Evaluation and treatment of recurrent pregnancy loss: A committee opinion

Fertility and Sterility

Volumn 98, Issue 5, 2012, Pages 1103-1111

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CLINICAL EVALUATION; CYTOGENETICS; ENVIRONMENTAL FACTOR; FERTILIZATION IN VITRO; GENETIC COUNSELING; GENETIC PREDISPOSITION; INFECTION; LIFESTYLE; MATERNAL AGE; METABOLIC DISORDER; OCCUPATIONAL HAZARD; PRIORITY JOURNAL; RECURRENT PREGNANCY LOSS; SPONTANEOUS ABORTION; THROMBOPHILIA; UTERUS MALFORMATION;

ABORTION, HABITUAL; AGE FACTORS; ANTIPHOSPHOLIPID SYNDROME; COMMUNICABLE DISEASES; ENVIRONMENT; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIFE STYLE; OCCUPATIONAL DISEASES; PREGNANCY; PROGNOSIS; RISK ASSESSMENT; RISK FACTORS; THROMBOPHILIA; UTERUS;

EID: 84867744217     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2012.06.048     Document Type: Article

References (94)

1. P.A. Jacobs, and T. Hassold Chromosome abnormalities: origin and etiology in abortions and livebirths F. Vogel, K. Sperling, Human genetics 1987 Springer-Verlag Berlin 233 244
2. E. van den Boogaard, S.P. Kaandorp, M.T. Franssen, B.W. Mol, and N.J. Leschot Consecutive or non-consecutive recurrent miscarriage: is there any difference in carrier status? Hum Reprod 25 2010 1411 1414
3. G.M. Stirrat Recurrent miscarriage Lancet 336 1990 673 675
4. O.B. Christiansen, A.-M.N. Andersen, E. Bosch, S. Daya, and P.J. Delves Evidence-based investigations and treatments of recurrent pregnancy loss Fert Steril 83 2005 821 839
5. M.D. Stephenson, and W. Kutteh Evaluation and management of recurrent early pregnancy loss Clin Obstet Gynecol 50 2007 132 145
6. Royal College of Obstetricians and Gynaecologists, Scientific Advisory Committee, Guideline No. 17. The Investigation and treatment of couples with recurrent miscarriage. Published May 2011. Available at: http://www.rcog.org.uk/ womens-health/clinical-guidance/investigation-and-treatment-couples-recurrent- miscarriage-green-top-. Accessed March 22, 2012.
7. M.D. Stephenson Frequency of factors associated with habitual abortion in 197 couples Fertil Steril 66 1996 24 29
8. C.R. Jaslow, J.L. Carney, and W.H. Kutteh Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses Fertil Steril 93 2010 1234 1243
9. R. Rai, and L. Regan Recurrent miscarriage Lancet 368 2006 601 611
10. T. Hassold, and D. Chiu Maternal age specific rates of numerical chromosome abnormalities with special reference to trisomy Hum Genet 70 1985 11 17
11. M.D. Stephenson, K.A. Awartani, and W.P. Robinson Cytogenetic analysis of miscarriages from couples with recurrent miscarriage: a case-control study Hum Reprod 17 2002 446 451
12. T. Philipp, K. Philipp, A. Reiner, F. Beer, and D.K. Kalousek Embroscopic and cytogenetic analysis of 233 missed abortions: factors involved in the pathogenesis of developmental defects of early failed pregnancies Hum Reprod 18 2003 1724 1732
13. A.J. Wilcox, C.R. Weinberg, J.F. O'Connor, D.D. Baird, and J.P. Schlatterer Incidence of early loss of pregnancy N Eng J Med 319 1988 189 194
14. D.K. Edmonds, K.S. Lindsay, J.F. Miller, E. Williamson, and P.J. Wood Early embryonic mortality in women Fertil Steril 38 1982 447 453
15. U.B. Knudsen, V. Hansen, S. Juul, and N.J. Secher Prognosis of a new pregnancy following previous spontaneous abortions Eur J Obstet Gynecol Reprod Biol 39 1991 31 36
16. M.T.M. Franssen, A.M. Musters, F. van der Veen, S. Repping, and N.J. Leschot Reproductive outcome after PGD in couples with recurrent miscarriage carrying a structural chromosome abnormality: a systematic review Hum Reprod Update 17 2011 467 475
