-
1
-
-
84918815964
-
Cancer incidence and mortality worldwide: Sources, methods and major patterns in globocan 2012
-
Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015; 136: E359-86.
-
(2015)
Int J Cancer
, vol.136
, pp. E359-E386
-
-
Ferlay, J.1
Soerjomataram, I.2
Dikshit, R.3
-
2
-
-
77957682309
-
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: A randomised openlabel trial
-
de Bono JS, Oudard S, Ozguroglu M, et al. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised openlabel trial. Lancet 2010; 376: 1147-54.
-
(2010)
Lancet
, vol.376
, pp. 1147-1154
-
-
De Bono, J.S.1
Oudard, S.2
Ozguroglu, M.3
-
3
-
-
84866948935
-
Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: Final overall survival analysis of the cou-Aa-301 randomised, double-blind, placebo-controlled phase 3 study
-
Fizazi K, Scher HI, Molina A, et al. Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study. Lancet Oncol 2012; 13: 983-92.
-
(2012)
Lancet Oncol
, vol.13
, pp. 983-992
-
-
Fizazi, K.1
Scher, H.I.2
Molina, A.3
-
4
-
-
84921846878
-
Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (cou-Aa-302): Final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study
-
Ryan CJ, Smith MR, Fizazi K, et al. Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study. Lancet Oncol 2015; 16: 152-60.
-
(2015)
Lancet Oncol
, vol.16
, pp. 152-160
-
-
Ryan, C.J.1
Smith, M.R.2
Fizazi, K.3
-
5
-
-
84866770294
-
Increased survival with enzalutamide in prostate cancer after chemotherapy
-
Scher HI, Fizazi K, Saad F, et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med 2012; 367: 1187-97.
-
(2012)
N Engl J Med
, vol.367
, pp. 1187-1197
-
-
Scher, H.I.1
Fizazi, K.2
Saad, F.3
-
6
-
-
84904871070
-
Enzalutamide in metastatic prostate cancer before chemotherapy
-
Beer TM, Armstrong AJ, Rathkopf DE, et al. Enzalutamide in metastatic prostate cancer before chemotherapy. N Engl J Med 2014; 371: 424-33.
-
(2014)
N Engl J Med
, vol.371
, pp. 424-433
-
-
Beer, T.M.1
Armstrong, A.J.2
Rathkopf, D.E.3
-
7
-
-
84880428467
-
Alpha emitter radium-223 and survival in metastatic prostate cancer
-
Parker C, Nilsson S, Heinrich D, et al. Alpha emitter radium-223 and survival in metastatic prostate cancer. N Engl J Med 2013; 369: 213-23.
-
(2013)
N Engl J Med
, vol.369
, pp. 213-223
-
-
Parker, C.1
Nilsson, S.2
Heinrich, D.3
-
8
-
-
79952284127
-
Hallmarks of cancer: The next genera tion
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next genera tion. Cell 2011; 144: 646-74.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
9
-
-
0036852241
-
Cancer immunoediting: From immunosurveillance to tumor escape
-
Dunn GP, Bruce AT, Ikeda H, et al. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol 2002; 3: 991-98.
-
(2002)
Nat Immunol
, vol.3
, pp. 991-998
-
-
Dunn, G.P.1
Bruce, A.T.2
Ikeda, H.3
-
10
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12: 252-64.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 252-264
-
-
Pardoll, D.M.1
-
11
-
-
84931043388
-
The immunocheckpoints in modern oncology: The next 15 years
-
Massari F, Santoni M, Ciccarese C et al. The immunocheckpoints in modern oncology: the next 15 years. Exp Opin Biol Ther 2015; 15: 917-21.
-
(2015)
Exp Opin Biol Ther
, vol.15
, pp. 917-921
-
-
Massari, F.1
Santoni, M.2
Ciccarese, C.3
-
12
-
-
77955066199
-
Sipuleucel-T immunotherapy for castration-resistant prostate cancer
-
Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 2010; 363: 411-22.
-
(2010)
N Engl J Med
, vol.363
, pp. 411-422
-
-
Kantoff, P.W.1
Higano, C.S.2
Shore, N.D.3
-
13
-
-
84894659759
-
Beyond sipuleucel-T: Immune approaches to treating prostate cancer
-
Cheng ML, Fong L. Beyond sipuleucel-T: immune approaches to treating prostate cancer. Curr Treat Options Oncol 2014; 15: 115-26.
-
(2014)
Curr Treat Options Oncol
, vol.15
, pp. 115-126
-
-
Cheng, M.L.1
Fong, L.2
-
14
-
-
25144483466
-
Autoantibody signatures in prostate cancer
-
Wang X, Yu J, Sreekumar A, et al. Autoantibody signatures in prostate cancer. N Engl J Med 2005; 353: 1224-35.
-
(2005)
N Engl J Med
, vol.353
, pp. 1224-1235
-
-
Wang, X.1
Yu, J.2
Sreekumar, A.3
-
15
-
-
0019461193
-
Prostate tumor biology and cell kinetics-Theory
-
Coffey DS, Isaacs JT. Prostate tumor biology and cell kinetics-Theory. Urology 1981; 17: 40-53.
-
(1981)
Urology
, vol.17
, pp. 40-53
-
-
Coffey, D.S.1
Isaacs, J.T.2
-
16
-
-
84905439880
-
Immunotherapy for prostate cancer: Lessons from responses to tumor-Associated antigens
-
Westdorp H, Sköld AE, Snijer BA, et al. Immunotherapy for prostate cancer: lessons from responses to tumor-Associated antigens. Front Immunol 2014; 5: 191.
