathogenesis of infertility and recurrent pregnancy loss in thyroid autoimmunity. J Autoimmun 2012; 38: J275-J281
28. Dabrowski FA, Grzechocinska B, Wielgos M. The role of Vitamin D in reproductive health-A trojan horse or the golden fleece? Nutrients 2015; 7: 4139-4153
29. Tavakoli M, Jeddi-Tehrani M, Salek-Moghaddam A, Rajaei S, Mohammadzadeh A, Sheikhhasani S et al. Effects of 1, 25(OH)2 Vitamin D3 on cytokine production by endometrial cells of women with recurrent spontaneous abortion. Fertil Steril 2011; 96: 751-757
30. Olmos-Ortiz A, Avila E, Durand-Carbajal M, Díaz L. Regulation of calcitriol biosynthesis and activity: focus on gestational Vitamin D deficiency and adverse pregnancy outcomes. Nutrients 2015; 7: 443-480
31. Grundmann M, Versen-Höynck F. Vitamin D-roles in women's reproductive health? Reprod Biol Endocrinol 2011; 9: 146
32. Andersen LB, Jørgensen JS, Jensen TK, Dalgård C, Barington T, Nielsen J et al. Vitamin D insufficiency is associated with increased risk of first-trimester miscarriage in the Odense Child Cohort. Am J Clin Nutr 2015; 102: 633-638
33. Ozkan S, Jindal S, Greenseid K, Shu J, Zeitlian G, Hickmon C et al. Replete Vitamin D stores predict reproductive success following IVF. Fertil Steril 2010; 94: 1314-1319
34. Møller UK, Streym S, Heickendorff L, Mosekilde L, Rejnmark L. Effects of 25OHD concentrations on chances of pregnancy and pregnancy outcomes: a cohort study in healthy Danish women. Eur J Clin Nutr 2012; 66: 862-868
35. Flood-Nichols SK, Tinnemore D, Huang RR, Napolitano P, Ippolito DL. Vitamin D deficiency in early pregnancy. PLoS ONE 2015; 10: e0123763
36. O'Brien KO, Li S, Cao C, Kent T, Young BV, Queenan RA et al. Placental CYP27B1 and CYP24A1 expression in human placental tissue and their association with maternal and neonatal calcitropic hormones. J Clin Endocrinol Metab 2014; 99: 1348-1356
37. Zehnder D, Evans KN, Kilby MD, Bulmer JN, Innes BA, Stewart PM et al. The ontogeny of 25-hydroxyVitamin D3 1alpha-hydroxylase expression in human placenta and decidua. Am J Pathol 2002; 161: 105-114
38. Sun W, Xie H, Ji J, Zhou X, Goltzman D, Miao D. Defective female reproductive function in 1,25(OH)2D-deficient mice results from indirect effect mediated by extracellular calcium and/or phosphorus. Am J Physiol Endocrinol Metab 2010; 299: E928-E935
39. He C, Lin Z, Robb SW, Ezeamama AE. Serum Vitamin D levels and polycystic ovary syndrome: a systematic review and meta-analysis. Nutrients 2015; 7: 4555-4577
40. Ghadimi R, Esmaeilzadeh S, Firoozpour M, Ahmadi A. Does Vitamin D status correlate with clinical and biochemical features of polycystic ovarysyndrome in high school girls? Caspian J Intern Med 2014; 5: 202-208
41. Velija-Asimi Z. Evaluation of the association of Vitamin D deficiency with gonadotropins and sex hormone in obese and non-obese women with polycystic ovary syndrome. Med Glas 2014; 11: 170-176
42. Paffoni A, Somigliana E, Vigano P, Benaglia L, Cardellicchio L, Pagliardini L et al. Vitamin D status in women with uterine leiomyomas. J Clin Endocrinol Metab 2013; 98: E1374-E1378
43. Ott J, Wattar L, Kurz C, Seemann R, Huber JC, Mayerhofer K et al. Parameters for calcium metabolism in women with polycystic ovary syndrome who undergo clomiphene citrate stimulation: a prospective cohort study. Eur J Endocrinol 2012; 166: 897-902