17. J. Hirshfeld-Cytron, M. Sugiura-Ogasawara, and M.D. Stephenson Management of Recurrent Pregnancy loss associated with a parental carrier of a reciprocal translocation: a systematic review Sem Reprod Med 29 2011 470 481
18. M. Sugiura-Ogasawara, Y. Ozaki, T. Sato, N. Suzumori, and K. Suzumori Poor prognosis of recurrent aborters with either maternal or paternal reciprocal translocations Fertil Steril 81 2004 367 373
19. S. Sierra, S. Langlois, and M.D. Stephenson Reproductive outcomes in patients with recurrent pregnancy loss associated with a structural chromosome abnormality Fertil Steril 80 2003 80 81
20. S. Sierra, and M. Stephenson Genetics of recurrent pregnancy loss SemsReprod Med 24 2006 17 24
21. R. Vissenberg, and M. Goddijn Is there a role for assisted reproductive technology in recurrent miscarriage? Sem Reprod Med 29 2011 548 556
22. K.L. Jarrett, R.C. Michaelis, M.C. Phelan, V.A. Vincent, and R.G. Best Microsatellite analysis reveals a high incidence of maternal cell contamination in 46, XX products of conception consisting of villi or a combination of villi and membranous material Am J Obstet Gynecol 185 2001 198 203
23. S. Miyakis, M.D. Lockshin, T. Atsumi, D.W. Branch, and R.L. Brey International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) J Thromb Haemost 4 2006 295 306
24. ACOG. Antiphospholipid syndrome. ACOG Practice Bulletin, No.118, January 2011.
25. D.L. Yetman, and W.H. Kutteh Antiphospholipid antibody panels and recurrent pregnancy loss: prevalence of anticardiolipin antibodies compared with other antiphospholipid antibodies Fertil Steril 66 1996 540 546
26. L. Opartrny, M. David, S.R. Kahn, I. Shrier, and E. Rey Association between antiphospholipid antibodies and recurrent fetal loss in women without autoimmune disease: a metaanalysis J Rheumatol 33 2006 2214 2221
27. R.R. Adler, A.K. Ng, and N.S. Rote Monoclonal antiphosphatidylserine antibody inhibits intercellular fusion of the choriocarcinoma line, JAR Biol Reprod 53 1995 905 910
28. N.S. Rote, T.W. Lyden, E. Vogt, and A.K. Ng Chapter 18: Antiphospholipid antibodies and placental development J.S. Hunst, Immunobiology of Reproduction 1994 Springer-Verlag New York 285 302
29. H. Katsuragawa, H. Kanzaki, T. Inoue, T. Hirano, T. Mori, and N.S. Rote Monoclonal antibody against phosphatidylserine inhibits in vitro human trophoblastic hormone production and invasion Biol Reprod 56 1997 50 58
30. 2- glycoprotein I Arth Rheum 43 2000 140 150
31. N.S. Rote, and B. Stetzer Autoimmune disease as a cause of reproductive failure Clinics Lab Med 23 2003 265 293
32. N. Di Simone, R. Castellani, D. Caliandro, and A. Caruso Monoclonal anti-annexin V antibody inhibits trophoblast gonadotropin secretion and induces syncytiotrophoblast apoptosis Biol Reprod 65 2001 1766 1770
33. E. Vogt, A.K. Ng, and N.S. Rote Antiphosphatidylserine antibody removes annexin V and facilitates the binding of prothrombin at the surface of a choriocarcinoma model of trophoblast differentiation Amer J Obstet Gynecol 177 1997 964 972
34. J.H. Rand The pathogenic role of annexin-V in the antiphospholipid syndrome Cure Rheumatol Rep 2 2000 246 251
35. J.H. Rand The antiphospholipid syndrome Ann Rev Med 54 2003 409 424
36. G. Girardi, R. Bulla, J.E. Salmon, and F. Tedesco The complement system in the pathophysiology of pregnancy Mole Immunol 43 2006 68 77
37. M. Empson, M. Lassere, J.C. Craig, and J.R. Scott Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials Obstet Gynecol 99 2002 135 144
