메뉴 건너뛰기




Volumn 287, Issue 30, 2012, Pages 25151-25162

Function of human α3β4α5 nicotinic acetylcholine receptors is reduced by the β5(D398N) variant

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACIDS; CO-INJECTION; NICOTINIC ACETYLCHOLINE RECEPTORS; PHARMACOLOGICAL PROFILES; PHARMACOLOGICAL PROPERTIES; PHENOTYPIC CHANGES; XENOPUS OOCYTE;

EID: 84864095401     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.379339     Document Type: Article
Times cited : (45)

References (46)
  • 2
    • 0032426910 scopus 로고    scopus 로고
    • Four pharmacologically distinct subtypes of α4β2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes
    • Zwart, R., and Vijverberg, H. P. (1998) Four pharmacologically distinct subtypes of α4β2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes. Mol. Pharmacol. 54, 1124-1131 (Pubitemid 29002058)
    • (1998) Molecular Pharmacology , vol.54 , Issue.6 , pp. 1124-1131
    • Zwart, R.1    Vijverberg, H.P.M.2
  • 3
    • 0037289747 scopus 로고    scopus 로고
    • Alternate stoichiometries of α4β2 nicotinic acetylcholine receptors
    • DOI 10.1124/mol.63.2.332
    • Nelson, M. E., Kuryatov, A., Choi, C. H., Zhou, Y., and Lindstrom, J. (2003) Alternate stoichiometries of α4β2 nicotinic acetylcholine receptors. Mol. Pharmacol. 63, 332-341 (Pubitemid 36158368)
    • (2003) Molecular Pharmacology , vol.63 , Issue.2 , pp. 332-341
    • Nelson, M.E.1    Kuryatov, A.2    Choi, C.H.3    Zhou, Y.4    Lindstrom, J.5
  • 5
    • 67650589051 scopus 로고    scopus 로고
    • Pentameric concatenated (α4)(2)(β2)(3) and (α4)(3)β2(2) nicotinic acetylcholine receptors. Subunit arrangement determines functional expression
    • Carbone, A. L., Moroni, M., Groot-Kormelink, P. J., and Bermudez, I. (2009) Pentameric concatenated (α4)(2)(β2)(3) and (α4)(3)β2)(2) nicotinic acetylcholine receptors. Subunit arrangement determines functional expression. Br. J. Pharmacol. 156, 970-981
    • (2009) Br. J. Pharmacol. , vol.156 , pp. 970-981
    • Carbone, A.L.1    Moroni, M.2    Groot-Kormelink, P.J.3    Bermudez, I.4
  • 12
    • 55749093830 scopus 로고    scopus 로고
    • The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer
    • Spitz, M. R., Amos, C. I., Dong, Q., Lin, J., and Wu, X. (2008) The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer. J. Natl. Cancer Inst. 100, 1552-1556
    • (2008) J. Natl. Cancer Inst. , vol.100 , pp. 1552-1556
    • Spitz, M.R.1    Amos, C.I.2    Dong, Q.3    Lin, J.4    Wu, X.5
  • 16
    • 34548604495 scopus 로고    scopus 로고
    • Nicotinic α5 subunit deletion locally reduces high-affinity agonist activation without altering nicotinic receptor numbers
    • DOI 10.1111/j.1471-4159.2007.04700.x
    • Brown, R. W., Collins, A. C., Lindstrom, J. M., and Whiteaker, P. (2007) Nicotinic α5 subunit deletion locally reduces high affinity agonist activation without altering nicotinic receptor numbers. J. Neurochem. 103, 204-215 (Pubitemid 47404196)
    • (2007) Journal of Neurochemistry , vol.103 , Issue.1 , pp. 204-215
    • Brown, R.W.B.1    Collins, A.C.2    Lindstrom, J.M.3    Whiteaker, P.4
  • 17
    • 37349116624 scopus 로고    scopus 로고
    • The α4η2α5 nicotinic cholinergic receptor in rat brain is resistant to up-regulation by nicotine in vivo
