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Volumn 9, Issue , 2016, Pages 2845-2853

Metformin induces apoptosis of human hepatocellular carcinoma HepG2 cells by activating an AMPK/p53/miR-23a/FOXA1 pathway

Author keywords

Apoptosis; FOXA1; Metformin; MiR 23a; P53

Indexed keywords

ADENYLATE KINASE; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; METFORMIN; MICRORNA; MICRORNA 23A; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 84968571741     PISSN: None     EISSN: 11786930     Source Type: Journal    
DOI: 10.2147/OTT.S99770     Document Type: Article
Times cited : (45)

References (36)
  • 1
    • 7044229778 scopus 로고    scopus 로고
    • Primary liver cancer: Worldwide incidence and trends
    • Bosch FX, Ribes J, Diaz M, Cleries R. Primary liver cancer: worldwide incidence and trends. Gastroenterology. 2004;127(5 suppl 1):S5-S16.
    • (2004) Gastroenterology , vol.127 , Issue.5 , pp. S5-S16
    • Bosch, F.X.1    Ribes, J.2    Diaz, M.3    Cleries, R.4
  • 2
    • 84943749410 scopus 로고    scopus 로고
    • Antitumor effect of metformin on cholangiocarcinoma: In vitro and in vivo studies
    • Fujimori T, Kato K, Fujihara S, et al. Antitumor effect of metformin on cholangiocarcinoma: in vitro and in vivo studies. Oncol Rep. 2015;34(6): 2987-2996.
    • (2015) Oncol Rep , vol.34 , Issue.6 , pp. 2987-2996
    • Fujimori, T.1    Kato, K.2    Fujihara, S.3
  • 3
    • 84942134312 scopus 로고    scopus 로고
    • Metformin increases sensitivity of pancreatic cancer cells to gemcitabine by reducing cd133(+) cell populations and suppressing erk/p70s6k signaling
    • Chai X, Chu H, Yang X, Meng Y, Shi P, Gou S. Metformin increases sensitivity of pancreatic cancer cells to gemcitabine by reducing CD133(+) cell populations and suppressing ERK/P70S6K signaling. Sci Rep. 2015;5:14404.
    • (2015) Sci Rep , vol.5 , pp. 14404
    • Chai, X.1    Chu, H.2    Yang, X.3    Meng, Y.4    Shi, P.5    Gou, S.6
  • 4
    • 84886419154 scopus 로고    scopus 로고
    • Prognostic significance of ampk activation and therapeutic effects of metformin in hepatocellular carcinoma
    • Zheng L, Yang W, Wu F, et al. Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma. Clin Cancer Res. 2013;19(19):5372-5380.
    • (2013) Clin Cancer Res , vol.19 , Issue.19 , pp. 5372-5380
    • Zheng, L.1    Yang, W.2    Wu, F.3
  • 5
    • 84943792809 scopus 로고    scopus 로고
    • Role of the lkb1/ampk pathway in tumor invasion and metastasis of cancer cells (review)
    • Li N, Huang D, Lu N, Luo L. Role of the LKB1/AMPK pathway in tumor invasion and metastasis of cancer cells (Review). Oncol Rep. 2015;34(6):2821-2826.
    • (2015) Oncol Rep , vol.34 , Issue.6 , pp. 2821-2826
    • Li, N.1    Huang, D.2    Lu, N.3    Luo, L.4
  • 6
    • 79551598347 scopus 로고    scopus 로고
    • Ampk and mtor regulate autophagy through direct phosphorylation of ulk1
    • Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011; 13(2):132-141.
    • (2011) Nat Cell Biol , vol.13 , Issue.2 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 7
    • 84904038165 scopus 로고    scopus 로고
    • Ampk at the nexus of energetics and aging
    • Burkewitz K, Zhang Y, Mair WB. AMPK at the nexus of energetics and aging. Cell Metab. 2014;20(1):10-25.
