Influence of Biophysical Parameters on Maintaining the Mesenchymal Stem Cell Phenotype

ACS Biomaterials Science and Engineering

Volumn 1, Issue 4, 2015, Pages 218-226

  Lee, Junmin ^a   Abdeen, Amr A ^a   Kim, Alex S ^a   Kilian, Kristopher A ^a  

^a University of Illinois at Urbana Champaign   (United States)

Author keywords

cell shape; hydrogels; matrix elasticity; mesenchymal stem cells; multipotency

Indexed keywords

ENDOGLIN; POLYACRYLAMIDE GEL; PROTEIN; STRO 1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BIOPHYSICS; CELL CONTACT; CELL COUNT; CELL CULTURE; CELL DENSITY; CELL DIFFERENTIATION; CELL FUNCTION; CELL LEVEL; CELL MIGRATION; CELL PROLIFERATION; CELL SELF-RENEWAL; CELL SHAPE; CELL SIZE; CELL STIMULATION; CELL SURFACE; CONTROLLED STUDY; CYTOARCHITECTURE; CYTOSKELETON; GEOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROGEL; IN VITRO STUDY; MECHANICAL STRESS; MESENCHYMAL STEM CELL; MICROENVIRONMENT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RIGIDITY; TENSION; UPREGULATION;

EID: 84969262887     PISSN: None     EISSN: 23739878     Source Type: Journal    
DOI: 10.1021/ab500003s     Document Type: Article

References (41)