    • DOI 10.1111/j.1471-4159.2007.05011.x
    • Mao, D., Perry, D. C., Yasuda, R. P., Wolfe, B. B., and Kellar, K. J. (2008) The α4η2α5 nicotinic cholinergic receptor in rat brain is resistant to up-regulation by nicotine in vivo. J. Neurochem. 104, 446-456 (Pubitemid 350293883)
    • (2008) Journal of Neurochemistry , vol.104 , Issue.2 , pp. 446-456
    • Mao, D.1    Perry, D.C.2    Yasuda, R.P.3    Wolfe, B.B.4    Kellar, K.J.5
  • 18
    • 78651336831 scopus 로고    scopus 로고
    • Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)2α5 AChR function
    • Kuryatov, A., Berrettini, W., and Lindstrom, J. (2011) Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)2α5 AChR function. Mol. Pharmacol. 79, 119-125
    • (2011) Mol. Pharmacol. , vol.79 , pp. 119-125
    • Kuryatov, A.1    Berrettini, W.2    Lindstrom, J.3
  • 19
    • 0028949913 scopus 로고
    • Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous systems
    • Zoli, M., Le Novère, N., Hill, J. A., Jr., and Changeux, J. P. (1995) Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous systems. J. Neurosci. 15, 1912-1939
    • (1995) J. Neurosci. , vol.15 , pp. 1912-1939
    • Zoli, M.1    Le Novère, N.2    Hill Jr., J.A.3    Changeux, J.P.4
  • 21
    • 77949565866 scopus 로고    scopus 로고
    • Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes
    • David, R., Ciuraszkiewicz, A., Simeone, X., Orr-Urtreger, A., Papke, R. L., McIntosh, J. M., Huck, S., and Scholze, P. (2010) Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. Eur. J. Neurosci. 31, 978-993
    • (2010) Eur. J. Neurosci. , vol.31 , pp. 978-993
    • David, R.1    Ciuraszkiewicz, A.2    Simeone, X.3    Orr-Urtreger, A.4    Papke, R.L.5    McIntosh, J.M.6    Huck, S.7    Scholze, P.8
  • 22
    • 0028940759 scopus 로고
    • Neurons can maintain multiple classes of nicotinic acetylcholine receptors distinguished by different subunit compositions
    • Conroy, W. G., and Berg, D. K. (1995) Neurons can maintain multiple classes of nicotinic acetylcholine receptors distinguished by different subunit compositions. J. Biol. Chem. 270, 4424-4431
    • (1995) J. Biol. Chem. , vol.270 , pp. 4424-4431
    • Conroy, W.G.1    Berg, D.K.2
  • 23
    • 0027538222 scopus 로고
    • Neurons assemble acetylcholine receptors with as many as three kinds of subunits while maintaining subunit segregation among receptor subtypes
    • DOI 10.1016/0896-6273(93)90333-M
    • Vernallis, A. B., Conroy, W. G., and Berg, D. K. (1993) Neurons assemble acetylcholine receptors with as many as three kinds of subunits while maintaining subunit segregation among receptor subtypes. Neuron 10, 451-464 (Pubitemid 23111736)
    • (1993) Neuron , vol.10 , Issue.3 , pp. 451-464
    • Vernallis, A.B.1    Conroy, W.G.2    Berg, D.K.3
  • 24
    • 39749147634 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptors in cancer. Multiple roles in proliferation and inhibition of apoptosis
    • Egleton, R. D., Brown, K. C., and Dasgupta, P. (2008) Nicotinic acetylcholine receptors in cancer. Multiple roles in proliferation and inhibition of apoptosis. Trends Pharmacol. Sci. 29, 151-158
    • (2008) Trends Pharmacol. Sci. , vol.29 , pp. 151-158
