Immunotoxicity of the commercial polybrominated diphenyl ether mixture DE-71 in ranch mink (Mustela vison)

Environmental Toxicology and Chemistry

Volumn 26, Issue 5, 2007, Pages 988-997

  Martin, Pamela A ^a   Mayne, Greg J ^a   Bursian, Steven J ^b   Tomy, Gregg ^c   Palace, Vince ^c   Pekarik, Cynthia ^a   Smits, Judit ^d  

^a ENVIRONMENT CANADA   (Canada)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c FRESHWATER INSTITUTE   (Canada)

^d UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Flame retardants; Immunotoxicology; Mink; Polybrominated diphenyl ethers

Indexed keywords

ANTIBODIES; BIOACCUMULATION; ECOSYSTEMS; FLAME RETARDANTS; HISTOLOGY; MIXTURES;

IMMUNOLOGICAL EFFECTS; IMMUNOTOXICOLOGY; ORGANOHALOGEN COMPOUNDS; POLYBROMINATED DIPHENYL ETHERS;

TOXICITY;

2,4 DINITROPHENOL; ANTIBODY; ETHOXYRESORUFIN DEETHYLASE; KEYHOLE LIMPET HEMOCYANIN; PHYTOHEMAGGLUTININ; POLYBROMINATED DIPHENYL ETHER;

ANTIBODY; DIET; DOSE-RESPONSE RELATIONSHIP; IMMUNOASSAY; MUSTELID; PBDE; PHYSIOLOGICAL RESPONSE; TOXICITY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MASS; CELL HYPERPLASIA; CONTROLLED STUDY; ENZYME ACTIVITY; FOOD INTAKE; GERMINAL CENTER; HEMATOCRIT; HEMATOLOGICAL PARAMETERS; HEMATOLOGY; HISTOPATHOLOGIC SKIN REACTION; HUMORAL IMMUNITY; IMMUNOTOXICITY; MALE; MINK; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; SPLEEN; TOXICOKINETICS; WEIGHT REDUCTION;

ANIMALS; B-LYMPHOCYTES; CANADA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FOOD CONTAMINATION; GERMINAL CENTER; GREAT LAKES REGION; MICROSOMES, LIVER; MINK; PHENYL ETHERS; POLYBROMINATED BIPHENYLS; POLYCHLORINATED BIPHENYLS; SPLEEN; UNITED STATES;

GREAT LAKES; NORTH AMERICA;

MUSTELA; MUSTELA VISON;

EID: 33847264041     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/06-246R.1     Document Type: Article

References (51)

