메뉴 건너뛰기




Volumn 16, Issue 2, 2016, Pages e132-e141

Mechanisms of diabetes-induced liver damage: The role of oxidative stress and inflammation

Author keywords

Diabetes mellitus; Inflammation; Liver diseases; Oxidative stress

Indexed keywords


EID: 84967103665     PISSN: 2075051X     EISSN: 20750528     Source Type: Journal    
DOI: 10.18295/squmj.2016.16.02.002     Document Type: Review
Times cited : (348)

References (57)
  • 1
    • 79959936188 scopus 로고    scopus 로고
    • National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: Systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants
    • Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ, Paciorek CJ, et al. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: Systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet 2011; 378: 31-40. doi: 10.1016/s0140-6736(11)60679-x.
    • (2011) Lancet , vol.378 , pp. 31-40
    • Danaei, G.1    Finucane, M.M.2    Lu, Y.3    Singh, G.M.4    Cowan, M.J.5    Paciorek, C.J.6
  • 3
  • 4
    • 33745009246 scopus 로고    scopus 로고
    • Effects of melatonin on streptozotocin-induced diabetic liver injury in rats
    • Guven A, Yavuz O, Cam M, Ercan F, Bukan N, Comunoglu C, et al. Effects of melatonin on streptozotocin-induced diabetic liver injury in rats. Acta Histochem 2006; 108: 85-93. doi: 10.1016/j.acthis.2006.03.005.
    • (2006) Acta Histochem , vol.108 , pp. 85-93
    • Guven, A.1    Yavuz, O.2    Cam, M.3    Ercan, F.4    Bukan, N.5    Comunoglu, C.6
  • 5
    • 30444461216 scopus 로고    scopus 로고
    • Insulin resistance, adiponectin, cytokines in NASH: Which is the best target to treat?
    • Larter CZ, Farrell GC. Insulin resistance, adiponectin, cytokines in NASH: Which is the best target to treat? J Hepatol 2006; 44: 253-61. doi: 10.1016/j.jhep.2005.11.030.
    • (2006) J Hepatol , vol.44 , pp. 253-261
    • Larter, C.Z.1    Farrell, G.C.2
  • 6
    • 34249650125 scopus 로고    scopus 로고
    • Insulin resistance in hepatocytes and sinusoidal liver cells: Mechanisms and consequences
    • Leclercq IA, Da Silva Morais A, Schroyen B, Van Hul N, Geerts A. Insulin resistance in hepatocytes and sinusoidal liver cells: Mechanisms and consequences. J Hepatol 2007; 47: 142-56. doi: 10.1016/j.jhep.2007.04.002.
    • (2007) J Hepatol , vol.47 , pp. 142-156
    • Leclercq, I.A.1    Da Silva Morais, A.2    Schroyen, B.3    Van Hul, N.4    Geerts, A.5
  • 7
    • 30944455145 scopus 로고    scopus 로고
    • Insulin resistance: A metabolic pathway to chronic liver disease
    • Bugianesi E, McCullough AJ, Marchesini G. Insulin resistance: A metabolic pathway to chronic liver disease. Hepatology 2005; 42: 987-1000. doi: 10.1002/hep.20920.
    • (2005) Hepatology , vol.42 , pp. 987-1000
    • Bugianesi, E.1    McCullough, A.J.2    Marchesini, G.3
  • 8
    • 77952551952 scopus 로고    scopus 로고
    • Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid
    • Manna P, Das J, Ghosh J, Sil PC. Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid. Free Radic Biol Med 2010; 48: 1465-84. doi: 10.1016/j.freeradbiomed.2010.02.025.
    • (2010) Free Radic Biol Med , vol.48 , pp. 1465-1484
    • Manna, P.1    Das, J.2    Ghosh, J.3    Sil, P.C.4
  • 9
    • 77953545677 scopus 로고    scopus 로고
    • Resveratrol attenuates hyperglycemia-mediated oxidative stress, proinflammatory cytokines and protects hepatocytes ultrastructure in streptozotocin-nicotinamide-induced experimental diabetic rats
    • Palsamy P, Sivakumar S, Subramanian S. Resveratrol attenuates hyperglycemia-mediated oxidative stress, proinflammatory cytokines and protects hepatocytes ultrastructure in streptozotocin-nicotinamide-induced experimental diabetic rats. Chem Biol Interact 2010; 186: 200-10. doi: 10.1016/j. cbi.2010.03.028.
