Liquid Crystalline Nanoparticles as an Ophthalmic Delivery System for Tetrandrine: Development, Characterization, and In Vitro and In Vivo Evaluation

Nanoscale Research Letters

Volumn 11, Issue 1, 2016, Pages

  Liu, Rui ^a   Wang, Shuangshuang ^a   Fang, Shiming ^a   Wang, Jialu ^a   Chen, Jingjing ^a   Huang, Xingguo ^a   He, Xin ^a   Liu, Changxiao ^b  

^a TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

Bioavailability; Central composite design; Corneal permeability; Glyceryl monoolein; Liquid crystalline nanoparticles; Microdialysis; Ophthalmic delivery; Pharmacokinetics; Pre ocular retention; Tetrandrine

Indexed keywords

BIOCHEMISTRY; BODY FLUIDS; DIALYSIS; DRUG PRODUCTS; EFFICIENCY; ENCAPSULATION; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; LIQUIDS; NANOPARTICLES; PARTICLE SIZE; PHARMACOKINETICS; POLYMER BLENDS; RESIDENCE TIME DISTRIBUTION; SKIN; TRANSMISSION ELECTRON MICROSCOPY; X RAY SCATTERING; ZETA POTENTIAL;

BIOAVAILABILITY; CENTRAL COMPOSITE DESIGNS; LIQUID CRYSTALLINE NANOPARTICLES; MICRO-DIALYSIS; MONOOLEIN; OPHTHALMIC DELIVERY; PRE-OCULAR RETENTION; TETRANDRINE;

CRYSTALLINE MATERIALS;

EID: 84969794887     PISSN: 19317573     EISSN: 1556276X     Source Type: Journal    
DOI: 10.1186/s11671-016-1471-0     Document Type: Article

References (41)

