메뉴 건너뛰기




Volumn 108, Issue 7, 2016, Pages

Veliparib alone or in combination with mitomycin C in patients with solid tumors with functional deficiency in homologous recombination repair

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CARBOPLATIN; DOXORUBICIN; FANCONI ANEMIA GROUP C PROTEIN; FANCONI ANEMIA GROUP D2 PROTEIN; HISTONE H2AX; MITOMYCIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PACLITAXEL; VELIPARIB; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR;

EID: 84968720519     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/djv437     Document Type: Article
Times cited : (24)

References (58)
  • 1
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    • Bryant HE, Schultz N, Thomas HD, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature. 2005;434(7035):913-917.
    • (2005) Nature. , vol.434 , Issue.7035 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3
  • 2
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H, McCabe N, Lord CJ, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 2005;434(7035):917-921.
    • (2005) Nature. , vol.434 , Issue.7035 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3
  • 3
    • 68149161777 scopus 로고    scopus 로고
    • Phase II trial of the oral PARP inhibitor olaparib in BRCA-deficient advanced breast cancer
    • Ab str CRA501)
    • Tutt A, Robson M, Garber J, et al. Phase II trial of the oral PARP inhibitor olaparib in BRCA-deficient advanced breast cancer. J Clin Oncol. 2009;27(Suppl;Ab str CRA501):18s.
    • (2009) J Clin Oncol. , vol.27 , pp. 18s
    • Tutt, A.1    Robson, M.2    Garber, J.3
  • 4
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong P, Boss D, Yap T, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med. 2009;361(2):123-134.
    • (2009) N Engl J Med. , vol.361 , Issue.2 , pp. 123-134
    • Fong, P.1    Boss, D.2    Yap, T.3
  • 5
    • 77955039099 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
    • Audeh W, Carmichael J, Penson RT, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet. 2010;376(9737):245-251.
    • (2010) Lancet. , vol.376 , Issue.9737 , pp. 245-251
    • Audeh, W.1    Carmichael, J.2    Penson, R.T.3
  • 6
    • 0037214260 scopus 로고    scopus 로고
    • Genetic basis of Fanconi anemia
    • Bagby GC Jr. Genetic basis of Fanconi anemia. Curr Opin Hematol. 2003;10(1):68-76.
    • (2003) Curr Opin Hematol. , vol.10 , Issue.1 , pp. 68-76
    • Bagby, G.C.1
  • 7
  • 8
    • 33846569450 scopus 로고    scopus 로고
    • Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer
    • Reid S, Schindler D, Hanenberg H, et al. Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer. Nat Genet. 2007;39(2):162-164.
    • (2007) Nat Genet. , vol.39 , Issue.2 , pp. 162-164
    • Reid, S.1    Schindler, D.2    Hanenberg, H.3
  • 9
    • 33846601829 scopus 로고    scopus 로고
    • Fanconi anemia is associated with a defect in the BRCA2 partner PALB2
    • Xia B, Dorsman JC, Ameziane N, et al. Fanconi anemia is associated with a defect in the BRCA2 partner PALB2. Nat Genet. 2007;39(2):159-161.
    • (2007) Nat Genet. , vol.39 , Issue.2 , pp. 159-161
    • Xia, B.1    Dorsman, J.C.2    Ameziane, N.3
  • 10
    • 34247110291 scopus 로고    scopus 로고
    • Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair
    • Smogorzewska A, Matsuoka S, Vinciguerra P, et al. Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell. 2007;129(2):289-301.
    • (2007) Cell. , vol.129 , Issue.2 , pp. 289-301
    • Smogorzewska, A.1    Matsuoka, S.2    Vinciguerra, P.3
  • 11
    • 79251632658 scopus 로고    scopus 로고
    • SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype
    • Kim Y, Lach FP, Desetty R, et al. SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. Nat Genet. 2011;43:138-141.
    • (2011) Nat Genet. , vol.43 , pp. 138-141
    • Kim, Y.1    Lach, F.P.2    Desetty, R.3
  • 12
    • 77951747926 scopus 로고    scopus 로고
    • Mutation of the RAD51C gene in a Fanconi anemia-like disorder
    • Vaz F, Hanenberg H, Schuster B, et al. Mutation of the RAD51C gene in a Fanconi anemia-like disorder. Nat Genet. 2010;42:406-409.
