Protective effects of melatonin against arsenic-induced apoptosis and oxidative stress in rat testes

Toxicology and Industrial Health

Volumn 32, Issue 5, 2016, Pages 848-859

  Uygur, Ramazan ^a   Aktas, Cevat ^a   Caglar, Veli ^a   Uygur, Emine ^a   Erdogan, Hasan ^a   Ozen, Oguz Aslan ^a  

^a NAMIK KEMAL UNIVERSITY   (Turkey)

Author keywords

apoptosis; Arsenic; melatonin; oxidative stress; testis

Indexed keywords

ARSENIC; CATALASE; CYCLINE; DNA NUCLEOTIDYLEXOTRANSFERASE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; MELATONIN; SUPEROXIDE DISMUTASE; ARSENITE SODIUM; ARSENOUS ACID DERIVATIVE; PROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; SODIUM DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SEMINIFEROUS TUBULE; SPERMATOGENESIS; TESTIS; TESTIS BIOPSY; TESTIS INJURY; TESTIS WEIGHT; TREATMENT DURATION; WEIGHT GAIN; ANIMAL; CELL PROLIFERATION; CHEMICALLY INDUCED; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; ORGAN SIZE; PATHOLOGY; TESTICULAR DISEASES; WISTAR RAT;

ANIMALS; APOPTOSIS; ARSENIC; ARSENITES; CATALASE; CELL PROLIFERATION; DNA NUCLEOTIDYLEXOTRANSFERASE; GENE EXPRESSION REGULATION; GLUTATHIONE PEROXIDASE; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MELATONIN; ORGAN SIZE; OXIDATIVE STRESS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTECTIVE AGENTS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SODIUM COMPOUNDS; SUPEROXIDE DISMUTASE; TESTICULAR DISEASES; TESTIS;

EID: 84968764956     PISSN: 07482337     EISSN: 14770393     Source Type: Journal    
DOI: 10.1177/0748233713512891     Document Type: Article

References (53)