    • Egleton, R.D.1    Brown, K.C.2    Dasgupta, P.3
  • 25
    • 80054792208 scopus 로고    scopus 로고
    • Functional characterization of the α5 (Asn-398) variant associated with risk for nicotine dependence in the α3β4α5 nicotinic receptor
    • Li, P., McCollum, M., Bracamontes, J., Steinbach, J. H., and Akk, G. (2011) Functional characterization of the α5 (Asn-398) variant associated with risk for nicotine dependence in the α3β4α5 nicotinic receptor. Mol. Pharmacol. 80, 818-827
    • (2011) Mol. Pharmacol. , vol.80 , pp. 818-827
    • Li, P.1    McCollum, M.2    Bracamontes, J.3    Steinbach, J.H.4    Akk, G.5
  • 26
    • 77951032908 scopus 로고    scopus 로고
    • Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes
    • Papke, R. L., Wecker, L., and Stitzel, J. A. (2010) Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J. Pharmacol. Exp. Ther. 333, 501-518
    • (2010) J. Pharmacol. Exp. Ther. , vol.333 , pp. 501-518
    • Papke, R.L.1    Wecker, L.2    Stitzel, J.A.3
  • 27
    • 78149430216 scopus 로고    scopus 로고
    • Human α3β4 neuronal nicotinic receptors show different stoichiometry if they are expressed in Xenopus oocytes or mammalian HEK293 cells
    • Krashia, P., Moroni, M., Broadbent, S., Hofmann, G., Kracun, S., Beato, M., Groot-Kormelink, P. J., and Sivilotti, L. G. (2010) Human α3β4 neuronal nicotinic receptors show different stoichiometry if they are expressed in Xenopus oocytes or mammalian HEK293 cells. PLoS ONE 5, e13611
    • (2010) PLoS ONE , vol.5
    • Krashia, P.1    Moroni, M.2    Broadbent, S.3    Hofmann, G.4    Kracun, S.5    Beato, M.6    Groot-Kormelink, P.J.7    Sivilotti, L.G.8
  • 28
    • 77954598197 scopus 로고    scopus 로고
    • α-Conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors
    • Grishin, A. A., Wang, C. I., Muttenthaler, M., Alewood, P. F., Lewis, R. J., and Adams, D. J. (2010) α-Conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors. J. Biol. Chem. 285, 22254-22263
    • (2010) J. Biol. Chem. , vol.285 , pp. 22254-22263
    • Grishin, A.A.1    Wang, C.I.2    Muttenthaler, M.3    Alewood, P.F.4    Lewis, R.J.5    Adams, D.J.6
  • 29
    • 77956218437 scopus 로고    scopus 로고
    • Nicotinic receptor subunit α5 modifies assembly, up-regulation, and response to pro-inflammatory cytokines
    • Gahring, L. C., and Rogers, S. W. (2010) Nicotinic receptor subunit α5 modifies assembly, up-regulation, and response to pro-inflammatory cytokines. J. Biol. Chem. 285, 26049-26057
    • (2010) J. Biol. Chem. , vol.285 , pp. 26049-26057
    • Gahring, L.C.1    Rogers, S.W.2
  • 30
    • 45749094140 scopus 로고    scopus 로고
    • Roles of accessory subunits in α4β2*nicotinic receptors
    • DOI 10.1124/mol.108.046789
    • Kuryatov, A., Onksen, J., and Lindstrom, J. (2008) Roles of accessory subunits in α4β2(*) nicotinic receptors. Mol. Pharmacol. 74, 132-143 (Pubitemid 351872165)
    • (2008) Molecular Pharmacology , vol.74 , Issue.1 , pp. 132-143
    • Kuryatov, A.1    Onksen, J.2    Lindstrom, J.3
  • 31
    • 78651375827 scopus 로고    scopus 로고
    • Expression of functional human α6β2β3*acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers
    • Kuryatov, A., and Lindstrom, J. (2011) Expression of functional human α6β2β3*acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers. Mol. Pharmacol. 79, 126-140
