Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T-cell activation

EMBO Journal

Volumn 35, Issue 11, 2016, Pages 1160-1174

  Bouchet, Jérôme ^a,b,c,e   Del Río Iñiguez, Iratxe ^a,b,c   Lasserre, Rémi ^a,b   Agüera Gonzalez, Sonia ^a,b,f   Cuche, Céline ^a,b,c,g   Danckaert, Anne ^a   McCaffrey, Mary W ^d   Di Bartolo, Vincenzo ^a,b,c   Alcover, Andrés ^a,b,c  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

^c INSERM   (France)

^d UNIVERSITY COLLEGE CORK   (Ireland)

^e INSTITUT COCHIN   (France)

^f AIX MARSEILLE UNIVERSITY   (France)

^g INSTITUT CURIE   (France)

Author keywords

actin cytoskeleton; immunological synapse; intracellular traffic; Rab11 FIP3; Rac1; recycling endosomes

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; ACTIN; FIP3 PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; INTERLEUKIN 2; POLYLYSINE; RAB11 PROTEIN; RAC1 PROTEIN; UNCLASSIFIED DRUG; I KAPPA B KINASE; IKBKG PROTEIN, HUMAN; IL2 PROTEIN, HUMAN; RAB PROTEIN; RAC1 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ACTIN FILAMENT; AMINO ACID SUBSTITUTION; ARTICLE; CELL SPREADING; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOSOME; GENETIC TRANSFECTION; HEK293 CELL LINE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOLOGICAL SYNAPSE; IMMUNOPRECIPITATION; LYMPHOCYTE MIGRATION; PRIORITY JOURNAL; PROTEIN TARGETING; REGULATORY MECHANISM; SURFACE PROPERTY; T LYMPHOCYTE ACTIVATION; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL LINE; GENETICS; JURKAT CELL LINE; METABOLISM;

ACTINS; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CELLS, CULTURED; ENDOSOMES; HUMANS; I-KAPPA B KINASE; IMMUNOLOGICAL SYNAPSES; INTERLEUKIN-2; JURKAT CELLS; RAB GTP-BINDING PROTEINS; RAC1 GTP-BINDING PROTEIN; RNA, SMALL INTERFERING;

EID: 84966377249     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201593274     Document Type: Article

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