    • (2010) Chem Biol Interact , vol.186 , pp. 200-210
    • Palsamy, P.1    Sivakumar, S.2    Subramanian, S.3
  • 10
    • 77953538684 scopus 로고    scopus 로고
    • Xanthine oxidase-induced oxidative stress causes activation of NF-kappaB and inflammation in the liver of type I diabetic rats
    • Romagnoli M, Gomez-Cabrera MC, Perrelli MG, Biasi F, Pallardó FV, Sastre J, et al. Xanthine oxidase-induced oxidative stress causes activation of NF-kappaB and inflammation in the liver of type I diabetic rats. Free Radic Biol Med 2010; 49: 171-7. doi: 10.1016/j.freeradbiomed.2010.03.024.
    • (2010) Free Radic Biol Med , vol.49 , pp. 171-177
    • Romagnoli, M.1    Gomez-Cabrera, M.C.2    Perrelli, M.G.3    Biasi, F.4    Pallardó, F.V.5    Sastre, J.6
  • 11
    • 77955463534 scopus 로고    scopus 로고
    • Newly diagnosed diabetes mellitus as a risk factor for serious liver disease
    • Porepa L, Ray JG, Sanchez-Romeu P, Booth GL. Newly diagnosed diabetes mellitus as a risk factor for serious liver disease. CMAJ 2010; 182: E526-31. doi: 10.1503/cmaj.092144.
    • (2010) CMAJ , vol.182 , pp. E526-E531
    • Porepa, L.1    Ray, J.G.2    Sanchez-Romeu, P.3    Booth, G.L.4
  • 12
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: Old questions and new insights
    • Cohen JC, Horton JD, Hobbs HH. Human fatty liver disease: Old questions and new insights. Science 2011; 332: 1519-23. doi: 10.1126/science.1204265.
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 13
    • 12744257669 scopus 로고    scopus 로고
    • Liver and biliary tract
    • Kumar V, Abbas AK, Fausto N, Aster JC, Eds, 8th ed. Philadelphia, Pennsylvania, USA: Saunders
    • Crawford JM, Iacobuzio-Donahue C. Liver and biliary tract. In: Kumar V, Abbas AK, Fausto N, Aster JC, Eds. Robbins and Cotran Pathologic Basis of Disease. 8th ed. Philadelphia, Pennsylvania, USA: Saunders, 2009. Pp. 833-90.
    • (2009) Robbins and Cotran Pathologic Basis of Disease , pp. 833-890
    • Crawford, J.M.1    Iacobuzio-Donahue, C.2
  • 15
    • 84862500687 scopus 로고    scopus 로고
    • Hepatic steatosis in type 1 diabetes
    • Regnell SE, Lernmark Å. Hepatic steatosis in type 1 diabetes. Rev Diabet Stud 2011; 8: 454-67. doi: 10.1900/rds.2011.8.454.
    • (2011) Rev Diabet Stud , vol.8 , pp. 454-467
    • Regnell, S.E.1    Å, L.2
  • 16
    • 1842420442 scopus 로고    scopus 로고
    • Ultrastructural, immunohistochemical and biochemical investigations of the rat liver exposed to experimental diabetes and acute hypoxia with and without application of Ginkgo extract
    • Welt K, Weiss J, Martin R, Dettmer D, Hermsdorf T, Asayama K, et al. Ultrastructural, immunohistochemical and biochemical investigations of the rat liver exposed to experimental diabetes and acute hypoxia with and without application of Ginkgo extract. Exp Toxicol Pathol 2004; 55: 331-45. doi: 10.1078/0940-2993-00337.
    • (2004) Exp Toxicol Pathol , vol.55 , pp. 331-345
    • Welt, K.1    Weiss, J.2    Martin, R.3    Dettmer, D.4    Hermsdorf, T.5    Asayama, K.6
  • 17
    • 33845317868 scopus 로고    scopus 로고
    • Diabetes and liver disease: An ominous association
    • Moscatiello S, Manini R, Marchesini G. Diabetes and liver disease: An ominous association. Nutr Metab Cardiovasc Dis 2007; 17: 63-70. doi: 10.1016/j.numecd.2006.08.004.