-
(2014)
Front Immunol
, vol.5
, pp. 191
-
-
Westdorp, H.1
Sköld, A.E.2
Snijer, B.A.3
-
17
-
-
43049149026
-
Prediction of bone metastases by combination of tartrate-resistant acid phosphatase, alkaline phosphatase and prostate specific antigen in patients with prostate cancer
-
Ozu C, Nakashima J, Horiguchi Y, et al. Prediction of bone metastases by combination of tartrate-resistant acid phosphatase, alkaline phosphatase and prostate specific antigen in patients with prostate cancer. Int J Urol 2008; 15: 419-22.
-
(2008)
Int J Urol
, vol.15
, pp. 419-422
-
-
Ozu, C.1
Nakashima, J.2
Horiguchi, Y.3
-
18
-
-
0034594917
-
Prostate stem cell antigen (psca) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer
-
Gu Z, Thomas G, Yamashiro J, et al. Prostate stem cell antigen (PSCA) expression increases with high Gleason score, advanced stage and bone metastasis in prostate cancer. Oncogene. 2000; 19: 1288-96.
-
(2000)
Oncogene
, vol.19
, pp. 1288-1296
-
-
Gu, Z.1
Thomas, G.2
Yamashiro, J.3
-
19
-
-
37449012409
-
Dominance of cd4+ lymphocytic infiltrates with disturbed effector cell characteristics in the tumor microenvironment of prostate carcinoma
-
Ebelt K, Babaryka G, Figel AM, et al. Dominance of CD4+ lymphocytic infiltrates with disturbed effector cell characteristics in the tumor microenvironment of prostate carcinoma. Prostate 2008; 68: 1-10.
-
(2008)
Prostate
, vol.68
, pp. 1-10
-
-
Ebelt, K.1
Babaryka, G.2
Figel, A.M.3
-
20
-
-
68749087029
-
Characterization of the intra-prostatic immune cell infiltration in androgen-deprived prostate cancer patients
-
Gannon PO, Poisson AO, Delvoye N, et al. Characterization of the intra-prostatic immune cell infiltration in androgen-deprived prostate cancer patients. J Immunol Methods 2009; 348: 9-17.
-
(2009)
J Immunol Methods
, vol.348
, pp. 9-17
-
-
Gannon, P.O.1
Poisson, A.O.2
Delvoye, N.3
-
21
-
-
0028032388
-
Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and apoptosis as determinants of long-Term prognosis in prostatic adenocarcinoma
-
Vesalainen S, Lipponen P, Talja M, et al. Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and apoptosis as determinants of long-Term prognosis in prostatic adenocarcinoma. Eur J Cancer 1994; 30A: 1797-803.
-
(1994)
Eur J Cancer
, vol.30 A
, pp. 1797-1803
-
-
Vesalainen, S.1
Lipponen, P.2
Talja, M.3
-
22
-
-
62949162336
-
Phenotypic characterization of the infiltrating immune cells in normal prostate, benign nodular prostatic hyperplasia and prostatic adenocarcinoma
-
Hussein MR, Al-Assiri M, Musalam AO. Phenotypic characterization of the infiltrating immune cells in normal prostate, benign nodular prostatic hyperplasia and prostatic adenocarcinoma. Exp Mol Pathol 2009; 86: 108-13.
-
(2009)
Exp Mol Pathol
, vol.86
, pp. 108-113
-
-
Hussein, M.R.1
Al-Assiri, M.2
Musalam, A.O.3
-
23
-
-
20944434107
-
Boosting antitumor responses of t lymphocytes infiltrating human prostate cancers
-
Bronte V, Kasic T, Gri G, et al. Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers. J Exp Med 2005; 20: 1257-68.
-
(2005)
J Exp Med
, vol.20
, pp. 1257-1268
-
-
Bronte, V.1
Kasic, T.2
Gri, G.3
-
24
-
-
65849449107
-
Prostate cancer lesions are surrounded by foxp3+, pd-1+ and b7-h1+ lymphocyte clusters
-
Ebelt K, Babaryka G, Frankenberger B, et al. Prostate cancer lesions are surrounded by FOXP3+, PD-1+ and B7-H1+ lymphocyte clusters. Eur J Cancer 2009; 45: 1664-72.
-
(2009)
Eur J Cancer
, vol.45
, pp. 1664-1672
-
-
Ebelt, K.1
Babaryka, G.2
Frankenberger, B.3
-
25
-
-
37249067503
-
Cd8+ foxp3+ regulatory t cells mediate immunosuppression in prostate cancer
-
Kiniwa Y, Miyahara Y, Wang HY, et al. CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancer. Clin Cancer Res. 2007; 13: 6947-58.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 6947-6958
-
-
Kiniwa, Y.1
Miyahara, Y.2
Wang, H.Y.3
-
26
-
-
28444496629
-
Tumour-infiltrating lymphocytes: A prognostic factor of psa-free survival in patients with local prostate carcinoma treated by radical prostatectomy
-
Kärjä V, Aaltomaa S, Lipponen P, et al. Tumour-infiltrating lymphocytes: A prognostic factor of PSA-free survival in patients with local prostate carcinoma treated by radical prostatectomy. Anticancer Res 2005; 25: 4435-38.
