The OECD program to validate the rat uterotrophic bioassay. Phase 2: Dietary phytoestrogen analyses

Environmental Health Perspectives

Volumn 111, Issue 12, 2003, Pages 1559-1567

  Owens, J Williams ^a   Ashby, John ^b   Odum, Jenny ^b   Onyon, Lesley ^c  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^c Environment Health and Safety Division   (France)

Author keywords

Coumestrol; Daidzein; Diet; Endocrine disruption; Estrogen; Genistein; Phytoestrogen; Rat uterus; Uterotrophic

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; COUMESTROL; DAIDZEIN; ESTROGEN RECEPTOR; GENISTEIN; ISOFLAVONE DERIVATIVE; NONYLPHENOL; PHYTOESTROGEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BIOASSAY; BODY WEIGHT; CALCULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ESTROGEN ACTIVITY; FEMALE; FOOD INTAKE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT; SHORT SURVEY; STATISTICAL ANALYSIS; UTERUS WEIGHT; VALIDATION PROCESS;

ANIMALIA;

EID: 0038464933     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.5949     Document Type: Short Survey

References (64)

1. Ashby J, Tinwell H, Haseman J. 1999a. Lack of effects for low dose levels of bisphenol A and diethylstilbestrol on the prostate gland of CH nice exposed in utero. Regul Toxicol Pharmacol 30:156-166.
2. Ashby J, Tinwell H, Odum J. 1999b. Uterotrophic activity of a "phytoestrogen-free" diet. Environ Health Perspect 108:A12-A13.
3. Ashby J, Tinwell H, Odum J. 2001. DNA adducts, estrogenicity and rodent diets. Mutat Res 483:105-106.
4. Ashby J, Tinwell H, Odum J, Kimber I, Brooks AN, Pate I, et al. 2000. Diet and the aetiology of temporal advances in human and rodent sexual development. J Appl Toxicol 20:343-347.
5. Bickoff EM, Livingston AL, Hendrickson AP, Booth AN. 1962 Relative potencies of several estrogen-like compounds found in forages. Agric Food Chem 10:410-412.
6. Boettger-Tong H, Murphy L, Chiappetta C, Kirkland JL, Goodwin B, Aldercreutz H, et al. 1998. A case of a laboratory animal feed with high estrogenic activity and its impact on in vivo responses to exogenously administered estrogens. Environ Health Perspect 106:369-373.
7. Branham WS, Dial SL, Moland CL, Hass BS, Blair RM, Fang H, et al. 2002. Phytoestrogens and mycoestrogens bind to the rat uterine estrogen receptor. J Nutr 132:658-664.
8. Brown NM, Setchell KDR. 2001. Animal models impacted by phytoestrogens in commercial chow: implications for pathways influenced by hormones. Lab Invest 81:735-747.
9. Cagen SZ, Waechter JM Jr, Dimond SS, Breslin WJ, Butala JH, Jekat FW, et al. 1999. Normal reproductive organ development in CF-1 mice following prenatal exposure to bisphenol A. Toxicol Sci 50:36-44.
10. Casanova M, You L, Gaido KW, Archibeque-Engle S, Jansen DB, Heck HA. 1999, Developmental effects of dietary phytoestrogens in Sprague-Dawley rats and interactions of genistein and daidzein with rat estrogen receptors α and β in vitro. Toxicol Sci 51:236-244.
11. Degen GH, Janning P, Diel P, Bolt HM. 2002. Estrogenic isoflavones in rodent diets. Toxicol Lett 128:145-157.
12. Delclos KB, Bucci TJ, Lomax LG, Latendresse JR, Warbritton A, Weiss CC, et al. 2001. Effects of dietary genistein exposure during development on male and female CD (Sprague-Dawley) rats. Reprod Toxicol 15:647-663.
13. Drane HM, Patterson DSP, Roberts BA , Saba N. 1975. The chance discovery of oestrogenic activity in laboratory rat cake. Food Cosmet Toxicol 13:425-427 (1975).
14. Drane HM, Patterson DSP, Roberts BA , Saba N. 1980. Oestrogenic activity of soya-bean products. Food Cosmet Toxicol 18:491-492 (1980).
15. Edgren RA, Calhoun DW. 1957. Estrogen antagonisms: inhibition of estrone-induced uterine growth by testosterone propionate, progesterone and 17-ethyl-19-nortestosterone. Proc Soc Exp Biol Med 94:537-539.
16. Edgren RA, Calhoun DW. 1960. Oestrogen antagonisms: the effects of oestriol and 16-epi-oestriol on oestrone-induced uterine growth in spayed rats. J Endocrinol 20:325-330.
17. Edgren RA, Calhoun DW. 1961. Oestrogen antagonisms: the effects of various steroids on oestrone-induced uterine growth in spayed rats. Endocrinology 68:633-638.
18. Farmakalidis E, Hathcock JN, Murphy PA. 1985. Oestrogenic potency of genistin and daidzin in mice. Food Chem Toxicol 23:741-745.