1. Hall AJ, Law RJ, Ross M, Kennedy S, Allchin CR, Campbell LA, Pomeroy PP. 1992. Organochlorine levels in common seals (Phoca vitulina) which were victims and survivors of the 1988 phocine distemper epizootic. Sci Total Environ 115:145-162.
2. De Swart RL, Ross PS, Vedder LJ, Timmerman HH, Heisterkamp SJ, van Loveren H, Vos JG, Reijnders PJH, Osterhaus AD. 1994. Impairment of immune function in harbor seals (Phoca vitulina) feeding on fish from polluted waters. Ambio 23:155-159.
3. Beckman KB, Blake JE, Ylitalo GM, Stott JL, O'Hara TM. 2003. Organochlorine contaminant exposure and associations with hematological and humoral immune functional assays with damage as a factor in free-ranging northern fur seal pups (Callorhinus ursinus). Mar Pollut Bull 46:594-606.
4. Grasman KA, Scanlon PF, Fox GA. 1998. Reproductive and physiological effects of environmental contaminants in fish-eating birds of the Great Lakes: A review of historical trends. Environ Monit Assess 53:117-145.
5. Grasman KA, Fox GA. 2004. Associations between altered immune function and organochlorine contamination in young Caspian terns (Sterna caspia) from Lake Huron, 1997-1999. Ecotoxicology 10:101-114.
6. Marvin CH, Painter S, Charlton MN, Fox ME, Thiessen PAL. 2003. Trends in spatial and temporal levels of persistent organic pollutants in Lake Erie sediments. Chemosphere 54:33-40.
7. Norstrom RJ, Simon M, Moisey J, Wakeford B, Weseloh DVC. 2002. Geographical distribution (2000) and temporal trends (1981-2000) of brominated diphenyl ethers in Great Lakes herring gull eggs. Environ Sci Technol 36:4783-4789.
8. de Wit CA. 2002. An overview of brominated flame retardants in the environment. Chemosphere 46:583-624.
9. Luross JM, Alaee M, Sergeant DB, Whittle DM, Solomon KR. 2000. Spatial and temporal distribution of polybrominated diphenyl ethers in lake trout from the Great Lakes. Organohalogen Compounds 47:73-76.
10. Gilbert FF, Nancekivell EG. 1982. Food habits of mink (Mustela vison) and otter (Lutra canadensis) in northeastern Alberta. Can J Zool 60:1282-1288.
11. Aulerich RJ, Bursian SJ, Breslin WJ, Olson BA, Ringer RK. 1985. Toxicological manifestations on 2,4,5, 2′,4′,5′-, 2,3,6, 2′,3′,6′-and 3,4,5, 3′,4′,5′- hexachlorobiphenyl and Aroclor 1254 in mink. J Toxicol Environ Health 15:63-79.
12. Wren CD. 1991. Cause-effect linkages between chemicals and populations of mink (Mustela vison) and otter (Lutra canadensis) in the Great Lakes basin. J Toxicol Environ Health 33:549-585.
13. Heaton SN, Bursian SJ, Giesy JP, Tillitt DE, Render JA, Jones PD, Verbrugge DA, Kubiak TJ, Aulerich RJ. 1995. Dietary exposure of mink to carp from Saginaw Bay, Michigan. I: Effects on reproduction and survival, and the potential risks to wild mink populations. Arch Environ Contam Toxicol 28:334-343.
14. Heaton SN, Bursian SJ, Giesy JP, Tillitt DE, Render JA, Jones PD, Verbrugge DA, Kubiak TJ, Aulerich RJ. 1995. Dietary exposure of mink to carp from Saginaw Bay, Michigan: 2. Hematology and liver pathology. Arch Environ Contam Toxicol 29: 411-417.
15. Restum JC, Bursian SJ, Giesy JP, Render J A, Helferich WG, Shipp EB, Verbrugge DA, Aulerich RJ. 1998. Multigenerational study of the effects of consumption of PCB-contaminated carp from Saginaw Bay, Lake Huron, on mink. 1. Effects on mink reproduction, kit growth and survival, and selected biological parameters. J Toxicol Environ Health 54:343-375.
16. Darnerud PO, Thuvander A. 1998. Studies on immunological effects of polybrominated diphenyl ethers (PBDE) and polychlorinated biphenyls (PCB) exposure in rats and mice. Organohalogen Compounds 35:415-418.
17. Thuvander A, Darnerud PO. 1999. Effects of polybrominated diphenyl ether (PBDE) and polychlorinated biphenyl (PCB) on some immunological parameters after oral exposure in rats and mice. Toxicol Environ Chem 70:229-242.
18. Fowles JR, Fairbrother A, Baecher-Steppan L, Kerkvliet NI. 1994. Immunologic and endocrine effects of the flame-retardant pentabromoninated diphenyl ether (DE-71) in C57BL/6J mice. Toxicology 86:49-61.
19. Orn U, Klasson-Wehler E. 1998. Metabolism of 2,2′,4,4′- tetrabromodiphenyl ether in rat and mouse. Xenobiotica 28:199-211.
20. Hakk H, Letcher RJ. 2003. Metabolism in the toxicokinetics and fate of brominated flame retardants - A review. Environ Int 29: 801-828.
21. Tomy GT, Palace VP, Halldorson T, Braekevelt E, Danell R, Wautier K, Evans B, Brinkworth L, Fisk AT. 2004. Bioaccumulation, biotransformation and biochemical effects of brominated diphenyl ethers in juvenile lake trout (Salvelinus namaycush). Environ Sci Technol 38:1496-1504.
22. Von Meyerinck L, Hufnagel B, Schmoldt A, Benthe HF. 1990. Induction of rat liver microsomal cytochrome P-450 by the pentabromodiphenyl ether Bromkal 70 and half-lives of its components in the adipose tissue. Toxicology 61:259-274.
23. Chernyak S IM, Rice CP, Quintal RT, Begnoche LJ, Hickey J P, Vinyard BT. 2005. Time trends (1983-1999) for organochlorines and polybrominated diphenyl ethers in rainbow smelt (Osmerus mordax) from Lakes Michigan, Huron, and Superior, USA. Environ Toxicol Chem 24:1632-1641.
24. Hale RC, La Guardia MJ, Harvey EP, Mainor TM, Duff WH, Gaylor MO. 2001. Polybrominated diphenyl ether flame retardants in Virginia freshwater fishes (USA). Environ Sci Technol 35:4585-4591.
