Solid lipid nanoparticles as drug carriers

Nanoparticulates as Drug Carriers

Volumn , Issue , 2006, Pages 187-212

  Mäder, Karsten ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG CARRIER; SOLID LIPID NANOPARTICLE (SLN);

DRUG DELIVERY;

EID: 84967647320     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1142/9781860949074_0009     Document Type: Chapter

References (118)

1. Eldem T, Speiser P and Hincal A (1991) Optimization of spray-dried and congealed lipid micropellets and characterization of their surface morphology by scanning electron microscopy. Pharm Res 8:47-54.
2. Speiser P (1990) Lipidnanopellets als Trägersystem für Arzneimittel zur peroralen Anwendung, European Patent EP 0167825.
3. Domb AJ (1993) Lipospheres for controlled delivery of substances. United States Patent No. 5188837.
4. Domb AJ (1995) Long acting injectable oxytetracycline-liposphere formulation. Int J Pharm 124:271-278.
5. Domb AJ (1993) Liposphere parenteral delivery system. Proc Intl Symp Control Rel Bioact Mater 20:346-347.
6. Siekmann B and Westesen K (1992) Submicron-sized parenetral carrier systems based on solid lipids, Pharm. Pharmacol Lett 1:123-126.
7. Müller RH, Lucks JS (1996) Arzneistoffträger aus festen Lipidteilchen, Feste Lipid-nanosphären (SLN). European Patent No. 0605497.
8. Müller RH, Mehnert W, Lucks JS, Schwarz C, zur Mühlen A, Weyhers H, Freitas C and Rühl D (1995) Solid Lipid Nanoparticles (SLN) - An Alternative Colloidal Carrier System for Controolled Drug Delivery. Eur J Pharm Biopharm 41:62-69.
9. Sjöström B and Bergenståhl B (1992) Preparation of submicron drug particles in lecithin-stabilized o/w emulsions. I. Model studies of the precipitation of cholesteryl acetate. Int J Pharm 88:53-62.
10. Cavalli R, Caputo O and Gasco MR (1993) Solid lipospheres of doxorubicin and idarubicin. Int J Pharm 89:R9-R12.
11. Gasco MR (1993) Method for producing solid lipid microspheres having a narrow size distribution. United States Patent No. 5250236.
12. Müller RH (1997) Pharmazeutische Technologie, Moderne Arzneiformen, Wiss. Verlagsges. Stuttgart.
13. Müller RH and Runge SA, Solid Lipid Nanoparticles (SLN) for controlled drug delivery, in Submicron Emulsions in Drug Targeting and Delivery, Benita S (ed.), Harwood Academic Publishers.
14. Small D (1986) Handbook of lipids. The physical chemistry of lipids: From alkanes to phospholipids, Plenum Press, New York.
15. Ahlin P, Kristi J and Šmid-Kobar J (1998) Optimization of procedure parameters and physical stability of solid lipid nanoparticles in dispersions. Acta Pharm 48:257-267.
16. Lippacher A, Müller RH and Mäder K (2000) Investigation on the viscoelastic properties of lipid based colloidal drug carriers. Int J Pharm 196:227-230.
17. zur Mühlen A and Mehnert W (1998) Drug release and release mechanism of prednisolone loaded solid lipid nanoparticles. Pharmazie 53:552-555.
18. zur Mühlen A, Schwarz C and Mehnert W (1998) Solid lipid nanoparticles (SLN) for controlled drug delivery - Drug release and release mechanism.
19. Lander R, Manger W, Scouloudis M, Ku A, Davis C and Lee A (2000) Gaulin homogenization: A mechanistic study. Biotechnol Prog 16:80-85.
20. Jahnke S (1998) The theory of high pressure homogenization, in Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs, Müller RH, Benita S and Böhm B (eds.), Medpharm Scientific Publishers: Stuttgart, pp. 177-200.
21. Siekmann B and Westesen K (1994) Melt-homogenized solid lipid nanoparticles stabilized by the nonionic surfactant tyloxapol, I. Preparation and particle size determination. Pharm Pharmacol Lett 3:194-197.
