Structure-Based Design of Peptidic Inhibitors of the Interaction between CC Chemokine Ligand 5 (CCL5) and Human Neutrophil Peptides 1 (HNP1)

Journal of Medicinal Chemistry

Volumn 59, Issue 9, 2016, Pages 4289-4301

  Wichapong, Kanin ^a   Alard, Jean Eric ^b   Ortega Gomez, Almudena ^b   Weber, Christian ^a,b,c   Hackeng, Tilman M ^a   Soehnlein, Oliver ^b,c,d   Nicolaes, Gerry A F ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINYLARGINYLTYROSYLGLYCYLTHREONYLSERYLLYSYLTYROSYLGLUTAMINE; HUMAN NEUTROPHIL PEPTIDE 1; NONAPEPTIDE; PEPTIDE; PROTEIN INHIBITOR; RANTES; UNCLASSIFIED DRUG; ALPHA DEFENSIN; CCL5 PROTEIN, HUMAN;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CELL ADHESION; COMPLEX FORMATION; COMPUTER MODEL; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; HUMAN; HUMAN CELL; MONOCYTE; ORTHOLOGY; PROTEIN PROTEIN INTERACTION; UMBILICAL VEIN ENDOTHELIAL CELL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CYTOLOGY; DIMERIZATION; METABOLISM; PROTEIN CONFORMATION; THERMODYNAMICS;

ALPHA-DEFENSINS; CELL ADHESION; CHEMOKINE CCL5; DIMERIZATION; DRUG DESIGN; HUMANS; MONOCYTES; PEPTIDES; PROTEIN CONFORMATION; THERMODYNAMICS;

EID: 84969627324     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01952     Document Type: Article

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