25. Johnson A, Olson N. 2001. Analysis and occurrence of polybrominated diphenyl ethers in Washington state freshwater fish. Arch Environ Contam Toxicol 41:339-344.
26. Kennedy SW, Jones SP. 1994. Simultaneous measurement of cytochrome P4501A catalytic activity and total protein concentration with a fluorescence plate reader. Anal Biochem 222:217-223.
27. Shields CA, Eales JG. 1986. Thyroxine 5′-monodeiodinase activity in hepatocytes of rainbow trout, Salmo gairdneri: Distribution, effects of starvation and exogenous inhibitors. Gen Comp Endocrinol 63:334-343.
28. Zar J. 1994. Biostatistical Analysis, 2nd ed. Prentice Hall, Englewood Cliffs, NJ, USA.
29. Aulerich RJ, Powell DC, Bursian SJ. 1999. Handbook of Biological Data for Mink. Michigan State University, East Lansing, MI, USA.
30. Bursian SJ, Beckett KJ, Yamini B, Martin PA, Kannan K, Shields KL, Mohr FC. 2006. Assessment of effects in mink caused by consumption of carp collected from the Saginaw River, Michigan, USA. Arch Environ Contam Toxicol 50:614-623.
31. Hardy ML. 2002. A comparison of the properties of the major commercial PBDO/PBDE product to those of major PBB and PCB products. Chemosphere 46:717-728.
32. Stapleton HM, Alaee M, Letcher RJ, Baker JE. 2004. Debromination of the flame retardant decabromodiphenyl ether by juvenile carp (Cyprinus carpio) following dietary exposure. Environ Sci Technol 38:112-119.
33. Smits JEG, Bortolotti GR. 2001. Antibody-mediated immunotoxicity in American kestrels (Falco sparverius) exposed to polychlorinated biphenyls. J Toxicol Environ Health 62:217-226.
34. Grasman KA, Scanlon PR Fox GA. 2000. Geographic variation in hematological variables in adult and prefledgling herring gulls (Larus argentatus) and possible associations with organochlorine exposure. Arch Environ Contam Toxicol 38:244-253.
35. Smits JEG, Blakley BR, Wobeser GA. 1996. Immunotoxicity studies in mink (Mustela vison) chronically exposed to dietary bleached kraft pulp mill effluent. J Wildl Dis 32:199-208.
36. Ross PS, De Swart RL, Reijnders PJH, Van Loveren H, Vos JG, Osterhaus ADME. 1995. Contaminant-related suppression of delayed-type hypersensitivity and antibody responses in harbor seals fed herring from the Baltic Sea. Environ Health Perspect 103: 162-167.
37. Vos JG, Van Logten MJ, Kreeftenberg JG, Kruizinga W 1979. Hexachlorobenzene-induced stimulation of the humoral immune response in rats. Ann N Y Acad Sci 320:535-550.
38. Michielsen CPPC, Bloksma N, Ultee A, Van Mil F, Vos JG. 1997. Hexachlorobenzene-induced immunomodulation and skin and lung lesions: A comparison between Brown, Norway, Lewis, and Wistar rat. Toxicol Appl Pharmacol 144:12-26.
39. Smits JEG, Haines DM, Blakley BR, Wobeser GA. 1996. Enhanced antibody responses in mink (Mustela vison) exposed to dietary bleached draft pulp mill effluent. Environ Toxicol Chem 15:1166-1170.
40. Smits JEG, Godson DL. 1996. Assessment of humoral immune response in mink (Mustela vison): Antibody production and detection. J Wildl Dis 32:358-364.
41. Ulrich P, Paul G, Perentes E, Mahl A, Roman D. 2004. Validation of immune function testing during a 4-week oral toxicity study with FK506. Toxicol Lett 149:123-131.
42. Abbas AK, Lichtman AH, Pober JS. 1991. Cellular and Molecular Immunology. W.B. Saunders, Philadelphia, PA, USA.
43. Franchimont D, Galon J, Gadina M, Visconti R, Zhou Y, Aringer M, Frucht DM, Chrousos GP, O'Shea JJ. 2000. Inhibition of Th1 immune response by glucocorticoids: Dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes. Immunology 164:1768-1774.
44. Harvey S, Phillips JG, Rees A, Hall TR. 1984. Stress and adrenal function. J Exp Zool 232:633-645.
45. Edelbauer M, Gerstmayr M, Loibichler C, Jost E, Huemer M, Urbanek R, Szépfalusi Z. 2002. Glucocorticoids enhance interleukin-4 production to neo-antigen (hyaluronidase) in children immunocompromised with cytostatic drugs. Pediatric Allergy and Immunology 13:1399-1438.
46. Spensely MS, Carlson GP, Harrold D. 1987. Plasma, red blood cell, total blood, and extracellular fluid volumes in health horse foals during growth. Am J Vet Res 48:1703-1707.
47. Aengwanich W, Chinrasri O. 2003. Effect of dexamethasone on differential white blood cell counts and heterophil/lymphocyte ratio in Japanese quails (Cotunix coturnix japonica). Songklanakarin Journal of Science and Technology 25:183-189.
48. Lyche JL, Larsen HJS, Skaare JU, Tverdal A, Dahl E, Johansen GM, Ropstad E. 2004. Effects of perinatal exposure to low doses of PCB 153 and PCB 126 on lymphocyte proliferation and hematology in goat kids. J Toxicol Environ Health A 67:889-904.
49. Latimer KS, Mahaffey EA, Prasse KW. 2003. Duncan and Prasse's Veterinary Laboratory Medicine; Clinical Pathology, 4th ed. Iowa State University Press, Ames, IA, USA.
50. Neale JCC, Gulland FMD, Schmelzer KR, Harvey JT, Berg EA, Allen SG, Greig DJ, Grigg EK, Tjeerdema RS. 2005. Contaminant loads and hematological correlates in the harbor seal (Phoca vitulina) of San Francisco Bay, California. J Toxicol Environ Health A 68:617-633.
51. Martin PA, McDaniel T, Hunter B. 2006. Temporal trends in chlorinated hydrocarbon concentrations in mink in Canadian Lake Erie - 1978 to 2002. Environ Monit Assess 113:245-263.