Heteromeric α7β2 Nicotinic Acetylcholine Receptors in the Brain

Trends in Pharmacological Sciences

Volumn 37, Issue 7, 2016, Pages 562-574

  Wu, Jie ^a,b   Liu, Qiang ^b   Tang, Pei ^c   Mikkelsen, Jens D ^d   Shen, Jianxin ^a   Whiteaker, Paul ^b   Yakel, Jerrel L ^e  

^a SHANTOU UNIVERSITY   (China)

^b BARROW NEUROLOGICAL INSTITUTE   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^e NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

acetylcholine; alpha 7 nicotinic acetylcholine receptor; choline; nicotine; nicotinic acetylcholine receptor

Indexed keywords

1 (5 CHLORO 2,4 DIMETHOXYPHENYL) 3 (5 METHYL 3 ISOXAZOLYL)UREA; ACETYLCHOLINE; ALPHA7 BETA2 NICOTINIC RECEPTOR; CARBACHOL; CHOLINE; CYTISINE; ENCENICLINE; EPIBATIDINE; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; PNU 282978; SSR 10891; TC 1698; TC 7020; UNCLASSIFIED DRUG; VARENICLINE; BUNGAROTOXIN RECEPTOR; NICOTINIC AGENT;

BRAIN; BRAIN DISEASE; BRAIN NERVE CELL; CELL FUNCTION; CHOLINERGIC TRANSMISSION; HETEROLOGOUS EXPRESSION; HUMAN; LEARNING; MEMORY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW; STOICHIOMETRY; ALLOSTERISM; ANIMAL; CHEMISTRY; DRUG EFFECTS; PHYSIOLOGY;

ALLOSTERIC REGULATION; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANIMALS; BRAIN; HUMANS; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS;

EID: 84969916699     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2016.03.005     Document Type: Review

References (66)