-
(2005)
Anticancer Res
, vol.25
, pp. 4435-4438
-
-
Kärjä, V.1
Aaltomaa, S.2
Lipponen, P.3
-
27
-
-
84875209263
-
Cd4 helper t cells, cd8 cytotoxic t cells, and foxp3(+) regulatory t cells with respect to lethal prostate cancer
-
Davidsson S, Ohlson AL, Andersson SO, et al. CD4 helper T cells, CD8 cytotoxic T cells, and FOXP3(+) regulatory T cells with respect to lethal prostate cancer. Mod Pathol 2013; 26: 448-55.
-
(2013)
Mod Pathol
, vol.26
, pp. 448-455
-
-
Davidsson, S.1
Ohlson, A.L.2
Andersson, S.O.3
-
28
-
-
84860133344
-
Increased cd8+ t-cell function following castration and immunization is countered by parallel expansion of regulatory t cells
-
Tang S, Moore ML, Grayson JM, et al. Increased CD8+ T-cell function following castration and immunization is countered by parallel expansion of regulatory T cells. Cancer Res 2012; 72: 1975-85.
-
(2012)
Cancer Res
, vol.72
, pp. 1975-1985
-
-
Tang, S.1
Moore, M.L.2
Grayson, J.M.3
-
29
-
-
84875744038
-
High tissue density of foxp3+ t cells is associated with clinical outcome in prostate cancer
-
Flammiger A, Weisbach L, Huland H, et al. High tissue density of FOXP3+ T cells is associated with clinical outcome in prostate cancer. Eur J Cancer 2013; 49: 1273-79.
-
(2013)
Eur J Cancer
, vol.49
, pp. 1273-1279
-
-
Flammiger, A.1
Weisbach, L.2
Huland, H.3
-
30
-
-
23444461765
-
Activation of thymic regeneration in mice and humans following androgen blockade
-
Sutherland JS, Goldberg GL, Hammett MV, et al. Activation of thymic regeneration in mice and humans following androgen blockade. J Immunol 2005; 175: 2741-53.
-
(2005)
J Immunol
, vol.175
, pp. 2741-2753
-
-
Sutherland, J.S.1
Goldberg, G.L.2
Hammett, M.V.3
-
31
-
-
0028962781
-
Enhanced production of b lymphocytes after castration
-
Wilson CA, Mrose SA, Thomas DW. Enhanced production of B lymphocytes after castration. Blood 1995; 85: 1535-39.
-
(1995)
Blood
, vol.85
, pp. 1535-1539
-
-
Wilson, C.A.1
Mrose, S.A.2
Thomas, D.W.3
-
32
-
-
20244380618
-
Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen
-
Drake CG, Doody AD, Mihalyo MA, et al. Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen. Cancer Cell 2005; 7: 239-49.
-
(2005)
Cancer Cell
, vol.7
, pp. 239-249
-
-
Drake, C.G.1
Doody, A.D.2
Mihalyo, M.A.3
-
33
-
-
0035807916
-
T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer
-
Mercader M, Bodner BK, Moser MT, et al. T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer. Proc Natl Acad Sci U S A 2001; 98: 14565-70.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 14565-14570
-
-
Mercader, M.1
Bodner, B.K.2
Moser, M.T.3
-
34
-
-
84898742280
-
Randomized phase II trial evaluating the optimal sequencing of sipuleucel-T and androgen-deprivation therapy (adt) in patients (pts) with biochemically recurrent prostate cancer (brpc
-
abstr 34
-
Antonarakis ES, Kibel A, Tyler RC, et al. Randomized phase II trial evaluating the optimal sequencing of sipuleucel-T and androgen-deprivation therapy (ADT) in patients (pts) with biochemically recurrent prostate cancer (BRPC). J Clin Oncol 2013; suppl 6: abstr 34.
-
(2013)
J Clin Oncol
-
-
Antonarakis, E.S.1
Kibel, A.2
Tyler, R.C.3
-
35
-
-
0036669785
-
The interaction properties of costimulatory molecules revisited
-
Collins AV, Brodie DW, Gilbert RJ, et al. The interaction properties of costimulatory molecules revisited. Immunity 2002; 17: 201-10.
-
(2002)
Immunity
, vol.17
, pp. 201-210
-
-
Collins, A.V.1
Brodie, D.W.2
Gilbert, R.J.3
-
36
-
-
65349119978
-
Cd28 and ctla-4 coreceptor expression and signal transduction
-
Rudd CE, Taylor A, Schneider H. CD28 and CTLA-4 coreceptor expression and signal transduction. Immunol Rev 2009; 229: 12-26.
-
(2009)
Immunol Rev
, vol.229
, pp. 12-26
-
-
Rudd, C.E.1
Taylor, A.2
Schneider, H.3
-
37
-
-
80051944092
-
Cell-Autonomous and -nonautonomous roles of ctla-4 in immune regulation
-
Wing K, Yamaguchi T, Sakaguchi S. Cell-Autonomous and -nonautonomous roles of CTLA-4 in immune regulation. Trends Immunol 2011; 32: 428-33.
-
(2011)
Trends Immunol
, vol.32
, pp. 428-433
-
-
Wing, K.1
Yamaguchi, T.2
Sakaguchi, S.3
-
38
-
-
1242315588
-
Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated
-
Demaria S, Ng B, Devitt ML, et al. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol 2004; 58: 862-70.