38. M. Empson, M. Lassere, J. Craig, and J. Scott Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant The Cochrane Database of Systemic Reviews 3 2005
39. P.D. Ziakis, M. Pavlou, and M. Voulgarelis Heparin treatment in antiphospholipid syndrome with recurrent pregnancy loss. A systematic review and meta-analyis Obstet Gynecol 115 2010 1256 1262
40. C.A. Laskin, C. Bombardier, M.E. Hannah, F.P. Mandel, and J.W. Ritchie Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss N Engl J Med 337 1997 148 153
41. D.W. Branch, R. Andres, K.B. Digre, N.S. Rote, and J.R. Scott The association of antiphospholipid antibodies with severe preeclampsia Obstet Gynecol 73 1989 541 545
42. K.E. Sletnes, F. Wisloff, N. Moe, and P.O. Dale Antiphospholipid antibodies in pre-eclamptic women: relation to growth retardation and neonatal outcome Acta Obstet Gynecol Scand 71 1992 112 117
43. T. Yamamoto, S. Yoshimura, Y. Geshi, Y. Sasamori, S. Okinaga, T. Kobayashi, and H. Mori Measurement of antiphospholipid antibody by ELISA using purified beta 2-glycoprotein I in preeclampsia Clin Exp Immunol 94 1993 196 200
44. G.A. Dekker, J.I. de Vries, P.M. Doelitzsch, P.C. Huijgens, B.M. von Blomberg, C. Jakobs, and H.P. van Geijn Underlying disorders associated with severe early-onset preeclampsia Amer J Obstet Gynecol 173 1995 1042 1048
45. J. Moodley, V. Bhoota, J. Duursma, D. Pudifin, S. Byrne, and D.G. Kennyer The association of antiphospholipid antibodies with severe early onset pre-eclampsia S Afr Med J 85 1995 105 107
46. J.Y. Allen, C. Tapia-Santiago, and W.H. Kutteh Antiphospholipid antibodies in patients with preeclampsia Amer J Reprod Immunol 36 1996 81 85
47. T. Yamamoto, Y. Takahashi, Y. Geshi, Y. Sasamori, and H. Mori Anti-phospholipid antibodies in preeclampsia and their binding ability for placental villous lipid fractions J Obstet Gynaecol Res 22 1996 275 283
48. M.G. Van Pampus, G.A. Dekker, H. Wolf, P.C. Huijgens, M.M. Koopman, B.M. von Blomberg, and H.R. Buller High prevalence of hemostatic abnormalities in women with a history of severe preeclampsia Amer J Obstet Gynecol 180 1999 1146 1150
49. D.W. Branch, R. Silver, S. Pierangeli, I. van Leeuwen, and E.N. Harris Antiphospholipid antibodies other than lupus anticoagulant and anticardiolipin antibodies in women with recurrent pregnancy loss, fertile controls, and antiphospholipid syndrome Obstet Gynecol 90 1997 642 644
50. G.F. Grimbizis, M. Camus, B.C. Tarlatzis, J.N. Bontis, and P. Devroey Clinical implications of uterine malformations and hysteroscopic treatment results Hum Reprod Update 7 2001 161 174
51. G. Lissalde-Lavigne, P. Fabbro-Peray, E. Cochery-Nouvellon, E. Mercier, and S. Ripart-Neveu Factor V Leiden and prothrombin G20210A polymorphisms as risk factors for miscarriage during a first intended pregnancy: the matched case-control "NOHA first" study J Thromb Haemost 3 2005 2178 2184
52. F.E. Preston, F.R. Rosendaal, I.D. Wlaher, E. Briet, and E. Berntorp Increased fetal loss in women with heritable thrombophilia Lancet 348 1996 913 916
53. D. Dizon-Townson, C. Miller, B. Sibai, C.Y. Spong, and E. Thom The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus Obstet Gynecol 106 2005 517 524
54. R.M. Silver, Y. Zhao, C.Y. Spong, B. Sibai, and G. Wendel Jr. Prothrombin gene G20210A mutation and obstetric complications Obstet Gynecol 115 2010 14 20
55. P.G. De Jong, M. Goddijn, and S. Middwldorp Testing for inherited thrombophilia in recurrent miscarriage Sem Reprod Med 29 2011 540 545
