메뉴 건너뛰기




Volumn 6, Issue , 2016, Pages

A Concerted Action of Estradiol and Insulin Like Growth Factor i Underlies Sex Differences in Mood Regulation by Exercise

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; IGF1 PROTEIN, HUMAN; SOMATOMEDIN C;

EID: 84969799098     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep25969     Document Type: Article
Times cited : (29)

References (60)
  • 1
    • 84903764451 scopus 로고    scopus 로고
    • Sex differences in anxiety and depression clinical perspectives
    • Altemus, M., Sarvaiya, N., Neill, E. C. Sex differences in anxiety and depression clinical perspectives. Front Neuroendocrinol. 35, 320-330 (2014).
    • (2014) Front Neuroendocrinol. , vol.35 , pp. 320-330
    • Altemus, M.1    Sarvaiya, N.2    Neill, E.C.3
  • 2
    • 80054102235 scopus 로고    scopus 로고
    • Molecular and cellular sex differences at the intersection of stress and arousal
    • Valentino, R. J., Reyes, B., Van, B. E., Bangasser, D. Molecular and cellular sex differences at the intersection of stress and arousal. Neuropharmacology 62, 13-20 (2012).
    • (2012) Neuropharmacology , vol.62 , pp. 13-20
    • Valentino, R.J.1    Reyes, B.2    Van, B.E.3    Bangasser, D.4
  • 4
    • 0035851899 scopus 로고    scopus 로고
    • Estrous cycle influences the response of female rats in the elevated plus-maze test
    • Marcondes, F. K., Miguel, K. J., Melo, L. L., Spadari-Bratfisch, R. C. Estrous cycle influences the response of female rats in the elevated plus-maze test. Physiol Behav. 74, 435-440 (2001).
    • (2001) Physiol Behav. , vol.74 , pp. 435-440
    • Marcondes, F.K.1    Miguel, K.J.2    Melo, L.L.3    Spadari-Bratfisch, R.C.4
  • 5
    • 84858631674 scopus 로고    scopus 로고
    • The many faces of insulin-like peptide signalling in the brain
    • Fernandez, A. M., Torres-Aleman, I. The many faces of insulin-like peptide signalling in the brain. Nat Rev Neurosci 13, 225-239 (2012).
    • (2012) Nat Rev Neurosci , vol.13 , pp. 225-239
    • Fernandez, A.M.1    Torres-Aleman, I.2
  • 6
    • 84880399924 scopus 로고    scopus 로고
    • Enriched early life experiences reduce adult anxiety-like behavior in rats: A role for insulin-like growth factor 1
    • Baldini, S. et al. Enriched early life experiences reduce adult anxiety-like behavior in rats: a role for insulin-like growth factor 1. J Neurosci 33, 11715-11723 (2013).
    • (2013) J Neurosci , vol.33 , pp. 11715-11723
    • Baldini, S.1
  • 7
    • 42949094583 scopus 로고    scopus 로고
    • Relationship between antidepressants and IGF-1 system in the brain: Possible role in cognition
    • Grunbaum-Novak, N. et al. Relationship between antidepressants and IGF-1 system in the brain: Possible role in cognition. Eur Neuropsychopharmacol. 18, 431-438 (2008).
    • (2008) Eur Neuropsychopharmacol. , vol.18 , pp. 431-438
    • Grunbaum-Novak, N.1
  • 8
    • 14944358464 scopus 로고    scopus 로고
    • Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects
    • Hoshaw, B. A., Malberg, J. E., Lucki, I. Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects. Brain Res. 1037, 204-208 (2005).
    • (2005) Brain Res. , vol.1037 , pp. 204-208
    • Hoshaw, B.A.1    Malberg, J.E.2    Lucki, I.3
  • 9
    • 34447134271 scopus 로고    scopus 로고
    • Increasing the levels of insulin-like growth factor-I by an IGF Binding protein inhibitor produces anxiolytic and antidepressant-like effects
    • Malberg, J. E. et al. Increasing the Levels of Insulin-Like Growth Factor-I by an IGF Binding Protein Inhibitor Produces Anxiolytic and Antidepressant-Like Effects. Neuropsychopharmacology 32, 2360-2368 (2007).