    • (2007) Nutr Metab Cardiovasc Dis , vol.17 , pp. 63-70
    • Moscatiello, S.1    Manini, R.2    Marchesini, G.3
  • 18
    • 40649103355 scopus 로고    scopus 로고
    • Hyperglycaemia, stress oxidant, liver dysfunction and histological changes in diabetic male rat pancreas and liver: Protective effect of 17 beta-estradiol
    • Hamden K, Carreau S, Boujbiha MA, Lajmi S, Aloulou D, Kchaou D, et al. Hyperglycaemia, stress oxidant, liver dysfunction and histological changes in diabetic male rat pancreas and liver: Protective effect of 17 beta-estradiol. Steroids 2008; 73: 495-501. doi: 10.1016/j.steroids.2007.12.026.
    • (2008) Steroids , vol.73 , pp. 495-501
    • Hamden, K.1    Carreau, S.2    Boujbiha, M.A.3    Lajmi, S.4    Aloulou, D.5    Kchaou, D.6
  • 19
    • 84924227542 scopus 로고    scopus 로고
    • Alloxan-induced diabetes causes morphological and ultrastructural changes in rat liver that resemble the natural history of chronic fatty liver disease in humans
    • Lucchesi AN, Cassettari LN, Spadella CT. Alloxan-induced diabetes causes morphological and ultrastructural changes in rat liver that resemble the natural history of chronic fatty liver disease in humans. J Diabetes Res 2015; 2015: 494578. doi: 10.1155/2015/494578.
    • (2015) J Diabetes Res , vol.2015 , pp. 494578
    • Lucchesi, A.N.1    Cassettari, L.N.2    Spadella, C.T.3
  • 20
    • 84877247095 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease, diabetes mellitus and cardiovascular disease: Newer data
    • Mavrogiannaki AN, Migdalis IN. Nonalcoholic fatty liver disease, diabetes mellitus and cardiovascular disease: Newer data. Int J Endocrinol 2013; 2013: 450639. doi: 10.1155/2013/450639.
    • (2013) Int J Endocrinol , vol.2013 , pp. 450639
    • Mavrogiannaki, A.N.1    Migdalis, I.N.2
  • 22
    • 21544436004 scopus 로고    scopus 로고
    • Liver enzymes, the metabolic syndrome, and incident diabetes: The Mexico City diabetes study
    • Nannipieri M, Gonzales C, Baldi S, Posadas R, Williams K, Haffner SM, et al. Liver enzymes, the metabolic syndrome, and incident diabetes: The Mexico City diabetes study. Diabetes Care 2005; 28: 1757-62. doi: 10.2337/diacare.28.7.1757.
    • (2005) Diabetes Care , vol.28 , pp. 1757-1762
    • Nannipieri, M.1    Gonzales, C.2    Baldi, S.3    Posadas, R.4    Williams, K.5    Haffner, S.M.6
  • 23
    • 84887424206 scopus 로고    scopus 로고
    • Current management of patients with nonalcoholic fatty liver disease
    • Elsheikh E, Henry LL, Younossi ZM. Current management of patients with nonalcoholic fatty liver disease. Expert Rev Endocrinol Metab 2013; 8: 549-58. doi: 10.1586/17446651.2013.846212.
    • (2013) Expert Rev Endocrinol Metab , vol.8 , pp. 549-558
    • Elsheikh, E.1    Henry, L.L.2    Younossi, Z.M.3
  • 24
    • 84898670730 scopus 로고    scopus 로고
    • Impact of the adipokine adiponectin and the hepatokine fetuin-A on the development of type 2 diabetes: Prospective cohort-and cross-sectional phenotyping studies
    • Stefan N, Sun Q, Fritsche A, Machann J, Schick F, Gerst F, et al. Impact of the adipokine adiponectin and the hepatokine fetuin-A on the development of type 2 diabetes: Prospective cohort-and cross-sectional phenotyping studies. PLoS One 2014; 9: e92238. doi: 10.1371/journal.pone.0092238.
    • (2014) PLoS One , vol.9 , pp. e92238
    • Stefan, N.1    Sun, Q.2    Fritsche, A.3    Machann, J.4    Schick, F.5    Gerst, F.6
  • 25
    • 84937522427 scopus 로고    scopus 로고
    • Hepatokines: Unlocking the multiorgan network in metabolic diseases
    • Iroz A, Couty JP, Postic C. Hepatokines: Unlocking the multiorgan network in metabolic diseases. Diabetologia 2015; 58: 1699-1703. doi: 10.1007/s00125-015-3634-4.