    • (2011) Mol. Pharmacol. , vol.79 , pp. 126-140
    • Kuryatov, A.1    Lindstrom, J.2
  • 32
    • 0037107163 scopus 로고    scopus 로고
    • Desensitization mechanism of GABA receptors revealed by single oocyte binding and receptor function
    • Chang, Y., Ghansah, E., Chen, Y., Ye, J., and Weiss, D. S. (2002) Desensitization mechanism of GABA receptors revealed by single oocyte binding and receptor function. J. Neurosci. 22, 7982-7990 (Pubitemid 35379103)
    • (2002) Journal of Neuroscience , vol.22 , Issue.18 , pp. 7982-7990
    • Chang, Y.1    Ghansah, E.2    Chen, Y.3    Ye, J.4    Weiss, D.S.5
  • 33
    • 80055098120 scopus 로고    scopus 로고
    • Reporter mutation studies show that nicotinic acetylcholine receptor (nAChR) α5 subunits and/or variants modulate function of α6*-nAChR
    • Dash, B., Chang, Y., and Lukas, R. J. (2011) Reporter mutation studies show that nicotinic acetylcholine receptor (nAChR) α5 subunits and/or variants modulate function of α6*-nAChR. J. Biol. Chem. 286, 37905-37918
    • (2011) J. Biol. Chem. , vol.286 , pp. 37905-37918
    • Dash, B.1    Chang, Y.2    Lukas, R.J.3
  • 34
    • 2942654670 scopus 로고    scopus 로고
    • Incomplete incorporation of tandem subunits in recombinant neuronal nicotinic receptors
    • DOI 10.1085/jgp.200409042
    • Groot-Kormelink, P. J., Broadbent, S. D., Boorman, J. P., and Sivilotti, L. G. (2004) Incomplete incorporation of tandem subunits in recombinant neuronal nicotinic receptors. J. Gen. Physiol. 123, 697-708 (Pubitemid 38781375)
    • (2004) Journal of General Physiology , vol.123 , Issue.6 , pp. 697-708
    • Groot-Kormelink, P.J.1    Broadbent, S.D.2    Boorman, J.P.3    Sivilotti, L.G.4
  • 35
    • 0037220541 scopus 로고    scopus 로고
    • 1 concatamers
    • DOI 10.1124/mol.63.1.243
    • Nicke, A., Rettinger, J., and Schmalzing, G. (2003) Monomeric and dimeric byproducts are the principal functional elements of higher order P2X1 concatamers. Mol. Pharmacol. 63, 243-252 (Pubitemid 36043828)
    • (2003) Molecular Pharmacology , vol.63 , Issue.1 , pp. 243-252
    • Nicke, A.1    Rettinger, J.2    Schmalzing, G.3
  • 36
    • 0029163027 scopus 로고
    • Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors
    • Labarca, C., Nowak, M. W., Zhang, H., Tang, L., Deshpande, P., and Lester, H. A. (1995) Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature 376, 514-516
    • (1995) Nature , vol.376 , pp. 514-516
    • Labarca, C.1    Nowak, M.W.2    Zhang, H.3    Tang, L.4    Deshpande, P.5    Lester, H.A.6
  • 38
    • 80052215644 scopus 로고    scopus 로고
    • Additional acetylcholine (ACh) binding site at α4/α4 interface of (α4β2)2α4 nicotinic receptor influences agonist sensitivity
    • Mazzaferro, S., Benallegue, N., Carbone, A., Gasparri, F., Vijayan, R., Biggin, P. C., Moroni, M., and Bermudez, I. (2011) Additional acetylcholine (ACh) binding site at α4/α4 interface of (α4β2)2α4 nicotinic receptor influences agonist sensitivity. J. Biol. Chem. 286, 31043-31054
    • (2011) J. Biol. Chem. , vol.286 , pp. 31043-31054
    • Mazzaferro, S.1    Benallegue, N.2    Carbone, A.3    Gasparri, F.4    Vijayan, R.5    Biggin, P.C.6    Moroni, M.7    Bermudez, I.8
