Polybrominated diphenyl ethers and perfluoroalkyl substances in serum of pregnant women: Levels, correlations, and potential health implications

Archives of Environmental Contamination and Toxicology

Volumn 67, Issue 1, 2014, Pages 9-20

  Vorkamp, Katrin ^a   Nielsen, Flemming ^b   Kyhl, Henriette Boye ^c   Husby, Steffen ^c   Nielsen, Lars Bo ^d   Barington, Torben ^c   Andersson, Anna Maria ^d   Jensen, Tina Kold ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c ODENSE UNIVERSITY HOSPITAL   (Denmark)

^d Mental Health Services CPH   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID; PERFLEXANE; PERFLUORODECANOIC ACID; PERFLUORONONANOIC ACID; PERFLUOROOCTANESULFONIC ACID; PERFLUOROOCTANOIC ACID; POLYBROMINATED DIPHENYL ETHER; DIPHENYL ETHER DERIVATIVE; FLUOROCARBON; POLLUTANT;

ARTICLE; CONTROLLED STUDY; DENMARK; FEMALE; HUMAN; PREGNANT WOMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; ADULT; BLOOD; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; POLLUTANT; PREGNANCY; STATISTICS AND NUMERICAL DATA;

ADULT; DENMARK; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; FEMALE; FLUOROCARBONS; HALOGENATED DIPHENYL ETHERS; HUMANS; MATERNAL EXPOSURE; PREGNANCY;

EID: 84904727991     PISSN: 00904341     EISSN: 14320703     Source Type: Journal    
DOI: 10.1007/s00244-013-9988-z     Document Type: Article

References (75)