    • (2010) Nat Genet. , vol.42 , pp. 406-409
    • Vaz, F.1    Hanenberg, H.2    Schuster, B.3
  • 13
    • 33746957852 scopus 로고    scopus 로고
    • UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation
    • Machida YJ, Machida Y, Chen Y, et al. UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. Mol Cell. 2006;23(4): 589-596.
    • (2006) Mol Cell. , vol.23 , Issue.4 , pp. 589-596
    • Machida, Y.J.1    Machida, Y.2    Chen, Y.3
  • 14
    • 2942664480 scopus 로고    scopus 로고
    • FANCL replaces BRCA1 as the likely ubiquitin ligase responsible for FANCD2 monoubiquitination
    • Meetei AR, Yan Z, Wang W. FANCL replaces BRCA1 as the likely ubiquitin ligase responsible for FANCD2 monoubiquitination. Cell Cycle. 2004;3(2): 179-181.
    • (2004) Cell Cycle. , vol.3 , Issue.2 , pp. 179-181
    • Meetei, A.R.1    Yan, Z.2    Wang, W.3
  • 15
    • 34249857115 scopus 로고    scopus 로고
    • Analysis of PALB2/FANCNassociated breast cancer families
    • Tischkowitz M, Xia B, Sabbaghian N, et al. Analysis of PALB2/FANCNassociated breast cancer families. Proc Natl Acad Sci U S A. 2007;104(16): 6788-6793.
    • (2007) Proc Natl Acad Sci U S A. , vol.104 , Issue.16 , pp. 6788-6793
    • Tischkowitz, M.1    Xia, B.2    Sabbaghian, N.3
  • 16
    • 0035105291 scopus 로고    scopus 로고
    • Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway
    • Garcia-Higuera I, Taniguchi T, Ganesan S, et al. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol Cell. 2000;7(2):249-262.
    • (2000) Mol Cell. , vol.7 , Issue.2 , pp. 249-262
    • Garcia-Higuera, I.1    Taniguchi, T.2    Ganesan, S.3
  • 17
    • 79251632658 scopus 로고    scopus 로고
    • SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype
    • Stoepker C, Hain K, Schuster B, et al. SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. Nat Genet. 2011;43:138-141.
    • (2011) Nat Genet. , vol.43 , pp. 138-141
    • Stoepker, C.1    Hain, K.2    Schuster, B.3
  • 18
    • 84877584276 scopus 로고    scopus 로고
    • Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia
    • Bogliolo M, Schuster B, Stoepker C, et al. Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia. Am J Hum Genet. 2013;92(5):800-806.
    • (2013) Am J Hum Genet. , vol.92 , Issue.5 , pp. 800-806
    • Bogliolo, M.1    Schuster, B.2    Stoepker, C.3
  • 19
    • 84926505383 scopus 로고    scopus 로고
    • Biallelic mutations in BRCA1 cause a new Fanconi Anemia subtype
    • Sawyer SL, Tian L, Kken M, et al. Biallelic mutations in BRCA1 cause a new Fanconi Anemia subtype. Cancer Discov. 2015;5(2):135-142.
    • (2015) Cancer Discov. , vol.5 , Issue.2 , pp. 135-142
    • Sawyer, S.L.1    Tian, L.2    Kken, M.3
  • 21
    • 0024543636 scopus 로고
    • International fanconi anemia registry: Relation of clinical symptoms to diepoxybutane sensitivity
    • Auerbach AD, Rogatko A, Schroeder-Kurth TM. International Fanconi Anemia Registry: relation of clinical symptoms to diepoxybutane sensitivity. Blood. 1989;73(2):391-396.
    • (1989) Blood. , vol.73 , Issue.2 , pp. 391-396
    • Auerbach, A.D.1    Rogatko, A.2    Schroeder-Kurth, T.M.3
  • 22
    • 84859640659 scopus 로고    scopus 로고
    • Cancer in fanconi anemia 1927-2001
    • Alter BP. Cancer in Fanconi anemia, 1927-2001. Blood. 2003;101(5):2072.