1. Aebi H, (1974) Catalase. In: Bergmeyer HU, (ed) Methods of Enzymatic Analysis. New York, NY: Academic Press, pp. 673-677.
2. Aitken RJ, Baker MA, (2006) Oxidative stress, sperm survival and fertility control. Molecular and Cellular Endocrinology 250: 66-69.
3. Altay B, Cetinkalp S, Doganavsargil B, Hekimgil M, Semerci B, (2003) Streptozotocin-induced diabetic effects on spermatogenesis with proliferative cell nuclear antigen immunostaining of adult rat testis. Fertility and Sterility 80 (Suppl 2): 828-831.
4. Arendt J, (1988) Melatonin. Clinical Endocrinology (. Oxf) 29: 205-229.
5. Balaban RS, Nemoto S, Finkel T, (2005) Mitochondria, oxidants, and aging. Cell 120: 483-495.
6. Buttke TM, Sandstrom PA, (1994) Oxidative stress as a mediator of apoptosis. Immunology Today 15: 7-10.
7. Cai L, Chen S, Evans T, Deng DX, Mukherjee K, Chakrabarti S, (2000) Apoptotic germ-cell death and testicular damage in experimental diabetes: prevention by endothelin antagonism. Urological Research 28: 342-347.
8. Chang SI, Jin B, Youn P, Park C, Park JD, Ryu DY, (2007) Arsenic-induced toxicity and the protective role of ascorbic acid in mouse testis. Toxicology and Applied Pharmacology 218: 196-203.
9. Chatterjee A, Das D, Chakraborti D, (1993) A study of ground water contamination by arsenic in the residential area of Behala, Calcutta due to industrial pollution. Environmental Pollution 80: 57-65.
10. Das J, Ghosh J, Manna P, Sinha M, Sil PC, (2009) Taurine protects rat testes against NaAsO(2)-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicology Letters 187: 201-210.
11. De Vizcaya-Ruiz A, Barbier O, Ruiz-Ramos R, Cebrian ME, (2009) Biomarkers of oxidative stress and damage in human populations exposed to arsenic. Mutation Research 674: 85-92.
12. Diaz-Villasenor A, Burns AL, Hiriart M, Cebrian ME, Ostrosky-Wegman P, (2007) Arsenic-induced alteration in the expression of genes related to type 2 diabetes mellitus. Toxicology and Applied Pharmacology 225: 123-133.
13. Draper HH, Hadley M, (1990) Malondialdehyde determination as index of lipid-peroxidation. Methods in Enzymology 186: 421-431.
14. Durak I, Yurtarslanl Z, Canbolat O, Akyol O, (1993) A methodological approach to superoxide dismutase (SOD) activity assay based on inhibition of nitroblue tetrazolium (NBT) reduction. Clinica Chimica Acta 214: 103-104.
15. El-Demerdash FM, Yousef MI, Radwan FM, (2009) Ameliorating effect of curcumin on sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs. Food and Chemical Toxicology 47: 249-254.
16. Ferreira M, Matos RC, Oliveira H, Nunes B, Pereira Mde L, (2012) Impairment of mice spermatogenesis by sodium arsenite. Human and Experimental Toxicology 31: 290-302.
17. Forsling ML, Stoughton RP, Zhou Y, Kelestimur H, Demaine C, (1993) The role of the pineal in the control of the daily patterns of neurohypophysial hormone secretion. Journal of Pineal Research 14: 45-51.
18. Fouad AA, Al-Sultan AI, Yacoubi MT, (2011) Coenzyme Q10 counteracts testicular injury induced by sodium arsenite in rats. European Journal of Pharmacology 655: 91-98.
19. Hsu SM, Raine L, Fanger H, (1981) Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. Journal of Histochemistry and Cytochemistry 29: 577-580.
20. Hu JH, Jiang J, Ma YH, Yang N, Zhang MH, Wu M, et al. (2003) Enhancement of germ cell apoptosis induced by ethanol in transgenic mice overexpressing Fas Ligand. Cell Research 13: 361-367.
21. Ilbey YO, Ozbek E, Simsek A, Otunctemur A, Cekmen M, Somay A, (2009) Potential chemoprotective effect of melatonin in cyclophosphamide-and cisplatin-induced testicular damage in rats. Fertility and Sterility 92: 1124-1132.
22. Jana K, Jana S, Samanta PK, (2006) Effects of chronic exposure to sodium arsenite on hypothalamo-pituitary-testicular activities in adult rats: possible an estrogenic mode of action. Reproductive Biology and Endocrinology 4: 9.
23. Ji YL, Wang H, Meng C, Zhao XF, Zhang C, Zhang Y, et al. (2012) Melatonin alleviates cadmium-induced cellular stress and germ cell apoptosis in testes. Journal of Pineal Research 52: 71-79.
24. Johnsen SG, (1970) Testicular biopsy score count: a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones 1: 2-25.
25. Jomova K, Jenisova Z, Feszterova M, Baros S, Liska J, Hudecova D, et al. (2011) Arsenic: toxicity, oxidative stress and human disease. Journal of Applied Toxicology 31: 95-107.
26. Kang MJ, Kim MK, Terhune A, Park JK, Kim YH, Koh GY, (1997) Cytoplasmic localization of cyclin D3 in seminiferous tubules during testicular development. Experimental Cell Research 234: 27-36.
27. Kanter M, (2010) Protective effects of melatonin on testicular torsion/detorsion-induced ischemia-reperfusion injury in rats. Experimental and Molecular Pathology 89: 314-320.
