Effects of the Commercial Flame Retardant Mixture DE-71 on Cytokine Production by Human Immune Cells

PLoS ONE

Volumn 11, Issue 4, 2016, Pages

  Mynster Kronborg, Thit ^a   Frohnert Hansen, Juliana ^a   Nielsen, Claus Henrik ^a   Ramhøj, Louise ^b   Frederiksen, Marie ^c   Vorkamp, Katrin ^d   Feldt Rasmussen, Ulla ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c AALBORG UNIVERSITY   (Denmark)

^d AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

FLAME RETARDANT; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; PHYTOHEMAGGLUTININ; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; DIPHENYL ETHER DERIVATIVE; LACTATE DEHYDROGENASE; LEUKOAGGLUTININS, PLANTS; LIPOPOLYSACCHARIDE; PENTABROMODIPHENYL ETHER;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; CYTOTOXICITY TEST; ESCHERICHIA COLI; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOCOMPETENT CELL; MACROPHAGE; MONOCYTE; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; BIOSYNTHESIS; DRUG EFFECTS; ENZYMOLOGY; FEMALE; IMMUNOLOGY; IN VITRO STUDY; MALE; METABOLISM; MONONUCLEAR CELL;

CYTOKINES; FEMALE; FLAME RETARDANTS; HALOGENATED DIPHENYL ETHERS; HUMANS; IN VITRO TECHNIQUES; L-LACTATE DEHYDROGENASE; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MALE; PHYTOHEMAGGLUTININS;

EID: 84966412984     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0154621     Document Type: Article

References (38)