1. Antignac J-P, Cariou R, Zalko D, Berrebi A, Cravedi J-P, Maume D et al (2009) Exposure assessment of French women and their newborn to brominated flame retardants: determination of tri- to deca-polybromodiphenylethers (PBDE) in maternal adipose tissue, serum, breast milk and cord serum. Environ Pollut 157:164-173
2. Apelberg BJ, Witter FR, Herbstman JB, Calafat AM, Halden RU, Needham LL et al (2007) Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth. Environ Health Perspect 115(11):1670-1676
3. Boon JP, Lewis WE, Tjoen-A-Choy MR, Allchin CR, Law RJ, De Boer J et al (2002) Levels of polybrominated diphenyl ether (PBDE) flame retardants in animals representing different trophic levels of the North Sea food web. Environ Sci Technol 36:4025-4032
4. Burreau S, Zebühr Y, Broman D, Ishaq R (2004) Biomagnification of polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) studied in pike (Esox lucius), perch (Perca fluviatilis) and roach (Rutilus rutilus) from the Baltic Sea. Chemosphere 55:1043-1052
5. Covaci A, Voorspoels S (2005) Optimization of the determination of polybrominated diphenyl ethers in human serum using solidphase extraction and gas chromatography-electron capture negative ionization mass spectrometry. J Chromatogr B 827:216-223
6. Darnerud PO (2008) Brominated flame retardants as possible endocrine disrupters. Int J Androl 31:152-160
7. De Boer J, Wells DE (2006) Pitfalls in the analysis of brominated flame retardants in environmental, human and food samples-including results of three international interlaboratory studies. Trans Anal Chem 25(4):364-372
8. De Wit C, Herzke D, Vorkamp K (2010) Brominated flame retardants in the Arctic-trends and new candidates. Sci Total Environ 408:2885-2918
9. Ellis DA, Martin JW, De Silva A, Mabury SA, Hurley MD, Andersen M P S et al (2004) Degradation of fluorotelomer alcohols: a likely atmospheric source of perfluorinated carboxylic acids. Environ Sci Technol 38:3316-3321
10. Eriksen KT, Sørensen M, McLaughlin JK, Tjønneland A, Overvad K, Raaschou-Nielsen O (2011) Determinants of plasma PFOA and PFOS levels among 652 Danish men. Environ Sci Technol 45:8137-8143
11. Eskenazi B, Chevrier J, Rauch SA, Kogut K, Harley KG, Johnson C et al (2013) In utero and childhood polybrominated diphenyl ether (PBDE) exposures and neurodevelopment in the CHAMA-COS study. Environ Health Perspect 121(2):257-262
12. Fängström B, Athanassiadis I, Odsjö T, Norén K, Bergman Å (2008) Temporal trend of polybrominated diphenyl ethers and hexabromocyclododecane in milk from Stockholm mothers, 1980-2004. Mol Nutr Food Res 52:187-193
13. Fei C, McLaughlin JK, Tarone RE, Olsen J (2007) Perfluorinated chemicals and fetal growth: a study within the Danish National Birth Cohort. Environ Health Perspect 115(11):1677-1682
14. Fraser AJ, Webster TF, McClean MD (2009) Diet contributes significantly to the body burden of PBDEs in the general U. S. population. Environ Health Perspect 117(10):1520-1525
15. Fraser AJ, Webster TF, Watkins DJ, Nelson JW, Stapleton HM, Calafat AM et al (2012) Polyfluorinated compounds in serum linked to indoor air in office environments. Environ Sci Technol 46:1209-1215
16. Frederiksen M, Vorkamp K, Knudsen LE, Thomsen M (2009a) Human internal and external exposure to PBDEs-a review of levels and sources. Int J Hyg Environ Health 212:109-134
17. Frederiksen M, Thomsen M, Vorkamp K, Knudsen LE (2009b) Concentration levels and congener patterns of polybrominated diphenyl ethers (PBDEs) in placental tissue of women in Denmark. Chemosphere 76:1464-1469
18. Frederiksen M, Thomsen C, Frøyshaug M, Vorkamp K, Thomsen M, Becher G et al (2010a) Polybrominated diphenyl ethers in paired samples of maternal and umbilical cord blood plasma and associations with house dust in a Danish cohort. Int J Hyg Environ Health 213:233-242