1. Ames P, Galor A (2015) Cyclosporine ophthalmic emulsions for the treatment of dry eye: a review of the clinical evidence. Clin Investig (Lond) 5:267–285
2. Chetoni P, Monti D, Tampucci S, Matteoli B, Ceccherini-Nelli L, Subissi A et al (2015) Liposomes as a potential ocular delivery system of distamycin A. Int J Pharm 492:120–126. doi:10.1016/j.ijpharm.2015.05.055
3. Davaran S, Lotfipour F, Sedghipour N, Sedghipour MR, Alimohammadi S, Salehi R (2015) Preparation and in vivo evaluation of in situ gel system as dual thermo-/pH-responsive nanocarriers for sustained ocular drug delivery. J Microencapsul 32:511–519. doi:10.3109/02652048.2015.1065915
4. Andrés-Guerrero V, Zong MM, Ramsay E, Rojas B, Sarkhel S, Gallego B et al (2015) Novel biodegradable polyesteramide microspheres for controlled drug delivery in ophthalmology. J Control Release 211:105–117. doi:10.1016/j.jconrel.2015.05.279
5. Katzer T, Chaves P, Bernardi A, Pohlmann A, Guterres SS, Ruver Beck RC (2014) Prednisolone-loaded nanocapsules as ocular drug delivery system: development, in vitro drug release and eye toxicity. J Microencapsul 31:519–528. doi:10.3109/02652048.2013.879930
6. Prosperi-Porta G, Kedzior S, Muirhead B, Sheardown H (2016) Phenylboronic-acid-based polymeric micelles for mucoadhesive anterior segment ocular drug delivery. Biomacromolecules 17:1449–1457. doi:10.1021/acs.biomac.6b0054
7. Avachat AM, Parpani SS (2015) Formulation and development of bicontinuous nanostructured liquid crystalline particles of efavirenz. Colloids Surf B Biointerfaces 126:87–97. doi:10.1016/j.colsurfb.2014.12.014
8. Johnsson M, Barauskas J, Norlin A, Tiberg F (2006) Physicochemical and drug delivery aspects of lipid-based liquid crystalline nanoparticles: a case study of intravenously administered propofol. J Nanosci Nanotechnol 6:3017–3024
9. Esposito E, Cortesi R, Drechsler M, Paccamiccio L, Mariani P, Contado C et al (2005) Cubosome dispersions as delivery systems for percutaneous administration of indomethacin. Pharm Res 22:2163–2173
10. Chung H, Kim J, Um JY, Kwon IC, Jeong SY (2002) Self-assembled “nanocubicle” as a carrier for peroral insulin delivery. Diabetologia 45:448–451
11. Bansal S, Kashyap CP, Aggarwal G, Harikumar SL (2012) A comparative review on vesicular drug delivery system and stability issues. Int J Res Pharm Chem 2:704–713
12. de Campo L, Yaghmur A, Sagalowicz L, Leser ME, Watzke H, Glatter O (2004) Reversible phase transitions in emulsified nanostructured lipid systems. Langmuir 20:5254–5261. doi:10.1021/la0499416
13. Yaghmur A, Glatter O (2009) Characterization and potential applications of nanostructured aqueous dispersions. Adv Colloid Interface Sci 147–148:333–342. doi:10.1016/j.cis.2008.07.007
14. Zeng N, Hu QY, Liu ZY, Gao XL, Hu RK, Song QX et al (2012) Preparation and characterization of paclitaxel-loaded DSPE-PEG-liquid crystalline nanoparticles (LCNPs) for improved bioavailability. Int J Pharm 424:58–66. doi:10.1016/j.ijpharm.2011.12.058
15. Guo LJ, Zhang XF, Zhang S (2002) An experimental study of inhibition of tetrandrine on posterior capsular opacification in rabbits. Zhonghua Yan Ke za Zhi 38:235–238
16. Huang P, Xu YS, Wei RX, Li HP, Tang Y, Liu J et al (2011) Efficacy of tetrandrine on lowering intraocular pressure in animal model with ocular hypertension. J Glaucoma 20:183–188. doi:10.1097/IJG.0b013e3181d7882a
17. Liang XC, Hagino N, Guo SS, Tsutsumi T, Kobayashi S (2002) Therapeutic efficacy of Stephania tetrandra S. Moore for treatment of neovascularization of retinal capillary (retinopathy) in diabetes—in vitro study. Phytomedicine 9:377–384. doi:10.1078/09447110260571599
18. Li J, Wu L, Wu WJ, Wang BY, Wang ZY, Xin HL et al (2013) A potential carrier based on liquid crystal nanoparticles for ophthalmic delivery of pilocarpine nitrate. Int J Pharm 455:75–84. doi:10.1016/j.ijpharm.2013.07.057
19. Ezzati Nazhad Dolatabadi J, Hamishehkar H, Valizadeh H (2015) Development of dry powder inhaler formulation loaded with alendronate solid lipid nanoparticles: solid-state characterization and aerosol dispersion performance. Drug Dev Ind Pharm 41:1431–1437. doi:10.3109/03639045.2014.956111
20. Hao JF, Wang XD, Bi YP, Teng YF, Wang JZ, Li F et al (2014) Fabrication of a composite system combining solid lipid nanoparticles and thermosensitive hydrogel for challenging ophthalmic drug delivery. Colloids Surf B Biointerfaces 114:111–120. doi:10.1016/j.colsurfb.2013.09.059
21. Muchtar S, Abdulrazik M, Frucht-Pery J, Benita S (1997) Ex-vivo permeation study of indomethacin from a submicron emulsion through albino rabbit cornea. J Control Release 44:55–64. doi:10.1016/S0168-3659(96)01503-9