    • (2007) Neuropsychopharmacology , vol.32 , pp. 2360-2368
    • Malberg, J.E.1
  • 10
    • 33645830486 scopus 로고    scopus 로고
    • Growth hormone is produced within the hippocampus where it responds to age, sex, stress
    • Donahue, C. P., Kosik, K. S., Shors, T. J. Growth hormone is produced within the hippocampus where it responds to age, sex, stress. Proc. Natl. Acad. Sci. USA 103, 6031-6036 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 6031-6036
    • Donahue, C.P.1    Kosik, K.S.2    Shors, T.J.3
  • 11
    • 0033080948 scopus 로고    scopus 로고
    • Phasic synaptic remodeling of the rat arcuate nucleus during the estrous cycle depends on insulin-like growth factor-I receptor activation
    • Fernandez-Galaz, M. C., Naftolin, F., Garcia-Segura, L. M. Phasic synaptic remodeling of the rat arcuate nucleus during the estrous cycle depends on insulin-like growth factor-I receptor activation. J Neurosci Res. 55, 286-292 (1999).
    • (1999) J Neurosci Res. , vol.55 , pp. 286-292
    • Fernandez-Galaz, M.C.1    Naftolin, F.2    Garcia-Segura, L.M.3
  • 12
    • 0347664057 scopus 로고    scopus 로고
    • IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    • Holzenberger, M. et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421, 182-187 (2003).
    • (2003) Nature , vol.421 , pp. 182-187
    • Holzenberger, M.1
  • 13
    • 84857046032 scopus 로고    scopus 로고
    • Neuron-specific deletion of a single copy of the insulin-like growth factor-1 receptor gene reduces fat accumulation during aging
    • Freude, S. et al. Neuron-specific deletion of a single copy of the insulin-like growth factor-1 receptor gene reduces fat accumulation during aging. Horm. Metab Res. 44, 99-104 (2012).
    • (2012) Horm. Metab Res. , vol.44 , pp. 99-104
    • Freude, S.1
  • 14
    • 84930869218 scopus 로고    scopus 로고
    • Aerobic exercise reduces symptoms of posttraumatic stress disorder: A randomized controlled trial
    • Fetzner, M. G., Asmundson, G. J. Aerobic Exercise Reduces Symptoms of Posttraumatic Stress Disorder: A Randomized Controlled Trial. Cogn Behav. Ther. 44, 1-13 (2014).
    • (2014) Cogn Behav. Ther. , vol.44 , pp. 1-13
    • Fetzner, M.G.1    Asmundson, G.J.2
  • 15
    • 46649096932 scopus 로고    scopus 로고
    • Exercise learned helplessness, the stress-resistant brain
    • Greenwood, B. N., Fleshner, M. Exercise, learned helplessness, the stress-resistant brain. Neuromolecular. Med 10, 81-98 (2008).
    • (2008) Neuromolecular. Med , vol.10 , pp. 81-98
    • Greenwood, B.N.1    Fleshner, M.2
  • 16
    • 0036602967 scopus 로고    scopus 로고
    • Exercise: A behavioral intervention to enhance brain health and plasticity
    • Cotman, C. W., Berchtold, N. C. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 25, 295-301 (2002).
    • (2002) Trends Neurosci. , vol.25 , pp. 295-301
    • Cotman, C.W.1    Berchtold, N.C.2
  • 17
    • 84855436269 scopus 로고    scopus 로고
    • Exposure to subliminal arousing stimuli induces robust activation in the amygdala, hippocampus, anterior cingulate, insular cortex and primary visual cortex: A systematic meta-analysis of fMRI studies
    • Brooks, S. J. et al. Exposure to subliminal arousing stimuli induces robust activation in the amygdala, hippocampus, anterior cingulate, insular cortex and primary visual cortex: a systematic meta-analysis of fMRI studies. Neuroimage. 59, 2962-2973 (2012).