    • (2014) Cell Metab , vol.20 , Issue.1 , pp. 10-25
    • Burkewitz, K.1    Zhang, Y.2    Mair, W.B.3
  • 8
    • 84901463217 scopus 로고    scopus 로고
    • Metformin induces apoptosis and cell cycle arrest mediated by oxidative stress, ampk and foxo3a in mcf-7 breast cancer cells
    • Queiroz EA, Puukila S, Eichler R, et al. Metformin induces apoptosis and cell cycle arrest mediated by oxidative stress, AMPK and FOXO3a in MCF-7 breast cancer cells. PLoS One. 2014;9(5):e98207.
    • (2014) Plos One , vol.9 , Issue.5
    • Queiroz, E.A.1    Puukila, S.2    Eichler, R.3
  • 9
    • 84942032851 scopus 로고    scopus 로고
    • Metformin causes g1-phase arrest via down-regulation of mir-221 and enhances trail sensitivity through dr5 up-regulation in pancreatic cancer cells
    • Tanaka R, Tomosugi M, Horinaka M, Sowa Y, Sakai T. Metformin causes G1-phase arrest via down-regulation of MiR-221 and enhances TRAIL sensitivity through DR5 Up-regulation in pancreatic cancer cells. PLoS One. 2015;10(5):e0125779.
    • (2015) Plos One , vol.10 , Issue.5
    • Tanaka, R.1    Tomosugi, M.2    Horinaka, M.3    Sowa, Y.4    Sakai, T.5
  • 10
    • 84910050492 scopus 로고    scopus 로고
    • Metformin inhibits cell growth by upregulating microrna-26a in renal cancer cells
    • Yang FQ, Wang JJ, Yan JS, et al. Metformin inhibits cell growth by upregulating microRNA-26a in renal cancer cells. Int J Clin Exp Med. 2014;7(10):3289-3296.
    • (2014) Int J Clin Exp Med , vol.7 , Issue.10 , pp. 3289-3296
    • Yang, F.Q.1    Wang, J.J.2    Yan, J.S.3
  • 11
    • 85015475971 scopus 로고    scopus 로고
    • Metformin may function as anti-cancer agent via targeting cancer stem cells: The potential biological significance of tumor-associated mirnas in breast and pancreatic cancers
    • Bao B, Azmi AS, Ali S, Zaiem F, Sarkar FH. Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumor-associated miRNAs in breast and pancreatic cancers. Ann Transl Med. 2014;2(6):59.
    • (2014) Ann Transl Med , vol.2 , Issue.6 , pp. 59
    • Bao, B.1    Azmi, A.S.2    Ali, S.3    Zaiem, F.4    Sarkar, F.H.5
  • 12
    • 84905095337 scopus 로고    scopus 로고
    • Metformin-induced metabolic reprogramming of chemoresistant aldhbright breast cancer cells
    • Cioce M, Valerio M, Casadei L, et al. Metformin-induced metabolic reprogramming of chemoresistant ALDHbright breast cancer cells. Oncotarget. 2014;5(12):4129-4143.
    • (2014) Oncotarget , vol.5 , Issue.12 , pp. 4129-4143
    • Cioce, M.1    Valerio, M.2    Casadei, L.3
  • 13
    • 84902585445 scopus 로고    scopus 로고
    • Effect of the anti-diabetic drug metformin in hepatocellular carcinoma in vitro and in vivo
    • Miyoshi H, Kato K, Iwama H, et al. Effect of the anti-diabetic drug metformin in hepatocellular carcinoma in vitro and in vivo. Int J Oncol. 2014;45(1):322-332.
    • (2014) Int J Oncol , vol.45 , Issue.1 , pp. 322-332
    • Miyoshi, H.1    Kato, K.2    Iwama, H.3
  • 14
    • 84891353803 scopus 로고    scopus 로고
    • Mir-23a inhibits e-cadherin expression and is regulated by ap-1 and nfat4 complex during fas-induced emt in gastrointestinal cancer
    • Zheng H, Li W, Wang Y, et al. miR-23a inhibits E-cadherin expression and is regulated by AP-1 and NFAT4 complex during Fas-induced EMT in gastrointestinal cancer. Carcinogenesis. 2014;35(1):173-183.