22. Gan L, Han S, Shen JQ, Zhu JB, Zhu CL, Zhang XX et al (2010) Self-assembled liquid crystalline nanoparticles as a novel ophthalmic delivery system for dexamethasone: improving preocular retention and ocular bioavailability. Int J Pharm 396:179–187. doi:10.1016/j.ijpharm.2010.06.015
23. Liu R, Liu ZD, Zhang CG, Zhang BL (2012) Nanostructured lipid carriers as novel ophthalmic delivery system for mangiferin: improving in vivo ocular bioavailability. J Pharm Sci 101:3833–3844. doi:10.1002/jps.23251
24. Verma S, Singh SK, Verma PRP, Ahsan MN (2014) Formulation by design of felodipine loaded liquid and solid self nanoemulsifying drug delivery systems using Box-Behnken design. Drug Dev Ind Pharm 40:1358–1370. doi:10.3109/03639045.2013.819884
25. Varshosaz J, Minayian M, Moazen E (2010) Enhancement of oral bioavailability of pentoxifylline by solid lipid nanoparticles. J Liposome Res 20:115–123. doi:10.3109/08982100903161456
26. Hao JF, Wang FG, Wang XD, Zhang DR, Bi YP, Gao YS et al (2012) Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design. Eur J Pharm Sci 47:497–505. doi:10.1016/j.ejps.2012.07.006
27. Ranjan OP, Nayak UY, Reddy MS, Dengale SJ, Musmade PB, Udupa N (2014) Optimization of chronomodulated delivery system coated with a blend of ethyl cellulose and eudragit L100 by central composite design: in vitro and in vivo evaluation. J Pharm Innov 9:95–105. doi:10.1007/s12247-014-9176-3
28. Wu J, Zhang H, Oturan N, Wang Y, Chen L, Oturan MA (2012) Application of response surface methodology to the removal of the antibiotic tetracycline by electrochemical process using carbon-felt cathode and DSA (Ti/RuO2-IrO2) anode. Chemosphere 87:614–620. doi:10.1016/j.chemosphere.2012.01.036
29. Singh J, Chhabra G, Pathak K (2014) Development of acetazolamide-loaded, pH-triggered polymeric nanoparticulate in situ gel for sustained ocular delivery: in vitro. Ex vivo evaluation and pharmacodynamic study. Drug Dev Ind Pharm 40:1223–1232. doi:10.3109/03639045.2013.814061
30. Levy MY, Schutze W, Fuhrer C, Benita S (1994) Characterization of diazepam submicron emulsion interface: role of oleic acid. J Microencapsul 11:79–92. doi:10.3109/02652049409040440
31. Luo Q, Lin TY, Zhang CY, Zhu TT, Wang L, Ji ZJ et al (2015) A novel glyceryl monoolein-bearing cubosomes for gambogenic acid: preparation, cytotoxicity and intracellular uptake. Int J Pharm 493:30–39. doi:10.1016/j.ijpharm.2015.07.036
32. Amar-Yuli I, Wachtel E, Shoshan EB, Danino D, Aserin A, Garti N (2007) Hexosome and hexagonal phases mediated by hydration and polymeric stabilizer. Langmuir 23:3637–3645. doi:10.1021/la062851b
33. Law SL, Huang KJ, Chiang CH (2000) Acyclovir-containing liposomes for potential ocular delivery: corneal penetration and absorption. J Control Release 63:135–140. doi:10.1016/S0168-3659(99)00192-3
34. Libster D, Ishai PB, Aserin A, Shoham G, Garti N (2009) Molecular interactions in reverse hexagonal mesophase in the presence of cyclosporin A. Int J Pharm 367:115–126. doi:10.1016/j.ijpharm.2008.09.048
35. Zheng DD, Dai WT, Zhang DR, Duan CX, Jia LJ, Liu Y et al (2012) In vivo studies on the oridonin-loaded nanostructured lipid carriers. Drug Deliv 19:286–291. doi:10.3109/10717544.2012.704096
36. Achouri D, Sergent M, Tonetto A, Piccerelle P, Andrieu V, Hornebecq V (2015) Self-assembled liquid crystalline nanoparticles as an ophthalmic drug delivery system. Part II: optimization of formulation variables using experimental design. Drug Dev Ind Pharm 41:493–501. doi:10.3109/03639045.2014.884113
37. Liu R, Liu ZD, Zhang CG, Zhang BL (2011) Gelucire 44/14 as a novel absorption enhancer for drugs with different hydrophilicities: in vitro and in vivo improvement on transcorneal permeation. J Pharm Sci 100:3186–3195. doi:10.1002/jps.22540
38. Liu R, Sun L, Fang SM, Wang ST, Chen JJ, Xiao XF et al (2015) Thermosensitive in situ nanogel as ophthalmic delivery system of curcumin: development, characterization, in vitro permeation and in vivo pharmacokinetic studies. Pharm Dev Technol 29:1–7. doi:10.3109/10837450.2015.1026607
39. Youshia J, Kamel AO, El Shamy A, Mansour S (2012) Design of cationic nanostructured heterolipid matrices for ocular delivery of methazolamide. Int J Nanomed 7:2483–2496. doi:10.2147/IJN.S28307
40. Karstens T, Kobs K (1980) Rhodamine B and rhodamine 101 as reference substances for fluorescence quantum yield measurements. J Phys Chem 84:1871–1872
41. Wu WJ, Li J, Wu L, Wang BY, Wang ZY, Xu QW et al (2013) Ophthalmic delivery of brinzolamide by liquid crystalline nanoparticles: in vitro and in vivo evaluation. AAPS PharmSciTech 14:1063–1071. doi:10.1208/s12249-013-9997-2