22. Bunjes H, Siekmann B and Westesen K (1998), Emulsions of supercooled melts - a novel drug delivery system, in Submicron Emulsions in Drug Targeting and Delivery, Benita S (ed.), Harwood Academic Publishers.
23. zur Mühlen A (1996) Feste Lipid-Nanopartikel mit prolongierter Wirkstoffliberation: Herstellung, Langzeitstabilität, Charakterisierung, Freisetzungsverhalten und - machanismen, PhD thesis, Free University of Berlin.
24. Friedrich I and Müller-Goymann CC (2003) Characterization of solidified reverse micellar solutions (SRMS) and production development of SRMS-based nanosuspensions. Eur J Pharm Biopharm 56:111-119.
25. Siekmann B and Westesen K (1996) Investigations on solid lipid nanoparticles prepared by precipitation in o/w emulsions. Eur J Pharm Biopharm 43:104-109.
26. Fessi H, Puisieux F, Ammoury N and Benita S (1989) Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int J Pharm 55:R1-R4.
27. Hu FQ, Yuan H, Zhang HH and Fang M (2002) Preparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization. Int J Pharm 239:121-128.
28. Schubert MA and Müller-Goymann CC (2003) Solvent injection as a new approach for manufacturing lipid nanoparticles-evaluation of the method and process parameters. Eur J Pharm Biopharm 55:125-131.
29. Danielsson I and Lindman B (1981) The definition of microemulsion. Coll Surf B 3: 391-392.
30. Gasco MR (1997) Solid lipid nanospheres from warm micro-emulsions. Pharma Technol Eur 52-58.
31. Boltri L, Canal T, Esposito PA and Carli J (1993) Lipid nanoparticles: Evaluation of some critical formulation parameters. Proc Inti Symp Control Rel Bioact Mater 20:346-347.
32. Cavalli R, Marengo E, Rodriguez L and Gasco MR (1996) Effect of some experimental factors on the production process of solid lipid nanoparticles. Eur J Pharm Biopharm 43:110-115.
33. Gasco MR, Morel S and Carpigno R (1992) Optimization of the incorporation of des-oxycortisone acetate in lipospheres. Eur J Pharm Biopharm 38:7-10.
34. Dahms G and Seidel H (2004) Method for the preparation of solid-lipid nanoparticles (SLNs) without high pressure homogenizer for pharmaceutical, cosmetic and food applications. German Patant application DE 2003-10312763 20030321.
35. Zuidam NJ, Lee SS, L and Crommelin DJA (1992) Sterilization of liposomes by heat treatment. Pharm Res 10:1591-1596.
36. Lukyanov AN and Torchilin VP (1994) Autoclaving of liposomes. J Microencap 11: 669-672.
37. Schwarz C and Mehnert W (1995) Sterilization of drug-free and tetracaine-loaded solid lipid nanoparticles (SLN). Proc 1st World Meeting APGI/APV, Budapest, 485-486.
38. Schwarz C, Freitas C, Mehnert W and Müller RH (1995) Sterilization and physical stability of drug-free and etomidate-loaded solid lipid nanoparticles. Proc Inti Symp Control Rel Bioct Mater 22:766-767.
39. Liedtke S, Jores K, Mehnert W and Mäder K (2000) Possibilities of non-invasive physicochemical characterisation of colloidal drug carriers, 27th Inti Symp Control Rel Bioact Mater Vol. 27, Controlled Release Society, Paris, 1088-1089.
40. Freitas C (1998) Feste Lipid-Nanopartikel (SLN): Mechanismen der physikalischen Destabilisierung und Stabilisierung. PhD thesis, Free University of Berlin.
41. Cavalli R, Caputo O, Carlotti ME, Trotta M, Scarnecchia and Gasco MR (1997) Sterilization and freeze-drying of drug-free and drug-loaded solid lipid nanoparticles. Int J Pharm 148:47-54.