-
(2004)
Int J Radiat Oncol
, vol.58
, pp. 862-870
-
-
Demaria, S.1
Ng, B.2
Devitt, M.L.3
-
39
-
-
12244252335
-
Immune-mediated inhibition of metastases after treatment with local radiation and ctla-4 blockade in a mouse model of breast cancer
-
Demaria S, Kawashima N, Yang AM, et al. Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clin Cancer Res 2005; 11: 728-34.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 728-734
-
-
Demaria, S.1
Kawashima, N.2
Yang, A.M.3
-
40
-
-
69949085196
-
Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-ctla-4 antibody
-
Dewan MZ, Galloway AE, Kawashima N, et al. Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res 2009; 15: 5379-88.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5379-5388
-
-
Dewan, M.Z.1
Galloway, A.E.2
Kawashima, N.3
-
42
-
-
84953874197
-
Radiation and checkpoint blockade immunotherapy: Radiosensitisation and potential mechanisms of synergy
-
Sharabi AB, Lim M, DeWeese TL, et al. Radiation and checkpoint blockade immunotherapy: radiosensitisation and potential mechanisms of synergy. Lancet Oncol 2015; 16: e498-509.
-
(2015)
Lancet Oncol
, vol.16
, pp. e498-e509
-
-
Sharabi, A.B.1
Lim, M.2
DeWeese, T.L.3
-
43
-
-
84880508629
-
Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: Results from an open-label, multicenter phase I/II study
-
Slovin SF, Higano CS, Hamid O, et al. Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study. Ann Oncol 2013; 24: 1813-21.
-
(2013)
Ann Oncol
, vol.24
, pp. 1813-1821
-
-
Slovin, S.F.1
Higano, C.S.2
Hamid, O.3
-
44
-
-
78449265248
-
A randomized phase II study of ipilimumab with androgen ablation compared with androgen ablation alone in patiets with advanced prostate cancer
-
abstr 168
-
Tollefson MK, Thompson RH, Granberg CF, et al. A randomized phase II study of ipilimumab with androgen ablation compared with androgen ablation alone in patiets with advanced prostate cancer. Genitourinary Cancer Symposium Meeting 2010; abstr 168.
-
(2010)
Genitourinary Cancer Symposium Meeting
-
-
Tollefson, M.K.1
Thompson, R.H.2
Granberg, C.F.3
-
45
-
-
84860455345
-
Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: A phase 1 dose-escalation trial
-
Madan RA, Mohebtash M, Arlen PM, et al. Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial. Lancet Oncol 2012; 13: 501-8.
-
(2012)
Lancet Oncol
, vol.13
, pp. 501-508
-
-
Madan, R.A.1
Mohebtash, M.2
Arlen, P.M.3
-
46
-
-
84896489380
-
A combination trial of vaccine plus ipilimumab in metastatic castration-resistant prostate cancer patients: Immune correlates
-
Jochems C, Tucker JA, Tsang KY, et al. A combination trial of vaccine plus ipilimumab in metastatic castration-resistant prostate cancer patients: immune correlates. Cancer Immunol Immunother 2014; 63: 407-18.
-
(2014)
Cancer Immunol Immunother
, vol.63
, pp. 407-418
-
-
Jochems, C.1
Tucker, J.A.2
Tsang, K.Y.3
-
47
-
-
84860436621
-
Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-Transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: A phase 1 dose-escalation trial
-
van den Eertwegh AJ, Versluis J, van den Berg HP, et al. Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-Transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial. Lancet Oncol 2012; 13: 509-17.
-
(2012)
Lancet Oncol
, vol.13
, pp. 509-517
-
-
Van Den Eertwegh, A.J.1
Versluis, J.2
Van Den Berg, H.P.3
-
48
-
-
58349090027
-
Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with ctla4 blockade and gm-csf
-
Fong L, Kwek SS, O'Brien S, et al. Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF. Cancer Res 2009; 69: 609-15.
-
(2009)
Cancer Res
, vol.69
, pp. 609-615
-
-
Fong, L.1
Kwek, S.S.2
O'Brien, S.3
-
49
-
-
37049036074
-
Randomized phase II study comparing 4 monthly doses of ipilimumab (mdx-010) as a single agent or in combination with a single dose of docetaxel in patients with hormone-refractory prostate cancer
-
Small E, Higano C, Tchekmedyian N, et al. Randomized phase II study comparing 4 monthly doses of ipilimumab (MDX-010) as a single agent or in combination with a single dose of docetaxel in patients with hormone-refractory prostate cancer. ASCO Meeting Abstracts. 2006; 24: 4609.
-
(2006)
ASCO Meeting Abstracts
, vol.24
, pp. 4609
-
-
Small, E.1
Higano, C.2
Tchekmedyian, N.3
-
50
-
-
84901641673
-
Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (ca184-043): A multicentre, randomised, double-blind, phase 3 trial
-
Kwon ED, Drake CG, Scher HI, et al. Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol 2014; 15: 700-12.
-
(2014)
Lancet Oncol
, vol.15
, pp. 700-712
-
-
Kwon, E.D.1
Drake, C.G.2
Scher, H.I.3
-
51
-
-
84908464295
-
Ipilimumab: A potential immunologic agent in the treatment of metastatic castration-resistant prostate cancer
-
Kittai A, Meshikhes M, Aragon-Ching JB. Ipilimumab: a potential immunologic agent in the treatment of metastatic castration-resistant prostate cancer. Cancer Biol Ther 2014; 15: 1299-300.
-
(2014)
Cancer Biol Ther
, vol.15
, pp. 1299-1300
-
-
Kittai, A.1
Meshikhes, M.2
Aragon-Ching, J.B.3
-
52
-
-
84901619235
-
A near miss for prostate cancer immunotherapy
-
Parker C. A near miss for prostate cancer immunotherapy. Lancet Oncol 2014; 15: 669-71.