1. Frederiksen M, Vorkamp K, Thomsen M, Knudsen LE. Human internal and external exposure to PBDEs - a review of levels and sources. Int J Hyg Environ Health 2009Mar; 212(2):109-34. doi: 10.1016/j.ijheh.2008.04.005 PMID: 18554980
2. BSEF, 2015. 2015. Bromine Science and Environmental Forum. Available: http://www.bsef.com/. Accessed 16 July 2015.
3. Birnbaum LS, Staskal DF. Brominated flame retardants: cause for concern? Environ Health Perspect 2004Jan; 112(1):9-17. PMID: 14698924
4. de Wit CA, Herzke D, Vorkamp K. Brominated flame retardants in the Arctic environment - trends and new candidates. Sci Total Environ 2010Jul 1; 408(15):2885-918. doi: 10.1016/j.scitotenv.2009.08.037 PMID: 19815253
5. Darnerud PO, Eriksen GS, Johannesson T, Larsen PB, Viluksela M. Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology. Environ Health Perspect 2001Mar; 109 Suppl 1:49-68. PMID: 11250805
6. de Wit CA. An overview of brominated flame retardants in the environment. Chemosphere 2002Feb; 46(5):583-624. PMID: 11999784
7. Zhang ZL, Leith C, Rhind SM, Kerr C, Osprey M, Kyle C, et al. Long term temporal and spatial changes in the distribution of polychlorinated biphenyls and polybrominated diphenyl ethers in Scottish soils. Sci Total Environ 2014Jan 15; 468-469:158-64. doi: 10.1016/j.scitotenv.2013.08.029 PMID: 24012902
8. Geyer HJ, Schramm K-W, Darnerud PO, Aune M, Feicht EA, Fried KW, et al. Terminal elimination half-lives of the brominated flame retardants TBBPA, HBCD, and lower brominated PBDEs in humans. 66, 3820-3825. 2004. Organohalogen Compounds.
9. Stapleton HM, Eagle S, Anthopolos R, Wolkin A, Miranda ML. Associations between polybrominated diphenyl ether (PBDE) flame retardants, phenolic metabolites, and thyroid hormones during pregnancy. Environ Health Perspect 2011Oct; 119(10):1454-9. doi: 10.1289/ehp.1003235 PMID: 21715241
10. Vorkamp K, Thomsen M, Frederiksen M, Pedersen M, Knudsen LE. Polybrominated diphenyl ethers (PBDEs) in the indoor environment and associations with prenatal exposure. Environ Int 2011Jan; 37 (1):1-10. doi: 10.1016/j.envint.2010.06.001 PMID: 20609475
11. Kim YR, Harden FA, Toms LM, Norman RE. Health consequences of exposure to brominated flame retardants: a systematic review. Chemosphere 2014Jul; 106:1-19. doi: 10.1016/j.chemosphere.2013.12.064 PMID: 24529398
12. Siddiqi MA, Laessig RH, Reed KD. Polybrominated diphenyl ethers (PBDEs): new pollutants-old diseases. Clin Med Res 2003Oct; 1(4):281-90. PMID: 15931321
13. Hennigar SR, Myers JL, Tagliaferro AR. Exposure of alveolar macrophages to polybrominated diphenyl ethers suppresses the release of pro-inflammatory products in vitro. Exp Biol Med (Maywood) 2012Apr; 237(4):429-34.
14. Lv QY, Wan B, Guo LH, Zhao L, Yang Y. In vitro immune toxicity of polybrominated diphenyl ethers on murine peritoneal macrophages: apoptosis and immune cell dysfunction. Chemosphere 2015Feb; 120:621-30. doi: 10.1016/j.chemosphere.2014.08.029 PMID: 25462306
15. Martin PA, Mayne GJ, Bursian FS, Tomy G, Palace V, Pekarik C, et al. Immunotoxicity of the commercial polybrominated diphenyl ether mixture DE-71 in ranch mink (Mustela vison). Environ Toxicol Chem 2007May; 26(5):988-97. PMID: 17521147
16. Peltier MR, Klimova NG, Arita Y, Gurzenda EM, Murthy A, Chawala K, et al. Polybrominated diphenyl ethers enhance the production of proinflammatory cytokines by the placenta. Placenta 2012Sep; 33 (9):745-9. doi: 10.1016/j.placenta.2012.06.005 PMID: 22749501
17. Bondy GS, Lefebvre DE, Aziz S, Cherry W, Coady L, Maclellan E, et al. Toxicologic and immunologic effects of perinatal exposure to the brominated diphenyl ether (BDE) mixture DE-71 in the Sprague-Dawley rat. Environ Toxicol 2013Apr; 28(4):215-28. doi: 10.1002/tox.20713 PMID: 21544923
18. Fair PA, Stavros HC, Mollenhauer MA, DeWitt JC, Henry N, Kannan K, et al. Immune function in female B(6)C(3)F(1) mice is modulated by DE-71, a commercial polybrominated diphenyl ether mixture. J Immunotoxicol 2012Jan; 9(1):96-107. doi: 10.3109/1547691X.2011.643418 PMID: 22214215
19. Fernlof G, Gadhasson I, Podra K, Darnerud PO, Thuvander A. Lack of effects of some individual polybrominated diphenyl ether (PBDE) and polychlorinated biphenyl (PCB) congeners on human lymphocyte functions in vitro. Toxicol Lett 1997Feb 7; 90(2-3):189-97. PMID: 9067487