    • (2012) Neuroimage. , vol.59 , pp. 2962-2973
    • Brooks, S.J.1
  • 18
    • 0035861380 scopus 로고    scopus 로고
    • The hippocampal formation-orbitomedial prefrontal cortex circuit in the attentional control of active memory
    • Wall, P. M., Messier, C. The hippocampal formation-orbitomedial prefrontal cortex circuit in the attentional control of active memory. Behav. Brain Res. 127, 99-117 (2001).
    • (2001) Behav. Brain Res. , vol.127 , pp. 99-117
    • Wall, P.M.1    Messier, C.2
  • 19
    • 33846591886 scopus 로고    scopus 로고
    • Exercise program for nursing home residents with Alzheimer's disease: A 1-year randomized, controlled trial
    • Rolland, Y. et al. Exercise program for nursing home residents with Alzheimer's disease: a 1-year randomized, controlled trial. J Am. Geriatr. Soc. 55, 158-165 (2007).
    • (2007) J Am. Geriatr. Soc. , vol.55 , pp. 158-165
    • Rolland, Y.1
  • 20
    • 84905842956 scopus 로고    scopus 로고
    • Phase I/II randomized trial of aerobic exercise in Parkinson disease in a community setting
    • Uc, E. Y. et al. Phase I/II randomized trial of aerobic exercise in Parkinson disease in a community setting. Neurology 83, 413-425 (2014).
    • (2014) Neurology , vol.83 , pp. 413-425
    • Uc, E.Y.1
  • 21
    • 74949118967 scopus 로고    scopus 로고
    • Effects of aerobic exercise on mild cognitive impairment: A controlled trial
    • Baker, L. D. et al. Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Arch. Neurol 67, 71-79 (2010).
    • (2010) Arch. Neurol , vol.67 , pp. 71-79
    • Baker, L.D.1
  • 22
    • 18144446836 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor i mediates effects of exercise on the brain
    • Carro, E., Nunez, A., Busiguina, S., Torres-Aleman, I. Circulating insulin-like growth factor I mediates effects of exercise on the brain. J Neurosci. 20, 2926-2933 (2000).
    • (2000) J Neurosci. , vol.20 , pp. 2926-2933
    • Carro, E.1    Nunez, A.2    Busiguina, S.3    Torres-Aleman, I.4
  • 23
    • 77956298301 scopus 로고    scopus 로고
    • Neuronal activity drives localized blood-brain-barrier transport of serum insulin-like growth factor-I into the CNS
    • Nishijima, T. et al. Neuronal activity drives localized blood-brain-barrier transport of serum insulin-like growth factor-I into the CNS. Neuron 67, 834-846 (2010).
    • (2010) Neuron , vol.67 , pp. 834-846
    • Nishijima, T.1
  • 24
    • 0035426212 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor i mediates the protective effects of physical exercise against brain insults of different etiology and anatomy
    • Carro, E., Trejo, J. L., Busiguina, S., Torres-Aleman, I. Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy. J Neurosci. 21, 5678-5684 (2001).
    • (2001) J Neurosci. , vol.21 , pp. 5678-5684
    • Carro, E.1    Trejo, J.L.2    Busiguina, S.3    Torres-Aleman, I.4
  • 25
    • 33644759222 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor i and functional recovery from spinal cord injury under enriched housing conditions
    • Koopmans, G. C. et al. Circulating insulin-like growth factor I and functional recovery from spinal cord injury under enriched housing conditions. Eur. J Neurosci 23, 1035-1046 (2006).