-
(2014)
Lancet Oncol
, vol.15
, pp. 669-671
-
-
Parker, C.1
-
53
-
-
84862754605
-
Phase i trial of tremelimumab in combination with short-Term androgen deprivation in patients with psa-recurrent prostate cancer
-
McNeel DG, Smith HA, Eickhoff JC, et al. Phase I trial of tremelimumab in combination with short-Term androgen deprivation in patients with PSA-recurrent prostate cancer. Cancer Immunol Immunother 2012; 61: 1137-47.
-
(2012)
Cancer Immunol Immunother
, vol.61
, pp. 1137-1147
-
-
McNeel, D.G.1
Smith, H.A.2
Eickhoff, J.C.3
-
54
-
-
0030005099
-
Expression of the pd-1 antigen on the surface of stimulated mouse t and b lymphocytes
-
Agata Y, Kawasaki A, Nishimura H, et al. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int Immunol 1996; 8: 765-72.
-
(1996)
Int Immunol
, vol.8
, pp. 765-772
-
-
Agata, Y.1
Kawasaki, A.2
Nishimura, H.3
-
55
-
-
0842325739
-
Pd-l1/b7h-1 inhibits the effector phase of tumor rejection by t cell receptor (tcr) transgenic cd8+ t cells
-
Blank C, Brown I, Peterson AC, et al. PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells. Cancer Res 2004; 64: 1140-5.
-
(2004)
Cancer Res
, vol.64
, pp. 1140-1145
-
-
Blank, C.1
Brown, I.2
Peterson, A.C.3
-
56
-
-
18544380239
-
Tumor-Associated b7-h1 promotes t-cell apoptosis: A potential mechanism of immune evasion
-
Dong H, Strome SE, Salomao DR, et al. Tumor-Associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002; 8: 793-800.
-
(2002)
Nat Med
, vol.8
, pp. 793-800
-
-
Dong, H.1
Strome, S.E.2
Salomao, D.R.3
-
57
-
-
44349150012
-
Inhibitory b7-family molecules in the tumor microenvironment
-
Zou W, Chen L. Inhibitory B7-family molecules in the tumor microenvironment. Nat Rev Immunol 2008; 8: 467-77.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 467-477
-
-
Zou, W.1
Chen, L.2
-
58
-
-
84859158384
-
Targeting the pd-1/b7-h1(pdl1) pathway to activate anti-Tumor immunity
-
Topalian SL, Drake CG, Pardoll DM. Targeting the PD-1/B7-H1(PDL1) pathway to activate anti-Tumor immunity. Curr Opin Immunol 2012; 24: 207-12.
-
(2012)
Curr Opin Immunol
, vol.24
, pp. 207-212
-
-
Topalian, S.L.1
Drake, C.G.2
Pardoll, D.M.3
-
59
-
-
84925222119
-
Nivolumab in previously untreated melanoma without braf mutation
-
Robert C, Long GV, Brady B, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med 2015; 372: 320-30.
-
(2015)
N Engl J Med
, vol.372
, pp. 320-330
-
-
Robert, C.1
Long, G.V.2
Brady, B.3
-
60
-
-
84929481481
-
Pembrolizumab versus ipilimumab in advanced melanoma
-
Robert C, Schachter J, Long GV, et al. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med 2015; 372: 2521-32.
-
(2015)
N Engl J Med
, vol.372
, pp. 2521-2532
-
-
Robert, C.1
Schachter, J.2
Long, G.V.3
-
61
-
-
84944937210
-
Nivolumab versus docetaxel in advanced non squamous non-small-cell lung cancer
-
Borghaei H, Paz-Ares L, Horn L, et al. Nivolumab versus docetaxel in advanced non squamous non-small-cell lung cancer. N Engl J Med 2015; 373: 1627-39.
-
(2015)
N Engl J Med
, vol.373
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
-
62
-
-
84936791837
-
Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
-
Brahmer J, Reckamp KL, Baas P, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med 2015; 373: 123-35.
-
(2015)
N Engl J Med
, vol.373
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
-
63
-
-
84946607195
-
Nivolumab versus everolimus in advanced renal-cell carcinoma
-
Motzer RJ, Escudier B, McDermott DF, et al. Nivolumab versus everolimus in advanced renal-cell carcinoma. N Engl J Med 2015; 373: 1803-13.
-
(2015)
N Engl J Med
, vol.373
, pp. 1803-1813
-
-
Motzer, R.J.1
Escudier, B.2
McDermott, D.F.3
-
64
-
-
84904024273
-
Association of pd-1, pd-1 ligands, and other features of the tumor immune microenvironment with response to anti-pd-1 therapy
-
Taube JM, Klein A, Brahmer JR, et al. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res 2014; 20: 5064-74.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 5064-5074
-
-
Taube, J.M.1
Klein, A.2
Brahmer, J.R.3
-
65
-
-
84944707536
-
Prognostic role of pd-l1 expression in renal cell carcinoma a systematic review and meta-Analysis
-
Iacovelli R, Nolè F, Verri E, et al. Prognostic role of PD-L1 expression in renal cell carcinoma. A systematic review and meta-Analysis. Target Oncol 2016; 11: 143-8.
