Chikusetsusaponin iva methyl ester isolated from the roots of achyranthes japonica suppresses LPS-Induced iNOS, TNF-α, IL-6, and IL-1β Expression by NF-eκB and AP-1 Inactivation

Biological and Pharmaceutical Bulletin

Volumn 39, Issue 5, 2016, Pages 657-664

  Lee, Hae Jun ^a   Shin, Ji Sun ^a,b   Lee, Woo Seok ^a   Shim, Heon Yong ^a   Park, Ji Min ^a   Jang, Dae Sik ^a   Lee, Kyung Tae ^a  

^a Kyung Hee University   (South Korea)

^b Kyung Hee University Hospital   (South Korea)

Author keywords

Achyranthes japonica; Activator protein (ap) 1; Anti inflammation; Chikusetsusaponin iva methyl ester (cs me); Nuclear factor (nf) e b

Indexed keywords

CHIKUSETSU SAPONIN; CHIKUSETSU SAPONIN METHYL ESTER; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E2; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; CHIKUSETSU SAPONIN IVA; ESTER; IL1B PROTEIN, MOUSE; NOS2 PROTEIN, MOUSE; OLEANOLIC ACID; PTGS2 PROTEIN, MOUSE; SAPONIN; TUMOR NECROSIS FACTOR;

ACHYRANTHES; ACHYRANTHES JAPONICA; ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; COX 2 GENE; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG EFFECT; DRUG ISOLATION; DRUG POTENCY; GENE EXPRESSION; IL 1BETA GENE; IL 6 GENE; INOS GENE; MACROPHAGE; MOUSE; NONHUMAN; PLANT ROOT; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; TNF ALPHA GENE; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; RAW 264.7 CELL LINE;

ACHYRANTHES; ANIMALS; ANTI-INFLAMMATORY AGENTS; CYCLOOXYGENASE 2; DINOPROSTONE; ESTERS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; OLEANOLIC ACID; PLANT ROOTS; RAW 264.7 CELLS; SAPONINS; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84966662512     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b15-00572     Document Type: Article

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