42. Heiati H, Tawashi R and Phillips NC (1998) Drug retention and stability of solid lipid nanoparticles containuing azidothymidine palmitate after autoclaving, storage and lyophilisation. J Microencap 15:173-184.
43. Sculier JP, Coune A, Brassine C, Laduron C, Atassi G, Ruysschert GM and Fruhling J (1986) Intravenous infusion of high doses of liposomes containing NSC 251635, a water insoluble cytostatic agent. A pilot sudy with pharmacokinetic data. J Clin Oncol 4:789-797.
44. Rupprecht H (1993) Physikalisch-chemische Grundlagen der Gefriertrocknung, in Essig D and Oschmann R (eds.), Lyophilization. Paperback APV, Band 35, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, pp. 13-38.
45. Pikal MJ, Shah S, Roy ML and Putman R (1990) The secondary drying stage of freeze drying: drying kinetics as a function of temperature and chamber pressure. Int J Pharm 60:203-217.
46. Schwarz C and Mehnert W (1997) Freeze-drying of drug-free and drug-loaded solid lipid nanoparicles. Int J Pharm 157:171-179.
47. Crowe LM, Crowe JH, Rudolph A, Womersley C and Appel L (1985) Preservation of Freeze-dried Liposomes by Trehalose. Arch Biochem Biophys 242:240-247.
48. Siekmann B and Westesen K (1994) Melt-homogenized solid lipid nanoparticles stabilized by the nonionic surfactant tyloxapol, II. Physicochemical characterization and lyophilisation. Pharm Pharmacol Lett 3:225-228.
49. Zimmermann E, Müller RH and Mäder K (2000) Influence of different parameters on reconstitution of lyophilized SLN. Int J Pharm 196:211-213.
50. Lim SJ, Lee MK and Kim CK (2004) Altered chemical and biological activities of all-trans retinoic acid incorporated in solid lipid nanoparticle powders. J Control Rel 100:53-61.
51. Marengo E, Cavalli R, Rovero G and Gasco MR (2003) Scale-up and optimization of an evaporative drying process applied to aqueous dispersions of solid lipid nanoparticles. Pharm Dev Techn 8:299-309.
52. Freitas C and Müller RH (1998) Spray-drying of solid lipid nanoparticles (SLN™). Eur J Pharm Biopharm 46:145-151.
53. Laggner P (1999) X-ray diffraction of lipids, in Spectral Properties of Lipids, Hamilton RJ and Cast J (eds.), Sheffield Academic Press.
54. Garti N and Sato K (eds.), (1998) Crystallization and Polymorphism of Fats and Fatty Acids, Marcel Dekker; New York and Basel.
55. Sjöström B, Kaplun A, Talmon Y and Cabane B (1995) Structures of nanoparticles prepared from oil in water emulsions. Pharm Res 12:39-48.
56. Siekmann B and Westesen K (1992) Sub-micron sized parenteral carrier systems based on solid lipid, Pharma Pharmacol Lett 1:123-126.
57. Illing A, Unruh T and Koch MHJ (2004) Investigation on particle self-assembly in solid lipid-based colloidal drug carrier systems. Pharm Res 21:592-597.
58. Jores K, Mehnert W, Drechsler M, Bunjes H, Johann C and Mäder K (2004) Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy. J Control Rel 95:217-227.
59. Jores K, Mehnert W and Mäder K (2003) Physicochemical investigations on solid lipid nanoparticles (SLN) and on oil-loaded solid lipid nanoparticles: A NMR- and ESR-study. Pharm Res 20:1274-1283.
60. zur Mühlen A, zur Mühlen E, Niehus H and Mehnert W (1996) Atomic force microscopy studies of solid lipid nanoparticles. Pharm Res 13:1411-1416.
61. Dingier A, Blum RP, Niehus H, Müller RH and Gohla S (1999) Solid lipid nanoparticles (SLN™/Lipopearls™) - a pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products. J Microencap 16:751-767.
62. Müller RH (1996) Zetapotential und Partikelladung - Kurze Theorie, praktische Meβ-durchführung, Dateninterpretation, Wissenschaftliche Verlagsgesellschaft Stuttgart.
