Statins use and risk of depression: A systematic review and meta-analysis

Journal of Affective Disorders

Volumn 160, Issue , 2014, Pages 62-67

  Parsaik, Ajay K ^a,b   Singh, Balwinder ^b   Hassan Murad, M ^b   Singh, Kuljit ^c   Mascarenhas, Soniya S ^d   Williams, Mark D ^b   Lapid, Maria I ^b   Richardson, Jarrett W ^b   West, Colin P ^b   Rummans, Teresa A ^b,e  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b MAYO CLINIC   (United States)

^c QUEEN ELIZABETH HOSPITAL   (Australia)

^d London Training College   (United Kingdom)

^e MAYO CLINIC   (United States)

Author keywords

Depression; Meta analysis; Statins; Systematic review

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ANTIDEPRESSANT ACTIVITY; DEPRESSION; DISEASE ASSOCIATION; DISEASE COURSE; DRUG USE; FOLLOW UP; HUMAN; META ANALYSIS; PATIENT COMPLIANCE; PRIORITY JOURNAL; PUBLISHING; QUALITY CONTROL; QUALITY OF LIFE; REVIEW; RISK; SYSTEMATIC REVIEW; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK ASSESSMENT;

DEPRESSION; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK ASSESSMENT;

EID: 84898597546     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2013.11.026     Document Type: Review

References (48)