    • (2003) Blood. , vol.101 , Issue.5 , pp. 2072
    • Alter, B.P.1
  • 23
    • 67349107395 scopus 로고    scopus 로고
    • Cellular and molecular consequences of defective fanconi anemia proteins in replication-coupled DNA repair: Mechanistic insights
    • Thompson LH, Hinz JM. Cellular and molecular consequences of defective fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights. Mutational Res. 2009;668:54-72.
    • (2009) Mutational Res. , vol.668 , pp. 54-72
    • Thompson, L.H.1    Hinz, J.M.2
  • 24
    • 30144439816 scopus 로고    scopus 로고
    • Disruption of the fanconi anemia/BRCA pathway in sporadic cancer
    • Lyakhovich A, Surralles J. Disruption of the Fanconi anemia/BRCA pathway in sporadic cancer. Cancer Lett. 2006;232(1):99-106.
    • (2006) Cancer Lett. , vol.232 , Issue.1 , pp. 99-106
    • Lyakhovich, A.1    Surralles, J.2
  • 25
    • 36248949158 scopus 로고    scopus 로고
    • Disruption of the FA/BRCA pathway in bladder cancer
    • Neveling K, Kalb R, Florl AR, et al. Disruption of the FA/BRCA pathway in bladder cancer. Cytogenet Genome Res. 2007;118(2-4):166-176.
    • (2007) Cytogenet Genome Res. , vol.118 , Issue.2-4 , pp. 166-176
    • Neveling, K.1    Kalb, R.2    Florl, A.R.3
  • 26
    • 0038075462 scopus 로고    scopus 로고
    • Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors
    • Taniguchi T, Tischkowitz M, Ameziane N, et al. Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors. Nat Med. 2003;9(5):568-574.
    • (2003) Nat Med. , vol.9 , Issue.5 , pp. 568-574
    • Taniguchi, T.1    Tischkowitz, M.2    Ameziane, N.3
  • 27
    • 33846978430 scopus 로고    scopus 로고
    • Altered expression of FANCL confers mitomycin C sensitivity in Calu-6 lung cancer cells
    • Zhang J, Wang X, Lin CJ, Couch FJ, Fei P. Altered expression of FANCL confers mitomycin C sensitivity in Calu-6 lung cancer cells. Cancer Biol Ther. 2006;5(12):1632-1636.
    • (2006) Cancer Biol Ther. , vol.5 , Issue.12 , pp. 1632-1636
    • Zhang, J.1    Wang, X.2    Lin, C.J.3    Couch, F.J.4    Fei, P.5
  • 28
    • 27144532118 scopus 로고    scopus 로고
    • In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor
    • van der Heijden MS, Brody JR, Dezentje DA, et al. In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor. Clin Cancer Res. 2005;11(20):7508-7515.
    • (2005) Clin Cancer Res. , vol.11 , Issue.20 , pp. 7508-7515
    • Van Der Heijden, M.S.1    Brody, J.R.2    Dezentje, D.A.3
  • 29
    • 84912034737 scopus 로고    scopus 로고
    • Evidence for clinical efficacy of mitomycin C in heavily pretreated ovarian cancer patients carrying germ-line BRCA1 mutation
    • Moiseyenko VM, Chubenko VA, Moiseyenko FV, et al. Evidence for clinical efficacy of mitomycin C in heavily pretreated ovarian cancer patients carrying germ-line BRCA1 mutation. Med Oncol. 2014;31(10):199.
    • (2014) Med Oncol. , vol.31 , Issue.10 , pp. 199
    • Moiseyenko, V.M.1    Chubenko, V.A.2    Moiseyenko, F.V.3
  • 30
    • 79961228580 scopus 로고    scopus 로고
    • Complete remission, in BRCA2 mutation carrier with metastatic pancreatic adenocarcinoma, treated with cisplatin based therapy
    • Sonnenblick A, Kadouri L, Appelbaum L, et al. Complete remission, in BRCA2 mutation carrier with metastatic pancreatic adenocarcinoma, treated with cisplatin based therapy.Cancer Biol Ther. 2011;12(3):165-168.