    • (2014) Carcinogenesis , vol.35 , Issue.1 , pp. 173-183
    • Zheng, H.1    Li, W.2    Wang, Y.3
  • 15
    • 84947230968 scopus 로고    scopus 로고
    • Mir-23a and mir-27a promote human granulosa cell apoptosis by targeting smad5
    • Nie M, Yu S, Peng S, Fang Y, Wang H, Yang X. miR-23a and miR-27a promote human granulosa cell apoptosis by targeting SMAD5. Biol Reprod. 2015;93(4):98.
    • (2015) Biol Reprod , vol.93 , Issue.4 , pp. 98
    • Nie, M.1    Yu, S.2    Peng, S.3    Fang, Y.4    Wang, H.5    Yang, X.6
  • 16
    • 84904431496 scopus 로고    scopus 로고
    • Berberine-induced tumor suppressor p53 up-regulation gets involved in the regulatory network of mir-23a in hepatocellular carcinoma
    • Wang N, Zhu M, Wang X, Tan HY, Tsao SW, Feng Y. Berberine-induced tumor suppressor p53 up-regulation gets involved in the regulatory network of MIR-23a in hepatocellular carcinoma. Biochim Biophys Acta. 2014;1839(9):849-857.
    • (2014) Biochim Biophys Acta , vol.1839 , Issue.9 , pp. 849-857
    • Wang, N.1    Zhu, M.2    Wang, X.3    Tan, H.Y.4    Tsao, S.W.5    Feng, Y.6
  • 17
    • 84885000772 scopus 로고    scopus 로고
    • Mir-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma
    • Wang N, Zhu M, Tsao SW, Man K, Zhang Z, Feng Y. MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma. Mol Cancer. 2013; 12(1):119.
    • (2013) Mol Cancer , vol.12 , Issue.1 , pp. 119
    • Wang, N.1    Zhu, M.2    Tsao, S.W.3    Man, K.4    Zhang, Z.5    Feng, Y.6
  • 18
    • 33751202983 scopus 로고    scopus 로고
    • Gata-3 maintains the differentiation of the luminal cell fate in the mammary gland
    • Kouros-Mehr H, Slorach EM, Sternlicht MD, Werb Z. GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell. 2006;127(5):1041-1055.
    • (2006) Cell , vol.127 , Issue.5 , pp. 1041-1055
    • Kouros-Mehr, H.1    Slorach, E.M.2    Sternlicht, M.D.3    Werb, Z.4
  • 19
    • 84861581164 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent spop, foxa1 and med12 mutations in prostate cancer
    • Barbieri CE, Baca SC, Lawrence MS, et al. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat Genet. 2012;44(6):685-689.
    • (2012) Nat Genet , vol.44 , Issue.6 , pp. 685-689
    • Barbieri, C.E.1    Baca, S.C.2    Lawrence, M.S.3
  • 20
    • 84931027844 scopus 로고    scopus 로고
    • Microrna-212 suppresses tumor growth of human hepatocellular carcinoma by targeting foxa1
    • Dou C, Wang Y, Li C, et al. MicroRNA-212 suppresses tumor growth of human hepatocellular carcinoma by targeting FOXA1. Oncotarget. 2015;6(15):13216-13228.
    • (2015) Oncotarget , vol.6 , Issue.15 , pp. 13216-13228
    • Dou, C.1    Wang, Y.2    Li, C.3
  • 21
    • 84946414610 scopus 로고    scopus 로고
    • Metformin: A novel but controversial drug in cancer prevention and treatment
    • Sui X, Xu Y, Wang X, Han W, Pan H, Xiao M. Metformin: a novel but controversial drug in cancer prevention and treatment. Mol Pharm. 2015;12(11):3783-3791.