    • (2015) Diabetologia , vol.58 , pp. 1699-1703
    • Iroz, A.1    Couty, J.P.2    Postic, C.3
  • 28
    • 84872406355 scopus 로고    scopus 로고
    • CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease
    • Leung TM, Nieto N. CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease. J Hepatol 2013; 58: 395-8. doi: 10.1016/j.jhep.2012.08.018.
    • (2013) J Hepatol , vol.58 , pp. 395-398
    • Leung, T.M.1    Nieto, N.2
  • 29
    • 77951770043 scopus 로고    scopus 로고
    • Carbon monoxide-releasing molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats
    • Wei Y, Chen P, de Bruyn MD, Zhang W, Bremer E, Helfrich W. Carbon monoxide-releasing molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats. BMC Gastroenterol 2010; 10: 42. doi: 10.1186/1471-230X-10-42.
    • (2010) BMC Gastroenterol , vol.10 , pp. 42
    • Wei, Y.1    Chen, P.2    de Bruyn, M.D.3    Zhang, W.4    Bremer, E.5    Helfrich, W.6
  • 30
    • 77953540524 scopus 로고    scopus 로고
    • Protective effects of Pycnogenol on hyperglycemia-induced oxidative damage in the liver of type 2 diabetic rats
    • Parveen K, Khan MR, Mujeeb M, Siddigui WA. Protective effects of Pycnogenol on hyperglycemia-induced oxidative damage in the liver of type 2 diabetic rats. Chem Biol Interact 2010; 186: 219-27. doi: 10.1016/j.cbi.2010.04.023.
    • (2010) Chem Biol Interact , vol.186 , pp. 219-227
    • Parveen, K.1    Khan, M.R.2    Mujeeb, M.3    Siddigui, W.A.4
  • 31
    • 33745791542 scopus 로고    scopus 로고
    • Mechanisms of liver injury: III - Role of glutathione redox status in liver injury
    • Han D, Hanawa N, Saberi B, Kaplowitz N. Mechanisms of liver injury: III - Role of glutathione redox status in liver injury. Am J Physiol Gastrointest Liver Physiol 2006; 291: G1-7. doi: 10.1152/ajpgi.00001.2006.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.291 , pp. G1-G7
    • Han, D.1    Hanawa, N.2    Saberi, B.3    Kaplowitz, N.4
  • 32
    • 11144324314 scopus 로고    scopus 로고
    • Advanced glycation endproducts: Role in pathology of diabetic complications
    • Ahmed N. Advanced glycation endproducts: Role in pathology of diabetic complications. Diabetes Res Clin Pract 2005; 67: 3-21. doi: 10.1016/j.diabres.2004.09.004.
    • (2005) Diabetes Res Clin Pract , vol.67 , pp. 3-21
    • Ahmed, N.1
  • 33
    • 0036129604 scopus 로고    scopus 로고
    • The liver is the main site for metabolism of circulating advanced glycation end products
    • Horiuchi S. The liver is the main site for metabolism of circulating advanced glycation end products. J Hepatol 2002; 36: 123-5. doi: 10.1016/S0168-8278(01)00293-8.
    • (2002) J Hepatol , vol.36 , pp. 123-125
    • Horiuchi, S.1
  • 34
    • 29344443061 scopus 로고    scopus 로고
    • Elevation of Nepsilon-(carboxymethyl)lysine-modified advanced glycation end products in chronic liver disease is an indicator of liver cirrhosis
    • Yagmur E, Tacke F, Weiss C, Lahme B, Manns MP, Keifer P, et al. Elevation of Nepsilon-(carboxymethyl)lysine-modified advanced glycation end products in chronic liver disease is an indicator of liver cirrhosis. Clin Biochem 2006; 39: 39-45. doi: 10.1016/j.clinbiochem.2005.07.016.