    • (2011) Cancer Biol Ther. , vol.12 , Issue.3 , pp. 165-168
    • Sonnenblick, A.1    Kadouri, L.2    Appelbaum, L.3
  • 31
    • 84934291165 scopus 로고    scopus 로고
    • The TNT trial: A randomized phase III trial of carboplatin (C) compared with docetaxel (D) for patients with metastatic or recurrent locally advanced triple negative or BRCA1/2 breast cancer (CRUK/07/012)
    • S3-S01
    • Tutt A, Ellis P, Kilburn L, et al. The TNT trial: A randomized phase III trial of carboplatin (C) compared with docetaxel (D) for patients with metastatic or recurrent locally advanced triple negative or BRCA1/2 breast cancer (CRUK/07/012). San Antonio Breast Cancer Symposium 2014;S3-S01.
    • (2014) San Antonio Breast Cancer Symposium
    • Tutt, A.1    Ellis, P.2    Kilburn, L.3
  • 32
    • 84873888067 scopus 로고    scopus 로고
    • Assesment of FANCD2 nuclear foci formation in paraffin embedded tumors: A potential patient enrichment strategy for treatment with DNA interstrand crosslink agents
    • Duan W, Gao L, Zhao W, et al. Assesment of FANCD2 nuclear foci formation in paraffin embedded tumors: a potential patient enrichment strategy for treatment with DNA interstrand crosslink agents. Transl Res. 2013;161(3): 156-164.
    • (2013) Transl Res. , vol.161 , Issue.3 , pp. 156-164
    • Duan, W.1    Gao, L.2    Zhao, W.3
  • 34
    • 66849106010 scopus 로고    scopus 로고
    • Phase 0 clinical trial of the poly (ADP-ribose) polymerase inhibitor ABT-888 in patients with advanced malignancies
    • Kummar S, Kinders R, Gutierrez ME, et al. Phase 0 clinical trial of the poly (ADP-ribose) polymerase inhibitor ABT-888 in patients with advanced malignancies. J Clin Oncol. 2009;27(16):2705-2711.
    • (2009) J Clin Oncol. , vol.27 , Issue.16 , pp. 2705-2711
    • Kummar, S.1    Kinders, R.2    Gutierrez, M.E.3
  • 35
    • 77956686608 scopus 로고    scopus 로고
    • Histone γh2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers
    • Redon C, Nakamura A, Zhang Y, et al. Histone γH2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic Biomarkers. Clin Cancer Res. 2010;16:4532.
    • (2010) Clin Cancer Res. , vol.16 , pp. 4532
    • Redon, C.1    Nakamura, A.2    Zhang, Y.3
  • 36
    • 84937128011 scopus 로고    scopus 로고
    • Genomic characterization of nonsmall cell lung cancer in African Americans by targeted massively parallel sequencing
    • Araujo L, Timmers CD, Hlavin-Bell E, et al. Genomic characterization of nonsmall cell lung cancer in African Americans by targeted massively parallel sequencing. J Clin Oncol. 2015;33(17):1966-1973.
    • (2015) J Clin Oncol. , vol.33 , Issue.17 , pp. 1966-1973
    • Araujo, L.1    Timmers, C.D.2    Hlavin-Bell, E.3
  • 37
    • 57849117384 scopus 로고    scopus 로고
    • New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
    • Eisenhauer E, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009;45:228-247.
    • (2009) Eur J Cancer. , vol.45 , pp. 228-247
    • Eisenhauer, E.1    Therasse, P.2    Bogaerts, J.3
  • 38
    • 33746036112 scopus 로고    scopus 로고
    • Consensus recommendations for the use of 18F-FDG PET as an indicator of therapeutic response in patients in national cancer institute trials
    • Shankar LK, Hoffman JM, Bacharach S, et al. Consensus recommendations for the use of 18F-FDG PET as an indicator of therapeutic response in patients in National Cancer Institute Trials. J Nucl Med. 2006;47:1059-1066.
    • (2006) J Nucl Med. , vol.47 , pp. 1059-1066
    • Shankar, L.K.1    Hoffman, J.M.2    Bacharach, S.3
  • 39
    • 77951720395 scopus 로고    scopus 로고
    • Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
    • Meindl A, Hellebrand H, Wiek C, et al. Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. Nat Genet. 2010;42(5):410-414.