19. Frederiksen M, Vorkamp K, Mathiesen L, Mose T, Knudsen LE (2010b) Transplacental transfer of the polybrominated diphenyl ethers BDE-47, BDE-99 and BDE-209 in a human placenta perfusion system. Environ Health 9:32
20. Fromme H, Tittlemier SA, Völkel W, Wilhelm M, Twardella D (2009) Perfluorinated compounds-exposure assessment for the general population in western countries. Int J Hyg Environ Health 212:239-270
21. Gascon M, Vrijheid M, Martínez D, Forns F, Grimalt JO, Torrent M et al (2011) Effects of pre- and postnatal exposure to low levels of polybromodiphenyl ethers on neurodevelopment and thyroid hormone levels at 4 years of age. Environ Int 37:605-611
22. Gascon M, Fort M, Martínez D, Carsin A-E, Forns J, Grimalt JO et al (2012) Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological developments in infants. Environ Health Perspect 120(12):1760-1765
23. Geyer HJ, Schramm K-W, Darnerud PO, Aune M, Feicht EA, Fried KW et al (2004) Terminal elimination half-lives of the brominated flame retardants TBBPA, HBCD, and lower brominated PBDEs in humans. Organohal Comp 66:3820-3825
24. Glynn A, Berger U, Bignert A, Ullah S, Aune M, Lignell S et al (2012) Perfluorinated alkyl acids in blood serum from primiparous women in Sweden: Serial sampling during pregnancy and nursing, and temporal trends 1996-2010. Environ Sci Technol 46:9071-9079
25. Gomara B, Herrero L, Ramos JJ, Mateo JR, Fernandez MA, Garcia JF et al (2007) Distribution of polybrominated diphenyl ethers in human umbilical cord serum, paternal serum, maternal serum, placentas, and breast milk from Madrid population, Spain. Environ Sci Technol 41:6961-6968
26. Grimvall E, Rylander L, Nilsson-Ehle P, Nilsson U, Strömberg U, Hagmar L et al (1997) Monitoring of polychlorinated biphenyls in human blood plasma: Methodological developments and influence of age, lactation, and fish consumption. Arch Environ Contam Toxicol 32:329-336
27. Hamm MP, Cherry NM, Chan E, Martin JW, Burstyn I (2010) Maternal exposure to perfluorinated acids and fetal growth. J Expos Sci Environ Epidemiol 20:589-597
28. Hardy ML (2002) A comparison of the properties of the major commercial PBDPO/PBDE product to those of major PBB and PCB products. Chemosphere 46:717-728
29. Harley KG, Marks AR, Chevrier J, Bradman A, Sjödin A, Eskenazi B (2010) PBDE concentrations in women's serum and fecundability. Environ Health Perspect 118(5):699-704
30. Harley KG, Chevrier J, Schall RA, Sjödin A, Bradman A, Eskenazi B (2011) Association of prenatal exposure to polybrominated diphenyl ethers and infant birth weight. Am J Epidemiol 174(8):885-892
31. Harrad S, Diamond M (2006) New directions: Exposure to polybrominated diphenyl etehrs (PBDEs) and polychlorinated biphenyls (PCBs): current and future scenarios. Atmos Environ 40:1187-1188
32. Harrad S, Wijesekera R, Hunter S, Halliwell C, Baker R (2004) Preliminary assessment of U. K. human dietary and inhalation exposure to polybrominated diphenyl ethers. Environ Sci Technol 38:2345-2350
33. Harrad S, De Wit CA, Abdallah MA-E, Bergh C, Björklund JA, Covaci A et al (2010) Indoor contamination with hexabromocyclododecanes, polybrominated diphenyl ethers, and perfluoroalkyl compounds: An important exposure pathway for people? Environ Sci Technol 44:3221-3231
34. Haug LS, Thomsen C, Becher G (2009) A sensitive method for determination of a broad range of perfluorinated compounds in serum suitable for large-scale human biomonitoring. J Chromatogr A 1216:385-393
35. Haug LS, Thomsen C, Brantsæter AL, Kvalem HE, Haugen M, Becher G et al (2010) Diet and particularly seafood are major sources of perfluorinated compounds in humans. Environ Int 36:772-778
36. Haug LS, Huber S, Becher G, Thomsen C (2011) Characterisation of human exposure pathways to perfluorinated compounds-comparing exposure estimates with biomarkers of exposure. Environ Int 37:687-693