    • (2006) Eur. J Neurosci , vol.23 , pp. 1035-1046
    • Koopmans, G.C.1
  • 26
    • 33244471101 scopus 로고    scopus 로고
    • Evidence of functional hyperemia in the rat hippocampus during mild treadmill running
    • Nishijima, T., Soya, H. Evidence of functional hyperemia in the rat hippocampus during mild treadmill running. Neurosci Res. 54, 186-191 (2006).
    • (2006) Neurosci Res. , vol.54 , pp. 186-191
    • Nishijima, T.1    Soya, H.2
  • 27
    • 84855343964 scopus 로고    scopus 로고
    • Gene expression patterns in the hippocampus and amygdala of endogenous depression and chronic stress models
    • Andrus, B. M. et al. Gene expression patterns in the hippocampus and amygdala of endogenous depression and chronic stress models. Mol Psychiatry 17, 49-61 (2012).
    • (2012) Mol Psychiatry , vol.17 , pp. 49-61
    • Andrus, B.M.1
  • 28
    • 84897450105 scopus 로고    scopus 로고
    • Distributed circuits underlying anxiety
    • Adhikari, A. Distributed circuits underlying anxiety. Front Behav. Neurosci 8, 112 (2014).
    • (2014) Front Behav. Neurosci , vol.8 , pp. 112
    • Adhikari, A.1
  • 29
    • 73449114573 scopus 로고    scopus 로고
    • Exercise and the growth hormone-insulin-like growth factor axis
    • Frystyk, J. Exercise and the growth hormone-insulin-like growth factor axis. Med Sci Sports Exerc. 42, 58-66 (2010).
    • (2010) Med Sci Sports Exerc. , vol.42 , pp. 58-66
    • Frystyk, J.1
  • 30
    • 0026026039 scopus 로고
    • Sex differences in animal tests of anxiety
    • Johnston, A. L., File, S. E. Sex differences in animal tests of anxiety. Physiol Behav. 49, 245-250 (1991).
    • (1991) Physiol Behav. , vol.49 , pp. 245-250
    • Johnston, A.L.1    File, S.E.2
  • 31
    • 0034490999 scopus 로고    scopus 로고
    • Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3alpha,5alpha-THP
    • Frye, C. A., Petralia, S. M., Rhodes, M. E. Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3alpha,5alpha-THP. Pharmacol. Biochem. Behav. 67, 587-596 (2000).
    • (2000) Pharmacol. Biochem. Behav. , vol.67 , pp. 587-596
    • Frye, C.A.1    Petralia, S.M.2    Rhodes, M.E.3
  • 32
    • 84899632427 scopus 로고    scopus 로고
    • Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice
    • Gapp, K. et al. Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice. Nat Neurosci 17, 667-669 (2014).
    • (2014) Nat Neurosci , vol.17 , pp. 667-669
    • Gapp, K.1
  • 33
    • 84875580072 scopus 로고    scopus 로고
    • Exercising the worry away: How inflammation, oxidative and nitrogen stress mediates the beneficial effect of physical activity on anxiety disorder symptoms and behaviours
    • Moylan, S. et al. Exercising the worry away: how inflammation, oxidative and nitrogen stress mediates the beneficial effect of physical activity on anxiety disorder symptoms and behaviours. Neurosci Biobehav. Rev 37, 573-584 (2013).
    • (2013) Neurosci Biobehav. Rev , vol.37 , pp. 573-584
    • Moylan, S.1
  • 34
    • 77955845034 scopus 로고    scopus 로고
    • Early social enrichment provided by communal nest increases resilience to depressionlike behavior more in female than in male mice
    • D'Andrea, I., Gracci, F., Alleva, E., Branchi, I. Early social enrichment provided by communal nest increases resilience to depressionlike behavior more in female than in male mice. Behav. Brain Res. 215, 71-76 (2010).