    • (2010) Nat Genet. , vol.42 , Issue.5 , pp. 410-414
    • Meindl, A.1    Hellebrand, H.2    Wiek, C.3
  • 40
    • 79953715693 scopus 로고    scopus 로고
    • Improving the assessment of the outcome of nonsynonymous SNVs with a consensus deleteriousness score, condel
    • Gonzez-Pez A, Lez-Bigas N. Improving the Assessment of the Outcome of Nonsynonymous SNVs with a Consensus Deleteriousness Score, Condel. Am J Hum Genet. 2011;88:440-449.
    • (2011) Am J Hum Genet. , vol.88 , pp. 440-449
    • Gonzez-Pez, A.1    Lez-Bigas, N.2
  • 41
    • 84868221110 scopus 로고    scopus 로고
    • Trapping of PARP1 and PARP2 by clinical PARP inhibitors
    • Murai J, Huang SY, Das BB, et al. Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors. Cancer Res. 2012;72(21):5588-5599.
    • (2012) Cancer Res. , vol.72 , Issue.21 , pp. 5588-5599
    • Murai, J.1    Huang, S.Y.2    Das, B.B.3
  • 42
    • 84894121635 scopus 로고    scopus 로고
    • Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib
    • Murai J, Huang SY, Renaud A, et al. Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib. Mol Cancer Ther. 2014;13(2):433-443.
    • (2014) Mol Cancer Ther. , vol.13 , Issue.2 , pp. 433-443
    • Murai, J.1    Huang, S.Y.2    Renaud, A.3
  • 43
    • 84887431012 scopus 로고    scopus 로고
    • Mechanisms of resistance to therapies targeting BRCAmutant cancers
    • Lord CJ, Ashworth A. Mechanisms of resistance to therapies targeting BRCAmutant cancers. Nat Med. 2013;19(11):1381-1388.
    • (2013) Nat Med. , vol.19 , Issue.11 , pp. 1381-1388
    • Lord, C.J.1    Ashworth, A.2
  • 44
    • 42349096328 scopus 로고    scopus 로고
    • Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance
    • Swisher EM, Sakai W, Karlan BY, Wurz K, Urban N, Taniguchi T. Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance. Cancer Res. 2008;68(8):2581-2586.
    • (2008) Cancer Res. , vol.68 , Issue.8 , pp. 2581-2586
    • Swisher, E.M.1    Sakai, W.2    Karlan, B.Y.3    Wurz, K.4    Urban, N.5    Taniguchi, T.6
  • 45
    • 80051642095 scopus 로고    scopus 로고
    • Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas
    • Norquist B, Wurz KA, Pennil CC, et al. Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas. J Clin Oncol. 2011;29(22):3008-3015.
    • (2011) J Clin Oncol. , vol.29 , Issue.22 , pp. 3008-3015
    • Norquist, B.1    Wurz, K.A.2    Pennil, C.C.3
  • 46
    • 84872971914 scopus 로고    scopus 로고
    • Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor
    • Barber LJ, Sandhu S, Chen L, et al. Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor. J Pathol. 2013;229(3):422-429.
    • (2013) J Pathol. , vol.229 , Issue.3 , pp. 422-429
    • Barber, L.J.1    Sandhu, S.2    Chen, L.3
  • 47
    • 68949221567 scopus 로고    scopus 로고
    • A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency
    • Cao L, Xu X, Bunting SF, et al. A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell. 2009;35(4):534-541.
    • (2009) Mol Cell. , vol.35 , Issue.4 , pp. 534-541
    • Cao, L.1    Xu, X.2    Bunting, S.F.3
  • 48
    • 77953291328 scopus 로고    scopus 로고
    • 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
    • Bouwman P, Aly A, Escandell JM, et al. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol. 2010;17(6):688-695.
    • (2010) Nat Struct Mol Biol. , vol.17 , Issue.6 , pp. 688-695
    • Bouwman, P.1    Aly, A.2    Escandell, J.M.3
  • 49
    • 61449182121 scopus 로고    scopus 로고
    • Principles of cancer therapy: Oncogene and non-oncogene addiction
    • Luo J, Somilini NL, Elledge SJ. Principles of cancer therapy: Oncogene and non-oncogene addiction. Cell. 2009;136:823-837.