1. R.J. Lukas, and et al. International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits Pharmacol. Rev. 51 1999 397 401
2. A.A. Jensen, and et al. Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations J. Med. Chem. 48 2005 4705 4745
3. J. Lindstrom, and et al. Structure and function of neuronal nicotinic acetylcholine receptors Prog. Brain Res. 109 1996 125 137
4. P.J. Whiting, and et al. Functional acetylcholine receptor in PC12 cells reacts with a monoclonal antibody to brain nicotinic receptors Nature 327 1987 515 518
5. C.M. Flores, and et al. A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment Mol. Pharmacol. 41 1992 31 37
6. M. Gopalakrishnan, and et al. Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor J. Pharmacol. Exp. Ther. 276 1996 289 297
7. J. Lindstrom Neuronal nicotinic acetylcholine receptors Ion Channels 4 1996 377 450
8. P. Seguela, and et al. Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium J. Neurosci. 13 1993 596 604
9. J. Wu, and R.J. Lukas Naturally-expressed nicotinic acetylcholine receptor subtypes Biochem. Pharmacol. 82 2011 800 807
10. A. Sfera, and et al. Non-neuronal acetylcholine: the missing link between sepsis, cancer, and delirium? Front. Med. 2 2015 56
11. K. Kawashima, and T. Fujii Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function Front. Biosci. 9 2004 2063 2085
12. J.L. Yakel Cholinergic receptors: functional role of nicotinic ACh receptors in brain circuits and disease Eur. J. Physiol. 465 2013 441 450
13. O.K. Steinlein, and D. Bertrand Neuronal nicotinic acetylcholine receptors: from the genetic analysis to neurological diseases Biochem. Pharmacol. 76 2008 1175 1183
14. L. Azam, and et al. Co-expression of alpha7 and beta2 nicotinic acetylcholine receptor subunit mRNAs within rat brain cholinergic neurons Neuroscience 119 2003 965 977
15. M. Moretti, and et al. The novel alpha7beta2-nicotinic acetylcholine receptor subtype is expressed in mouse and human basal forebrain: biochemical and pharmacological characterization Mol. Pharmacol. 86 2014 306 317
16. M.S. Thomsen, and et al. Alpha7 and beta2 nicotinic acetylcholine receptor subunits form heteromeric receptor complexes that are expressed in the human cortex and display distinct pharmacological properties PLoS ONE 10 2015 e0130572
17. L.R. Britto, and et al. Neurons of the chick brain and retina expressing both alpha-bungarotoxin-sensitive and alpha-bungarotoxin-insensitive nicotinic acetylcholine receptors: an immunohistochemical analysis Brain Res. 590 1992 193 200
18. R. Anand, and et al. Pharmacological characterization of alpha-bungarotoxin-sensitive acetylcholine receptors immunoisolated from chick retina: contrasting properties of alpha 7 and alpha 8 subunit-containing subtypes Mol. Pharmacol. 44 1993 1046 1050
19. R. Anand, and et al. Homomeric and native alpha 7 acetylcholine receptors exhibit remarkably similar but non-identical pharmacological properties, suggesting that the native receptor is a heteromeric protein complex FEBS Lett. 327 1993 241 246
20. P.C. Pugh, and et al. Novel subpopulation of neuronal acetylcholine receptors among those binding alpha-bungarotoxin Mol. Pharmacol. 47 1995 717 725
21. D.S. McGehee, and et al. Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors Science 269 1995 1692 1696
22. C.R. Yu, and L.W. Role Functional contribution of the alpha7 subunit to multiple subtypes of nicotinic receptors in embryonic chick sympathetic neurones J. Physiol. 509 1998 651 665
23. J. Cuevas, and D.K. Berg Mammalian nicotinic receptors with alpha7 subunits that slowly desensitize and rapidly recover from alpha-bungarotoxin blockade J. Neurosci. 18 1998 10335 10344
24. M.M. Zarei, and et al. Distributions of nicotinic acetylcholine receptor alpha7 and beta2 subunits on cultured hippocampal neurons Neuroscience 88 1999 755 764
25. S.S. Khiroug, and et al. Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channels J. Physiol. 540 2002 425 434
26. Q. Liu, and et al. A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides J. Neurosci. 29 2009 918 929
27. T.A. Murray, and et al. Alpha7beta2 nicotinic acetylcholine receptors assemble, function, and are activated primarily via their alpha7-alpha7 interfaces Mol. Pharmacol. 81 2012 175 188
28. R. Zwart, and et al. Unique pharmacology of heteromeric alpha7beta2 nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes Eur. J. Pharmacol. 726 2014 77 86
29. Q. Liu, and et al. Functional alpha7beta2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid beta peptides BMC Neurosci. 13 2012 155
30. Z. Shao, and J.L. Yakel Single channel properties of neuronal nicotinic ACh receptors in stratum radiatum interneurons of rat hippocampal slices J. Physiol. 527 2000 507 513
31. S.N. Sudweeks, and J.L. Yakel Functional and molecular characterization of neuronal nicotinic ACh receptors in rat CA1 hippocampal neurons J. Physiol. 527 2000 515 528
32. T.K. Mehta, and et al. Defining pre-synaptic nicotinic receptors regulated by beta amyloid in mouse cortex and hippocampus with receptor null mutants J. Neurochem. 109 2009 1452 1458