    • (2010) Behav. Brain Res. , vol.215 , pp. 71-76
    • D'Andrea, I.1    Gracci, F.2    Alleva, E.3    Branchi, I.4
  • 35
    • 0037422552 scopus 로고    scopus 로고
    • Estradiol differentially regulates lipocalin-type prostaglandin D synthase transcript levels in the rodent brain: Evidence from high-density oligonucleotide arrays and in situ hybridization
    • Mong, J. A. et al. Estradiol differentially regulates lipocalin-type prostaglandin D synthase transcript levels in the rodent brain: Evidence from high-density oligonucleotide arrays and in situ hybridization. Proc. Natl. Acad. Sci. USA 100, 318-323 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 318-323
    • Mong, J.A.1
  • 36
    • 38649115676 scopus 로고    scopus 로고
    • The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis
    • Trejo, J. L., Llorens-Martin, M. V., Torres-Aleman, I. The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis. Mol Cell Neurosci 37, 402-411 (2008).
    • (2008) Mol Cell Neurosci , vol.37 , pp. 402-411
    • Trejo, J.L.1    Llorens-Martin, M.V.2    Torres-Aleman, I.3
  • 37
    • 0033594893 scopus 로고    scopus 로고
    • Normal growth and development in the absence of hepatic insulin-like growth factor i
    • Yakar, S. et al. Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc. Natl. Acad. Sci. USA 96, 7324-7329 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7324-7329
    • Yakar, S.1
  • 38
    • 84941730988 scopus 로고    scopus 로고
    • Signaling mechanisms mediating the regulation of synaptic plasticity and memory by estradiol
    • Arevalo, M. A., Azcoitia, I., Gonzalez-Burgos, I., Garcia-Segura, L. M. Signaling mechanisms mediating the regulation of synaptic plasticity and memory by estradiol. Horm. Behav. 74, 19-27 (2015).
    • (2015) Horm. Behav. , vol.74 , pp. 19-27
    • Arevalo, M.A.1    Azcoitia, I.2    Gonzalez-Burgos, I.3    Garcia-Segura, L.M.4
  • 39
    • 84896717932 scopus 로고    scopus 로고
    • Antagonism of brain insulin-like growth factor-1 receptors blocks estradiol effects on memory and levels of hippocampal synaptic proteins in ovariectomized rats
    • Nelson, B. S., Springer, R. C., Daniel, J. M. Antagonism of brain insulin-like growth factor-1 receptors blocks estradiol effects on memory and levels of hippocampal synaptic proteins in ovariectomized rats. Psychopharmacology (Berl) 231, 899-907 (2014).
    • (2014) Psychopharmacology (Berl) , vol.231 , pp. 899-907
    • Nelson, B.S.1    Springer, R.C.2    Daniel, J.M.3
  • 40
    • 77958568334 scopus 로고    scopus 로고
    • Effect of short-and long-term gonadectomy on neuroactive steroid levels in the central and peripheral nervous system of male and female rats
    • Caruso, D. et al. Effect of short-and long-term gonadectomy on neuroactive steroid levels in the central and peripheral nervous system of male and female rats. J Neuroendocrinol. 22, 1137-1147 (2010).
    • (2010) J Neuroendocrinol. , vol.22 , pp. 1137-1147
    • Caruso, D.1
  • 41
    • 33748438509 scopus 로고    scopus 로고
    • Blockade of the insulin-like growth factor i receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: New cues into the human disease?
    • Carro, E. et al. Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease? Neurobiol. Aging 27, 1618-1631 (2006).
    • (2006) Neurobiol. Aging , vol.27 , pp. 1618-1631
    • Carro, E.1
  • 42
    • 0034953302 scopus 로고    scopus 로고
    • Engineering of a mouse for the in vivo profiling of estrogen receptor activity
    • Ciana, P. et al. Engineering of a mouse for the in vivo profiling of estrogen receptor activity. Mol Endocrinol. 15, 1104-1113 (2001).
