Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 16, 2012, Pages 6078-6083

  Wang, Feng ^a,b   Marshall, Christopher B ^a,b   Yamamoto, Kazuo ^a,b   Li, Guang Yao ^a,b   Gasmi Seabrook, Geneviève M C ^a,b   Okada, Hitoshi ^a,b   Mak, Tak W ^a,b   Ikura, Mitsuhiko ^a,b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Intrinsic disorder; NMR solution structure; Promiscuous binding

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; HISTONE ACETYLTRANSFERASE PCAF; TRANSCRIPTION FACTOR FKHRL1;

ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; DISSOCIATION CONSTANT; MUTAGENESIS; MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; TRANSACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CALORIMETRY; CELLS, CULTURED; CIRCULAR DICHROISM; FORKHEAD TRANSCRIPTION FACTORS; HCT116 CELLS; HEK293 CELLS; HUMANS; KINETICS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; MYELOID-LYMPHOID LEUKEMIA PROTEIN; P300-CBP TRANSCRIPTION FACTORS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MYB; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTIONAL ACTIVATION;

EID: 84860004855     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1119073109     Document Type: Article

References (27)

1. Burgering BM (2008) A brief introduction to FOXOlogy. Oncogene 27:2258-2262.
2. Greer EL, Brunet A (2005) FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24:7410-7425. (Pubitemid 41637981)
3. Wang F, et al. (2008) Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53. J Mol Biol 384:590-603.
4. Nasrin N, et al. (2000) DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc Natl Acad Sci USA 97:10412-10417.
5. So CW, Cleary ML (2002) MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function. Mol Cell Biol 22:6542-6552.
6. Wang F, et al. (2009) Synergistic interplay between promoter recognition and CBP/ p300 coactivator recruitment by FOXO3a. ACS Chem Biol 4:1017-1027.
7. De Guzman RN, Goto NK, Dyson HJ, Wright PE (2006) Structural basis for cooperative transcription factor binding to the CBP coactivator. J Mol Biol 355:1005-1013. (Pubitemid 43012143)
8. Radhakrishnan I, et al. (1997) Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: A model for activator:coactivator interactions. Cell 91:741-752. (Pubitemid 28007731)
9. Lee CW, Arai M, Martinez-Yamout MA, Dyson HJ, Wright PE (2009) Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP. Biochemistry 48:2115-2124.
10. Spiegelman BM, Heinrich R (2004) Biological control through regulated transcriptional coactivators. Cell 119:157-167. (Pubitemid 39360899)
11. Matsuzaki H, et al. (2005) Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl Acad Sci USA 102:11278-11283. (Pubitemid 41153811)
12. So CW, Cleary ML (2003) Common mechanism for oncogenic activation of MLL by forkhead family proteins. Blood 101:633-639. (Pubitemid 36077587)
13. Nakae J, et al. (2006) The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity. J Clin Invest 116:2473-2483. (Pubitemid 44330146)
14. Brachmann CB, et al. (1995) The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev 9: 2888-2902.
15. Brunet A, et al. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303:2011-2015. (Pubitemid 38393275)
16. Greer EL, et al. (2007) The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem 282:30107-30119. (Pubitemid 350035296)
17. You H, et al. (2006) FOXO3a-dependent regulation of Puma in response to cytokine/ growth factor withdrawal. J Exp Med 203:1657-1663. (Pubitemid 44036270)
18. Mittag T, Kay LE, Forman-Kay JD (2010) Protein dynamics and conformational disorder in molecular recognition. J Mol Recognit 23:105-116.
19. Shoemaker BA, Portman JJ,Wolynes PG (2000) Speeding molecular recognition by using the folding funnel: The fly-casting mechanism. Proc Natl Acad Sci USA 97:8868-8873. (Pubitemid 30626639)
20. Huang Y, Liu Z (2009) Kinetic advantage of intrinsically disordered proteins in coupled folding-binding process: A critical assessment of the "fly-casting" mechanism. J Mol Biol 393:1143-1159.
21. Sunters A, et al. (2003) FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem 278:49795-49805. (Pubitemid 37548813)
22. Teufel DP, Freund SM, Bycroft M, Fersht AR (2007) Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53. Proc Natl Acad Sci USA 104:7009-7014. (Pubitemid 47186000)
23. Mas C, et al. (2011) Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF). Proc Natl Acad Sci USA 108:10484-10489.
24. Smock RG, Gierasch LM (2009) Sending signals dynamically. Science 324:198-203.
25. Dansen TB, et al. (2009) Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity. Nat Chem Biol 5:664-672.
26. Altarejos JY, Montminy M (2011) CREB and the CRTC co-activators: Sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol 12:141-151.
27. Lee CW, Ferreon JC, Ferreon AC, Arai M, Wright PE (2010) Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation. Proc Natl Acad Sci USA 107:19290-19295.