37. Herbstman JB, Sjödin A, Kurzon M, Lederman SA, Jones RS, Rauh V et al (2010) Prenatal exposure to PBDEs and neurodevelopment. Environ Health Perspect 118(5):712-719
38. Hoffman K, Adgent M, Goldman BD, Sjödin A, Daniels JL (2012) Lactational exposure to polybrominated diphenyl ethers and its relation to social and emotional development among toddlers. Environ Health Perspect 120(10):1438-1442
39. Hölzer J, Göen T, Just P, Reupert R, Rauchfuss K, Kraft M et al (2011) Perfluorinated compounds in fish and blood of anglers at Lake Möhne, Sauerland area, Germany. Environ Sci Technol 45:8046-8052
40. Inoue K, Okada F, Ito R, Kato S, Sasaki S, Nakajima S et al (2004) Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds in human maternal and cord blood samples: assessment of PFOS exposure in a susceptible population during pregnancy. Environ Health Perspect 112(11):1204-1207
41. Jones PD, Hu W, De Coen W, Newsted JL, Giesy JP (2003) Binding of perfluorinated fatty acids to serum proteins. Environ Toxicol Chem 22(11):2639-2649
42. Kalantzi OI, Geens T, Covaci A, Siskos PA (2011) Distribution of polybrominated diphenyl ethers (PBDEs) and other persistent organic pollutants in human serum from Greece. Environ Int 37:349-353
43. Karlsson M, Julander A, Van Bavel B, Hardell L (2007) Levels of brominated flame retardants in blood in relation to levels in household air and dust. Environ Int 33:62-69
44. Kato K, Wong L-Y, Jia LT, Kuklenyik Z, Calafat AM (2011) Trends in exposure to polyfluoroalkyl chemicals in the U. S. population: 1999-2008. Environ Sci Technol 45:8037-8045
45. Kiviranta H, Ovaskainen M-L, Vartiainen T (2004) Market basket study on dietary intake of PCDD/Fs, PCBs, and PBDEs in Finland. Environ Int 30:923-932
46. La Guardia MJ, Hale RC, Harvey E (2006) Detailed polybrominated diphenyl ether (PBDE) congener composition of the widely used penta-, octa- and deca-PBDE technical flame-retardant mixtures. Environ Sci Technol 40:6247-6254
47. Lau C, Anitole K, Hodes C, Lai D, Pfahles-Hutchens A, Seed J (2007) Perfluoroalkyl acids: a review of monitoring and toxicological findings. Toxicol Sci 99(2):366-394
48. Lee H, Mabury SA (2011) A pilot survey of legacy and current commercial fluorinated chemicals in human sera from United States donors in 2009. Environ Sci Technol 45:8067-8074
49. Main KM, Kiviranta H, Virtanen HE, Sundqvist E, Tuomisto JT, Tuomisto J et al (2007) Flame retardants in placenta and breast milk and crytorchidism in newborn boys. Environ Health Perspect 115(10):1519-1526
50. Olsen GW, Burris JM, Ehresman DJ, Froehlich JW, Seacat AM, Butenhoff JL et al (2007) Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers. Environ Health Perspect 115(9):1298-1305
51. Phillips DL, Perkle JL, Burse VW, Bernert JT, Henderson LO, Needham LL (1989) Chlorinated hydrocarbon levels in human serum: effects of fasting and feeding. Arch Environ Contam Toxicol 18(4):495-500
52. Roosens L, Abdallah MA-E, Harrad S, Neels H, Covaci A (2009) Factors influencing concentrations of polybrominated diphenyl ethers (PBDEs) in students from Antwerp, Belgium. Environ Sci Technol 43:3535-3541
53. Roosens L, D'Hollander W, Bervoets L, Reynders H, Van Campenhout K, Cornelis C et al (2010) Brominated flame retardants and perfluorinated chemicals, two groups of persistent contaminants in Belgian human blood and milk. Environ Pollut 158:2546-2552
54. Roze E, Meijer L, Bakker A, Van Braeckel K N J A, Sauer P J J, Bos AF (2009) Prenatal exposure to organohalogens, including brominated flame retardants, influences motor, cognitive and behavioural performance at school age. Environ Health Perspect 117(12):1953-1958
55. Savitz DA, Stein CR, Bartell SM, Elston B, Gong J, Shin H-M et al (2012) Perfluorooctanoic acid exposure and pregnancy outcome in a highly exposed community. Epidemiology 23(3):386-392
