Imaging latent tuberculosis infection with radiolabeled nitroimidazoles

Clinical and Translational Imaging

Volumn 4, Issue 2, 2016, Pages 157-159

  Ankrah, Alfred O ^a,b   Glaudemans, Andor W J M ^a   Sathekge, Mike M ^b   Klein, Hans C ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

(1 (2 1 (1H METHYL) ETHOXY) METHYL 2 NITROIMIDAZOLE F 18; 1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL F 18; FLORTANIDAZOLE F 18; FLUOROAZOMYCIN ARABINOSIDE F 18; FLUOROERYTHRONITROIMIDAZOLE F 18; METRONIDAZOLE; NITROGEN DIOXIDE; NITROIMIDAZOLE; NITROREDUCTASE; PIMONIDAZOLE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ARTICLE; DIAGNOSTIC IMAGING; DNA SYNTHESIS; ECHINOCOCCOSIS; ECHINOCOCCUS MULTILOCULARIS; ENTAMOEBA HISTOLYTICA; GRANULOMA; HUMAN; HYPOXIA; ISOTOPE LABELING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PET-CT SCANNER; PRIORITY JOURNAL; TUBERCULOSIS;

EID: 84966783938     PISSN: 22815872     EISSN: 22817565     Source Type: Journal    
DOI: 10.1007/s40336-016-0166-y     Document Type: Article

References (10)

1. Ankrah AO, van der Werf TS, de Vries EF, Dierckx RA Sathekge MM, Glaudemans AW (2016) PET/CT imaging of Mycobacterium tuberculosis infection. Clin Transl Imaging. doi:10.1007/s40336-016-0164-0
2. Wayne LG, Hayes LG (1996) An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect Immun 64(6):2062–2069
3. Alsaad N, Wilffert B, van Altena R, de Lange WC, van der Werf TS, Kosterink JG, Alffenaar JW (2014) Potential antimicrobial agents for the treatment of multidrug-resistant tuberculosis. Eur Respir J 43(3):884–897. doi:10.1183/09031936.00113713
4. Apte S, Chin FT, Graves EE (2011) Molecular imaging of hypoxia: strategies for probe design and application. Curr Org Synth 8(4):593–603
5. Via LE, Lin PL, Ray SM, Carrillo J, Allen SS, Eum SY et al (2008) Tuberculous granulomas are hypoxic in guinea pigs, rabbits and nonhuman primates. Infect Immun 76(6):2333–2340. doi:10.1128/IAI.01515-07
6. Krohn KA, Link JM, Mason RP (2008) Molecular imaging of hypoxia. J Nucl Med 49(Suppl 2):129S–148S. doi:10.2967/jnumed.107.045914
7. Liu RS, Chu LS, Yen SH, Chang CP, Chou KL, Wu LC et al (1996) Detection of anaerobic odontogenic infections by fluorine-18 fluoromisonidazole. Eur J Nucl Med 23(10):1384–1387
8. Rolle AM, Soboslay PT, Reischl G, Hoffmann WH, Pichler BJ, Wiehr S (2015) Evaluation of the metabolic activity of Echinococcus multilocularis in rodents using positron emission tomography tracers. Mol Imaging Biol 17(4):512–520. doi:10.1007/s11307-014-0815-3
9. Leitsch D, Schlosser S, Burgess A, Duchene M (2012) Nitroimidazoles drugs vary in their mode of action in the human parasite Giadia lamblia. Int J Parasitol Drugs Drug Resist 2:166–170. doi:10.1016/j.ijpddr.2012.04.002
10. Klinkenberg LG, Sutherland LA, Bishai WR, Karakousis PC (2008) Metronidazole lacks activity against Mycobacterium tuberculosis in an in vivo hypoxic model of latency. J Infect Dis 198(2):275–283. doi:10.1086/589515