    • (2009) Cell. , vol.136 , pp. 823-837
    • Luo, J.1    Somilini, N.L.2    Elledge, S.J.3
  • 50
    • 41349102391 scopus 로고    scopus 로고
    • Evolutionary plasticity of genetic interaction networks
    • Tischler J, Lehner B, Frazer AG. Evolutionary plasticity of genetic interaction networks. Nat Gen. 2008;40:390-391.
    • (2008) Nat Gen. , vol.40 , pp. 390-391
    • Tischler, J.1    Lehner, B.2    Frazer, A.G.3
  • 51
    • 84866559001 scopus 로고    scopus 로고
    • Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib
    • Daemen A, Wolf DM, Korkola JE, et al. Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib. Breast Cancer Res Treat. 2012;135(2):505-517.
    • (2012) Breast Cancer Res Treat. , vol.135 , Issue.2 , pp. 505-517
    • Daemen, A.1    Wolf, D.M.2    Korkola, J.E.3
  • 52
    • 84879286238 scopus 로고    scopus 로고
    • Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer
    • Ihnen M, zu Eulenburg C, Kolarova T, et al. Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer. Mol Cancer Ther. 2013;12(6):1002-1015.
    • (2013) Mol Cancer Ther. , vol.12 , Issue.6 , pp. 1002-1015
    • Ihnen, M.1    Zu Eulenburg, C.2    Kolarova, T.3
  • 53
    • 84901664854 scopus 로고    scopus 로고
    • Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers
    • Watkins JA, Irshad S, Grigoriadis A, Tutt AN. Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers. Breast Cancer Res. 2014;3;16(3):211.
    • (2014) Breast Cancer Res. , vol.3-16 , Issue.3 , pp. 211
    • Watkins, J.A.1    Irshad, S.2    Grigoriadis, A.3    Tutt, A.N.4
  • 54
    • 84979268929 scopus 로고    scopus 로고
    • Evaluation of an in vitro derived signature of olaparib response (PARPi-7) as a predictive biomarker of response to veliparib/ carboplatin plus standard neoadjuvant therapy in high risk breast ccer: Results from the I-SPY 2 Trial
    • Wolf DM, Yau C, Sanil A, et al. Evaluation of an in vitro derived signature of olaparib response (PARPi-7) as a predictive biomarker of response to veliparib/ carboplatin plus standard neoadjuvant therapy in high risk breast ccer: Results from the I-SPY 2 Trial. San Antonio Breast Cancer Symposium. 2014;P3-06-05.
    • (2014) San Antonio Breast Cancer Symposium. , pp. P306-P405
    • Wolf, D.M.1    Yau, C.2    Sanil, A.3
  • 55
    • 84884576079 scopus 로고    scopus 로고
    • BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency
    • Shen Y, Rehman FL, Feng Y, et al. BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency. Clin Cancer Res. 2013;19(18):5003-5015.
    • (2013) Clin Cancer Res. , vol.19 , Issue.18 , pp. 5003-5015
    • Shen, Y.1    Rehman, F.L.2    Feng, Y.3
  • 56
    • 84979225708 scopus 로고    scopus 로고
    • First-in-human trial of novel oral PARP inhibitor BMN 673 in patients with solid tumors
    • Abstr 2580
    • First-in-human trial of novel oral PARP inhibitor BMN 673 in patients with solid tumors. J Clin Oncol Suppl. 2013;31:Abstr 2580.
    • (2013) J Clin Oncol Suppl. , vol.31
  • 57
    • 33748065304 scopus 로고    scopus 로고
    • Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition
    • McCabe N, Turner NC, Lord CJ, et al. Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. Cancer Res. 2006;66(16):8109-8115.
    • (2006) Cancer Res. , vol.66 , Issue.16 , pp. 8109-8115
    • McCabe, N.1    Turner, N.C.2    Lord, C.J.3
  • 58
    • 84893470371 scopus 로고    scopus 로고
    • Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas
    • Pennington KP, Walsh T, Harell MI, et al. Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas. Clin Cancer Res. 2014;20(3):764-775.
    • (2014) Clin Cancer Res. , vol.20 , Issue.3 , pp. 764-775
    • Pennington, K.P.1    Walsh, T.2    Harell, M.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.