Enhanced generation of cytotoxic T lymphocytes by heat shock protein 70 fusion proteins harboring both CD8+ T cell and CD4+ T cell epitopes

Molecular Pharmaceutics

Volumn 7, Issue 5, 2010, Pages 1715-1723

  Takemoto, Seiji ^a   Nishikawa, Makiya ^a   Guan, Xin ^a   Ohno, Yuji ^a   Yata, Tomoya ^a   Takakura, Yoshinobu ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

antigen delivery; CD4+ T cell epitope; CD8+ T cell epitope; CTL; Hsp70; OVA; protein vaccine

Indexed keywords

DENDRITIC CELL VACCINE; EPITOPE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 70 OVALBUMIN[257-264] FUSION PROTEIN; HYBRID PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OVALBUMIN; OVALBUMIN[323-339] HEAT SHOCK PROTEIN 70 FUSION PROTEIN; OVALBUMIN[323-339] HEAT SHOCK PROTEIN 70 OVALBUMIN[257-264] FUSION PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG RESPONSE; FEMALE; IMMUNIZATION; LYMPHOCYTE FUNCTION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR; VACCINATION;

ANIMALS; ANTIGEN PRESENTATION; CANCER VACCINES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CELL LINE, TUMOR; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; EPITOPES, T-LYMPHOCYTE; FEMALE; HSP70 HEAT-SHOCK PROTEINS; IMMUNIZATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MODELS, IMMUNOLOGICAL; OVALBUMIN; PEPTIDE FRAGMENTS; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; VACCINES, SYNTHETIC;

EID: 77957723884     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp1001069     Document Type: Article

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