56. J.L. Mills, J.L. Simpson, S.G. Driscoll, L. Jovanovic-Peterson, and M. Van Allen Incidence of spontaneous abortion among normal women and insulin-dependent diabetic women whose pregnancies were identified within 21 days of conception N Eng J Med 319 1988 1617 1623
57. U. Hanson, B. Persson, and S. Thunell Relationship between haemoglobin A1C in early type 1 (insulin-dependent) diabetic pregnancy and the occurrence of spontaneous abortion and fetal malformation in Sweden Diabetologia 33 1990 100 104
58. T.I. Chang, and M.R. Loeker Genotoxicity and diabetic embryopathy: impaired expression of developmental control genes as cause of defective morphogenesis Semin Reprod Endocrinol 17 1999 153 165
59. M. Abalovich, S. Gutierrez, G. Alcaraz, G. Maccallini, A. Garcia, and O. Levalle Overt and subclinical hypothyroidism complicating pregnancy Thyroid 12 2002 63 68
60. M. Abalovich, N. Amino, L.A. Barbour, R.H. Cobin, and L.J. De Groot Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline J Clin Endocrinol Metab 92 2007 S1 S47
61. L. Jovanovic, H. Knopp, H. Kim, W.T. Cefalu, and X.D. Zhu Elevated pregnancy losses at high and low extremes of maternal glucose in early normal and diabetic pregnancies: evidence for a protective adaptation in diabetes Diabetes Care 28 2005 1113 1117
62. F. Hirahara, N. Andoh, K. Sawai, T. Hirabuki, T. Uemura, and H. Minaguchi Hyperprolactinemic recurrent miscarriage and results of randomized bromocriptine treatment trials Fertil Steril 70 1998 246 252
63. A.J. Wilcox, D.D. Baird, and C.R. Weinberg Time of implantation of the conceptus and loss of pregnancy N Engl J Med 340 1999 1796 1799
64. American Society for Reproductive Medicine Clinical relevance of luteal phase deficiency Fertil Steril 98 2012 1112 1117
65. M.J. Murray, W.R. Meyer, R.J. Zaino, B.A. Lessey, and D.B. Novotny A critical analysis of the accuracy, reproducibility, and clinical utility of histologic endometrial dating in fertile women Fertil Steril 81 2004 1333 1343
66. C. Coutifaris, E.R. Myers, D.S. Guzick, M.P. Diamond, and S.A. Carson Histological dating of timed endometrial biopsy tissue is not related to fertility status Fertil Steril 82 2004 1264 1272
67. D.M. Haas, and P.S. Ramsey Progestogen for preventing miscarriage Cochrane Database Syst Rev 2 2008
68. P. Goldstein, J. Berrier, S. Rosen, H.S. Sacks, and T.C. Chalmers A meta-analysis of randomized control trials of progestational agents in pregnancy Br J Obstet Gynaecol 96 1989 265 274
69. R.M. Oates-Whitehead, D.M. Haas, and J.A. Carrier Progestogen for preventing miscarriage Cochrane Database Syst Rev 4 2003 CD003511
70. S. Daya Efficacy of progesterone support for pregnancy in women with recurrent miscarriage. A meta-analysis of controlled trials Brit J Obstet Gynaecol 96 1989 275 280
71. M. Penta, A. Lukic, M.P. Conte, F. Chiarini, and D. Fioriti Infectious agents in tissues from spontaneous abortions in the first trimester of pregnancy New Microbiol 26 2003 329 337
72. J.A. Hill, A.F. Abbott, and J.A. Politch Sperm morphology and recurrent abortions Fertil Steril 61 1994 776 778
73. D.T. Carrell, L. Liu, C.M. Peterson, K.P. Jones, H.H. Hatasaka, L. Erickson, and B. Campbell Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss Arch Androl 49 2003 49 55
74. M. Benchaib, J. Lornage, C. Mazoyer, H. Lejeune, B. Salle, and J. Francois Guerin Sperm deoxyribonucleic acid fragmentation as a prognostic indicator of assisted reproductive technology outcome Fertil Steril 87 2007 93 100
75. C. Rubio, M. Gil-Salom, C. Simon, F. Vidal, and L. Rodrigo Incidence of sperm chromosomal abnormalities in a risk population: relationship with sperm quality and ICSI outcome Hum Reprod 16 2001 2084 2092