    • (2001) Mol Endocrinol. , vol.15 , pp. 1104-1113
    • Ciana, P.1
  • 43
    • 33745348771 scopus 로고    scopus 로고
    • New roles for estrogen receptor beta in behavior and neuroendocrinology
    • Bodo, C., Rissman, E. F. New roles for estrogen receptor beta in behavior and neuroendocrinology. Front Neuroendocrinol. 27, 217-232 (2006).
    • (2006) Front Neuroendocrinol. , vol.27 , pp. 217-232
    • Bodo, C.1    Rissman, E.F.2
  • 44
    • 12344334398 scopus 로고    scopus 로고
    • Novel actions of estrogen receptor-beta on anxiety-related behaviors
    • Lund, T. D., Rovis, T., Chung, W. C., Handa, R. J. Novel actions of estrogen receptor-beta on anxiety-related behaviors. Endocrinology 146, 797-807 (2005).
    • (2005) Endocrinology , vol.146 , pp. 797-807
    • Lund, T.D.1    Rovis, T.2    Chung, W.C.3    Handa, R.J.4
  • 45
    • 54049130931 scopus 로고    scopus 로고
    • Estradiol or diarylpropionitrile decrease anxiety-like behavior of wildtype, but not estrogen receptor beta knockout, mice
    • Walf, A. A., Koonce, C. J., Frye, C. A. Estradiol or diarylpropionitrile decrease anxiety-like behavior of wildtype, but not estrogen receptor beta knockout, mice. Behav. Neurosci 122, 974-981 (2008).
    • (2008) Behav. Neurosci , vol.122 , pp. 974-981
    • Walf, A.A.1    Koonce, C.J.2    Frye, C.A.3
  • 47
    • 9444289385 scopus 로고    scopus 로고
    • 17beta-estradiol differentially regulates blood-brain barrier permeability in young and aging female rats
    • Bake, S., Sohrabji, F. 17beta-estradiol differentially regulates blood-brain barrier permeability in young and aging female rats. Endocrinology 145, 5471-5475 (2004).
    • (2004) Endocrinology , vol.145 , pp. 5471-5475
    • Bake, S.1    Sohrabji, F.2
  • 48
    • 84914674938 scopus 로고    scopus 로고
    • Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin
    • Yau, S. Y. et al. Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin. Proc. Natl. Acad. Sci. USA 111, 15810-15815 (2014).
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 15810-15815
    • Yau, S.Y.1
  • 49
    • 18244394308 scopus 로고    scopus 로고
    • IGF-1 in the brain as a regulator of reproductive neuroendocrine function
    • Daftary, S. S., Gore, A. C. IGF-1 in the brain as a regulator of reproductive neuroendocrine function. Exp. Biol Med (Maywood. ) 230, 292-306 (2005).
    • (2005) Exp. Biol Med (Maywood. ) , vol.230 , pp. 292-306
    • Daftary, S.S.1    Gore, A.C.2
  • 50
    • 84947865344 scopus 로고    scopus 로고
    • Sex differences in anxiety disorders: Interactions between fear, stress, gonadal hormones
    • Maeng, L. Y., Milad, M. R. Sex differences in anxiety disorders: Interactions between fear, stress, gonadal hormones. Horm. Behav. 76, 106-117 (2015).
    • (2015) Horm. Behav. , vol.76 , pp. 106-117
    • Maeng, L.Y.1    Milad, M.R.2
  • 51
    • 0034597926 scopus 로고    scopus 로고
    • Anxiety and arousal: Physiological changes and their perception
    • Hoehn-Saric, R., McLeod, D. R. Anxiety and arousal: physiological changes and their perception. J Affect. Disord. 61, 217-224 (2000).
    • (2000) J Affect. Disord. , vol.61 , pp. 217-224
    • Hoehn-Saric, R.1    McLeod, D.R.2
  • 52
    • 84155163218 scopus 로고    scopus 로고
    • Reduced brain insulin-like growth factor i function during aging
    • Muller, A. P. et al. Reduced brain insulin-like growth factor I function during aging. Mol Cell Neurosci 49, 9-12 (2012).