1. Li, L.; Xie, T. Stem cell niche: structure and function Annu. Rev. Cell Dev. Biol. 2005, 21, 605-631 10.1146/annurev.cellbio.21.012704.131525
2. Scadden, D. T. The stem-cell niche as an entity of action Nature 2006, 441, 1075-1079 10.1038/nature04957
3. Jones, D. L.; Wagers, A. J. No place like home: anatomy and function of the stem cell niche Nat. Rev. Mol. Cell Biol. 2008, 9, 11-21 10.1038/nrm2319
4. Da Silva Meirelles, L.; Chagastelles, P. C.; Nardi, N. B. Mesenchymal stem cells reside in virtually all post-natal organs and tissues J. Cell Sci. 2006, 119, 2204-2213 10.1242/jcs.02932
5. Crisan, M.; Yap, S.; Casteilla, L.; Chen, C.-W.; Corselli, M.; Park, T. S.; Andriolo, G.; Sun, B.; Zheng, B.; Zhang, L. et al. A perivascular origin for mesenchymal stem cells in multiple human organs Cell Stem Cell 2008, 3, 301-313 10.1016/j.stem.2008.07.003
6. Kilian, K. A.; Mrksich, M. Directing stem cell fate by controlling the affinity and density of ligand-receptor interactions at the biomaterials interface Angew. Chem., Int. Ed. Engl. 2012, 51, 4891-4895 10.1002/anie.201108746
7. Hennrick, K. T.; Keeton, A. G.; Nanua, S.; Kijek, T. G.; Goldsmith, A. M.; Sajjan, U. S.; Bentley, J. K.; Lama, V. N.; Moore, B. B.; Schumacher, R. E. et al. Lung cells from neonates show a mesenchymal stem cell phenotype Am. J. Respir. Crit. Care Med. 2007, 175, 1158-1164 10.1164/rccm.200607-941OC
8. Keating, A. Mesenchymal stromal cells: new directions Cell Stem Cell 2012, 10, 709-716 10.1016/j.stem.2012.05.015
9. Engler, A. J.; Sen, S.; Sweeney, H. L.; Discher, D. E. Matrix elasticity directs stem cell lineage specification Cell 2006, 126, 677-689 10.1016/j.cell.2006.06.044
10. Rowlands, A. S.; George, P. A.; Cooper-White, J. J. Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation Am. J. Physiol. 2008, 295, C1037-C1044 10.1152/ajpcell.67.2008
11. Tse, J. R.; Engler, A. J. Stiffness gradients mimicking in vivo tissue variation regulate mesenchymal stem cell fate PLoS One 2011, 6, e15978 10.1371/journal.pone.0015978
12. Lee, J.; Abdeen, A. A.; Huang, T. H.; Kilian, K. A. Controlling cell geometry on substrates of variable stiffness can tune the degree of osteogenesis in human mesenchymal stem cells J. Mech. Behav. Biomed. Mater. 2014, 38, 209-218 10.1016/j.jmbbm.2014.01.009
13. Abdeen, A. A.; Weiss, J. B.; Lee, J.; Kilian, K. A. Matrix Composition and Mechanics Direct Proangiogenic Signaling from Mesenchymal Stem Cells Tissue Eng., Part A 2014, 20, 2737-2745 10.1089/ten.tea.2013.0661
14. Winer, J. P.; Janmey, P. A.; McCormick, M. E.; Funaki, M. Bone marrow-derived human mesenchymal stem cells become quiescent on soft substrates but remain responsive to chemical or mechanical stimuli Tissue Eng., Part A 2009, 15, 147-154 10.1089/ten.tea.2007.0388
15. Lee, J.; Abdeen, A. A.; Kilian, K. A. Rewiring mesenchymal stem cell lineage specification by switching the biophysical microenvironment Sci. Rep. 2014, 4, 5188 10.1038/srep05188
16. Khalil, A. S.; Xie, A. W.; Murphy, W. L. Context clues: the importance of stem cell-material interactions ACS Chem. Biol. 2014, 9, 45-56 10.1021/cb400801m
17. Murphy, W. L.; Mcdevitt, T. C.; Engler, A. J. Materials as stem cell regulators Nat. Mater. 2014, 13, 547-557 10.1038/nmat3937
18. Higuchi, A.; Ling, Q.; Chang, Y.; Hsu, S.; Umezawa, A. Physical Cues of Biomaterials Guide Stem Cell Differentiation Fate Chem. Rev. 2013, 113, 3297-3328 10.1021/cr300426x
19. Guilak, F.; Cohen, D. M.; Estes, B. T.; Gimble, J. M.; Liedtke, W.; Chen, C. S. Control of stem cell fate by physical interactions with the extracellular matrix Cell Stem Cell 2009, 5, 17-26 10.1016/j.stem.2009.06.016
20. Ghaemi, S. R.; Harding, F. J.; Delalat, B.; Gronthos, S.; Voelcker, N. H. Exploring the mesenchymal stem cell niche using high throughput screening Biomaterials 2013, 34, 7601-7615 10.1016/j.biomaterials.2013.06.022
21. Gilbert, P. M.; Havenstrite, K. L.; Magnusson, K. E. G.; Sacco, A.; Leonardi, N. A.; Kraft, P.; Nguyen, N. K.; Thrun, S.; Lutolf, M. P.; Blau, H. M. Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture Science 2010, 329, 1078-1081 10.1126/science.1191035