1. J. Benito-León, E.D. Louis, S. Vega, and F. Bermejo-Pareja Statins and cognitive functioning in the elderly: a population-based study J. Alzheimer's Dis. 21 1 2010 95 102
2. R.M. Carney, and K.E. Freedland Depression in patients with coronary heart disease Am. J. Med. 121 11 Suppl. 2 2008 S20 S27
3. K.A. Chan, S.E. Andrade, and M. Boles et al. Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women Lancet 355 9222 2000 2185 2188 (Pubitemid 30394324)
4. W. Cochran The combination of estimates from different experiments Biometrics 10 1954 101 129
5. J. Cohen Coefficient of agreement for nominal scales educational and psychological measurement Educ. Psychol. Meas. 20 1960 37 46
6. G. Davey Smith, and J. Pekkanen Should there be a moratorium on the use of cholesterol lowering drugs? Br. Med. J. 304 6824 1992 431 434
7. R. DerSimonian, and N. Laird Meta-analysis in clinical trials Controll. Clin. Trials 7 3 1986 177 188 (Pubitemid 17189972)
8. J.R. Downs, G. Oster, and N.C. Santanello HMG CoA reductase inhibitors and quality of life JAMA: J. Am. Med. Assoc. 269 24 1993 3107 3108 (Pubitemid 23171703)
9. J.R. Downs, M. Clearfield, and S. Weis et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study JAMA: J. Am. Med. Assoc. 279 20 1998 1615 1622 (Pubitemid 28248586)
10. H. Engelberg Low serum cholesterol and suicide Lancet 339 8795 1992 727 729
11. D.S. Freedman, T. Byers, D.H. Barrett, N.E. Stroup, E. Eaker, and H. Monroe-Blum Plasma lipid levels and psychologic characteristics in men Am. J. Epidemiol. 141 6 1995 507 517
12. R.B. Goldberg, M.J. Mellies, and F.M. Sacks et al. Cardiovascular events and their reduction with pravastatin in diabetic and glucose-intolerant myocardial infarction survivors with average cholesterol levels: subgroup analyses in the cholesterol and recurrent events (CARE) trial. The Care Investigators Circulation 98 23 1998 2513 2519 (Pubitemid 29001188)
13. N.F. Hall, C.R. Gale, H. Syddall, D.I. Phillips, and C.N. Martyn Risk of macular degeneration in users of statins: cross sectional study Br. Med. J. 323 7309 2001 375 376 (Pubitemid 32762463)
14. R.W. Harrison, and C.H. Ashton Do cholesterol-lowering agents affect brain activity? A comparison of simvastatin, pravastatin, and placebo in healthy volunteers Br. J. Clin. Pharmacol. 37 3 1994 231 236 (Pubitemid 24212181)
15. J.P. Higgins, S.G. Thompson, J.J. Deeks, and D.G. Altman Measuring inconsistency in meta-analyses Br. Med. J. 327 7414 2003 557 560 (Pubitemid 37088507)
16. M. Hillbrand, R.T. Spitz, and H.G. Foster Serum cholesterol and aggression in hospitalized male forensic patients J. Behav. Med. 18 1 1995 33 43
17. H. Jick, G.L. Zornberg, S.S. Jick, S. Seshadri, and D.A. Drachman Statins and the risk of dementia Lancet 356 9242 2000 1627 1631
18. A. Keech, R. Collins, and S. MacMahon et al. Three-year follow-up of the Oxford Cholesterol Study: assessment of the efficacy and safety of simvastatin in preparation for a large mortality study Eur. Heart J. 15 2 1994 255 269 (Pubitemid 24110705)
19. G. Lindberg, and J. Hallas Cholesterol-lowering drugs and antidepressants - a study of prescription symmetry Pharmacoepidemiol. Drug Saf. 7 6 1998 399 402 (Pubitemid 29047896)
20. J. Marx Alzheimer's disease. Bad for the heart, bad for the mind? Science 294 5542 2001 508 509
21. F.A. McAlister, F.M. Lawson, K.K. Teo, and P.W. Armstrong Randomised trials of secondary prevention programmes in coronary heart disease: systematic review Br. Med. J. 323 7319 2001 957 962 (Pubitemid 33016042)
22. C.R. Meier, R.G. Schlienger, M.E. Kraenzlin, B. Schlegel, and H. Jick HMG-CoA reductase inhibitors and the risk of fractures JAMA: J. Am. Med. Assoc. 283 24 2000 3205 3210 (Pubitemid 30422037)
23. D. Moher, A. Liberati, J. Tetzlaff, and D.G. Altman Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement Br. Med. J. 339 2009 b2535
24. M.F. Muldoon Injury, death, and cholesterol Ann. Intern. Med. 121 9 1994 719 720
25. M.F. Muldoon, S.B. Manuck, and K.A. Matthews Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials Br. Med. J. 301 6747 1990 309 314 (Pubitemid 20238057)
26. A. O'Neil, L. Sanna, and C. Redlich et al. The impact of statins on psychological wellbeing: a systematic review and meta-analysis BMC Med. 10 2012 154
27. M.F. Oliver Doubts about preventing coronary heart disease Br. Med. J. 304 6824 1992 393 394
28. C. Otte, S. Zhao, and M.A. Whooley Statin use and risk of depression in patients with coronary heart disease: longitudinal data from the Heart and Soul Study J. Clin. Psychiatry 73 5 2012 610 615
29. J.A. Pasco, F.N. Jacka, and L.J. Williams et al. Clinical implications of the cytokine hypothesis of depression: the association between use of statins and aspirin and the risk of major depression Psychother. Psychosom. 79 5 2010 323 325
30. T.R. Pedersen, K. Berg, and T.J. Cook et al. Safety and tolerability of cholesterol lowering with simvastatin during 5 years in the Scandinavian Simvastatin Survival Study Arch. Intern. Med. 156 18 1996 2085 2092 (Pubitemid 26346967)
31. F.M. Sacks, M.A. Pfeffer, and L.A. Moye et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators N. Engl. J. Med. 335 14 1996 1001 1009 (Pubitemid 26338729)
32. M. Sano, K.L. Bell, and D. Galasko et al. A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease Neurology 77 6 2011 556 563
33. T. Santos, M.M. Baungratz, and S.P. Haskel et al. Behavioral interactions of simvastatin and fluoxetine in tests of anxiety and depression J. Neuropsychiatr. Dis. Treat. 8 2012 413 422
34. Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) Lancet 344 8934 1994 1383 1389
35. H.D. Scott, and K. Laake Statins for the reduction of risk of Alzheimer's disease Cochrane Database Syst. Rev. 3 2001 CD003160
36. L. Stafford, and M. Berk The use of statins after a cardiac intervention is associated with reduced risk of subsequent depression: proof of concept for the inflammatory and oxidative hypotheses of depression? J. Clin. Psychiatry 72 9 2011 1229 1235
37. D.C. Steffens, D.R. McQuoid, and K.R. Krishnan Cholesterol-lowering medication and relapse of depression Psychopharmacol. Bull. 37 4 2003 92 98
38. J.A. Sterne, D. Gavaghan, and M. Egger Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature J. Clin. Epidemiol. 53 11 2000 1119 1129
39. M. Virkkunen, and H. Penttinen Serum cholesterol in aggressive conduct disorder: a preliminary study Biol. Psychiatry 19 3 1984 435 439 (Pubitemid 14130682)
40. P.J. van der Most, A.M. Dolga, I.M. Nijholt, P.G. Luiten, and U.L. Eisel Statins: mechanisms of neuroprotection Prog. Neurobiol. 88 1 2009 64 75
41. P.S. Wang, D.H. Solomon, H. Mogun, and J. Avorn HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients. JAMA: J. Am. Med. Assoc. 283 24 2000 3211 3216 (Pubitemid 30422038)
42. J. Wardle, J. Armitage, R. Collins, K. Wallendszus, A. Keech, and A. Lawson Randomised placebo controlled trial of effect on mood of lowering cholesterol concentration. Oxford Cholesterol Study Group Br. Med. J. 313 7049 1996 75 78 (Pubitemid 26257756)
43. Wells Gas, B., O'Connell, D., Peterson, J., Welch, V., Losos, M., Tugwell, P., 2013. The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomized Studies in Meta-Analyses. Available from: http://wwwohrica/ programs/clinical-epidemiology/oxfordasp (accessed 19.02.13).
44. A. While, and L. Keen The effects of statins on mood: a review of the literature Eur. J. Cardiovasc. Nurs.: J. Work. Group Cardiovasc. Nurs. Eur. Soc. Cardiol. 11 1 2012 85 96
45. B. Wolozin, W. Kellman, P. Ruosseau, G.G. Celesia, and G. Siegel Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3- methyglutaryl coenzyme A reductase inhibitors Arch. Neurol. 57 10 2000 1439 1443
46. C.C. Yang, S.S. Jick, and H. Jick Lipid-lowering drugs and the risk of depression and suicidal behavior Arch. Intern. Med. 163 16 2003 1926 1932 (Pubitemid 37082704)
47. Y. Young-Xu, A. Chan, J.K. Liao, S. Ravid, and C.M. Blatt Long-term statin use and psychological well-being in the elderly J. Am. Coll. Cardiol. 41 6 2003 153A-A
48. J. Zhang, and K.F. Yu What's the relative risk?A method of correcting the odds ratio in cohort studies of common outcomes JAMA: J. Am. Med. Assoc. 280 19 1998 1690 1691 (Pubitemid 28532993)