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Volumn 2, Issue , 2012, Pages 166-170

Nitroimidazole drugs vary in their mode of action in the human parasite Giardia lamblia

Author keywords

Nitroimidazoles; Protein binding; Thiol depletion; Translation elongation factor 1

Indexed keywords

2 NITROIMIDAZOLE; ELONGATION FACTOR; METRONIDAZOLE; RONIDAZOLE; THIOREDOXIN REDUCTASE; TINIDAZOLE;

EID: 84861465108     PISSN: 22113207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpddr.2012.04.002     Document Type: Article
Times cited : (51)

References (25)
  • 2
    • 0022355341 scopus 로고
    • A comparison of the in-vitro activity of some 5-nitroimidazoles and other compounds against Giardia intestinalis
    • Boreham P.F., Phillips R.E., Shepherd R.W. A comparison of the in-vitro activity of some 5-nitroimidazoles and other compounds against Giardia intestinalis. J. Antimicrob. Chemother. 1985, 16:589-595.
    • (1985) J. Antimicrob. Chemother. , vol.16 , pp. 589-595
    • Boreham, P.F.1    Phillips, R.E.2    Shepherd, R.W.3
  • 3
    • 51149116819 scopus 로고    scopus 로고
    • Pathophysiology of enteric infections with Giardia duodenalis
    • Buret A.G. Pathophysiology of enteric infections with Giardia duodenalis. Parasite 2008, 15:261-265.
    • (2008) Parasite , vol.15 , pp. 261-265
    • Buret, A.G.1
  • 4
    • 0036136292 scopus 로고    scopus 로고
    • The effects of the antiprotozoal drugs metronidazole and furazolidone on trophozoites of Giardia lamblia (P1 strain)
    • Campanati L., Monteiro-Real L.H. The effects of the antiprotozoal drugs metronidazole and furazolidone on trophozoites of Giardia lamblia (P1 strain). Parasitol. Res. 2002, 88:80-85.
    • (2002) Parasitol. Res. , vol.88 , pp. 80-85
    • Campanati, L.1    Monteiro-Real, L.H.2
  • 5
    • 0027522732 scopus 로고
    • Nitroimidazole drugs - action and resistance mechanisms. I. Mechanisms of action
    • Edwards D.I. Nitroimidazole drugs - action and resistance mechanisms. I. Mechanisms of action. J. Antimicrob. Chemother. 1993, 31:9-20.
    • (1993) J. Antimicrob. Chemother. , vol.31 , pp. 9-20
    • Edwards, D.I.1
  • 6
    • 33644516605 scopus 로고    scopus 로고
    • Tinidazole: a nitroimidazole antiprotozoal agent
    • Fung H.B., Doan T.L. Tinidazole: a nitroimidazole antiprotozoal agent. Clin. Ther. 2005, 27:1859-1884.
    • (2005) Clin. Ther. , vol.27 , pp. 1859-1884
    • Fung, H.B.1    Doan, T.L.2
  • 7
    • 77953661535 scopus 로고    scopus 로고
    • Oxidative stress-induced cell cycle blockage and a protease-independent programmed cell death in microaerophilic Giardia lamblia
    • Ghosh E., Ghosh A., Ghosh A.N., Nozaki T., Ganguly S. Oxidative stress-induced cell cycle blockage and a protease-independent programmed cell death in microaerophilic Giardia lamblia. Drug Des. Dev. Ther. 2009, 3:103-110.
    • (2009) Drug Des. Dev. Ther. , vol.3 , pp. 103-110
    • Ghosh, E.1    Ghosh, A.2    Ghosh, A.N.3    Nozaki, T.4    Ganguly, S.5
  • 8
    • 0020651210 scopus 로고
    • Axenic culture of Giardia lamblia in TYI-S-33 medium supplemented with bile
    • Keister D.B. Axenic culture of Giardia lamblia in TYI-S-33 medium supplemented with bile. Trans. R. Soc. Trop. Med. Hyg. 1983, 77:487-488.
    • (1983) Trans. R. Soc. Trop. Med. Hyg. , vol.77 , pp. 487-488
    • Keister, D.B.1
  • 11
    • 34548290340 scopus 로고    scopus 로고
    • Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase
    • Leitsch D., Kolarich D., Wilson I.B.H., Altmann F., Duchêne M. Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase. PLoS Biol. 2007, 5:e211.
    • (2007) PLoS Biol. , vol.5
    • Leitsch, D.1    Kolarich, D.2    Wilson, I.B.H.3    Altmann, F.4    Duchêne, M.5
  • 12
    • 64149123281 scopus 로고    scopus 로고
    • Trichomonas vaginalis: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance
    • Duchêne
    • Leitsch D., Kolarich D., Binder M., Stadlmann J., Altmann F., Duchêne Trichomonas vaginalis: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance. Mol. Microbiol. 2009, 72:518-536.
    • (2009) Mol. Microbiol. , vol.72 , pp. 518-536
    • Leitsch, D.1    Kolarich, D.2    Binder, M.3    Stadlmann, J.4    Altmann, F.5
  • 13
    • 79960472745 scopus 로고    scopus 로고
    • Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia
    • Leitsch D., Burgess A.G., Dunn L.A., Krauer K.G., Tan K., Duchêne M., Upcroft P., Eckmann L., Upcroft J.A. Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia. J. Antimicrob. Chemother. 2011, 66:1756-1766.
    • (2011) J. Antimicrob. Chemother. , vol.66 , pp. 1756-1766
    • Leitsch, D.1    Burgess, A.G.2    Dunn, L.A.3    Krauer, K.G.4    Tan, K.5    Duchêne, M.6    Upcroft, P.7    Eckmann, L.8    Upcroft, J.A.9
  • 15
