Carotenoids in Age-related maculopathy Italian study (CARMIS): Two-year results of a randomized study

European Journal of Ophthalmology

Volumn 22, Issue 2, 2012, Pages 216-225

  Piermarocchi, Stefano ^a   Saviano, Sandro ^b   Parisi, Vincenzo ^c   Tedeschi, Massimiliano ^c   Panozzo, Giacomo ^d   Scarpa, Giuseppe ^e   Boschi, Giorgio ^e   Giudice, Giuseppe Lo ^f  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c GB Bietti Eye Foundation   (Italy)

^d Foundation 'Theia'   (Italy)

^e CA FONCELLO HOSPITAL   (Italy)

^f S ANTONIO HOSPITAL   (Italy)

Author keywords

Age related macular degeneration; Carotenoids; Lutein; Macular pigment; Zeaxanthin

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; ASTAXANTHIN; CAROTENOID; XANTHOPHYLL; ZEAXANTHIN; ZINC;

ADULT; AGED; ARTICLE; CLINICAL EVALUATION; CONTRAST SENSITIVITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; DRUG EFFICACY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NATIONAL EYE INSTITUTE VISUAL FUNCTION QUESTIONNAIRE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RETINA MACULA AGE RELATED DEGENERATION; TREATMENT DURATION; VISUAL ACUITY; VITAMIN SUPPLEMENTATION;

ADMINISTRATION, ORAL; AGED; AGED, 80 AND OVER; ANTIOXIDANTS; ASCORBIC ACID; CAROTENOIDS; CONTRAST SENSITIVITY; COPPER; DIETARY SUPPLEMENTS; FEMALE; FOLLOW-UP STUDIES; HUMANS; ITALY; LUTEIN; MACULAR DEGENERATION; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; QUESTIONNAIRES; SICKNESS IMPACT PROFILE; VISUAL ACUITY; VITAMIN E; VITAMINS; XANTHOPHYLLS; ZINC COMPOUNDS;

EID: 84857609672     PISSN: 11206721     EISSN: None     Source Type: Journal    
DOI: 10.5301/ejo.5000069     Document Type: Article

References (24)

1. Bressler NM. Age-related macular degeneration is the leading cause of blindness. JAMA 2004; 291: 1900-1.
2. Vannewkirk MR, Nanjan MB, Wang JJ, Mitchell P, Taylor HR, McCarty CA. The prevalence of age-related maculopathy: the visual impairment project. Ophthalmology 2000; 107: 1593-600.
3. Mitchell P, Smith W, Attebo K, Wang JJ. Prevalence of agerelated maculopathy in Australia: The Blue Mountains Eye Study. Ophthalmology 1995; 102: 1450-60.
4. Klein R, Klein BE, Linton KL. Prevalence of age-related maculopathy: The Beaver Dam Eye Study. Ophthalmology 1992; 99: 933-43.
5. Beatty S, Koh HH, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol 2000; 45: 115-34.
6. Eter N, Krohne TU, Holz FG. New pharmacologic approaches to therapy for age-related macular degeneration. Biodrugs 2006; 20: 167-79.
7. Gragoudas ES, Adamis AP, Cunningham ET Jr, Feinsod M, Guyer DR, VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group. Pegaptanib for neovascular age-related macular degeneration. N Engl J Med 2004; 351: 2805-16.
8. Rosenfeld PJ, Brown DM, Heier JS, et al, MARINA Study Group. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2006; 355: 1419-31.
9. Bone RA, Landrum JT, Tarsis SL. Preliminary identification of the human macular pigment. Vision Res 1985; 25: 1531-5.
10. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG. Carotenoids in the human macula and whole retina. Invest Ophthalmol Vis Sci 1988; 29: 850-5.
11. Khachik F, Bernstein PS, Garland DL. Identification of lutein and zeaxanthin oxidation products in human and monkey retinas. Invest Ophthalmol Vis Sci 1997; 38: 1802-11.
12. Bone RA, Landrum JT, Cains A. Optical density spectra of the macular pigment in vivo and in vitro. Vision Res 1992; 32: 105-10.
13. Landrum JT, Bone RA, Kilburn MD. The macular pigment: a possible role in protection from age-related macular degeneration. Adv Pharmacol 1997; 38: 537-56.
14. Sommerburg OG, Siems WG, Hurst JS, Lewis JW, Kliger DS, van Kuijk FJ. Lutein and zeaxanthin are associated with photoreceptors in the human retina. Curr Eye Res 1999; 19: 491-5.
15. Rapp LM, Maple SS, Choi JH. Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal and peripheral human retina. Invest Ophthalmol Vis Sci 2000; 41: 1200-9.
16. Bernstein PS, Zhao DY, Wintch SW, Ermakov IV, McClane RW, Gellermann W. Resonance Raman measurement of macular carotenoids in normal subjects and in age-related macular degeneration patients. Ophthalmology 2002; 109: 1780-7.
17. Seddon JM, Ajani UA, Sperduto RD, et al, Eye Disease Case-Control Study Group. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. JAMA 1994; 272: 1413-20.
18. Richer S, Stiles W, Statkute L, et al. Double-masked, placebo- controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry 2004; 75: 216-30.
19. Trieschmann M, Beatty S, Nolan JM, et al. Changes in macular pigment optical density and serum concentrations of its constituent carotenoids following supplemental lutein and zeaxanthin: the LUNA study. Exp Eye Res 2007; 84: 718-28.
20. Sangiovanni JP, Chew EY, Clemons TE, et al, Age-Related Eye Disease Study Research Group. The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. Arch Ophthalmol 2007; 125: 1225-32.
21. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 2001; 119: 1417-36.
22. Mangione CM, Lee PP, Gutierrez PR, Spritzer K, Berry S, Hays RD, National Eye Institute Visual Function Questionnaire Field Test Investigators. Development of the 25-item National Eye Institute Visual Function Questionnaire. Arch Ophthalmol 2001; 119: 1050-8.
23. Higuera-Ciapara I, Félix-Valenzuela L, Goycoolea FM. Astaxanthin: a review of its chemistry and applications. Crit Rev Food Sci Nutr 2006; 46: 185-96.
24. Hussein G, Sankawa U, Goto H, Matsumoto K, Watanabe H. Astaxanthin, a carotenoid with potential in human health and nutrition. J Nat Prod 2006; 69: 443-9.