19. Farmakalidis E, Murphy PA. 1984. Oestrogenic response of the CD-1 mouse to the soya-bean isoflavones genistein, genistin and daidzin. Food Chem Toxicol 22:237-239.
20. Fritz WA, Coward L, Wang J, Lamartiniere CA. 1998. Dietary genistein: perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat. Carcinogenesis 19:2151-2158.
21. Howdeshell KL, Hotchkiss AK, Thayer KA, Vandenbergh JG, vom Saal FS. Exposure to bisphenol A advances puberty. Nature 2000; 401:763-764.
22. Huggins C, Jensen EV, Cleveland AS. 1954. Chemical structure of steroids in relation to promotion of growth of the vagina and uterus of the hypophysectomized rat. J Exp Med 100:225-243.
23. ICCVAM (Intraagency Coordinating Committee on the Validation of Alternative Methods). 1997. Validation and Regulatory Acceptance of Toxicological Test 5ethods. A 5eport of the Ad Hoc Interagency Coordinating Committee on the Validation of Alternative Methods. NIH Report No. 97-3981. Research Triangle Park, NC:National Institute of Environmental Health Sciences.
24. Jefferson WN, Newbold RR. 2000. Potential endocrine-modulating effects of various phytoestrogens in the diet. Nutrition 16:658-662.
25. Kanno J, Onyon L, Haseman J, Fenner-Crisp P, Ashby J, Owens W. 2001. The OECD program to validate the rat uterotrophic bioassay to screen compounds for in vivo estrogenic responses: phase 1. Environ Health Perspect 109:785-794.
26. Kanno J, Onyon L, Haseman J, Fenner-Crisp P, Ashby J, Owens W. 2003a. The OECD program to validate the rat uterotrophic bioassay. Phase 2: coded single-dose studies. Environ Health Perspect 111:1550-1558.
27. Kanno J, Onyon L, Peddada S, Ashby J, Jacob E, Owens W. 2003b. The OECD program to validate the rat uterotrophic bioassay. Phase 2: dose-response studies. Environ Health Perspect 111:1530-1549.
28. Kanno J, Onyon L, Peddada S, Ashby J, Jacob E, Owens W. 2003b. The OECD program to validate the rat uterotrophic bioassay. Phase 2: coded single dose studies. Environ Health Perspect 111:1550-1558.
29. Kuiper GG, Carlsson B, Grandien K, Enmark E, Häggblad J, Nilsson S, et al. 1997. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138:863-870.
30. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson J-Å. 1996. Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93:5925-5930.
31. Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, et al. 1998. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor Endocrinology 139:4252-4263.
32. MAFF UK (Ministry of Agriculture, Fisheries and Food of the United Kingdom). 1998. Plant oestrogens in soya-based infant formulae. MAFF Food Surveillance Information Sheet 167:1-8.
33. Markaverich BM, Webb B, Densmore CL, Gregory RR. 1995. Effects of coumestrol on estrogen receptor function and uterine growth in ovariectomized rats. Environ Health Perspect 103:574-581.
34. McKenna NJ, Lanz RB, O'Malley BW. 1999. Nuclear receptor coregulators: cellular and molecular biology. Endocr Rev 20:321-344.
35. Moore JA. Institute for Evaluating Health Risks Expert Scientific Committee. 1995. An assessment of lithium using the IEHR evaluative process for assessing human developmental and reproductive toxicity of agents. Reprod Toxicol 9:175-210.
36. Moras D, Gronemeyer H. 1998. The nuclear receptor ligand-binding domain: structure and function. Curr Opin Cell Biol 10:384-391.
37. Morton MS, Wilcox G, Wahlqvist ML, Griffiths K. 1994. Determination of lignins and isoflavonoids in human female plasma following dietary supplementation. J Endocrinol 142:251-259.
38. Nagel SC, vom Saal FS, Thayer KA, Dhar MG, Boechler M, Welshons WV. 1997. Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol. Environ Health Perspect 105:70-76.
39. Newbold RR, Banks ED, Bullock B, Jefferson WN. 2001. Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res 61:4325-4328.
40. Odum J, Lefevre PA, Tittensor S, Paton D, Routledge EJ, Beresford NA, et al. 1997. The rodent uterotrophic bioassay: critical protocol features, studies with nonylphenols, and comparison with a yeast estrogenicity assay. Regul Toxicol Pharmacol 25:176-188.
41. Odum J, Tinwell H, Jones K, Van Miller JP, Joiner RL, Tobin G, et al. 2001. Effect of rodent diets on the sexual development of the rat. Toxicol Sci 61:115-127.
42. OECD (Organisation for Economic Co-operation and Development). 1998a. Report of the First Meeting of the OECD Endocrine Disrupter Testing and Assessment (EDTA) Working Group, 10-11 March 1998. ENV/MC/CHEM/RA(98)5. Paris:OECD.