63. Lai SL, Guo JY, Petrova V, Ramanath G and Allen LH (1996) Size-Dependent Melting Properties of Small Tin Particles: Nanocalorimetric Measurements. Phys Rev Lett 77:99-103.
64. Westesen K, Siekmann B and Koch MHJ (1993) Investigations on the physical state of lipid nanoparticles by synchrotron radiation X-ray diffraction. Int J Pharm 93:189-199.
65. Westesen K and Bunjes H (1995) Do nanoparticles prepared from lipids solid at room temperature always possess a solid matrix? Int J Pharm 115:129-131.
66. Bunjes H, Koch MHJ and Westesen K (2003) Influence of emulsifiers on the crystallization of solid lipid nanoparticles. J Pharm Sci 92:1509-1520.
67. Bunjes H, Koch MHJ and Westesen K (2000) Effect of particle size on colloidal solid triglycerides. Langmuir 16:5234-5241.
68. Illing A, Unruh T and Koch MHJ (2004) Investigation on Particle Self-Assembly in Solid Lipid-Based Colloidal Drug Carrier Systems. Pharm Res 21:592-597.
69. Jores K (2004) Lipid nanodispersions as drug carrier systems - a physicochemical characterization, Thesis, University of Halle (http://sundoc.bibliothek.uni-halle.de/diss-online/04/04H310/prom.pdf).
70. Lippacher A, Müller RH and Mäder K (2004) Liquid and semisolid SLN dispersions for topical application: Rheological characterization. Eur J Pharm Biopharm 58:561-567.
71. Lippacher A, Müller RH and Mäder K (2001) Preparation of semisolid drug carriers for topical application based on solid lipid nanoparticles. Int J Pharm 214:9-12.
72. Lippacher A, Müller RH and Mäder K (2002) Semisolid SLN dispersions for topical application: Influence of formulation and production parameters on viscoelastic properties. Eur J Pharm Biopharm 53:155-160.
73. Tiling A and Unruh T (2004) Investigation on the flow behavior of dispersions of solid triglyceride nanoparticles. Int J Pharm 284:123-131.
74. Souto EB, Wissing SA, Barbosa CM and Müller RH (2004) Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations. Eur J Pharm Biopharm 58:83-90.
75. Westesen K and Siekmann B (1997) Investigation of the gel formation of phospholipids stabilized solid lipid nanoparticles. Int J Pharm 151:35-45.
76. Bunjes H, Westesen K and Koch MHJ (1996) Crystallization tendency and polymorphic transitions in triglyceride nanoparticles. Int J Pharm 129:159-173.
77. Zimmermann E, Liedtke S, Müller RH and Mäder K (1999) H-NMR as a method to characterize colloidal carrier systems, Proc Inc Symp Control Rel Bioact Mater 26: 591-592.
78. Shahgaldian P, Da Silva E, Coleman AW, Rather Beth and Zaworotko MJ (2003) Paraacyl-calix-arene based solid lipid nanoparticles (SLNs): A detailed study of preparation and stability parameters. Int J Pharm 253:23-38.
79. Wissing, S A, Müller RH, Manthei L and Mayer C (2004) Structural Characterization of QlO-Loaded Solid Lipid Nanoparticles by NMR Spectroscopy. Pharm Res 21:400-405.
80. Ahlin P, Kristi J, Pecar S, Strancar J and Sentjurc M (2003) The effect of lipophilicity of spin-labeled compounds on their distribution in solid lipid nanoparticle dispersions studied by electron paramagnetic resonance. J Pharm Sci 92:58-66.
81. S Liedtke, E Zimmermann, RH Müller and K Mäder (1999) Physical characterisation of solid lipid nanoparticles (SLN™), Proc Inti Symp Control Rel Bioact Mater 26:595-596.
82. Kristi J, Volk B, Ahlin P, Gombac K and Sentjurc M (2003) Interactions of solid lipid nanoparticles with model membranes and leukocytes studied by EPR. Int J Pharm 256:133-140.