20. Galbiati V, Mitjans M, Corsini E. Present and future of in vitro immunotoxicology in drug development. J Immunotoxicol 2010Oct; 7(4):255-67. doi: 10.3109/1547691X.2010.509848 PMID: 20735150
21. Hansen JF, Nielsen CH, Brorson MM, Frederiksen H, Hartoft-Nielsen ML, Rasmussen AK, et al. Influence of Phthalates on in vitro Innate and Adaptive Immune Responses. PLoS One 2015; 10(6): e0131168. doi: 10.1371/journal.pone.0131168 PMID: 26110840
22. Vorkamp K, Nielsen F, Kyhl HB, Husby S, Nielsen LB, Barington T, et al. Polybrominated diphenyl ethers and perfluoroalkyl substances in serum of pregnant women: levels, correlations, and potential health implications. Arch Environ Contam Toxicol 2014Jul; 67(1):9-20. doi: 10.1007/s00244-013-9988-z PMID: 24435476
23. de Waal MR, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991Nov 1; 174(5):1209-20. PMID: 1940799
24. Siewe L, Bollati-Fogolin M, Wickenhauser C, Krieg T, Muller W, Roers A. Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA. Eur J Immunol 2006Dec; 36(12):3248-55. PMID: 17111348
25. Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005Nov; 6(11):1123-32. PMID: 16200070
26. Huang W, Na L, Fidel PL, Schwarzenberger P. Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis 2004Aug 1; 190(3):624-31. PMID: 15243941
27. Ouyang W, Kolls JK, Zheng Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 2008Apr; 28(4):454-67. doi: 10.1016/j.immuni.2008.03.004 PMID: 18400188
28. Cope A, Le FG, Cardone J, Kemper C. The Th1 life cycle: molecular control of IFN-gamma to IL-10 switching. Trends Immunol 2011Jun; 32(6):278-86. doi: 10.1016/j.it.2011.03.010 PMID: 21531623
29. Koike E, Yanagisawa R, Takigami H, Takano H. Brominated flame retardants stimulate mouse immune cells in vitro. J Appl Toxicol 2013Dec; 33(12):1451-9. doi: 10.1002/jat.2809 PMID: 22972382
30. Lundgren M, Darnerud PO, Blomberg J, Friman G, Ilback NG. Polybrominated diphenyl ether exposure suppresses cytokines important in the defence to coxsackievirus B3 infection in mice. Toxicol Lett 2009Jan 30; 184(2):107-13. doi: 10.1016/j.toxlet.2008.10.021 PMID: 19022362
31. Koike E, Yanagisawa R, Takigami H, Takano H. Penta- and octa-bromodiphenyl ethers promote proinflammatory protein expression in human bronchial epithelial cells in vitro. Toxicol In Vitro 2014Mar; 28 (2):327-33. doi: 10.1016/j.tiv.2013.10.014 PMID: 24184330
32. LaA Guardia MJ, Hale RC, Harvey E. Detailed polybrominated diphenyl ether (PBDE) congener composition of the widely used penta-, octa-, and deca-PBDE technical flame-retardant mixtures. Environ Sci Technol 2006Oct 15; 40(20):6247-54. PMID: 17120549
33. Wirth JR, Peden-Adams MM, White ND, Bossart GD, Fair PA. In vitro exposure of DE-71, a penta-PBDE mixture, on immune endpoints in bottlenose dolphins (Tursiops truncatus) and B6C3F1 mice. J Appl Toxicol 2014Apr 7.
34. Frederiksen M, Thomsen C, Froshaug M, Vorkamp K, Thomsen M, Becher G, et al. Polybrominated diphenyl ethers in paired samples of maternal and umbilical cord blood plasma and associations with house dust in a Danish cohort. Int J Hyg Environ Health 2010Jul; 213(4):233-42. doi: 10.1016/j.ijheh.2010.04.008 PMID: 20471317
35. Groothuis FA, Heringa MB, Nicol B, Hermens JL, Blaauboer BJ, Kramer NI. Dose metric considerations in in vitro assays to improve quantitative in vitro-in vivo dose extrapolations. Toxicology 2015Jun 5; 332:30-40. doi: 10.1016/j.tox.2013.08.012 PMID: 23978460
36. Ali N, Harrad S, Goosey E, Neels H, Covaci A. "Novel" brominated flame retardants in Belgian and UK indoor dust: implications for human exposure. Chemosphere 2011May; 83(10):1360-5. doi: 10.1016/j.chemosphere.2011.02.078 PMID: 21458020
37. Dodson RE, Perovich LJ, Covaci A, Van den Eede N, Ionas AC, Dirtu AC, et al. After the PBDE phaseout: a broad suite of flame retardants in repeat house dust samples from California. Environ Sci Technol 2012Dec 18; 46(24):13056-66. doi: 10.1021/es303879n PMID: 23185960
38. Frederiksen M, Vorkamp K, Nielsen JB, Sørensen LS, Webster TF, Vazakas M, et al. Human exposure to novel flame retardants - from materials to humans. 76, 1344-1347. 2014. Organohalogen Compound.