Phase II metabolism of the soy isoflavones genistein and daidzein in humans, rats and mice: a cross-species and sex comparison

Archives of Toxicology

Volumn 90, Issue 6, 2016, Pages 1335-1347

  Soukup, Sebastian T ^a   Helppi, Jussi ^b   Müller, Dennis R ^c   Zierau, Oliver ^d   Watzl, Bernhard ^a   Vollmer, Günter ^d   Diel, Patrick ^c   Bub, Achim ^a   Kulling, Sabine E ^a  

^a FEDERAL RESEARCH INSTITUTE OF NUTRITION AND FOOD   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^c GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Glucuronides; Human; Isoflavones; Mouse; Rat; Sulfates

Indexed keywords

DAIDZEIN; DAIDZEIN 4' BETA DEXTRO GLUCURONIDE; DAIDZEIN 7' BETA DEXTRO GLUCURONIDE; DAIDZEIN 7' BETA DEXTRO GLUCURONIDE 4' SULFATE; EQUOL; GENISTEIN; GENISTEIN 4' BETA DEXTRO GLUCURONIDE; GENISTEIN 7' BETA DEXTRO GLUCURONIDE 4' SULFATE; ISOFLAVONE DERIVATIVE; SOY ISOFLAVONE; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ARTICLE; BODY MASS; BODY WEIGHT; CONTROLLED STUDY; DRUG DETERMINATION; DRUG METABOLISM; DRUG URINE LEVEL; FEMALE; GRAVIMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOMER; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MICROBIAL METABOLISM; MOUSE; NONHUMAN; NORMAL HUMAN; PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RAT; SEX DIFFERENCE; SPECIES COMPARISON; TANDEM MASS SPECTROMETRY; URINALYSIS; URINARY EXCRETION; ANIMAL; BAGG ALBINO MOUSE; BIOTRANSFORMATION; BLOOD; CHEMISTRY; METABOLISM; MIDDLE AGED; POSTMENOPAUSE; SOYBEAN; SPECIES DIFFERENCE; WISTAR RAT; XENOBIOTIC METABOLISM;

ADULT; ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GENISTEIN; HUMANS; ISOFLAVONES; LIMIT OF DETECTION; MALE; MASS SPECTROMETRY; METABOLIC DETOXICATION, PHASE II; MICE, INBRED BALB C; MIDDLE AGED; POSTMENOPAUSE; RATS, WISTAR; SEX FACTORS; SOYBEANS; SPECIES SPECIFICITY;

EID: 84969513713     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-016-1663-5     Document Type: Article

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