Design of a small molecule against an oncogenic noncoding RNA

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 21, 2016, Pages 5898-5903

  Velagapudi, Sai Pradeep ^a   Cameron, Michael D ^a   Haga, Christopher L ^a   Rosenberg, Laura H ^a   Lafitte, Marie ^a   Duckett, Derek R ^a   Phinney, Donald G ^a   Disney, Matthew D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Chemistry; Drug design; Noncoding RNA; Nucleic acids; RNA

Indexed keywords

ANTINEOPLASTIC AGENT; MICRORNA; MICRORNA 96; SHORT HAIRPIN RNA; TARGAPRIMIR 96; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; ANTAGOMIR; DROSHA PROTEIN, HUMAN; MIRN96 MICRORNA, HUMAN; MOLECULAR LIBRARY; RIBONUCLEASE III;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BINDING AFFINITY; BREAST CANCER CELL LINE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER MODEL; CONTROLLED STUDY; CROSS LINKING; DRUG BINDING; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG METABOLISM; DRUG POTENCY; DRUG STABILITY; FEMALE; GENE TARGETING; MOUSE; MOUSE MODEL; MUTAGENICITY; NONHUMAN; ONCOGENE; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA BINDING; TRIPLE NEGATIVE BREAST CANCER; TUMOR VOLUME; ADENOCARCINOMA; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CONFORMATION; DRUG SCREENING; GENE SILENCING; GENETICS; HUMAN; METABOLISM; MOLECULAR LIBRARY; NONOBESE DIABETIC MOUSE; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHARMACOKINETICS; PHARMACOLOGY; SCID MOUSE; SIGNAL TRANSDUCTION; TRIPLE NEGATIVE BREAST NEOPLASMS; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; ANTAGOMIRS; BASE SEQUENCE; BINDING SITES; CELL LINE, TUMOR; DRUG DESIGN; FEMALE; GENE SILENCING; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; MICRORNAS; NUCLEIC ACID CONFORMATION; RIBONUCLEASE III; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; TRIPLE NEGATIVE BREAST NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84969765254     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1523975113     Document Type: Article

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