    • 0022272171 scopus 로고
    • Mechanism of toxicity of nitro compounds used in chemotherapy of trichomoniasis
    • Moreno S.N.J., Docampo R. Mechanism of toxicity of nitro compounds used in chemotherapy of trichomoniasis. Environ. Health Perspect. 1985, 64:199-208.
    • (1985) Environ. Health Perspect. , vol.64 , pp. 199-208
    • Moreno, S.N.J.1    Docampo, R.2
  • 16
    • 0020536580 scopus 로고
    • Mode of action of metronidazole on anaerobic bacteria and protozoa
    • Müller M. Mode of action of metronidazole on anaerobic bacteria and protozoa. Surgery 1983, 93:165-171.
    • (1983) Surgery , vol.93 , pp. 165-171
    • Müller, M.1
  • 17
    • 29944435490 scopus 로고    scopus 로고
    • In vitro effects of thiazolides on Giardia lamblia WB clone C6 cultured axenically and in coculture with Caco2 cells
    • Müller J., Rühle G., Müller N., Rossignol J.F., Hemphill A. In vitro effects of thiazolides on Giardia lamblia WB clone C6 cultured axenically and in coculture with Caco2 cells. Antimicrob. Agents Chemother. 2006, 50:162-170.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 162-170
    • Müller, J.1    Rühle, G.2    Müller, N.3    Rossignol, J.F.4    Hemphill, A.5
  • 18
    • 79954583944 scopus 로고    scopus 로고
    • Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs
    • Nillius N., Müller J., Müller N. Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs. J. Antimicrob. Chemother. 2011, 66:1029-1035.
    • (2011) J. Antimicrob. Chemother. , vol.66 , pp. 1029-1035
    • Nillius, N.1    Müller, J.2    Müller, N.3
  • 19
    • 0028016206 scopus 로고
    • Evaluation of the effects of albendazole and metronidazole on the ultrastructure of Giardia duodenalis, Trichomonas vaginalis and Spironucleus muris using transmission electron microscopy
    • Oxberry M.E., Thompson R.C., Reynoldson J.A. Evaluation of the effects of albendazole and metronidazole on the ultrastructure of Giardia duodenalis, Trichomonas vaginalis and Spironucleus muris using transmission electron microscopy. Int. J. Parasitol. 1994, 24:695-703.
    • (1994) Int. J. Parasitol. , vol.24 , pp. 695-703
    • Oxberry, M.E.1    Thompson, R.C.2    Reynoldson, J.A.3
  • 20
    • 0018826389 scopus 로고
    • The reductive metabolism of metronidazole and ronidazole by aerobic liver microsomes
    • Pervez-Reyes E., Kalyanaraman B., Mason R.P. The reductive metabolism of metronidazole and ronidazole by aerobic liver microsomes. Mol. Pharmacol. 1980, 17:239-244.
    • (1980) Mol. Pharmacol. , vol.17 , pp. 239-244
    • Pervez-Reyes, E.1    Kalyanaraman, B.2    Mason, R.P.3
  • 21
    • 0032780258 scopus 로고    scopus 로고
    • Why metronidazole is active against both bacteria and parasites
    • Samuelson J. Why metronidazole is active against both bacteria and parasites. Antimicrob. Agents Chemother. 1999, 43:1533-1541.
    • (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 1533-1541
    • Samuelson, J.1
  • 22
  • 23
    • 0030221888 scopus 로고    scopus 로고
    • Characterisation and purification of pyruvate:ferredoxin oxidoreductase from Giardia duodenalis
    • Townson S.M., Upcroft J.A., Upcroft P. Characterisation and purification of pyruvate:ferredoxin oxidoreductase from Giardia duodenalis. Mol. Biochem. Parasitol. 1996, 79:183-193.
    • (1996) Mol. Biochem. Parasitol. , vol.79 , pp. 183-193
    • Townson, S.M.1    Upcroft, J.A.2    Upcroft, P.3
  • 24
    • 0019944285 scopus 로고
    • Drug residue formation from ronidazole, a 5-nitroimidazole. I. Characterization of in vitro protein alkylation
    • West S.B., Wislocki P.G., Fiorentini K.M., Alvaro R., Wolf F.J., Lu A.Y.H. Drug residue formation from ronidazole, a 5-nitroimidazole. I. Characterization of in vitro protein alkylation. Chem. Biol. Interact. 1982, 41:265-279.
    • (1982) Chem. Biol. Interact. , vol.41 , pp. 265-279
    • West, S.B.1    Wislocki, P.G.2    Fiorentini, K.M.3    Alvaro, R.4    Wolf, F.J.5    Lu, A.Y.H.6
  • 25
    • 0021321685 scopus 로고
    • Drug residue formation from ronidazole, a 5-nitroimidazole. V. Cysteine adducts formed upon reduction of ronidazole by dithionite or rat liver enzymes in the presence of cysteine
    • Wislocki P.G., Bagan E.S., Vandenheuvel W.J.A., Walker R.A., Alvaro R.F., Arison B.H., Lu Y.H., Wolf F.J. Drug residue formation from ronidazole, a 5-nitroimidazole. V. Cysteine adducts formed upon reduction of ronidazole by dithionite or rat liver enzymes in the presence of cysteine. Chem. Biol. Interact. 1984, 49:13-25.
    • (1984) Chem. Biol. Interact. , vol.49 , pp. 13-25
    • Wislocki, P.G.1    Bagan, E.S.2    Vandenheuvel, W.J.A.3    Walker, R.A.4    Alvaro, R.F.5    Arison, B.H.6    Lu, Y.H.7    Wolf, F.J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.