56. Schecter A, Päpke O, Tung KC, Joseph J, Harris TR, Dahlgren J (2005) Polybrominated diphenyl ether flame retardants in the U. S. population: Current levels, temporal trends, and comparison with dioxins, dibenzofurans, and polychlorinated biphenyls. J Occup Environ Med 47(3):199-211
57. Staskal D, Hakk H, Bauer D, Diliberto JJ, Birnbaum LS (2006) Toxicokinetics of polybrominated diphenyl ether congeners 47, 99, 100, and 153 in mice. Toxicol Sci 94(1):28-37
58. Steenland K, Fletcher T, Savitz DA (2010) Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA). Environ Health Perspect 118(8):1100-1108
59. Stein CR, Savitz DA, Dougan M (2009) Serum levels of perfluorooctanoic acid and perfluorooctane sulfonate and pregnancy outcome. Am J Epidemiol 170(7):837-846
60. Stein CR, Wolff MS, Calafat AM, Kato K, Engel SM (2012) Comparison of polyfluoroalkyl compound concentrations in maternal serum and amniotic fluid: a pilot study. Reprod Toxicol 34:312-316
61. Thomsen C, Liane VH, Becher G (2007) Automated solid-phase extraction for the determination of polybrominated diphenyl ethers and polychlorinated biphenyls in serum-application on archived Norwegian samples from 1977 to 2003. J Chromatogr B 846:252-263
62. Thomsen C, Stigum H, Frøshaug M, Broadwell SL, Becher G, Eggesbø M (2010) Determinants of brominated flame retardants in breast milk from a large scale Norwegian study. Environ Int 36:68-74
63. Thuresson K, Höglund P, Hagmar L, Sjödin A, Bergman Å, Jakobsson K (2006) Apparent half-lives of hepta- to decabrominated diphenyl ethers in human serum as determined in occupationally exposed workers. Environ Health Perspect 114(2):176-181
64. Tomy GT, Budakowski W, Halldorson T, Helm PA, Stern GA, Friesen K et al (2004) Fluorinated organic compounds in an eastern Arctic marine food web. Environ Sci Technol 38:6475-6481
65. Vestergaard S, Nielsen F, Andersson A-M, Hjøllund NH, Grandjean P, Andersen HR et al (2012) Associations between perfluorinated compounds and time to pregnancy in a prospective cohort of Danish couples attempting to conceive. Hum Reprod 27(3):873-880
66. Vestergren R, Cousins IT (2009) Tracking the pathways of human exposure to perfluorocarboxylates. Environ Sci Technol 43:5565-5575
67. Viberg H, Fredriksson A, Eriksson P (2003) Neonatal exposure to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors in adult mice. Toxicol Appl Pharmacol 192:95-106
68. Vizcaino E, Grimalt JO, Lopez-Espinosa M-J, Llop S, Bebagliato M, Ballester F (2011) Polybromodiphenyl ethers in mothers and their newborns from non-occupationally exposed population (Valencia, Spain). Environ Int 37:152-157
69. Voorspoels S, Covaci A, Neels H, Schepens P (2007) Dietery PBDE intake: a market-basket study in Belgium. Environ Int 33:93-97
70. Vorkamp K (2012) Brominated flame retardants: Biomarkers and human biomonitoring. In: Knudsen LE, Merlo DF (eds) Biomarkers and human biomonitoring. Volume 1: Ongoing programs and exposures. Issues in Toxicology No. 9, Royal Society of Chemistry, UK, pp. 288-321
71. Vorkamp K, Christensen JH, Riget F (2004) Polybrominated diphenyl ethers and organochlorine compounds in biota from the marine environment of East Greenland. Sci Total Environ 331(1-3):143-155
72. Vorkamp K, Thomsen M, Falk K, Leslie H, Møller S, Sørensen PB (2005) Temporal development of brominated flame retardants in peregrine falcon (Falco peregrinus) eggs from South Greenland (1986-2003). Environ Sci Technol 39:8199-8206
73. Vorkamp K, Thomsen M, Frederiksen M, Pedersen M, Knudsen LE (2011) Polybrominated diphenyl ethers (PBDEs) in the indoor environment and associations with prenatal exposure. Environ Int 37:1-10
74. Washino N, Saijo Y, Sasaki S, Kato S, Ban S, Konishi K et al (2009) Correlations between prenatal exposure to perfluorinated chemicals and decreased fetal growth. Environ Health Perspect 117(4):660-667
75. Zhu L, Ma B, Hites RA (2009) Brominated flame retardants in serum from the general population in Northern China. Environ Sci Technol 43:6963-6968