    • (2015) Mol Pharm , vol.12 , Issue.11 , pp. 3783-3791
    • Sui, X.1    Xu, Y.2    Wang, X.3    Han, W.4    Pan, H.5    Xiao, M.6
  • 23
    • 84940453827 scopus 로고    scopus 로고
    • Metformin decreases growth of pancreatic cancer cells by decreasing reactive oxygen species: Role of nox4
    • Cheng G,Lanza-Jacoby S. Metformin decreases growth of pancreatic cancer cells by decreasing reactive oxygen species: Role of NOX4. Biochem Biophys Res Commun. 2015;465(1):41-46.
    • (2015) Biochem Biophys Res Commun , vol.465 , Issue.1 , pp. 41-46
    • Cheng, G.1    Lanza-Jacoby, S.2
  • 24
    • 84929892552 scopus 로고    scopus 로고
    • Upregulation of microrna-23a regulates proliferation and apoptosis by targeting in laryngeal carcinoma
    • Zhang XW, Liu N, Chen S, et al. Upregulation of microRNA-23a regulates proliferation and apoptosis by targeting in laryngeal carcinoma. Oncol Lett. 2015;10(1):410-416.
    • (2015) Oncol Lett , vol.10 , Issue.1 , pp. 410-416
    • Zhang, X.W.1    Liu, N.2    Chen, S.3
  • 25
    • 84944463093 scopus 로고    scopus 로고
    • Mir-23a sensitizes nasopharyngeal carcinoma to irradiation by targeting il-8/stat3 pathway
    • Qu JQ, Yi HM, Ye X, et al. MiR-23a sensitizes nasopharyngeal carcinoma to irradiation by targeting IL-8/Stat3 pathway. Oncotarget. 2015;6(29):28341-28356.
    • (2015) Oncotarget , vol.6 , Issue.29 , pp. 28341-28356
    • Qu, J.Q.1    Yi, H.M.2    Ye, X.3
  • 26
    • 84930820084 scopus 로고    scopus 로고
    • Oncogenic mir-23a in pancreatic ductal adenocarcinogenesis via inhibiting apaf1
    • Liu N, Sun YY, Zhang XW, et al. Oncogenic miR-23a in pancreatic ductal adenocarcinogenesis via inhibiting APAF1. Dig Dis Sci. 2015; 60(7):2000-2008.
    • (2015) Dig Dis Sci , vol.60 , Issue.7 , pp. 2000-2008
    • Liu, N.1    Sun, Y.Y.2    Zhang, X.W.3
  • 27
    • 84856008906 scopus 로고    scopus 로고
    • Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
    • Ross-Innes CS, Stark R, Teschendorff AE, et al. Differential oestrogen receptor binding is associated with clinical outcome in breast cancer. Nature. 2012;481(7381):389-393.
    • (2012) Nature , vol.481 , Issue.7381 , pp. 389-393
    • Ross-Innes, C.S.1    Stark, R.2    Teschendorff, A.E.3
  • 28
    • 84862909192 scopus 로고    scopus 로고
    • Foxa1 and foxa2 are essential for sexual dimorphism in liver cancer
    • Li Z, Tuteja G, Schug J, Kaestner KH. Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer. Cell. 2012;148(1-2):72-83.
    • (2012) Cell , vol.148 , Issue.1-2 , pp. 72-83
    • Li, Z.1    Tuteja, G.2    Schug, J.3    Kaestner, K.H.4
  • 29
    • 84938660437 scopus 로고    scopus 로고
    • Interplay of estrogen receptors and foxa factors in the liver cancer
    • Zhao Y, Li Z. Interplay of estrogen receptors and FOXA factors in the liver cancer. Mol Cell Endocrinol. 2015;418(pt 3):334-339.
