In vitro and in silico studies on substrate recognition and acceptance of human PKMYT1, a Cdk1 inhibitory kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 1219-1223

  Rohe, Alexander ^a   Erdmann, Frank ^b   Bäßler, Claudia ^a   Wichapong, Kanin ^a   Sippl, Wolfgang ^a   Schmidt, Matthias ^a,b  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b MAX PLANCK RESEARCH UNIT FOR ENZYMOLOGY OF PROTEIN FOLDING   (Germany)

Author keywords

CDC2 protein kinase; Fluorescence polarization; Human PKMYT1 protein; Molecular dynamics simulation; Substrate specificity

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1 PKMYT1; PEPTIDE; PROTEIN TYROSINE KINASE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; FLUORESCENCE POLARIZATION IMMUNOASSAY; HUMAN; IMMUNOBLOTTING; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN STRUCTURE;

ANTIBODIES, MONOCLONAL; FLUORESCENCE POLARIZATION IMMUNOASSAY; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES;

EID: 84855675652     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.11.064     Document Type: Article

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