-
(2016)
Target Oncol
, vol.11
, pp. 143-148
-
-
Iacovelli, R.1
Nolè, F.2
Verri, E.3
-
66
-
-
84966935409
-
Association of tumor pd-l1 expression and immune biomarkers with clinical activity in patients (pts) with advanced solid tumors treated with nivolumab (anti-pd-1; bms-936558; ono-4538
-
abstr 3016
-
Grosso J, Horak CE, Inzunza D, et al. Association of tumor PD-L1 expression and immune biomarkers with clinical activity in patients (pts) with advanced solid tumors treated with nivolumab (anti-PD-1; BMS-936558; ONO-4538). J Clin Oncol 2013; 31 suppl: abstr 3016.
-
(2013)
J Clin Oncol
, vol.31
-
-
Grosso, J.1
Horak, C.E.2
Inzunza, D.3
-
67
-
-
84905090973
-
Pd-l1 expression in non-clear cell renal cell carcinoma
-
abstr 424
-
Fay AP, Callea M, Gray KP, et al. PD-L1 expression in non-clear cell renal cell carcinoma. J Clin Oncol 2014; 32 suppl 4: abstr 424.
-
(2014)
J Clin Oncol
, vol.32
-
-
Fay, A.P.1
Callea, M.2
Gray, K.P.3
-
68
-
-
84926678589
-
Pd-l1 expression in melanoma shows marked heterogeneity within and between patients: Implications for anti-pd-1/pd-l1 clinical trials
-
Madore J, Vilain R, Menzies AM, et al. PD-L1 expression in melanoma shows marked heterogeneity within and between patients: implications for anti-PD-1/PD-L1 clinical trials. Pigment Cell Melanoma Res 2015; 28: 245-53.
-
(2015)
Pigment Cell Melanoma Res
, vol.28
, pp. 245-253
-
-
Madore, J.1
Vilain, R.2
Menzies, A.M.3
-
69
-
-
84931075074
-
Clinical impact of programmed cell death ligand 1 (pd-l1), programmed cell death 1 (pd-1), and cd8 expression in pancreatic cancer
-
abstr e15258
-
Shim H-J, Hwang J-E, Jung S-I, et al. Clinical impact of programmed cell death ligand 1 (PD-L1), programmed cell death 1 (PD-1), and CD8 expression in pancreatic cancer. J Clin Oncol 2014; 32suppl: abstr e15258.
-
(2014)
J Clin Oncol
, vol.32
-
-
Shim, H.-J.1
Hwang, J.-E.2
Jung, S.-I.3
-
70
-
-
84947031227
-
Paucity of pd-l1 expression in prostate cancer: Innate and adaptive immune resistance
-
Martin AM, Nirschl TR, Nirschl CJ, et al. Paucity of PD-L1 expression in prostate cancer: innate and adaptive immune resistance. Prostate Cancer Prostatic Dis 2015; 18: 325-32.
-
(2015)
Prostate Cancer Prostatic Dis
, vol.18
, pp. 325-332
-
-
Martin, A.M.1
Nirschl, T.R.2
Nirschl, C.J.3
-
71
-
-
84975839985
-
Magnitude of pd-1,pd-l1 and t lymphocyte expression on tissue from castration-resistant prostate adenocarcinoma: An exploratory analysis
-
[Epub ahead of print]
-
Massari F, Ciccarese C, Caliò A, et al. Magnitude of PD-1, PD-L1 and T lymphocyte expression on tissue from castration-resistant prostate adenocarcinoma: an exploratory analysis. Target Oncol 2015 [Epub ahead of print].
-
(2015)
Target Oncol
-
-
Massari, F.1
Ciccarese, C.2
Caliò, A.3
-
72
-
-
70349485580
-
Human prostate-infiltrating cd8+ t lymphocytes are oligoclonal and pd-1+
-
Sfanos KS, Bruno TC, Meeker AK, et al. Human prostate-infiltrating CD8+ T lymphocytes are oligoclonal and PD-1+. Prostate 2009; 69: 1694-703.
-
(2009)
Prostate
, vol.69
, pp. 1694-1703
-
-
Sfanos, K.S.1
Bruno, T.C.2
Meeker, A.K.3
-
73
-
-
84966935447
-
The immune checkpoint regulator pd-l1 is highly expressed in aggressive primary prostate cancer
-
[Epub ahead of print]
-
Gevensleben H, Dietrich D, Golletz C, et al. The immune checkpoint regulator PD-L1 is highly expressed in aggressive primary prostate cancer. Clin Cancer Res 2015 [Epub ahead of print].
-
(2015)
Clin Cancer Res
-
-
Gevensleben, H.1
Dietrich, D.2
Golletz, C.3
-
74
-
-
84928722323
-
Pd-l1 is highly expressed in enzalutamide resistant prostate cancer
-
[Epub ahead of print]
-
Bishop JL, Sio A, Angeles A, et al. PD-L1 is highly expressed in enzalutamide resistant prostate cancer. Oncotarget 2014 [Epub ahead of print].
-
(2014)
Oncotarget
-
-
Bishop, J.L.1
Sio, A.2
Angeles, A.3
-
75
-
-
84959388122
-
Tumor stroma-derived factors skew monocyte to dendritic cell differentiation toward a suppressive cd14+ pd-l1+ phenotype in prostate cancer
-
Spary LK, Salimu J, Webber JP, et al. Tumor stroma-derived factors skew monocyte to dendritic cell differentiation toward a suppressive CD14+ PD-L1+ phenotype in prostate cancer. Oncoimmunol 2014; 3: e955331.