    • (2006) Clin Biochem , vol.39 , pp. 39-45
    • Yagmur, E.1    Tacke, F.2    Weiss, C.3    Lahme, B.4    Manns, M.P.5    Keifer, P.6
  • 35
    • 9644291555 scopus 로고    scopus 로고
    • Processing of protein glycation, oxidation and nitrosation adducts in the liver and the effect of cirrhosis
    • Ahmed N, Thornalley PJ, Lüthen R, Häussinger D, Sebekova K, Schinzel R, et al. Processing of protein glycation, oxidation and nitrosation adducts in the liver and the effect of cirrhosis. J Hepatol 2004; 41: 913-19. doi: 10.1016/j.jhep.2004.08.007.
    • (2004) J Hepatol , vol.41 , pp. 913-919
    • Ahmed, N.1    Thornalley, P.J.2    Lüthen, R.3    Häussinger, D.4    Sebekova, K.5    Schinzel, R.6
  • 36
    • 77449130866 scopus 로고    scopus 로고
    • Elevated advanced oxidation protein products levels in patients with liver cirrhosis
    • Zuwała-Jagiełło J, Pazgan-Simon M, Simon K, Warwas M. Elevated advanced oxidation protein products levels in patients with liver cirrhosis. Acta Biochim Pol 2009; 56: 679-85.
    • (2009) Acta Biochim Pol , vol.56 , pp. 679-685
    • Zuwała-Jagiełło, J.1    Pazgan-Simon, M.2    Simon, K.3    Warwas, M.4
  • 37
    • 0036126560 scopus 로고    scopus 로고
    • Markedly elevated levels of plasma advanced glycation end products in patients with liver cirrhosis: Amelioration by liver transplantation
    • Sebeková K, Kupcová V, Schinzel R, Heidland A. Markedly elevated levels of plasma advanced glycation end products in patients with liver cirrhosis: Amelioration by liver transplantation. J Hepatol 2002; 36: 66-71. doi: 10.1016/S0168-8278(01)00232-X.
    • (2002) J Hepatol , vol.36 , pp. 66-71
    • Sebeková, K.1    Kupcová, V.2    Schinzel, R.3    Heidland, A.4
  • 38
    • 0034545719 scopus 로고    scopus 로고
    • Quantification and significance of protein oxidation in biological samples
    • Shacter E. Quantification and significance of protein oxidation in biological samples. Drug Metab Rev 2000; 32: 307-26. doi: 10.1081/DMR-100102336.
    • (2000) Drug Metab Rev , vol.32 , pp. 307-326
    • Shacter, E.1
  • 39
    • 84901379933 scopus 로고    scopus 로고
    • Functional roles of protein nitration in acute and chronic liver diseases
    • Abdelmegeed MA, Song BJ. Functional roles of protein nitration in acute and chronic liver diseases. Oxid Med Cell Longev 2014; 2014: 149627. doi: 10.1155/2014/149627.
    • (2014) Oxid Med Cell Longev , vol.2014 , pp. 149627
    • Abdelmegeed, M.A.1    Song, B.J.2
  • 40
    • 18844471606 scopus 로고    scopus 로고
    • Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure
    • Witko-Sarsat V, Friendlander M, Nguyen Khoa T, Capeillère-Blandin C, Nguyen AT, Canteloup S, et al. Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure. J Immunol 1998; 161: 2524-32.
    • (1998) J Immunol , vol.161 , pp. 2524-2532
    • Witko-Sarsat, V.1    Friendlander, M.2    Nguyen Khoa, T.3    Capeillère-Blandin, C.4    Nguyen, A.T.5    Canteloup, S.6
  • 41
    • 33947503467 scopus 로고    scopus 로고
    • Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients
    • Nazratun N, Mahmood AA, Kuppusamy UR, Ahmad TS, Tan SY. Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients. Vasc Med 2006; 11: 245-50. doi: 10.1177/1358863x06072202.
    • (2006) Vasc Med , vol.11 , pp. 245-250
    • Nazratun, N.1    Mahmood, A.A.2    Kuppusamy, U.R.3    Ahmad, T.S.4    Tan, S.Y.5
  • 42
    • 33744977508 scopus 로고    scopus 로고
    • The structural and pharmacokinetic properties of oxidized human serum albumin, advanced oxidation protein products (AOPP)
    • Iwao Y, Anraku M, Hiraike M, Kawai K, Nakajou K, Kai T, et al. The structural and pharmacokinetic properties of oxidized human serum albumin, advanced oxidation protein products (AOPP). Drug Metab Pharmacokinet 2006; 21: 140-6. doi: 10.2133/dmpk.21.140.
