Does simvastatin affect mood and steroid hormone levels in hypercholesterolemic men? A randomized double-blind trial

Psychoneuroendocrinology

Volumn 28, Issue 2, 2003, Pages 181-194

  Hyyppä, Markku T ^a   Kronholm, Erkki ^a   Virtanen, Arja ^a   Leino, Aila ^a,b   Jula, Antti ^a  

^a Res Ctr of Social Ins Institution   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Diet; Hypercholesterolemia; Men; Mood; Randomized trial; Statins; Steroid hormones

Indexed keywords

PLACEBO; PRASTERONE; SIMVASTATIN; STEROID HORMONE;

ADULT; AGGRESSION; ANXIETY; ARTICLE; BRAIN FUNCTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DIET; DOUBLE BLIND PROCEDURE; DRUG DETERMINATION; DRUG EFFECT; HOSTILITY; HUMAN; HYPERCHOLESTEROLEMIA; IMMUNOLOGY; MAJOR CLINICAL STUDY; MALE; MEDICAL ASSESSMENT; MOOD DISORDER; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SOMATIZATION; STATISTICAL SIGNIFICANCE; STEROID BLOOD LEVEL; TESTOSTERONE BLOOD LEVEL; TYPES OF STUDY;

EID: 0037295226     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4530(02)00014-8     Document Type: Article

References (31)

1. Achermann J.C., Silvermann B.L. Dehydroepiandrosterone replacement for patients with adrenal insufficiency. Lancet. 357:2001;1381-1382.
2. Boston P.F., Dursun S.M., Reveley M.A. Cholesterol and mental disorder. Br. J. Psychiat. 169:1996;682-689.
3. Derogatis L.R., Melisaratos N. The brief symptom inventory: an introductory report. Psychol. Med. 13:1983;595-605.
4. Dobs A.S., Miller S., Gilberto N., Weiss S., Tate A.C., Shapiro D.R., Musliner T.A. Effects of simvastatin and provastatin on gonadal function in male hypercholesterolemic patients. Metabolism. 49:2000;115-121.
5. Dobs A.S., Schrott H., Davidson M.H., Bays H., Stein E.A., Kush D., Wu M., Mitchel Y., Illingworth R.D. Effects of high-dose simvastatin on adrenal and gonadal steroidogenesis in men with hypercholesterolemia. Metabolism. 49:2000;1234-1238.
6. Engelberg H. Low serum cholesterol and suicide. Lancet. 339:1992;727-729.
7. Golomb B.A. Cholesterol and violence: is there a connection? Ann. Intern. Med. 128:1998;478-487.
8. Jula A., Marniemi J., Huupponen R., Virtanen A., Rastas M., Rönnemaa T. Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men. A randomized controlled trial. JAMA. 287:2002;598-605.
9. Lamberts S.W.J., van der Beld A.W., Van der Lely A-J. The endocrinology of aging. Science. 278:1997;419-424.
10. Mantzoros C.S., Georgiadis E.I., Trichopoulos D. Contribution of dihydrotestosterone to male sexual behaviour. Br. Med. J. 310:1995;1289-1291.
11. Muldoon M.F., Manuck S.B. Health through cholesterol reduction: Are there unforseen risks? Ann. Behav. Med. 14:1992;101-108.
12. Muldoon M.F., Barger S.D., Ryan C.M., Flory J.D., Lehoczky J.P., Matthews K.A., Manuck S.B. Effects of lovastatin on cognitive function and psychological well-being. Am. J. Med. 108:2000;538-547.
13. Second report of the Expert Panel on Detection, Evaluation, and Treatment of High Cholesterol in Adults (Adult Treatment Panel II). Circulation. 89:1994;1329-1445.
14. Nilsson P.M., Møller L., Solstad K. Adverse effects of psychosocial stress on gonadal function and insulin levels in middle-aged males. J. Intern. Med. 237:1995;479-486.
15. Rubinow D.R., Schmidt P.J. Androgens, brain, and behavior. Am. J. Psychiat. 153:1996;974-984.
16. Ryman A. Cholesterol, violent death, and mental disorder. Br. Med. J. 309:1994;421-422.
17. Saheki A., Terasaki T., Tsuji A. In vivo and in vitro blood-brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. Pharm. Res. 11:1994;305-311.
18. Schweiger U., Deuschle M., Weber B., Körner A., Lammer C.-H., Schmider J., Gotthardt U., Heuser I. Testosterone, gonadotropin, and cortisol secretion in male patients with major depression. Psychosom. Med. 61:1999;292-296.
19. Seidman S.N., Araujo A.B., Roose S.P., McKinlay J.B. Testosterone level, androgen receptor polymorphism, and depression symtoms in middle-aged men. Biol. Psychiat. 50:2001;371-376.
20. Smals A.G.H., Weusten J.J.A.M., Benraad T.J., Kloppenborg P.W.C. The HMG-CoA reductase inhibitor simvastatin suppresses human testicular testosterone synthesis in vitro by a selective inhibitory effect on 17-ketosteroid-oxidoreductase enzyme activity. J. Steroid Biochem. Mol. Biol. 38:1991;465-468.
21. Smyth J., Ockenfels M.C., Porter L., Kirschbaum C., Hellhammer D.H., Stone A.A. Stressors and mood measures on a momentarily basis are associated with salivary cortisol secretion. Psychoneuroendocrinology. 23:1998;353-370.
22. Spielberger C.D., Gorsuch R.L., Lushene R.E., Vagg P., Jacobs G. Manual for the State-Trait Anxiety Inventory. 1983;Consulting Psychologist Press, Palo Alto, CA.
23. Steegmans P.H.A., Hoes A.W., Bak A.A.A., van der Does E., Grobbee D.E. Higher prevalence of depressive symptoms in middle-aged men with low serum cholesterol levels. Psychosom. Med. 62:2000;205-211.
24. Sternbach H. Age-associated testosterone decline in men: clinical issues for psychiatry. Am. J. Psychiat. 155:1998;1310-1318.
25. Stewart R.A., Sharples K.J., North F.M., Menkes D.B., Baker J., Simes J. Long-term assessment of psychological well-being in a randomized placebo-controlled trial of cholesterol reduction with pravastatin. Arch. Intern. Med. 160:2000;3144-3155.
26. Strandberg T.E., Räikkönen K., Partinen M., Pihl S., Vanhanen H., Miettinen T.A. Associations of cholesterol lowering by statins with anger and hostility in hypercholesterolemic men. Biol. Psychiat. 35:1994;575-577.
27. Strauss M.A., Gilles R.J., Steinmetz S.K. Behind Closed Doors: Violence in Family. 1979;Doubleday Anchor, New York.
28. Vickers A.J., Altman D.G. Analysing controlled trials with baseline and follow up measurements. Br. Med. J. 323:2001;1123-1124.
29. Wardle J., Armitage J., Collins R., Wallendszus K., Keech A., Lawson A. Randomised placebo controlled trial of effect on mood of lowering cholesterol concentration. Br. Med. J. 313:1996;75-78.
30. Wardle J., Rogers P., Judd P., Taylor M.A., Rapoport L., Green M., Nicholson Perry K. Randomized trial of the effects of cholesterol-lowering dietary treatment on psychological function. Am. J. Med. 108:2000;547-553.
31. Weidner G., Connor S.L., Hollis J.F., Connor W.E. Improvements in hostility and depression in relation to dietary change and cholesterol lowering. The Family Heart Study. Ann. Intern. Med. 117:1992;820-823.