28. Kerr JB, (1992) Spontaneous degeneration of germ cells in normal rat testes: assessment of cell types and frequency during the spermatogenic cycle. Journal of Reproduction and Fertility 95: 825-830.
29. Kim YJ, Chung JY, Lee SG, Kim JY, Park JE, Kim WR, et al. (2011) Arsenic trioxide-induced apoptosis in TM4 Sertoli cells: the potential involvement of p21 expression and p53 phosphorylation. Toxicology 285: 142-151.
30. Kus I, Akpolat N, Ozen OA, Songur A, Kavakli A, Sarsilmaz M, (2002) Effects of melatonin on Leydig cells in pinealectomized rat: an immunohistochemical study. Acta Histochemica 104: 93-97.
31. Kus I, Sarsilmaz M, Ogeturk M, Yilmaz B, Kelestimur H, Oner H, (2000) Ultrastructural interrelationship between the pineal gland and the testis in the male rat. Archives of Andrology 45: 119-124.
32. Longoni B, Salgo MG, Pryor WA, Marchiafava PL, (1998) Effects of melatonin on lipid peroxidation induced by oxygen radicals. Life Sciences 62: 853-859.
33. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ, (1951) Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 193: 265-275.
34. Manna P, Sinha M, Sil PC, (2008) Protection of arsenic-induced testicular oxidative stress by arjunolic acid. Redox Report 13: 67-77.
35. Miller WH Jr, Schipper HM, Lee JS, Singer J, Waxman S, (2002) Mechanisms of action of arsenic trioxide. Cancer Research 62: 3893-3903.
36. Momeni HR, Oryan S, Eskandari N, (2012) Effect of vitamin E on sperm number and testis histopathology of sodium arsenite-treated rats. Reproductive Biology 12: 171-181.
37. Navas-Acien A, Sharrett AR, Silbergeld EK, Schwartz BS, Nachman KE, Burke TA, et al. (2005) Arsenic exposure and cardiovascular disease: a systematic review of the epidemiologic evidence. American Journal of Epidemiology 162: 1037-1049.
38. Ozen OA, Kus MA, Kus I, Alkoc OA, Songur A, (2008) Protective effects of melatonin against formaldehyde-induced oxidative damage and apoptosis in rat testes: an immunohistochemical and biochemical study. Systems Biology in Reproductive Medicine 54: 169-176.
39. Paglia DE, Valentine WN, (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. Journal of Laboratory and Clinical Medicine 70: 158-169.
40. Pant N, Murthy RC, Srivastava SP, (2004) Male reproductive toxicity of sodium arsenite in mice. Human and Experimental Toxicology 23: 399-403.
41. Patrick L, (2003) Toxic metals and antioxidants: Part II. The role of antioxidants in arsenic and cadmium toxicity. Alternative Medicine Review 8: 106-128.
42. Ramanathan K, Shila S, Kumaran S, Panneerselvam C, (2003) Protective role of ascorbic acid and alpha-tocopherol on arsenic-induced microsomal dysfunctions. Human and Experimental Toxicology 22: 129-136.
43. Reddy PS, Rani GP, Sainath SB, Meena R, Supriya C, (2011) Protective effects of N-acetylcysteine against arsenic-induced oxidative stress and reprotoxicity in male mice. Journal of Trace Elements in Medicine and Biology 25: 247-253.
44. Reiter RJ, Tan DX, Osuna C, Gitto E, (2000) Actions of melatonin in the reduction of oxidative stress. A review. Journal of Biomedical Science 7: 444-458.
45. Sanghamitra S, Hazra J, Upadhyay SN, Singh RK, Amal RC, (2008) Arsenic induced toxicity on testicular tissue of mice. Indian Journal of Physiology and Pharmacology 52: 84-90.
46. Sarkar M, Chaudhuri GR, Chattopadhyay A, Biswas NM, (2003) Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats. Asian Journal of Andrology 5: 27-31.
47. Sun Y, Oberley LW, Li Y, (1988) A simple method for clinical assay of superoxide dismutase. Clinical Chemistry 34: 497-500.
48. Tas U, Ogeturk M, Meydan S, Kus I, Kuloglu T, Ilhan N, et al. (2011) Hepatotoxic activity of toluene inhalation and protective role of melatonin. Toxicology and Industrial Health 27: 465-473.
49. Vahidnia A, van der Voet GB, de Wolff FA, (2007) Arsenic neurotoxicity: a review. Human and Experimental Toxicology 26: 823-832.
50. Vaux DL, Flavell RA, (2000) Apoptosis genes and autoimmunity. Current Opinion in Immunology 12: 719-724.
51. Wu MM, Chiou HY, Wang TW, Hsueh YM, Wang IH, Chen CJ, et al. (2001) Association of blood arsenic levels with increased reactive oxidants and decreased antioxidant capacity in a human population of northeastern Taiwan. Environmental Health Perspectives 109: 1011-1017.
52. Yamanaka K, Hasegawa A, Sawamura R, Okada S, (1991) Cellular response to oxidative damage in lung induced by the administration of dimethylarsinic acid, a major metabolite of inorganic arsenics, in mice. Toxicology and Applied Pharmacology 108: 205-213.
53. Zararsiz I, Kus I, Ogeturk M, Akpolat N, Kose E, Meydan S, et al. (2007) Melatonin prevents formaldehyde-induced neurotoxicity in prefrontal cortex of rats: an immunohistochemical and biochemical study. Cell Biochemistry and Function 25: 413-418.