    • (2006) Drug Metab Pharmacokinet , vol.21 , pp. 140-146
    • Iwao, Y.1    Anraku, M.2    Hiraike, M.3    Kawai, K.4    Nakajou, K.5    Kai, T.6
  • 43
    • 9644281586 scopus 로고    scopus 로고
    • Hepatic clearance of advanced glycation end products (AGEs): Myth or truth?
    • Svistounov D, Smedsrød B. Hepatic clearance of advanced glycation end products (AGEs): Myth or truth? J Hepatol 2004; 41: 1038-40. doi: 10.1016/j.jhep.2004.10.004.
    • (2004) J Hepatol , vol.41 , pp. 1038-1040
    • Svistounov, D.1    Smedsrød, B.2
  • 44
    • 0037700820 scopus 로고    scopus 로고
    • Hepatic function enzymes and lipid peroxidation in streptozotocininduced diabetic rats fed bitter yam (Dioscorea polygonoides) steroidal sapogenin extract
    • McNuff MA, Omoruyi FO, Morrison EY, Asemota HN. Hepatic function enzymes and lipid peroxidation in streptozotocininduced diabetic rats fed bitter yam (Dioscorea polygonoides) steroidal sapogenin extract. Diabetol Croat 2003; 32: 17-23.
    • (2003) Diabetol Croat , vol.32 , pp. 17-23
    • McNuff, M.A.1    Omoruyi, F.O.2    Morrison, E.Y.3    Asemota, H.N.4
  • 45
    • 35948964347 scopus 로고    scopus 로고
    • Hepatic stellate cells and liver fibrosis
    • Moreira RK. Hepatic stellate cells and liver fibrosis. Arch Pathol Lab Med 2007; 131: 1728-34.
    • (2007) Arch Pathol Lab Med , vol.131 , pp. 1728-1734
    • Moreira, R.K.1
  • 46
    • 84868655005 scopus 로고    scopus 로고
    • Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats
    • Mahmoud AM, Ashour MB, Abdel-Moneim A, Ahmed OM. Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats. J Diabetes Complications 2012; 26: 483-90. doi: 10.1016/j.jdiacomp.2012.06.001.
    • (2012) J Diabetes Complications , vol.26 , pp. 483-490
    • Mahmoud, A.M.1    Ashour, M.B.2    Abdel-Moneim, A.3    Ahmed, O.M.4
  • 47
    • 33746185764 scopus 로고    scopus 로고
    • Dietary caloric restriction modifies inflammatory responses in the livers of streptozotocininduced diabetic rats
    • Ugochukwu NH, Figgers CL. Dietary caloric restriction modifies inflammatory responses in the livers of streptozotocininduced diabetic rats. Nutr Res 2006; 26: 221-6. doi: 10.1016/j. nutres.2006.05.003.
    • (2006) Nutr Res , vol.26 , pp. 221-226
    • Ugochukwu, N.H.1    Figgers, C.L.2
  • 48
    • 4644305395 scopus 로고    scopus 로고
    • Effects of vitamin E supplementation on oxidative stress in streptozotocin induced diabetic rats: Investigation of liver and plasma
    • Seven A, Guzel S, Seymen O, Civelek S, Bolayirli M, Uncu M, et al. Effects of vitamin E supplementation on oxidative stress in streptozotocin induced diabetic rats: Investigation of liver and plasma. Yonsei Med J 2004; 45: 703-10. doi: 10.3349/ ymj.2004.45.4.703.
    • (2004) Yonsei Med J , vol.45 , pp. 703-710
    • Seven, A.1    Guzel, S.2    Seymen, O.3    Civelek, S.4    Bolayirli, M.5    Uncu, M.6
  • 49
    • 84861329882 scopus 로고    scopus 로고
    • Interleukin-1 (IL-1) family of cytokines: Role in type 2 diabetes
    • Banerjee M, Saxena M. Interleukin-1 (IL-1) family of cytokines: Role in type 2 diabetes. Clin Chim Acta 2012; 413: 1163-70. doi: 10.1016/j.cca.2012.03.021.