43. OECD (Organisation for Economic Co-operation and Development). 1998b. The Validation of Test Methods Considered for Adoption as OECD Test Guidelines. ENV/MC/CHEM(98)6. Paris:OECD.
44. OECD (Organisation for Economic Co-operation and Development). 2000. Guidance Document on the Recognition, Assessment, and Use of Clinical Signs as Humane Endpoints for Experimental Animals Used in Safety Evaluation. OECD Environmental Health and Safety Publications. Series on Testing and Assessment, No. 19. ENV/JM/MOMO(2000)7. Paris:OECD.
45. Perel E, Linder HR. 1970. Dissociation of uterotrophic action from implantation-inducing activity in two non-steroidal oestrogens (coumestrol and genistein). J Reprod Fertil 21:171-175.
46. Safe SH, Pallaroni L, Yoon K, Gaido K, Ross S, Saville B, et al. 2001. Toxicology of environmental estrogens. Reprod Fertil Dev 13:307-315.
47. Santell RC. Chang YC, Nair MG. Helferich WG. 1997. Dietary genistein exerts estrogenic effects upon the uterus, mammary gland and the hypothalamic/pituitary axis in rats. J Nutr 127:263-269.
48. Setchell KDR, Welsh MB, Lim CK. 1987. High performance liquid chromatographic analysis of phytoestrogens in soy protein preparations with ultraviolet, electrochemical and thermospray mass spectrometric detection. J Chromatogr 386:315-323.
49. Setchell KDR, Zimmer-Nechemias L, Cai J, Heubi JE. 1997. Exposure of infants to phyto-oestrogens from soy-based infant formula. Lancet 350:23-27.
50. Shang Y, Brown M. 2002. Molecular determinants for the tissue specificity of SERMs. Science 295:2465-2468.
51. Thigpen JE, Li L-A, Richter CB, Lebetkin EH, Jameson CW. 1987a. The mouse bioassay for the detection of estrogenic activity in rodent diets. II. Comparative estrogenic activity of purified, certified and standard open and closed formula rodent diets. Lab Anim Sci 37:602-605.
52. Thigpen JE, Lebetkin EH, Dawes ML, Richter CB, Crawford D. 1987b. The mouse bioassay for the detection of estrogenic activity in rodent diets. III. Stimulation of uterine weight by dextrose, sucrose and corn starch. Lab Anim Sci 37:606-609.
53. Thigpen JE, Setchell KD, Goelz MF, Forsythe DB. 1999a. The phytoestrogen content of rodent diets [Letter]. Environ Health Perspect 107:A182-A183.
54. Thigpen JE, Setchell KD, Ahlmark KB, Locklear J, Spahr T, Caviness GF, et al. 1999b. Phytoestrogen content of purified, open and closed-formula laboratory animal diets. Lab Anim Sci 49:530-536.
55. vom Saal FS, Cooke PS, Buchanan DL, Palanza P, Thayer KA, Nagel SC, et al. 1998. A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production and behavior. Toxicol Ind Health 14:239-260.
56. Wiseman H, Casey K, Clarke DB, Barnes KA. Bowey E. 2002. Isoflavone aglycon and glucoconjugate content of high- and low-soy U.K. foods used in nutritional studies. J Agric Food Chem 50:1404-1410.
57. Whitten PL, Naftolin F. 1992. Effects of a phytoestrogen diet on estrogen-dependent reproductive processes in immature female rats. Steroids 57:56-61.
58. Whitten PL, Patisaul HB. 2001. Cross-species and interassay comparisons of phytoestrogen action. Environ Health Perspect 109(suppl 1):5-20.
59. Whitten PL, Russell E, Naftolin F. 1992. Effects of a normal, human-concentration, phytoestrogen diet on rat uterine growth. Steroids 57:98-106.
60. Xu L, Glass CK, Rosenfeld MG. 1999. Coactivator and corepressor complexes in nuclear receptor function. Curr Opin Gen Dev 9:140-147.
61. Yamasaki K, Sawaki M, Noda S, Wada T, Hara T, Takatsuki M. 2002. Immature uterotrophic assay of estrogenic compounds in rats given different phytoestrogen content diets and the ovarian changes in the immature rat uterotrophic of estrogenic compounds with ICI 182,780 or antide. Arch Toxicol 76:613-620.
62. You L, Casanova M, Bartolucci EJ, Fyczynski MW, Dorman DC, et al. 2002a. Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague-Dawley rats: genistein and methoxychlor. Toxicol Sci 66:91-104.
63. You L, Sar M, Bartolucci EJ, McIntyre BS, Sriperumbudur R. 2002b. Modulation of mammary gland development in prepubertal male rats exposed to genistein and methoxychlor. Toxicol Sci 66:216-225.
64. Zarrow MX, Lazo-Wasem EA, Shoger RL. 1953. Estrogenic activity in a commercial animal ration. Science 118:650-651.