83. Müller RH and Heinemann S (1994) Fat emulsions for parenteral nutrition IV: Lipofundin MCT/LCT regimens for total parenteral nutrition (TPN) with high electrolyte load. Int J Pharm 107:121-132.
84. Klang SH, Parnas M and Benita S (1998) Emulsions as drug carriers - possibilities, limitations and future perspectives, in Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs, RH Müller, S Benita and BBöhm (eds.), Medpharm Scientific Publishers, Stuttgart, pp. 31-65.
85. Davis SS, Washington C, West P and Ilium L (1987) Lipid emulsions as drug delivery systems. Ann N Y Acad Sci 507:75-88.
86. Müller RH and Runge SA (1998) Solid lipid nanoparticles (SLN) for controlled drug delivery, in Submicron Emulsions in Drug Targeting and Delivery, Benita S (ed.), Harwood Academic Publishers; Amsterdam, pp. 219-234.
87. Mehnert W and Mäder K (2001) Solid lipid nanoparticles: Production, characterization and applications. Adv Drug Del Rev 47:165-196.
88. Westesen K (2000) Novel lipid-based colloidal dispersions as potential drug administration systems. Expectations and reality. Coll Polym Sci 278:608-618.
89. Heydenreich AV, Westmeier R, Pedersen N, Poulsen HS and Kristensen HG (2003) Preparation and purification of cationic solid lipid nanospheres - Effects on particle size, physical stability, and cell toxicity. Int J Pharm 254:83-87.
90. Wissing SA, Kayser O and Müller RH (2004) Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Del Rev 56:1257-1272.
91. Müller RH, Radtke M and Wissing SA (2002) Nanostructured lipid matrices for improved microencapsulation of drugs. Int J Pharm 242:121-128.
92. Bunjes H, Drechsler M, Koch MHJ and Westesen K (2001) Incorporation of the model drug ubidecarenone into solid lipid nanoparticles. Pharm Res 18:287-293.
93. Sivaramakrishnan R, Nakamura C, Mehnert W, Korting HC, Kramer KD and Schäfer-Korting M (2004) Glucocorticoid entrapment into lipid carriers - characterization by parelectric spectroscopy and influence on dermal uptake. J Control Rel 97:493-502.
94. Lukowski G and Kasbohm (2001) Energy Dispersive X-ray Analysis of loaded solid lipid nanoparticles. J Proceedings - 28th International Symposium on Controlled Release of Bioactive Materials and 4th Consumer & Diversified Products Conference, San Diego, CA, United States, 516-517.
95. Frederiksen HK, Kristensen HG and Pedersen M (2003) Solid lipid microparticle formulations of the pyrethroid gamma-cyhalothrin-incompatibility of the lipid and the pyrethroid and biological properties of the formulations. J Control Rel 86:243-252.
96. Kristi J, Volk B, Gasperlin M, Sentjurc M and Jurkovic P (2003) Effect of colloidal carriers on ascorbyl palmitate stability. Eur J Pharm Sci 19:181-189.
97. Olbrich C, Kayser O and Müller RH (2002) Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN) - effect of surfactants, storage time and crystallinity. Int J Pharm 237:119-128.
98. Olbrich C, Kayser O and Müller RH (2002) Enzymatic Degradation of Dynasan 114 SLN - Effect of Surfactants and Particle Size. J Nanopar Res 4:121-129.
99. Zimmermann E and Müller RH (2001) Electrolyte- and pH-stabilities of aqueous solid lipid nanoparticle (SLN) dispersions in artificial gastrointestinal media. Eur J Pharm Biopharm 52:203-210.
100. Mei Z, Li X, Wu Q, Hu S and Yang X (2005) The research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticle. Pharmacol Res 51:345-351.
101. Hu LD, Tang X and Cui FD (2004) Solid lipid nanoparticles (SLNs) to improve oral bioavailability of poorly soluble drugs. J Pharm Pharmacol 56:1527-1535.