  • 39
    • 31044443411 scopus 로고    scopus 로고
    • Constraining the expression of nicotinic acetylcholine receptors by using pentameric constructs
    • DOI 10.1124/mol.105.019356
    • Groot-Kormelink, P. J., Broadbent, S., Beato, M., and Sivilotti, L. G. (2006) Constraining the expression of nicotinic acetylcholine receptors by using pentameric constructs. Mol. Pharmacol. 69, 558-563 (Pubitemid 43121953)
    • (2006) Molecular Pharmacology , vol.69 , Issue.2 , pp. 558-563
    • Groot-Kormelink, P.J.1    Broadbent, S.2    Beato, M.3    Sivilotti, L.G.4
  • 41
    • 79960953776 scopus 로고    scopus 로고
    • Unraveling the high and low sensitivity agonist responses of nicotinic acetylcholine receptors
    • Harpsøe, K., Ahring, P. K., Christensen, J. K., Jensen, M. L., Peters, D., and Balle, T. (2011) Unraveling the high and low sensitivity agonist responses of nicotinic acetylcholine receptors. J. Neurosci. 31, 10759-10766
    • (2011) J. Neurosci. , vol.31 , pp. 10759-10766
    • Harpsøe, K.1    Ahring, P.K.2    Christensen, J.K.3    Jensen, M.L.4    Peters, D.5    Balle, T.6
  • 43
    • 67650473173 scopus 로고    scopus 로고
    • The positive allosteric modulator morantel binds at noncanonical subunit interfaces of neuronal nicotinic acetylcholine receptors
    • Seo, S., Henry, J. T., Lewis, A. H., Wang, N., and Levandoski, M. M. (2009) The positive allosteric modulator morantel binds at noncanonical subunit interfaces of neuronal nicotinic acetylcholine receptors. J. Neurosci. 29, 8734-8742
    • (2009) J. Neurosci. , vol.29 , pp. 8734-8742
    • Seo, S.1    Henry, J.T.2    Lewis, A.H.3    Wang, N.4    Levandoski, M.M.5
  • 44
    • 79953246461 scopus 로고    scopus 로고
    • Habenular α5 nicotinic receptor subunit signaling controls nicotine intake
    • Fowler, C. D., Lu, Q., Johnson, P. M., Marks, M. J., and Kenny, P. J. (2011) Habenular α5 nicotinic receptor subunit signaling controls nicotine intake. Nature 471, 597-601
    • (2011) Nature , vol.471 , pp. 597-601
    • Fowler, C.D.1    Lu, Q.2    Johnson, P.M.3    Marks, M.J.4    Kenny, P.J.5
  • 45
    • 0037731430 scopus 로고    scopus 로고
    • The nicotinic acetylcholine receptor subunit α5 mediates short-term effects of nicotine in vivo
    • DOI 10.1124/mol.63.5.1059
    • Salas, R., Orr-Urtreger, A., Broide, R. S., Beaudet, A., Paylor, R., and De Biasi, M. (2003) The nicotinic acetylcholine receptor subunit α 5 mediates short term effects of nicotine in vivo. Mol. Pharmacol. 63, 1059-1066 (Pubitemid 36529924)
    • (2003) Molecular Pharmacology , vol.63 , Issue.5 , pp. 1059-1066
    • Salas, R.1    Orr-Urtreger, A.2    Broide, R.S.3    Beaudet, A.4    Paylor, R.5    De Biasi, M.6
  • 46
    • 84875119945 scopus 로고    scopus 로고
    • Functional properties of concatenated α3β4 and α3β4α5 nicotinic receptors
    • Abst.
    • George, A. A., Bhakta, M., Lucero, L. M., Lukas, R. J., and Whiteaker, P. (2011) Functional properties of concatenated α3β4 and α3β4α5 nicotinic receptors. Soc. Neurosci. Abst. 34, 864.20
    • (2011) Soc. Neurosci. , vol.34
    • George, A.A.1    Bhakta, M.2    Lucero, L.M.3    Lukas, R.J.4    Whiteaker, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.