Thermosensitive in situ nanogel as ophthalmic delivery system of curcumin: development, characterization, in vitro permeation and in vivo pharmacokinetic studies

Pharmaceutical Development and Technology

Volumn 21, Issue 5, 2016, Pages 576-582

  Liu, Rui ^a   Sun, Lu ^a   Fang, Shiming ^b   Wang, Shuting ^a   Chen, Jingjing ^a   Xiao, Xuefeng ^a   Liu, Changxiao ^c  

^a Department of Pharmacognosy   (China)

^b TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

Cationic nanostructured lipid carriers; microdialysis; ocular drug delivery; pharmacokinetics; thermosensitive in situ nanogel

Indexed keywords

CATIONIC NANOSTRUCTURED LIPID CARRIER; CURCUMIN; GELLING AGENT; NANOCARRIER; POLOXAMER; UNCLASSIFIED DRUG; DRUG CARRIER; EYE DROPS; MACROGOL DERIVATIVE; NANOGEL; NONSTEROID ANTIINFLAMMATORY AGENT; POLYETHYLENEIMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APPARENT PERMEABILITY; AQUEOUS HUMOR; AREA UNDER THE CURVE; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; CORNEA EPITHELIUM; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG FORMULATION; DRUG PENETRATION; EYE IRRITATION; GELATION; HEAT SENSITIVITY; IN VITRO STUDY; IN VIVO STUDY; LACRIMAL FLUID; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MICRODIALYSIS; NANOFABRICATION; NANOPHARMACEUTICS; NEW ZEALAND WHITE (RABBIT); NONHUMAN; PHYSICAL CHEMISTRY; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; TOPICAL TREATMENT; TRANSITION TEMPERATURE; VISCOSITY; ANIMAL; CORNEA; DRUG DELIVERY SYSTEM; DRUG EFFECTS; DRUG RELEASE; METABOLISM; PERMEABILITY; PHYSIOLOGY; PROCEDURES; RABBIT; TEMPERATURE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CORNEA; CURCUMIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; OPHTHALMIC SOLUTIONS; PERMEABILITY; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; RABBITS; TEMPERATURE;

EID: 84969256592     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450.2015.1026607     Document Type: Article

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