An exploratory study evaluating the effects of macular carotenoid supplementation in various retinal diseases

Clinical Ophthalmology

Volumn 10, Issue , 2016, Pages 835-844

  Crosby Nwaobi, Roxanne ^a   Hykin, Philip ^a   Peto, Tunde ^a   Sivaprasad, Sobha ^a  

^a Moorfields NIHR Ophthalmology Biomedical Research Centre   (United Kingdom)

Author keywords

Age related macular degeneration; Central serous retinopathy; Diabetes; Macular pigment optical density

Indexed keywords

CAROTENOID; LUTEIN PLUS ZEAXANTHIN; UNCLASSIFIED DRUG; VISUAL PIGMENT;

ADULT; ARTICLE; AUTOFLUORESCENCE; CLINICAL EVALUATION; CLINICAL TRIAL (TOPIC); DRUG SAFETY; EXPLORATORY RESEARCH; EYE EXAMINATION; FEMALE; FOOD FREQUENCY QUESTIONNAIRE; GLARE; HETEROCHROMATIN; HUMAN; MAJOR CLINICAL STUDY; MALE; NATIONAL EYE INSTITUTE VISUAL FUNCTION QUESTIONNAIRE; OPTICAL COHERENCE TOMOGRAPHY; PATIENT COMPLIANCE; PHOTOMETRY; QUALITY OF LIFE ASSESSMENT; RETINA DISEASE; SUPPLEMENTATION; TREATMENT DURATION; TREATMENT OUTCOME; VISION; VISUAL DISCRIMINATION;

EID: 84968572497     PISSN: 11775467     EISSN: 11775483     Source Type: Journal    
DOI: 10.2147/OPTH.S102798     Document Type: Article

References (41)

