Upregulation of microRNA-23a regulates proliferation and apoptosis by targeting APAF-1 in laryngeal carcinoma

Oncology Letters

Volumn 10, Issue 1, 2015, Pages 410-416

  Zhang, Xiao Wen ^a   Liu, Ning ^a   Chen, Sheng ^a   Wang, Ye ^a   Sun, Kai Lai ^a   Xu, Zhen Ming ^b   Fu, Wei Neng ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b The 463 Hospital of Chinese PLA   (China)

Author keywords

Apoptosis; Apoptotic protease activating factor 1; Laryngeal squamous cell carcinoma; MicroRNA 23a; Proliferation

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; MICRORNA; MICRORNA 23A; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LARYNX CARCINOMA; LUCIFERASE ASSAY; MAJOR CLINICAL STUDY; MALE; MTT ASSAY; PROTEIN BINDING; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

EID: 84929892552     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2015.3238     Document Type: Article

References (29)

1. Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin 63: 11-30, 2013.
2. Morshed K, Polz-Dacewicz M, Szymański M and Polz D: Short-fragment PCR assay for highly sensitive broad-spectrum detection of human papillomaviruses in laryngeal squamous cell carcinoma and normal mucosa: Clinico-pathological evaluation. Eur Arch Otorhinolaryngol 265 (Suppl 1): S89-S96, 2008.
3. Wang W, Lin P, Han C, Cai W, Zhao X and Sun B: Vasculogenic mimicry contributes to lymph node metastasis of laryngeal squamous cell carcinoma. J Exp Clin Cancer Res 29: 60, 2010.
4. Li J, Tan S, Kooger R, Zhang C and Zhang Y: MicroRNAs as novel biological targets for detection and regulation. Chem Soc Rev 43: 506-517, 2014.
5. Bhatt K, Mi QS and Dong Z: MicroRNAs in kidneys: Biogenesis, regulation and pathophysiological roles. Am J Physiol Renal Physiol 300: F602-F610, 2011.
6. Calin GA, Liu CG, Sevignani C, et al: MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc Natl Acad Sci USA 101: 11755-11760, 2004.
7. Bhaumik D, Scott GK, Schokrpur S, Patil CK, Campisi J and Benz CC: Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells. Oncogene 27: 5643-5647, 2008.
8. Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP and James RJ: Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res 1: 882-891, 2003.
9. Zhang B, Pan X, Cobb GP and Anderson TA: microRNAs as oncogenes and tumor suppressors. Dev Biol 302: 1-12, 2007.
10. Kozaki K, Imoto I, Mogi S, Omura K and Inazawa J: Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. Cancer Res 68: 2094-2105, 2008.
11. Saumet A, Vetter G, Bouttier M, et al: Transcriptional repression of microRNA genes by PML-RARA increases expression of key cancer proteins in acute promyelocytic leukemia. Blood 113: 412-421, 2009.
12. Xi Y, Shalgi R, Fodstad O, Pilpel Y and Ju J: Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer. Clin Cancer Res 12: 2014-2024, 2006.
13. Mi S, Lu J, Sun M, et al: MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proc Natl Acad Sci USA 104: 19971-19976, 2007.
14. Ciafrè SA, Galardi S, Mangiola A, et al: Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun 334: 1351-1358, 2005.
15. Huang S, He X, Ding J, et al: Upregulation of miR-23a approximately 27a approximately 24 decreases transforming growth factor-beta-induced tumor-suppressive activities in human hepatocellular carcinoma cells. Int J Cancer 123: 972-978, 2008.
16. Li L, Zhang ZM, Liu Y, et al: DNA microarrays-based microRNA expression profiles derived from formalin-fixed paraffin-embedded tissue blocks of squammous cell carcinoma of larynx. Zhonghua Bing Li Xue Za Zhi 39: 391-395, 2010 (In Chinese).
17. Chen Q, Xu J, Li L, et al: MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis. Cell Death Dis 5: e1132, 2014.
18. Lian S, Shi R, Bai T, et al: Anti-miRNA-23a oligonucleotide suppresses glioma cells growth by targeting apoptotic protease activating factor-1. Curr Pharm Des 19: 6382-6389, 2013.
19. Shang J, Yang F, Wang Y, et al: MicroRNA-23a antisense enhances 5-fluorouracil chemosensitivity through APAF-1/caspase-9 apoptotic pathway in colorectal cancer cells. J Cell Biochem 115: 772-784, 2014.
20. Huerta S, Heinzerling JH, Anguiano-Hernandez YM, et al: Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: Roles of Fas, Apaf-1, NF kappaB, IAPs, Smac/DIABLO and AIF. J Surg Res 142: 184-194, 2007.
21. Zang YS, Zhong YF, Fang Z, Li B and An J: MiR-155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of APAF-1 expression. Cancer Gene Ther 19: 773-778, 2012.
22. Huang DF, Fu WN, Shang C, Xu ZM, Li ZG and Sun KL: Expression and promoter methylation of Apaf-1 gene in laryngeal squamous cell carcinoma. Yi Chuan Xue Bao 31: 1327-1331, 2004 (In Chinese).
23. Fu WN, Bertoni F, Kelsey SM, McElwaine SM, Cotter FE, Newland AC and Jia L: Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia. Oncogene 22: 451-455, 2003.
24. Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell 144: 646-674, 2011.
25. Hanahan D and Weinberg RA: The hallmarks of cancer. Cell 100: 57-70, 2000.
26. Nakano H, Yamada Y, Miyazawa T and Yoshida T: Gain-of-function microRNA screens identify miR-193a regulating proliferation and apoptosis in epithelial ovarian cancer cells. Int J Oncol 42: 1875-1882, 2013.
27. Christensen LL, Holm A, Rantala J, et al: Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer. PLoS One 9: e96767, 2014.
28. Taylor RC Cullen SP and Martin SJ: Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 9: 231-241, 2008.
29. Campioni M, Santini D, Tonini G, Murace R, Dragonetti E Spugnini EP and Baldi A: Role of Apaf-1, a key regulator of apoptosis, in melanoma progression and chemoresistance. Exp Dermatol 14: 811-818, 2005.