Low doses of ethanolic extract of Boldo (Peumus boldus) can ameliorate toxicity generated by cisplatin in normal liver cells of mice in vivo and in WRL-68 cells in vitro, but not in cancer cells in vivo or in vitro

Journal of Integrative Medicine

Volumn 12, Issue 5, 2014, Pages 425-438

  Mondal, Jesmin ^a   Bishayee, Kausik ^a   Panigrahi, Ashis Kumar ^a   Khuda Bukhsh, Anisur Rahman ^a  

^a UNIVERSITY OF KALYANI   (India)

Author keywords

anti oxidant; cytotoxicity; drug related toxicity; liver; Peumus boldus; plant ethanolic extract

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CISPLATIN; CYTOCHROME C; GLUTATHIONE; LACTATE DEHYDROGENASE; PEUMUS BOLDUS EXTRACT; PLANT EXTRACT; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

A549 CELL LINE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL DEATH; CELL ENLARGEMENT; CELL MEMBRANE; CELL VACUOLE; CELL VIABILITY; CELL VIABILITY ASSAY; CONTROLLED STUDY; DNA BINDING; DNA DAMAGE; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG DNA INTERACTION; FEMALE; HELA CELL LINE; HEPG2 CELL LINE; IN VITRO STUDY; IN VIVO STUDY; LD 50; LIVER CANCER; LIVER CELL; LIVER HISTOLOGY; LIVER INJURY; LIVER PROTECTION; LIVER STRUCTURE; LIVER TOXICITY; LOW DRUG DOSE; MALE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PEUMUS BOLDUS; PHASE CONTRAST MICROSCOPY; PROTEIN EXPRESSION; STAINING; TISSUE DEGENERATION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; DRUG EFFECTS; HUMAN; METABOLISM; NEOPLASMS; PATHOLOGY; TOXICITY;

ANIMALS; ANTINEOPLASTIC AGENTS; CELLS, CULTURED; CISPLATIN; DNA DAMAGE; FEMALE; GLUTATHIONE; HEPATOCYTES; HUMANS; MALE; MICE; NEOPLASMS; PEUMUS; PLANT EXTRACTS;

EID: 84908295689     PISSN: 20954964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2095-4964(14)60045-5     Document Type: Article

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