33. O. Lykhmus, and et al. Mitochondria express several nicotinic acetylcholine receptor subtypes to control various pathways of apoptosis induction Int. J. Biochem. Cell Biol. 53 2014 246 252
34. G. Gergalova, and et al. alpha7 nicotinic acetylcholine receptors control cytochrome c release from isolated mitochondria through kinase-mediated pathways Int. J. Biochem. Cell Biol. 49 2014 26 31
35. J. Wu, and et al. Beta-amyloid directly inhibits human alpha4beta2-nicotinic acetylcholine receptors heterologously expressed in human SH-EP1 cells J. Biol. Chem. 279 2004 37842 37851
36. P. Buchhave, and et al. Longitudinal study of CSF biomarkers in patients with Alzheimer's disease PLoS ONE 4 2009 e6294
37. E.J. Molinari, and et al. Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands Eur. J. Pharmacol. 347 1998 131 139
38. Q. Liu, and et al. A novel nicotinic mechanism underlies beta-amyloid-induced neuronal hyperexcitation J. Neurosci. 33 2013 7253 7263
39. Q. Liu, and et al. A novel nicotinic mechanism underlies beta-amyloid-induced neurotoxicity Neuropharmacology 97 2015 457 463
40. P. Flood, and et al. Alpha 4 beta 2 neuronal nicotinic acetylcholine receptors in the central nervous system are inhibited by isoflurane and propofol, but alpha 7-type nicotinic acetylcholine receptors are unaffected Anesthesiology 86 1997 859 865
41. T. Mori, and et al. Modulation of neuronal nicotinic acetylcholine receptors by halothane in rat cortical neurons Mol. Pharmacol. 59 2001 732 743
42. D. Willenbring, and et al. The role of structured water in mediating general anesthetic action on alpha4beta2 nAChR Phys. Chem. Chem. Phys. 12 2010 10263 10269
43. D. Mowrey, and et al. Unresponsive correlated motion in alpha7 nAChR to halothane binding explains its functional insensitivity to volatile anesthetics J. Phys. Chem. B 114 2010 7649 7655
44. L.T. Liu, and et al. General anesthetic binding to neuronal alpha4beta2 nicotinic acetylcholine receptor and its effects on global dynamics J. Phys. Chem. B 113 2009 12581 12589
45. T. Cui, and et al. Anesthetic effects on the structure and dynamics of the second transmembrane domains of nAChR alpha4beta2 Biochim. et Biophys. Acta 1798 2010 161 166
46. D.D. Mowrey, and et al. Insights into distinct modulation of alpha7 and alpha7beta2 nicotinic acetylcholine receptors by the volatile anesthetic isoflurane J. Biol. Chem. 288 2013 35793 35800
47. 3 subtype J. Pharmacol. Exp. Ther. 348 2014 46 58
48. A. Kuryatov, and J. Lindstrom Expression of functional human α6β2β3∗acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers Mol. Pharmacol. 79 2011 126 140
49. A.A. George, and et al. Function of human α3β4α5 nicotinic acetylcholine receptors is reduced by the α5(D398N) variant J. Biol. Chem. 287 2012 25151 25162
50. 2 nicotinic acetylcholine receptors: subunit arrangement determines functional expression Br. J. Pharmacol. 156 2009 970 981
51. 2α4 nicotinic receptor influences agonist sensitivity J. Biol. Chem. 286 2011 31043 31054
52. M. Bencherif, and et al. Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases Cell. Mol. Life Sci. 68 2011 931 949
53. Y. Liu, and et al. Activation of alpha7 nicotinic acetylcholine receptors protects astrocytes against oxidative stress-induced apoptosis: implications for Parkinson's disease Neuropharmacology 91 2015 87 96
54. A.J. Kucinski, and et al. Alpha7 neuronal nicotinic receptors as targets for novel therapies to treat multiple domains of schizophrenia Curr. Pharm. Biotechnol. 12 2011 437 448
55. R. Freedman Alpha7-nicotinic acetylcholine receptor agonists for cognitive enhancement in schizophrenia Annu. Rev. Med. 65 2014 245 261
56. H. Yoshikawa, and et al. Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7 Clin. Exp. Immunol. 146 2006 116 123
57. A. Aicher, and et al. Nicotine strongly activates dendritic cell-mediated adaptive immunity: potential role for progression of atherosclerotic lesions Circulation 107 2003 604 611
58. R.D. Shytle, and et al. Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors J. Neurochem. 89 2004 337 343
59. H. Wang, and et al. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation Nature 421 2003 384 388
60. W.H. Piao, and et al. Nicotine and inflammatory neurological disorders Acta Pharmacol. Sin. 30 2009 715 722
61. W.Y. Cui, and M.D. Li Nicotinic modulation of innate immune pathways via alpha7 nicotinic acetylcholine receptor J. Neuroimmune Pharmacol. 5 2010 479 488
62. J.X. Shen, and et al. Roles of nicotinic acetylcholine receptors in stem cell survival/apoptosis, proliferation and differentiation Curr. Mol. Med. 13 2013 1455 1464
63. W. Lin, and et al. Role of alpha7-nicotinic acetylcholine receptor in normal and cancer stem cells Curr. Drug. Targets 13 2012 656 665
64. X.W. Li, and H. Wang Non-neuronal nicotinic alpha 7 receptor, a new endothelial target for revascularization Life Sci. 78 2006 1863 1870
65. Y. Wang, and et al. Human bronchial epithelial and endothelial cells express alpha7 nicotinic acetylcholine receptors Mol. Pharmacol. 60 2001 1201 1209
66. C. Heeschen, and et al. A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors J. Clin. Invest. 110 2002 527 536