    • (2012) Clin Chim Acta , vol.413 , pp. 1163-1170
    • Banerjee, M.1    Saxena, M.2
  • 50
    • 20444424991 scopus 로고    scopus 로고
    • Quercetin attenuates nuclear factor-kappaB activation and nitric oxide production in interleukin-1beta-activated rat hepatocytes
    • Martínez-Flórez S, Gutiérrez-Fernández B, Sánchez-Campos S, González-Gallego J, Tuñón MJ. Quercetin attenuates nuclear factor-kappaB activation and nitric oxide production in interleukin-1beta-activated rat hepatocytes. J Nutr 2005; 135: 1359-65.
    • (2005) J Nutr , vol.135 , pp. 1359-1365
    • Martínez-Flórez, S.1    Gutiérrez-Fernández, B.2    Sánchez-Campos, S.3    González-Gallego, J.4    Tuñón, M.J.5
  • 51
    • 26444584958 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and liver carcinogenesis
    • Arsura M, Cavin LG. Nuclear factor-kappaB and liver carcinogenesis. Cancer Lett 2005; 229: 157-69. doi: 10.1016/j. canlet.2005.07.008.
    • (2005) Cancer Lett , vol.229 , pp. 157-169
    • Arsura, M.1    Cavin, L.G.2
  • 52
    • 84866259297 scopus 로고    scopus 로고
    • Molecular mechanisms of liver injury and hepatocarcinogenesis: Focusing on the role of stress-activated MAPK
    • Nakagawa H, Maeda S. Molecular mechanisms of liver injury and hepatocarcinogenesis: Focusing on the role of stress-activated MAPK. Patholog Res Int 2012; 2012: 172894. doi: 10.1155/2012/172894.
    • (2012) Patholog Res Int , vol.2012 , pp. 172894
    • Nakagawa, H.1    Maeda, S.2
  • 53
    • 84886689057 scopus 로고    scopus 로고
    • Pathophysiologic approach to therapy in patients with newly diagnosed type 2 diabetes
    • DeFronzo RA, Eldor R, Abdul-Ghani M. Pathophysiologic approach to therapy in patients with newly diagnosed type 2 diabetes. Diabetes Care 2013; 36: S127-38. doi: 10.2337/dcS13-2011.
    • (2013) Diabetes Care , vol.36 , pp. S127-S138
    • DeFronzo, R.A.1    Eldor, R.2    Abdul-Ghani, M.3
  • 54
    • 33645536593 scopus 로고    scopus 로고
    • Treatment of non-alcoholic fatty liver disease
    • Adams LA, Angulo P. Treatment of non-alcoholic fatty liver disease. Postgrad Med J 2006; 82: 315-22. doi: 10.1136/ pgmj.2005.042200.
    • (2006) Postgrad Med J , vol.82 , pp. 315-322
    • Adams, L.A.1    Angulo, P.2
  • 55
    • 67449123052 scopus 로고    scopus 로고
    • Beneficial effects of Chinese prescription Kangen-karyu on diabetes associated with hyperlipidemia, advanced glycation endproducts, and oxidative stress in streptozotocin-induced diabetic rats
    • Kim HY, Okamoto T, Yokozawa T. Beneficial effects of Chinese prescription Kangen-karyu on diabetes associated with hyperlipidemia, advanced glycation endproducts, and oxidative stress in streptozotocin-induced diabetic rats. J Ethnopharmacol 2009; 124: 263-9. doi: 10.1016/j.jep.2009.04.032.
    • (2009) J Ethnopharmacol , vol.124 , pp. 263-269
    • Kim, H.Y.1    Okamoto, T.2    Yokozawa, T.3
  • 57
    • 67349179553 scopus 로고    scopus 로고
    • L-cysteine supplementation lowers blood glucose, glycated hemoglobin, CRP, MCP-1, oxidative stress and inhibits NFkappaB activation in the livers of Zucker diabetic rats
    • Jain SK, Velusamy T, Croad JL, Bull R. L-cysteine supplementation lowers blood glucose, glycated hemoglobin, CRP, MCP-1, oxidative stress and inhibits NFkappaB activation in the livers of Zucker diabetic rats. Free Radic Biol Med 2009; 46: 1633-38. doi: 10.1016/j.freeradbiomed.2009.03.014.
    • (2009) Free Radic Biol Med , vol.46 , pp. 1633-1638
    • Jain, S.K.1    Velusamy, T.2    Croad, J.L.3    Bull, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.