76. N. Brier Understanding and managing the emotional reactions to a miscarriage Obstet Gynecol 93 1999 151 155
77. N. Brier Anxiety after miscarriage: a review of the empirical literature and implications for clinical practice Birth 31 2004 138 142
78. B. Stray-Pedersen, and S. Stray-Pedersen Etiologic factors and subsequent reproductive performance in 195 couples with a prior history of habitual abortion Amer J Obstet Gynecol 148 1984 140 146
79. B. Stray-Pedersen, and S. Stray-Pedersen Recurrent abortion: the role of psychotherapy R.W. Beard, F. Ship, Early pregnancy loss: mechanisms and treatment 1988 Springer-Verlag New York 433 440
80. M. Sugiura-Ogasawara, T.A. Furukawa, Y. Nakano, S. Hori, K. Aoki, and T. Kitamura Depression as a potential causal factor in subsequent miscarriage in recurrent spontaneous aborters Hum Reprod 17 2002 2580 2584
81. K. Clifford, R. Rai, and L. Regan Future pregnancy outcome in unexplained recurrent first trimester miscarriage Hum Reprod 12 1997 387 389
82. S.A. Brigham, C. Conlon, and R.G. Farquharson A longitudinal study of pregnancy outcome following idiopathic recurrent miscarriage Hum Reprod 14 1999 2868 2871
83. T.F. Porter, Y. LaCoursiere, and J.R. Scott Immunotherapy for recurrent miscarriage The Cochrane Database of Systemic Reviews 2006
84. C.B. Coulam, L. Krysa, J.J. Stern, and M. Bustillo Intravenous immunoglobulin for treatment of recurrent pregnancy loss Am J Reprod Immunol 34 1995 333 337
85. O.B. Christiansen, O. Mathiesen, M. Husth, K.L. Rasmussen, H.J. Ingerslev, J.G. Lauritsen, and N. Grunnet Placebo-controlled trial of treatment of unexplained secondary recurrent spontaneous abortions and recurrent late spontaneous abortions with i.v. immunoglobulin Hum Reprod 10 1995 2690 2695
86. M.D. Stephenson, K. Dreher, E. Houlihan, and V. Wu Prevention of unexplained recurrent spontaneous abortion using intravenous immunoglobulin: a prospective, randomized, double-blinded, placebo-controlled trial Am J Reprod Immunol 39 1998 82 88
87. B. Hutton, R. Sharma, D. Fergusson, A. Tinmouth, P. Hebert, J. Jamieson, and M. Walker Use of intravenous immunoglobulin for treatment of recurrent miscarriage: a systematic review Brit J ObstetGynecol 114 2007 134 142
88. B. Ata, S.L. Tan, F. Shehata, H. Holzer, and W. Buckett A systematic review of intravenous immunoglobulin for treatment of unexplained recurrent miscarriage Fertil Steril 95 2011 1080 1085
89. M.L. Lindbohm, M. Sallmen, and H. Taskinen Effects of exposure to environmental tobacco smoke on reproductive health Scand J Work Environ Health 28 Suppl 2 2002 84 86
90. C. Boots, and M.D. Stephenson Does obesity increase the risk of miscarriage in spontaneous conception: a systematic review Semin Reprod Med 29 2011 507 513
91. R.B. Ness, J.A. Grisso, N. Hirshinger, N. Markovic, L.M. Shaw, and N.L. Day Cocaine and tobacco use and the risk of spontaneous abortion N Engl J Med 340 1999 333 339
92. U. Kesmodel, K. Wisborg, S.F. Olsen, T.B. Henriksen, and N.J. Secher Moderate alcohol intake in pregnancy and the risk of spontaneous abortion Alcohol 37 2002 435 444
93. A.N. Andersen, J. Wohlfahrt, P. Christens, J. Olsen, and M. Melbye Maternal age and fetal loss: population based register linkage study BMJ 320 2000 1708 1712
94. M. Lund, M. Kamper-Jorgensen, H.S. Nielsen, O. Lidegaard, A.M. Andersen, and O.B. Christiansen Prognosis for live birth in women with recurrent miscarriage: what is the best measure of success? Obstet Gynecol 119 2012 37 43