22. Skardal, A.; Mack, D.; Atala, A.; Soker, S. Substrate elasticity controls cell proliferation, surface marker expression and motile phenotype in amniotic fluid-derived stem cells J. Mech. Behav. Biomed. Mater. 2013, 17, 307-316 10.1016/j.jmbbm.2012.10.001
23. Oh, S.; Brammer, K. S.; Li, Y. S. J.; Teng, D.; Engler, A. J.; Chien, S.; Jin, S. Stem cell fate dictated solely by altered nanotube dimension Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 2130-2135 10.1073/pnas.0813200106
24. Park, J.; Bauer, S.; von der Mark, K.; Schmuki, P. Nanosize and vitality: TiO2 nanotube diameter directs cell fate Nano Lett. 2007, 7, 1686-1691 10.1021/nl070678d
25. McMurray, R. J.; Gadegaard, N.; Tsimbouri, P. M.; Burgess, K. V.; McNamara, L. E.; Tare, R.; Murawski, K.; Kingham, E.; Oreffo, R. O. C.; Dalby, M. J. Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency Nat. Mater. 2011, 10, 637-644 10.1038/nmat3058
26. Chen, C. S.; Mrksich, M.; Huang, S.; Whitesides, G. M.; Ingber, D. E. Geometric control of cell life and death Science 1997, 276, 1425-1428 10.1126/science.276.5317.1425
27. Kilian, K. A.; Bugarija, B.; Lahn, B. T.; Mrksich, M. Geometric cues for directing the differentiation of mesenchymal stem cells Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 4872-4877 10.1073/pnas.0903269107
28. Fu, J.; Wang, Y. K.; Yang, M. T.; Desai, R. A.; Yu, X.; Liu, Z.; Chen, C. S. Mechanical regulation of cell function with geometrically modulated elastomeric substrates Nat. Methods 2010, 7, 733-736 10.1038/nmeth.1487
29. Lee, J.; Abdeen, A. A.; Zhang, D.; Kilian, K. A. Directing stem cell fate on hydrogel substrates by controlling cell geometry, matrix mechanics and adhesion ligand composition Biomaterials 2013, 34, 8140-8148 10.1016/j.biomaterials.2013.07.074
30. Ruiz, S. A.; Chen, C. S. Emergence of patterned stem cell differentiation within multicellular structures Stem Cells 2008, 26, 2921-2927 10.1634/stemcells.2008-0432
31. Nelson, C. M.; Jean, R. P.; Tan, J. L.; Liu, W. F.; Sniadecki, N. J.; Spector, A. A.; Chen, C. S. Emergent patterns of growth controlled by multicellular form and mechanics Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 11594-11599 10.1073/pnas.0502575102
32. Zhang, D.; Kilian, K. A. Biomaterials The effect of mesenchymal stem cell shape on the maintenance of multipotency Biomaterials 2013, 34, 3962-3969 10.1016/j.biomaterials.2013.02.029
33. Tse, J. R.; Engler, A. J. Preparation of hydrogel substrates with tunable mechanical properties Curr. Protoc. Cell Biol. 2010, 47, 10.16.1-10.16.16 10.1002/0471143030.cb1016s47
34. Damljanović, V.; Lagerholm, B. C.; Jacobson, K. Bulk and micropatterned conjugation of extracellular matrix proteins to characterized polyacrylamide substrates for cell mechanotransduction assays Biotechniques 2005, 39, 847-851 10.2144/000112026
35. Dalby, M. J.; Gadegaard, N.; Tare, R.; Andar, A.; Riehle, M. O.; Herzyk, P.; Wilkinson, C. D. W.; Oreffo, R. O. C. The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder Nat. Mater. 2007, 6, 997-1003 10.1038/nmat2013
36. Yang, C.; Tibbitt, M. W.; Basta, L.; Anseth, K. S. Mechanical memory and dosing influence stem cell fate Nat. Mater. 2014, 13, 645-652 10.1038/nmat3889
37. Re, F.; Zanetti, A.; Sironi, M.; Polentarutti, N.; Lanfrancone, L.; Dejana, E.; Colotta, F. Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells J. Cell Biol. 1994, 127, 537-546 10.1083/jcb.127.2.537
38. McBeath, R.; Pirone, D. M.; Nelson, C. M.; Bhadriraju, K.; Chen, C. S. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment Dev. Cell 2004, 6, 483-495 10.1016/S1534-5807(04)00075-9
39. Khetan, S.; Guvendiren, M.; Legant, W. R.; Cohen, D. M.; Chen, C. S.; Burdick, J. A. Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels Nat. Mater. 2013, 12, 1-8 10.1038/nmat3586
40. Guvendiren, M.; Burdick, J. A. Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics Nat. Commun. 2012, 3, 792 10.1038/ncomms1792
41. Sart, S.; Tsai, A. C.; Li, Y.; Ma, T. Three-Dimensional Aggregates of Mesenchymal Stem Cells Tissue Eng., Part B 2014, 20, 365-380 10.1089/ten.teb.2013.0537