    • (2015) Mol Cell Endocrinol , vol.418 , pp. 334-339
    • Zhao, Y.1    Li, Z.2
  • 30
    • 84891382131 scopus 로고    scopus 로고
    • Amp-activated protein kinase induces p53 by phosphorylating mdmx and inhibiting its activity
    • He G, Zhang YW, Lee JH, et al. AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity. Mol Cell Biol. 2014;34(2):148-157.
    • (2014) Mol Cell Biol , vol.34 , Issue.2 , pp. 148-157
    • He, G.1    Zhang, Y.W.2    Lee, J.H.3
  • 31
    • 84891681108 scopus 로고    scopus 로고
    • Metformin suppresses expression of the selenoprotein p gene via an amp-activated kinase (ampk)/ foxo3a pathway in h4iiec3 hepatocytes
    • Takayama H, Misu H, Iwama H, et al. Metformin suppresses expression of the selenoprotein P gene via an AMP-activated kinase (AMPK)/ FoxO3a pathway in H4IIEC3 hepatocytes. J Biol Chem. 2014;289(1): 335-345.
    • (2014) J Biol Chem , vol.289 , Issue.1 , pp. 335-345
    • Takayama, H.1    Misu, H.2    Iwama, H.3
  • 32
    • 84860004855 scopus 로고    scopus 로고
    • Structures of kix domain of cbp in complex with two foxo3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment
    • Wang F, Marshall CB, Yamamoto K, et al. Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment. Proc Natl Acad Sci U S A. 2012;109(16):6078-6083.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.16 , pp. 6078-6083
    • Wang, F.1    Marshall, C.B.2    Yamamoto, K.3
  • 33
    • 84954358441 scopus 로고    scopus 로고
    • Biochemical and structural characterization of an intramolecular interaction in foxo3a and its binding with p53
    • Wang F, Marshall CB, Yamamoto K, et al. Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53. J Mol Biol. 2008;384(3):590-603.
    • (2008) J Mol Biol , vol.384 , Issue.3 , pp. 590-603
    • Wang, F.1    Marshall, C.B.2    Yamamoto, K.3
  • 34
    • 84883740345 scopus 로고    scopus 로고
    • Interferon-beta gene-modified human bone marrow mesenchymal stem cells attenuate hepatocellular carcinoma through inhibiting akt/foxo3a pathway
    • Xie C, Xie DY, Lin BL, et al. Interferon-beta gene-modified human bone marrow mesenchymal stem cells attenuate hepatocellular carcinoma through inhibiting AKT/FOXO3a pathway. Br J Cancer. 2013; 109(5):1198-1205.
    • (2013) Br J Cancer , vol.109 , Issue.5 , pp. 1198-1205
    • Xie, C.1    Xie, D.Y.2    Lin, B.L.3
  • 35
    • 84864004532 scopus 로고    scopus 로고
    • Upregulator of cell proliferation predicts poor prognosis in hepatocellular carcinoma and contributes to hepatocarcinogenesis by downregulating foxo3a
    • Xie C, Song LB, Wu JH, et al. Upregulator of cell proliferation predicts poor prognosis in hepatocellular carcinoma and contributes to hepatocarcinogenesis by downregulating FOXO3a. PLoS One. 2012; 7(7):e40607.
    • (2012) Plos One , vol.7 , Issue.7
    • Xie, C.1    Song, L.B.2    Wu, J.H.3
  • 36
    • 84855296257 scopus 로고    scopus 로고
    • Cardiac hypertrophy is positively regulated by microrna mir-23a
    • Wang K, Lin ZQ, Long B, Li JH, Zhou J, Li PF. Cardiac hypertrophy is positively regulated by MicroRNA miR-23a. J Biol Chem. 2012; 287(1):589-599.
    • (2012) J Biol Chem , vol.287 , Issue.1 , pp. 589-599
    • Wang, K.1    Lin, Z.Q.2    Long, B.3    Li, J.H.4    Zhou, J.5    Li, P.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.