    • (2012) Mol Cell Neurosci , vol.49 , pp. 9-12
    • Muller, A.P.1
  • 53
    • 79551593475 scopus 로고    scopus 로고
    • Exercise for the treatment of depression and anxiety
    • Carek, P. J., Laibstain, S. E., Carek, S. M. Exercise for the treatment of depression and anxiety. Int J Psychiatry Med 41, 15-28 (2011).
    • (2011) Int J Psychiatry Med , vol.41 , pp. 15-28
    • Carek, P.J.1    Laibstain, S.E.2    Carek, S.M.3
  • 54
    • 84940742212 scopus 로고    scopus 로고
    • Long-term mild, rather than intense, exercise enhances adult hippocampal neurogenesis and greatly changes the transcriptomic profile of the hippocampus
    • Inoue, K. et al. Long-Term Mild, rather than Intense, Exercise Enhances Adult Hippocampal Neurogenesis and Greatly Changes the Transcriptomic Profile of the Hippocampus. PLoS One 10, e0128720 (2015).
    • (2015) PLoS One , vol.10 , pp. e0128720
    • Inoue, K.1
  • 55
    • 34347207241 scopus 로고    scopus 로고
    • The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
    • Walf, A. A., Frye, C. A. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat Protoc. 2, 322-328 (2007).
    • (2007) Nat Protoc. , vol.2 , pp. 322-328
    • Walf, A.A.1    Frye, C.A.2
  • 56
    • 84856934652 scopus 로고    scopus 로고
    • The tail suspension test
    • Can, A. et al. The tail suspension test. J Vis. Exp. 59, 3769 (2012).
    • (2012) J Vis. Exp. , vol.59 , pp. 3769
    • Can, A.1
  • 57
    • 9644299852 scopus 로고    scopus 로고
    • Sex differences in mouse behavior following pyrilamine treatment: Role of histamine 1 receptors in arousal
    • Easton, A., Norton, J., Goodwillie, A., Pfaff, D. W. Sex differences in mouse behavior following pyrilamine treatment: role of histamine 1 receptors in arousal. Pharmacol. Biochem. Behav. 79, 563-572 (2004).
    • (2004) Pharmacol. Biochem. Behav. , vol.79 , pp. 563-572
    • Easton, A.1    Norton, J.2    Goodwillie, A.3    Pfaff, D.W.4
  • 58
    • 84862776164 scopus 로고    scopus 로고
    • Regulation of the phosphatase calcineurin by insulin-like growth factor i unveils a key role of astrocytes in Alzheimer's pathology
    • Fernandez, A. M. et al. Regulation of the phosphatase calcineurin by insulin-like growth factor I unveils a key role of astrocytes in Alzheimer's pathology. Mol Psychiatry 17, 705-718 (2012).
    • (2012) Mol Psychiatry , vol.17 , pp. 705-718
    • Fernandez, A.M.1
  • 59
    • 36549062949 scopus 로고    scopus 로고
    • Central actions of liver-derived insulin-like growth factor i underlying its pro-cognitive effects
    • Trejo, J. L. et al. Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects. Mol Psychiatry 12, 1118-1128 (2007).
    • (2007) Mol Psychiatry , vol.12 , pp. 1118-1128
    • Trejo, J.L.1
  • 60
    • 0036917631 scopus 로고    scopus 로고
    • Serum insulin-like growth factor i regulates brain amyloidbeta levels
    • Carro, E., Trejo, J. L., Gomez-Isla, T., LeRoith, D., Torres-Aleman, I. Serum insulin-like growth factor I regulates brain amyloidbeta levels. Nat Med 8, 1390-1397 (2002).
    • (2002) Nat Med , vol.8 , pp. 1390-1397
    • Carro, E.1    Trejo, J.L.2    Gomez-Isla, T.3    LeRoith, D.4    Torres-Aleman, I.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.