102. Bargoni A, Cavalli R, Zara GP, Fundaro A, Caputo O and Gasco MR (2001) Transmucosal transport of tobramycin incorporated in solid lipid nanoparticles (SLN) after duodenal administration to rats. Part II. Tissue distribution. Pharmacol Res 43:497-502.
103. Cavalli R, Bargoni A, Podio V, Muntoni E, Zara GP and Gasco MR (2003) Duodenal administration of solid lipid nanoparticles loaded with different percentages of tobramycin. J Pharm Sci 92:1085-1094.
104. Zara GP, Bargoni A, Cavalli R, Fundaro A, Vighetto D and Gasco MR (2002) Pharmacokinetics and tissue distribution of idarubicin-loaded solid lipid nanoparticles after duodenal administration to rats. J Pharm Sci 91:1324-1333.
105. Zara GP, Cavalli R, Bargoni A, Fundaro A, Vighetto D and Gasco MR (2002) Intravenous administration to rabbits of non-stealth and stealth doxorubicin-loaded solid lipid nanoparticles at increasing concentrations of stealth agent: Pharmacokinetics and distribution of doxorubicin in brain and other tissues. J Drug Targ 10:327-335.
106. Chen D, Lu W, Yang T, Li J and Zhang Q (2002) Preparation and characterization of long-circulating solid lipid nanoparticles containing paclitaxel. Yixueban 34:57-60.
107. Müller RH, Radtke M and Wissing SA (2002) Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Del Rev 54(Suppl 1):S131-S155.
108. Wissing SA and Müller RH (2002) The influence of the cry stallinity of lipid nanoparticles on their occlusive properties. Int J Pharm 242:377-379.
109. Wissing SA and Müller RH (2003) The influence of solid lipid nanoparticles on skin hydration and viscoelasticity - in vivo study. Eur J Pharm Biopharm 56:67-72.
110. Wissing SA and Müller RH (2001) Solid lipid nanoparticles (SLN) - a novel carrier for UV blockers. Pharmazie 56:783-786.
111. Maia CS, Mehnert W, Schaller M, Korting HC, Gysler A, Haberland A and Schäfer-Korting M (2002) Drug targeting by solid lipid nanoparticles for dermal use. J Drug Targ 10:489-495.
112. Rudolph C, Schillinger U, Ortiz, A, Tabatt K, Plank C, Müller RH and Rosenecker J (2004) Application of Novel Solid Lipid Nanoparticle (SLN)-Gene Vector Formulations Based on a Dimeric HIV-1 TAT-Peptide in vitro and in vivo. Pharm Res 21:1662-1669.
113. Gasco MR, Zara GP, Saettone MF and PCT Int. Appl. (2004) Pharmaceutical compositions suitable for the treatment of ophthalmic diseases. Patent application WO 2004039351.
114. Videira MA, Botelho MF, Santos AC, Gouveia LF, Pedroso De Lima JJ and Almeida AJ (2002) Lymphatic uptake of pulmonary delivered radiolabelled solid lipid nanoparticles. J Drug Targ 10:607-613.
115. Stevens PJ, Sekido M and Lee RJ (2004) Synthesis and evaluation of a hematoporphyrin derivative in a folate receptor-targeted solid-lipid nanoparticle formulation. Anticancer Res 24:161-165.
116. Peira E, Marzola P, Podio V, Aime S, Sbarbati A and Gasco MR (2003) In vitro and in vivo study of solid lipid nanoparticles loaded with superparamagnetic iron oxide. J Drug Targ 11:19-24.
117. Wang JX, Sun X and Zhang ZR (2002) Enhanced brain targeting by synthesis of 3′,5′- dioctanoyl-5-fluoro-2′-deoxyuridine and incorporation into solid lipid nanoparticles. Eur J Pharm Biopharm 54:285-290.
118. Zara GP, Cavalli R, Bargoni A, Fundaro A, Vighetto D and Gasco MR (2002) Intravenous administration to rabbits of non-stealth and stealth doxorubicin-loaded solid lipid nanoparticles at increasing concentrations of stealth agent: Pharmacokinetics and distribution of doxorubicin in brain and other tissues. J Drug Targ 10:327-335.