-
(2014)
Oncoimmunol
, vol.3
, pp. e955331
-
-
Spary, L.K.1
Salimu, J.2
Webber, J.P.3
-
76
-
-
84862859820
-
Safety, activity, and immune correlates of anti-pd-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012; 366: 2443-54.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
77
-
-
84886948036
-
B7 family checkpoint regulators in immune regulation and disease
-
Ceeraz S, Nowak EC, Noelle RJ. B7 family checkpoint regulators in immune regulation and disease. Trends Immunol 2013; 34: 556-63.
-
(2013)
Trends Immunol
, vol.34
, pp. 556-563
-
-
Ceeraz, S.1
Nowak, E.C.2
Noelle, R.J.3
-
78
-
-
37649013179
-
B7-h3 and b7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome
-
Zang X, Thompson RH, Al-Ahmadie HA, et al. B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome. Proc Natl Acad Sci U S A 2007; 104: 19458-63.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19458-19463
-
-
Zang, X.1
Thompson, R.H.2
Al-Ahmadie, H.A.3
-
79
-
-
79954990698
-
Expression of b7-h3 in hypopharyngeal squamous cell carcinoma as a predictive indicator for tumor metastasis and prognosis
-
Katayama A, Takahara M, Kishibe K, et al. Expression of B7-H3 in hypopharyngeal squamous cell carcinoma as a predictive indicator for tumor metastasis and prognosis. Int J Oncol 2011; 38: 1219-26.
-
(2011)
Int J Oncol
, vol.38
, pp. 1219-1226
-
-
Katayama, A.1
Takahara, M.2
Kishibe, K.3
-
80
-
-
84859099360
-
B7-h3 contributes to the metastatic capacity of melanoma cells by modulation of known metastasis-Associated genes
-
Tekle C, Nygren MK, Chen YW, et al. B7-H3 contributes to the metastatic capacity of melanoma cells by modulation of known metastasis-Associated genes. Int J Cancer 2012; 130: 2282-90.
-
(2012)
Int J Cancer
, vol.130
, pp. 2282-2290
-
-
Tekle, C.1
Nygren, M.K.2
Chen, Y.W.3
-
81
-
-
78650151049
-
B7-h3 ligand expression by primary breast cancer and associated with regional nodal metastasis
-
Arigami T, Narita N, Mizuno R, et al. B7-h3 ligand expression by primary breast cancer and associated with regional nodal metastasis. Ann Surg 2010; 252: 1044-51.
-
(2010)
Ann Surg
, vol.252
, pp. 1044-1051
-
-
Arigami, T.1
Narita, N.2
Mizuno, R.3
-
82
-
-
33644689145
-
Relationship between co-stimulatory molecule b7-h3 expression and gastric carcinoma histology and prognosis
-
Wu CP, Jiang JT, Tan M, et al. Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis. World J Gastroenterol 2006; 12: 457-9.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 457-459
-
-
Wu, C.P.1
Jiang, J.T.2
Tan, M.3
-
83
-
-
34548046956
-
B7-h3 ligand expression by prostate cancer: A novel marker of prognosis and potential target for therapy
-
Roth TJ, Sheinin Y, Lohse CM, et al. B7-H3 ligand expression by prostate cancer: a novel marker of prognosis and potential target for therapy. Cancer Res 2007; 67: 7893-900.
-
(2007)
Cancer Res
, vol.67
, pp. 7893-7900
-
-
Roth, T.J.1
Sheinin, Y.2
Lohse, C.M.3
-
84
-
-
80051550965
-
B7-h3 over expression in prostate cancer promotes tumor cell progression
-
Yuan H, Wei X, Zhang G, et al. B7-H3 over expression in prostate cancer promotes tumor cell progression. J Urol 2011; 186: 1093-99.
-
(2011)
J Urol
, vol.186
, pp. 1093-1099
-
-
Yuan, H.1
Wei, X.2
Zhang, G.3
-
85
-
-
84864299061
-
Is the clinical malignant phenotype of prostate cancer a result of a highly proliferative immune-evasive b7-h3-expressing cell population
-
Liu Y, Vlatkovic L, Sæter T, et al. Is the clinical malignant phenotype of prostate cancer a result of a highly proliferative immune-evasive B7-H3-expressing cell population Int J Urol 2012; 19: 749-56.
-
(2012)
Int J Urol
, vol.19
, pp. 749-756
-
-
Liu, Y.1
Vlatkovic, L.2
Sæter, T.3
-
86
-
-
79952703623
-
Evaluation of b7-h3 expression as a biomarker of biochemical recurrence after salvage radiation therapy for recurrent prostate cancer
-
Parker AS, Heckman MG, Sheinin Y, et al. Evaluation of B7-H3 expression as a biomarker of biochemical recurrence after salvage radiation therapy for recurrent prostate cancer. Int J Radiat Oncol Biol Phys 2011; 79: 1343-49.
-
(2011)
Int J Radiat Oncol Biol Phys
, vol.79
, pp. 1343-1349
-
-
Parker, A.S.1
Heckman, M.G.2
Sheinin, Y.3
-
87
-
-
63549150834
-
Expression of immunosuppresive b7-h3 ligand by hormone-Treated prostate cancer tumors and metastases
-
Chavin G, Sheinin Y, Crispen PL, et al. Expression of immunosuppresive B7-H3 ligand by hormone-Treated prostate cancer tumors and metastases. Clin Cancer Res 2009; 15: 2174-80.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2174-2180
-
-
Chavin, G.1
Sheinin, Y.2
Crispen, P.L.3
-
88
-
-
84912141505
-
B7-h4 expression is correlated with tumor progression and clinical outcome in urothelial cell carcinoma
-
Fan M, Zhuang Q, Chen Y, et al. B7-H4 expression is correlated with tumor progression and clinical outcome in urothelial cell carcinoma. Int J Clin Exp Pathol 2014; 7: 6768-75.