1. Loughman J, Nolan JM, Howard AN, Connolly E, Meagher K, Beatty S. The impact of macular pigment augmentation on visual performance using different carotenoid formulations. Invest Ophthalmol Vis Sci. 2012; 53(12):7871–7880.
2. Subczynski WK, Wisniewska A, Widomska J. Location of macular xanthophylls in the most vulnerable regions of photoreceptor outer-segment membranes. Arch Biochem Biophys. 2010;504(1):61–66.
3. Lien EL, Hammond BR. Nutritional influences on visual development and function. Prog Retin Eye Res. 2011;30(3):188–203.
4. Beatty S, Koh H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol. 2000;45(2):115–134.
5. Kowluru RA, Kowluru A, Mishra M, Kumar B. Oxidative stress and epigenetic modifications in the pathogenesis of diabetic retinopathy. Prog Retin Eye Res. 2015;48:40–61.
6. Nolan JM, Beatty S, Meagher KA, Howarth PA, Kelly D, Thurnham DI. Verification of meso-zeaxanthin in Fish. J Food Process Technol. 2014; 5(6):335.
7. Maoka T, Arai A, Shimizu M, Matsuno T. The first isolation of enantio-meric and meso-zeaxanthin in nature. Comp Biochem Physiol B. 1986; 83(1):121–124.
8. Bone RA, Landrum JT, Fernandez L, Tarsis SL. Analysis of the macular pigment by HPLC: Retinal distribution and age study. Invest Ophthalmol Vis Sci. 1988;29(6):843–849.
9. Johnson EJ, Neuringer M, Russell RM, Schalch W, Snodderly DM. Nutritional manipulation of primate retinas, III: Effects of lutein or zeaxanthin supplementation on adipose tissue and retina of xanthophyll-free monkeys. Invest Ophthalmol Vis Sci. 2005;46(2):692–702.
10. Nolan JM, Meagher K, Kashani S, Beatty S. What is meso-zeaxanthin, and where does it come from? Eye (Lond). 2013;27(8):899–905.
11. Trieschmann M, Beatty S, Nolan JM, et al. Changes in macular pigment optical density and serum concentrations of its constituent carotenoids following supplemental lutein and zeaxanthin: the LUNA study. Exp Eye Res. 2007;84(4):718–728.
12. Mares JA, LaRowe TL, Snodderly DM, et al; CAREDS Macular Pigment Study Group and Investigators. Predictors of optical density of lutein and zeaxanthin in retinas of older women in the carotenoids in age-related eye disease study, an ancillary study of the women’s health initiative. Am J Clin Nutr. 2006;84(5):1107–1122.
13. Howells O, Eperjesi F, Bartlett H. Measuring macular pigment optical density in vivo: A review of techniques. Graefes Arch Clin Exp Ophthalmol. 2011;249(3):315–347.
14. Bartlett H, Acton J, Eperjesi F. Clinical evaluation of the MacuScope macular pigment densitometer. Br J Ophthalmol. 2010;94(3):328–331.
15. Gallaher KT, Mura M, Todd WA, et al; Health ABC Study. Estimation of macular pigment optical density in the elderly: test-retest variability and effect of optical blur in pseudophakic subjects. Vision Res. 2007; 47(9):1253–1259.
16. Robson AG, Moreland JD, Pauleikhoff D, et al. Macular pigment density and distribution: comparison of fundus autofluorescence with minimum motion photometry. Vision Res. 2003;43(16):1765–1775.
17. Degli Esposti S, Egan C, Bunce C, Moreland JD, Bird AC, Robson AG. Macular pigment parameters in patients with macular telangiectasia (MacTel) and normal subjects: implications of a novel analysis. Invest Ophthalmol Vis Sci. 2012;53(10):6568–6575.
18. Bone RA, Landrum JT, Gibert JC. Macular pigment and the edge hypothesis of flicker photometry. Vision Res. 2004;44(26):3045–3051.
19. Hammond BR Jr, Fletcher LM, Elliott JG. Glare disability, photostress recovery, and chromatic contrast: Relation to macular pigment and serum lutein and zeaxanthin. Invest Ophthalmol Vis Sci. 2013;54(1): 476–481.
20. Mangione CM, Lee PP, Gutierrez PR, et al; National Eye Institute Visual Function Questionnaire Field Test Investigators. Development of the 25-item National Eye Institute visual function questionnaire. Arch Ophthalmol. 2001;119(7):1050–1058.
21. Rabin R, De Charro F. EQ-5D: A measure of health status from the EuroQol group. Ann Med. 2001;33(5):337–343.
22. Nolan JM, Akkali MC, Loughman J, Howard AN, Beatty S. Macular carotenoid supplementation in subjects with atypical profiles of macular pigment. Exp Eye Res. 2012;101:9–15.
23. Canovas R, Lima VC, Garcia P, Morini C, Prata TS, Rosen RB. Comparison between macular pigment optical density measurements using two-wavelength autofluorescence and heterochromatic flicker photometry techniques. Invest Ophthalmol Vis Sci. 2010;51(6): 3152–3156.
24. Gong X, Rubin LP. Role of macular xanthophylls in prevention of common neovascular retinopathies: retinopathy of prematurity and diabetic retinopathy. Arch Biochem Biophys. 2015;572:40–48.
25. Liu R, Wang T, Zhang B, et al. Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2014;56(1):252–258.
26. Sabour-Pickett S, Beatty S, Connolly E, et al. Supplementation with three different macular carotenoid formulations in patients with early age-related macular degeneration. Retina. 2014;34(9):1757–1766.
27. Sasamoto Y, Gomi F, Sawa M, Tsujikawa M, Nishida K. Effect of 1-year lutein supplementation on macular pigment optical density and visual function. Graefes Arch Clin Exp Ophthalmol. 2011;249(12): 1847–1854.
28. Zeimer M, Dietzel M, Hense HW, Heimes B, Austermann U, Pauleikhoff D. Profiles of macular pigment optical density and their changes following supplemental lutein and zeaxanthin: new results from the LUNA study. Invest Ophthalmol Vis Sci. 2012;53(8):4852–4859.
29. Li B, Vachali P, Bernstein PS. Human ocular carotenoid-binding proteins. Photochem Photobiol Sci. 2010;9:1418–1425.
30. Barker FM, Snodderly DM, Johnson EJ, et al. Nutritional manipulation of primate retinas, V: effects of lutein, zeaxanthin, and n-3 fatty acids on retinal sensitivity to blue-light-induced damage. Invest Ophthalmol Vis Sci. 2011;52:3934–3942.
31. Weigert G, Kaya S, Pemp B, et al. Effects of lutein supplementation on macular pigment optical density and visual acuity in patients with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011; 52(11):8174–8178.
32. Patel PJ, Chen FK, Rubin GS, Tufail A. Intersession repeatability of visual acuity scores in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2008;49(10):4347–4352.
33. Patel PJ, Chen FK, Rubin GS, Tufail A. Intersession repeatability of contrast sensitivity scores in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2009;50(6):2621–2625.
34. Bartlett H., Eperjesi F. Effect of lutein and antioxidant dietary supplementation on contrast sensitivity in age-related macular disease: a randomised controlled trial. Eur J Clin Nutr. 2007;61:1121–1127.
35. Piermarocchi S, Saviano S, Parisi V, et al; Carmis Study Group. Carotenoids in Age-related Maculopathy Italian Study (CARMIS): two-year results of a randomized study. Eur J Ophthalmol. 2012;22:216–225.
36. Ma L, Yan SF, Huang YM, et al. Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degeneration. Ophthalmology. 2012;119:2290–2297.
37. Pesudovs K, Gothwal VK, Wright T, Lamoureux EL. Remediating serious flaws in the National Eye Institute visual function questionnaire. J Cataract Refract Surg. 2010;36(5):718–732.
38. Bharmal M, Thomas J 3rd. Comparing the EQ-5D and the SF-6D descriptive systems to assess their ceiling effects in the US general population. Value Health. 2006;9(4):262–271.
39. Wu J, Han Y, Zhao FL, Zhou J, Chen Z, Sun H. Validation and comparison of EuroQoL-5 dimension (EQ-5D) and Short Form-6 dimension (SF-6D) among stable angina patients. Health Qual Life Outcomes. 2014; 12(1):156.
40. Owsley C, McGwin G Jr, Scilley K, Kallies K. Development of a questionnaire to assess vision problems under low luminance in age-related maculopathy. Invest Ophthalmol Vis Sci. 2006;47(2): 528–535.
41. Mangione CM, Lee PP, Gutierrez PR, Spritzer K, Berry S, Hays RD; National Eye Institute Visual Function Questionnaire Field Test Investigators. Development of the 25-item National Eye Institute Visual Function Questionnaire. Arch Ophthalmol. 2001;119(7):1050–1058.