-
(2014)
Int J Clin Exp Pathol
, vol.7
, pp. 6768-6775
-
-
Fan, M.1
Zhuang, Q.2
Chen, Y.3
-
89
-
-
33745886516
-
B7-h4 expression in renal cell carcinoma and tumor vasculature: Associations with cancer progression and survival
-
Krambeck AE, Thompson RH, Dong H, et al. B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival. Proc Natl Acad Sci U S A 2006; 103: 10391-96.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 10391-10396
-
-
Krambeck, A.E.1
Thompson, R.H.2
Dong, H.3
-
90
-
-
84927581227
-
B7-h4 overexpression correlates with a poor prognosis for cervical cancer patients
-
Liu W, Shibata K, Koya Y, et al. B7-H4 overexpression correlates with a poor prognosis for cervical cancer patients. Mol Clin Oncol 2014; 2: 219-25.
-
(2014)
Mol Clin Oncol
, vol.2
, pp. 219-225
-
-
Liu, W.1
Shibata, K.2
Koya, Y.3
-
91
-
-
79959708884
-
B7-h4 expression associates with cancer progression and predicts patient's survival in human esophageal squamous cell carcinoma
-
Chen LJ, Sun J, Wu HY, et al. B7-H4 expression associates with cancer progression and predicts patient's survival in human esophageal squamous cell carcinoma. Cancer Immunol Immunother 2011; 60: 1047-55.
-
(2011)
Cancer Immunol Immunother
, vol.60
, pp. 1047-1055
-
-
Chen, L.J.1
Sun, J.2
Wu, H.Y.3
-
92
-
-
78649661358
-
Expression of b7-h4 in blood of patients with gastric cancer predicts tumor progression and prognosis
-
Arigami T, Uenosono Y, Hirata M, et al. Expression of B7-H4 in blood of patients with gastric cancer predicts tumor progression and prognosis. J Surg Oncol 2010; 102: 748-52.
-
(2010)
J Surg Oncol
, vol.102
, pp. 748-752
-
-
Arigami, T.1
Uenosono, Y.2
Hirata, M.3
-
93
-
-
79952115249
-
Expression of b7-h4 in prostate cancer and its clinical significance
-
Qian Y, Yao HP, Shen L, et al. Expression of B7-H4 in prostate cancer and its clinical significance. Zhejiang Da Xue Xue Bao Yi Xue Ban 2010; 39: 345-9.
-
(2010)
Zhejiang Da Xue Xue Bao Yi Xue Ban
, vol.39
, pp. 345-349
-
-
Qian, Y.1
Yao, H.P.2
Shen, L.3
-
94
-
-
84962022213
-
Ablation of b7-h3 but not b7-h4 results in highly increased tumor burden in a murine model of spontaneous prostate cancer
-
Kreymborg K, Haak S, Murali R, et al. Ablation of B7-H3 but not B7-H4 results in highly increased tumor burden in a murine model of spontaneous prostate cancer. Cancer Immunol Res 2015; 3: 849-54.
-
(2015)
Cancer Immunol Res
, vol.3
, pp. 849-854
-
-
Kreymborg, K.1
Haak, S.2
Murali, R.3
-
95
-
-
79960918412
-
Emerging tim-3 functions in antimicrobial and tumor immunity
-
Sakuishi K, Jayaraman P, Behar SM, et al. Emerging Tim-3 functions in antimicrobial and tumor immunity. Trends Immunol 2011; 32: 345-9.
-
(2011)
Trends Immunol
, vol.32
, pp. 345-349
-
-
Sakuishi, K.1
Jayaraman, P.2
Behar, S.M.3
-
96
-
-
84857159981
-
Tim-3 expression characterizes regulatory t cells in tumor tissues and is associated with lung cancer progression
-
Gao X, Zhu Y, Li G, et al. TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression. PLoS One 2012; 7: e30676.
-
(2012)
PLoS One
, vol.7
, pp. e30676
-
-
Gao, X.1
Zhu, Y.2
Li, G.3
-
97
-
-
77957723967
-
Upregulation of tim-3 and pd-1 expression is associated with tumor antigen-specific cd8+ t cell dysfunction in melanoma patients
-
Fourcade J, Sun Z, Benallaoua M, et al. Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. J Exp Med 2010; 207: 2175-86.
-
(2010)
J Exp Med
, vol.207
, pp. 2175-2186
-
-
Fourcade, J.1
Sun, Z.2
Benallaoua, M.3
-
98
-
-
84886033686
-
The expression of tim-3 in peripheral blood of ovarian cancer
-
Wu J, Liu C, Qian S, et al. The expression of Tim-3 in peripheral blood of ovarian cancer. DNA Cell Biol 2013; 32: 648-53.
-
(2013)
DNA Cell Biol
, vol.32
, pp. 648-653
-
-
Wu, J.1
Liu, C.2
Qian, S.3
-
99
-
-
84939874105
-
Analysis of tim-3 as a therapeutic target in prostate cancer
-
Piao YR, Jin ZH, Yuan KC, et al. Analysis of Tim-3 as a therapeutic target in prostate cancer. Tumour Biol 2014; 35: 11409-14.
-
(2014)
Tumour Biol
, vol.35
, pp. 11409-11414
-
-
Piao, Y.R.1
Jin, Z.H.2
Yuan, K.C.3
|